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Human Trafficking

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3301. Trafficking and health Full Text available with Trip Pro

Trafficking and health 15178619 2004 06 18 2018 11 13 1756-1833 328 7452 2004 Jun 05 BMJ (Clinical research ed.) BMJ Trafficking and health. 1369-71 Busza Joanna J Centre for Population Studies, London School of Hygiene and Tropical Medicine, London WC1B 3DP. joanna.busza@lshtm.ac.uk Castle Sarah S Diarra Aisse A eng Journal Article England BMJ 8900488 0959-8138 AIM IM Cambodia Child Child Abuse Employment legislation & jurisprudence statistics & numerical data Female Health Policy Health (...) Status Humans Mali Risk-Taking Sex Work legislation & jurisprudence statistics & numerical data Transients and Migrants legislation & jurisprudence statistics & numerical data Vietnam 2004 6 5 5 0 2004 6 24 5 0 2004 6 5 5 0 ppublish 15178619 10.1136/bmj.328.7452.1369 328/7452/1369 PMC420297 Lancet. 2003 Jun 7;361(9373):1983 12801757 Reprod Health Matters. 2001 May;9(17):72-81 11468849

2004 BMJ : British Medical Journal

3302. Trafficking in women: the Canadian perspective Full Text available with Trip Pro

Trafficking in women: the Canadian perspective 15997036 2005 10 14 2008 11 20 1488-2329 173 1 2005 Jul 05 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Trafficking in women: the Canadian perspective. 25-6 Stewart Donna E DE Women's Health Program, University Health Network, University of Toronto, Ont. Gajic-Veljanoski Olga O eng Journal Article Canada CMAJ 9711805 0820-3946 AIM IM Adult Canada Child Child Welfare Commerce Crime Victims Education (...) Emigration and Immigration Female Human Rights Humans Public Policy Social Problems Women's Health 2005 7 6 9 0 2005 10 15 9 0 2005 7 6 9 0 ppublish 15997036 173/1/25 10.1503/cmaj.1041360 PMC1167803

2005 CMAJ : Canadian Medical Association Journal

3303. Children are main victims of trafficking in Africa Full Text available with Trip Pro

Children are main victims of trafficking in Africa 15117787 2004 05 19 2012 03 06 1756-1833 328 7447 2004 May 01 BMJ (Clinical research ed.) BMJ Children are main victims of trafficking in Africa. 1036 Fleck Fiona F eng News England BMJ 8900488 0959-8138 AIM IM Adolescent Africa Child Child Abuse Emigration and Immigration Humans Poverty Social Problems 2004 5 1 5 0 2004 5 20 5 0 2004 5 1 5 0 ppublish 15117787 10.1136/bmj.328.7447.1036-b 328/7447/1036-b PMC403882

2004 BMJ : British Medical Journal

3304. Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking Full Text available with Trip Pro

Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking Yeast Nhx1 [Na+(K+)/H+ exchanger 1] is an intracellular Na+(K+)/H+ exchanger, localizing to the late endosome where it is important for ion homoeostasis and vesicle trafficking. Phylogenetic analysis of NHE (Na+/H+ exchanger) sequences has identified orthologous proteins, including HsNHE6 (human NHE6), HsNHE7 and HsNHE9 of unknown physiological role. These appear (...) distinct from well-studied mammalian plasma membrane isoforms (NHE1-NHE5). To explore the differences between plasma membrane and intracellular NHEs and understand the link between ion homoeostasis and vesicle trafficking, we examined the consequence of replacing residues in the intramembranous H10 loop of Nhx1 between transmembrane segments 9 and 10. The critical role for the carboxy group of Glu355 in ion transport is consistent with the invariance of this residue in all NHEs. Surprisingly, residues

2006 Biochemical Journal

3305. MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells Full Text available with Trip Pro

MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells The hemopexin-like domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) enables MT1-MMP to form oligomers that facilitate the activation of pro-matrix metalloproteinase-2 (pro-MMP-2) at the cell surface. To investigate the role of the MT1-MMP hemopexin domain in the trafficking of MT1-MMP to the cell surface we have examined the activity of two MT1-MT4-MMP (...) chimaeras in which the hemopexin domain of MT1-MMP has been replaced with that of human or mouse MT4-MMP. We show that MT1-MMP bearing the hemopexin domain of MT4-MMP was incapable of activating pro-MMP-2 or degrading gelatin in cell based assays. Furthermore, cell surface biotinylation and indirect immunofluorescence show that transiently expressed MT1-MT4-MMP chimaeras failed to reach the plasma membrane and were retained in the endoplasmic reticulum. Functional activity could be restored by replacing

2006 Biochemical Journal

3306. Policies to prevent firearm trafficking Full Text available with Trip Pro

Policies to prevent firearm trafficking 17446245 2007 09 04 2018 11 13 1353-8047 13 2 2007 Apr Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention Inj. Prev. Policies to prevent firearm trafficking. 78-9 Vernick Jon S JS Johns Hopkins Center for Gun Policy and Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. jvernick@jhsph.edu Webster Daniel W DW eng Journal Article Review England Inj Prev 9510056 1353-8047 IM (...) Commerce legislation & jurisprudence Crime prevention & control Firearms legislation & jurisprudence Humans Licensure Public Policy United States 24 2007 4 21 9 0 2007 9 5 9 0 2007 4 21 9 0 ppublish 17446245 13/2/78 10.1136/ip.2007.015487 PMC2610592 J Urban Health. 2006 Sep;83(5):778-87 16937085 Inj Prev. 2006 Dec;12(6):365-72 17170183 J Law Med Ethics. 2006 Winter;34(4):765-75 17199819 Inj Prev. 1999 Dec;5(4):259-63 10628912 Inj Prev. 2006 Aug;12(4):225-30 16887943 Inj Prev. 2003 Jun;9(2):147-50

2007 Injury Prevention

3307. Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways Full Text available with Trip Pro

Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways Establishing a complete pathway which links occupancy of the insulin receptor to GLUT4 translocation has been particularly elusive because of the complexities involved in studying both signalling and membrane trafficking processes. However, Lienhard's group has now discovered two related molecules that could function in this linking role. These proteins, Tbc1d4 (also known as AS160) and now Tbc1d1, as reported (...) in this issue of the Biochemical Journal, have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt (protein kinase B) and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. The data from Leinhard and colleagues suggest that high levels of Rab GAP activity lead to suppression of GLUT4 translocation and this observation has wide significance and is likely to be relevant to the recent discovery that mutations in the Tbc1d1 gene lead

2007 Biochemical Journal

3308. Israeli transplant surgeon is arrested for suspected organ trafficking Full Text available with Trip Pro

Israeli transplant surgeon is arrested for suspected organ trafficking 17494004 2007 05 22 2012 03 06 1756-1833 334 7601 2007 May 12 BMJ (Clinical research ed.) BMJ Israeli transplant surgeon is arrested for suspected organ trafficking. 973 Sarig Merav M eng News England BMJ 8900488 0959-8138 AIM IM Humans Israel Kidney Transplantation legislation & jurisprudence Tissue and Organ Procurement legislation & jurisprudence 2007 5 12 9 0 2007 5 23 9 0 2007 5 12 9 0 ppublish 17494004 334/7601/973

2007 BMJ : British Medical Journal

3309. Copper Trafficking and Extracellular Superoxide Dismutase Activity: Kinky Hair, Kinky Vessels Full Text available with Trip Pro

Copper Trafficking and Extracellular Superoxide Dismutase Activity: Kinky Hair, Kinky Vessels 18768396 2008 11 13 2018 11 13 1524-4563 52 5 2008 Nov Hypertension (Dallas, Tex. : 1979) Hypertension Copper trafficking and extracellular superoxide dismutase activity: kinky hair, kinky vessels. 811-2 10.1161/HYPERTENSIONAHA.108.117770 Rudolph Volker V Rudolph Tanja K TK Freeman Bruce A BA eng R01 HL058115 HL NHLBI NIH HHS United States R01 HL064937 HL NHLBI NIH HHS United States HL58115 HL NHLBI (...) NIH HHS United States R01 HL64937 HL NHLBI NIH HHS United States Editorial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment 2008 09 02 United States Hypertension 7906255 0194-911X 0 Cation Transport Proteins 31C4KY9ESH Nitric Oxide 789U1901C5 Copper EC 1.15.1.1 Superoxide Dismutase EC 3.6.1.- Adenosine Triphosphatases EC 3.6.3.54 ATP7A protein, human EC 3.6.3.54 Copper-transporting ATPases IM Hypertension. 2008 Nov;52(5):945-51 18768397 Adenosine Triphosphatases

2008 Hypertension

3310. Prolactin Activation of Srcs Accelerates Receptor Internalization, Modulating Trafficking and Signaling in Breast Cancer Cells. Full Text available with Trip Pro

Prolactin Activation of Srcs Accelerates Receptor Internalization, Modulating Trafficking and Signaling in Breast Cancer Cells. Despite the growing body of evidence supporting prolactin (PRL) actions in human breast cancer, little is known regarding PRL regulation of its own receptor in these cells. Ligand-initiated endocytosis is a key process in the regulation of receptor availability and signaling cascades that may lead to oncogenic actions. Although exposure to exogenous PRL accelerates (...) for optimal phosphorylation of ERK1/2 and Akt, but not for Janus kinase 2 or signal transducer and activator of transcription 5, indicating that internalization selectively modulates signaling cascades. Together, these data indicate that SFKs are key mediators of ligand-initiated lPRLR internalization, down-regulation, and signal transduction in breast cancer cells, and underscore the importance of target cell context in receptor trafficking and signal transduction.

2008 Molecular Endocrinology

3311. Phosphorylation-dependent interaction with 14-3-3 regulates Bad trafficking in retinal ganglion cells. Full Text available with Trip Pro

Phosphorylation-dependent interaction with 14-3-3 regulates Bad trafficking in retinal ganglion cells. To focus on the proteomic analysis of 14-3-3 proteins and to determine their cellular localization and functional role during glaucomatous neurodegeneration.Complementary proteomic approaches were used to identify phosphorylated proteins in a chronic pressure-induced rat model of glaucoma. To detect interacting proteins, specific protein complexes were eluted using coimmunoprecipitation (...) and recombinant protein-based affinity pull-down for subsequent mass spectrometric analysis. Western blot analysis was performed for validation of the proteomic findings, and immunohistochemical analysis of rat eyes and human donor eyes determined the cellular localization of 14-3-3 proteins. In addition, in vivo treatment experiments were conducted using JNK and protein phosphatase inhibitors.Findings of mass spectrometry, Western blotting, and tissue immunolabeling revealed the presence of different 14-3-3

2008 Investigative Ophthalmology & Visual Science

3312. Organ trafficking and transplant tourism: a commentary on the global realities. Full Text available with Trip Pro

Organ trafficking and transplant tourism: a commentary on the global realities. The extent of organ sales from commercial living donors (CLDs) or vendors has now become evident. At the Second Global Consultation on Human Transplantation of the World Health Organization's (WHO) in March 2007, it was estimated that organ trafficking accounts for 5-10% of the kidney transplants performed annually throughout the world. Patients with sufficient resources in need of organs may travel from one country

2008 American Journal of Transplantation

3313. Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking. Full Text available with Trip Pro

unaffected in all three HPS genotypes. These data demonstrate that the three initially identified subtypes of human HPS exhibit distinct defects in the trafficking of various melanocyte-specific proteins. (...) Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking. Hermansky-Pudlak Syndrome (HPS) is a genetically heterogeneous disorder in which mutations in one of several genes interrupts biogenesis of melanosomes, platelet dense bodies, and lysosomes. Affected patients have oculocutaneous albinism, a bleeding diathesis, and sometimes develop granulomatous colitis or pulmonary fibrosis. In order to assess the role of HPS genes

2005 Journal of Investigative Dermatology

3314. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Full Text available with Trip Pro

Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. The hyperpolarization-activated nucleotide-gated channel--HCN4 plays a major role in the diastolic depolarization of sinus atrial node cells. Mutant HCN4 channels have been found to be associated with inherited sinus bradycardia.Sixteen members of a family with sinus bradycardia were evaluated. Evaluation included a clinical (...) mutation, G480R, in the ion channel pore domain in all affected family members. Function analysis, including expression of HCN4 wild-type and G480R in Xenopus oocytes and human embryonic kidney 293 cells, revealed that mutant channels were activated at more negative voltages compared with wild-type channels. Synthesis and expression of the wild-type and mutant HCN4 channel on the plasma membrane tested in human embryonic kidney 293 cells using biotinylation and Western blot analysis demonstrated

2007 Circulation

3315. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Full Text available with Trip Pro

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11.1 alpha-subunit of the rapidly activating delayed rectifier K+ current (IKr) in the heart. Type 2 congenital long-QT syndrome (LQT2) results from KCNH2 mutations that cause loss of Kv11.1 channel function. Several mechanisms have been identified, including disruption of Kv11.1 channel synthesis (class 1), protein trafficking (...) (class 2), gating (class 3), or permeation (class 4). For a few class 2 LQT2-Kv11.1 channels, it is possible to increase surface membrane expression of Kv11.1 current (IKv11.1). We tested the hypotheses that (1) most LQT2 missense mutations generate trafficking-deficient Kv11.1 channels, and (2) their trafficking-deficient phenotype can be corrected.Wild-type (WT)-Kv11.1 channels and 34 missense LQT2-Kv11.1 channels were expressed in HEK293 cells. With Western blot analyses, 28 LQT2-Kv11.1 channels

2006 Circulation

3316. Kinetics of metastatic breast cancer cell trafficking in bone. Full Text available with Trip Pro

Kinetics of metastatic breast cancer cell trafficking in bone. In vivo studies have focused on the latter stages of the bone metastatic process (osteolysis), whereas little is known about earlier events, e.g., arrival, localization, and initial colonization. Defining these initial steps may potentially identify the critical points susceptible to therapeutic intervention.MDA-MB-435 human breast cancer cells engineered with green fluorescent protein were injected into the cardiac left ventricle

2006 Clinical Cancer Research

3317. Transmembrane S1 mutations in CNGA3 from achromatopsia 2 patients cause loss of function and impaired cellular trafficking of the cone CNG channel. Full Text available with Trip Pro

Transmembrane S1 mutations in CNGA3 from achromatopsia 2 patients cause loss of function and impaired cellular trafficking of the cone CNG channel. Achromatopsia 2, an inherited retinal disorder resulting in attenuation or loss of cone function, is caused by mutations in the alpha subunit of the cone cyclic nucleotide-gated (CNG) channel gene CNGA3. Examination of mutations that cluster in the first transmembrane segment of the protein may provide insight into its role in CNG channel structure (...) , function, biogenesis, and pathophysiology.The human CNGA3 gene was tagged at the C terminus with green fluorescent protein. Four mutations, Y181C, N182Y, L186F, and C191Y, were expressed in human embryonic kidney cells. Protein expression was evaluated with immunoblot analysis and cellular localization was determined by immunocytochemistry. Channel function was evaluated by patch-clamp electrophysiology.All the mutations result in loss of channel function, as determined by the failure of cGMP

2005 Investigative Ophthalmology & Visual Science

3318. Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking. Full Text available with Trip Pro

Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking. Heparan sulfate (HS) proteoglycans by playing key roles in the leukocyte-endothelial interactions are thought to mediate inflammatory cell influx in proliferative glomerulonephritis. Here, we evaluated the specific features within glomerular endothelial HS that promote leukocyte adhesion. Mouse and human glomerular endothelial cells activated by tumor necrosis factor (TNF)-alpha (...) of endothelial HS or addition of sulfated heparinoids. Specific antibodies that block N- and 6-O-sulfated HS domains on activated mouse endothelial cells reduced the number of rolling and firmly adhering leukocytes under dynamic flow conditions, while they increased the average leukocyte-rolling velocity. Our study shows that N- and 6-O-sulfated domains in HS on activated glomerular endothelium are crucial for leukocyte trafficking and are possible therapeutic targets.

2007 Kidney International

3319. Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. (Abstract)

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. We undertook a quantitative trait locus (QTL) analysis in mice to identify modifier genes that might influence the severity of human iron disorders. We identified a strong QTL on mouse chromosome 9 that differentially affected macrophage iron burden in C57BL/10J and SWR/J mice. A C57BL/10J missense allele of an evolutionarily conserved gene, Mon1a, cosegregated with the QTL in congenic mouse (...) lines. We present evidence that Mon1a is involved in trafficking of ferroportin, the major mammalian iron exporter, to the surface of iron-recycling macrophages. Differences in amounts of surface ferroportin correlate with differences in cellular iron content. Mon1a is also important for trafficking of cell-surface and secreted molecules unrelated to iron metabolism, suggesting that it has a fundamental role in the mammalian secretory apparatus.

2007 Nature Genetics

3320. Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor. Full Text available with Trip Pro

Caveolin-1 regulates cellular trafficking and function of the glucagon-like Peptide 1 receptor. The glucagon-like peptide 1 receptor (GLP-1R) mediates important effects on beta-cell function and glucose homeostasis and is one of the most promising therapeutic targets for type 2, and possibly type 1, diabetes. Yet, little is known regarding the molecular and cellular mechanisms that regulate its function. Therefore, we examined the cellular trafficking of the GLP-1R and the relation between (...) receptor localization and signaling activity. In resting human embryonic kidney 293 and insulinoma MIN6 cells, a fully functional green fluorescent protein-tagged GLP-1R was localized both at the cell membrane and in highly mobile intracellular compartments. Real-time confocal fluorescence microscopy allowed direct visualization of constitutive cycling of the receptor. Overexpression of K44A-dynamin increased the number of functional receptors at the cell membrane. Immunoprecipitation, sucrose

2006 Molecular Endocrinology

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