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Human Papilloma Virus Vaccine

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141. Spontanuous Demand For Meningococcal B Vaccination: Effects On Appropriateness And Timing Full Text available with Trip Pro

therefore decided to use a self-administered questionnaire in order to investigate the parents' socio-demographic data; their children's history of other recommended vaccinations (against measles, mumps and rubella, varicella, meningococcus C and, for females, human papilloma virus); the information sources concerning meningococcal vaccination; and the timing of its administration. The questionnaire was completed by 565 parents, and the results showed that the requests mainly came from the parents (...) Spontanuous Demand For Meningococcal B Vaccination: Effects On Appropriateness And Timing When the meningococcus B vaccine was introduced into Italy in 2017, it was recommended for newborns based on national epidemiological data indicating that they were at greater risk. However, the vaccination service of the local health authority of L'Aquila had already been receiving spontaneous parental requests to provide vaccination for children in lower-risk age groups from the beginning of 2016. We

2018 Human vaccines & immunotherapeutics

142. Increasing Healthcare Engagement Via Routine Vaccination Among Young Black Men Who Have Sex With Men

/treatment Phase Meningitis HPV - Anogenital Human Papilloma Virus Infection Hepatitis A Behavioral: POL arm Behavioral: Comparison arm Not Applicable Detailed Description: For young black men who have sex with men (YBMSM), being at the intersection of racial and sexual minority status negatively impacts their access to healthcare and health seeking behavior, both of which fuel health disparities—particularly in infectious diseases. Prominent illustrations of these health disparities can be seen (...) for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Virus Diseases Meningitis Papilloma Hepatitis A Hepatitis Papillomavirus Infections Central Nervous System Diseases Nervous System Diseases Neoplasms, Squamous Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Hepatitis, Viral, Human Enterovirus Infections Picornaviridae Infections RNA Virus

2018 Clinical Trials

143. Human papilloma virus vaccination programs reduce health inequity in most scenarios: a simulation study. Full Text available with Trip Pro

Human papilloma virus vaccination programs reduce health inequity in most scenarios: a simulation study. The global and within-country epidemiology of cervical cancer exemplifies health inequity. Public health programs may reduce absolute risk but increase inequity; inequity may be further compounded by screening programs. In this context, we aimed to explore what the impact of human papillomavirus (HPV) vaccine might have on health equity allowing for uncertainty surrounding the long-term (...) , vaccination would lead to a better outcome for a population or subgroup with that combination of parameters. Regardless of vaccine effectiveness and coverage, most simulations led to lower rates of disease.If vaccination coverage and screening uptake are high, then communities are always better off with a vaccination program. The findings highlight the importance of achieving and maintaining high immunization coverage and screening uptake in high risk groups in the interest of health equity.

2012 BMC Public Health

144. Knowledge, attitudes, and acceptability of a human papilloma virus vaccine among students, parents and teachers in Thailand. (Abstract)

Knowledge, attitudes, and acceptability of a human papilloma virus vaccine among students, parents and teachers in Thailand. The purpose of this study was to assess the knowledge and attitudes about human papilloma virus (HPV) and cervical cancer, and the acceptability of HPV vaccine among students, parents and teachers in secondary schools in Bangkok, Thailand. We conducted a school-based cross-sectional study at four public secondary schools in Bangkok. A total of 644 students aged 12-15 (...) years, 664 parents and 304 teachers were recruited into the study. Data were collected by self-administered questionnaires. The percentages of students, parents and teachers who were willing to be vaccinated were 26, 49 and 43%, respectively. Forty-one percent of parents wanted their children to be vaccinated. Students, parents and teachers had a moderate knowledge of HPV, cervical cancer and the HPV vaccine with mean scores of 6.91 (SD = 1.75), 6.82 (SD = 1.88), and 6.70 (SD = 1.89), respectively

2012 Southeast Asian Journal of Tropical Medicine and Public Health

145. The use of vaccines in HIV-positive adults

London BHIVA guidelines on the use of vaccines in HIV-­-positive adults 2015 November 2015 2 Table of contents 1. INTRODUCTION 3 2. SUMMARY OF RECOMMENDATIONS TABLE 8 3. ANTHRAX 9 4. CHOLERA 11 5. DIPHTHERIA 14 6. HAEMOPHILUS INFLUENZAE SEROTYPE b 16 7. HEPATITIS A 19 8. HEPATITIS B 22 9. HUMAN PAPILLOMA VIRUS 29 10. INFLUENZA 36 11. JAPANESE ENCEPHALITIS 42 12. MEASLES, MUMPS AND RUBELLA 44 13. MENINGOCOCCUS 48 14. PERTUSSIS (WHOOPING COUGH) 51 15. PNEUMOCOCCUS 54 16. POLIOMYELITIS 61 17. RABIES 64 (...) infection becomes greater than the risk of live vaccine-­-related adverse events. Important examples of replicating vaccines that can be used in HIV-­-positive persons with good immunity include those for measles, mumps and rubella (MMR), varicella-­-zoster virus (VZV) and yellow fever. For vaccinated individuals, the importance of infection avoidance and infection control should continue to be emphasised. It is envisaged that the HIV specialist should provide overall guidance on vaccine use and enlist

2015 British HIV Association

146. Specific immunity to human papilloma virus (HPV) in patients with genital warts. Full Text available with Trip Pro

Specific immunity to human papilloma virus (HPV) in patients with genital warts. A study of human papilloma virus (HPV) specific cellular and humoral immunity in 30 patients with genital warts is reported. By in vivo testing with purified, inactivated plantar wart virus, a cell-mediated immunity to HPV was determined in 60% of patients. Circulating antibodies, evaluated by immunofluorescence testing, were rare, but these increased after an intradermal test had been carried out, especially (...) in patients with a positive skin test, suggesting a booster effect. No significant difference was found between this group of patients and those having skin warts. Our results showed a specific immune response to HPV in most patients, confirming the role of the viral agent in the induction of genital warts.

1978 British Journal of Venereal Diseases

147. Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings. Full Text available with Trip Pro

Human Papilloma Virus (HPV) Oral Prevalence in Scotland (HOPSCOTCH): A Feasibility Study in Dental Settings. The purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral Human Papilloma Virus (HPV) in Scotland via dental settings. Male and female patients aged 16-69 years were recruited by Research Nurses in 3 primary care and dental outreach teaching centres and 2 General Dental Practices (GDPs (...) the baseline questionnaire and 380 provided a baseline oral specimen. Follow-up rate was 61.6% at 6 months. While recruitment was no different in Research Nurse vs Dental Care Team models the Nurse model ensured more rapid recruitment. There were relatively few missing responses in the questionnaire and high levels of disclosure of risk behaviours (99% answered some of the sexual history questions). Data linkage of participant data to routine health records including HPV vaccination data was successful

2016 PLoS ONE

148. A global review of national influenza immunization policies: Analysis of the 2014 WHO/UNICEF Joint Reporting Form on immunization Full Text available with Trip Pro

or upper middle income (p<0.0001); to have introduced birth dose hepatitis B virus vaccine (p<0.0001), pneumococcal conjugate vaccine (p=0.032), or human papilloma virus vaccine (p=0.002); to have achieved global goals for diphtheria-tetanus-pertussis vaccine coverage (p<0.0001); and to have a functioning National Immunization Technical Advisory Group (p<0.0001).The 2014 revision of the JRF permitted a global assessment of national influenza immunization policies. The 59% of countries reporting (...) A global review of national influenza immunization policies: Analysis of the 2014 WHO/UNICEF Joint Reporting Form on immunization The WHO recommends annual influenza vaccination to prevent influenza illness in high-risk groups. Little is known about national influenza immunization policies globally.The 2014 WHO/UNICEF Joint Reporting Form (JRF) on Immunization was adapted to capture data on influenza immunization policies. We combined this dataset with additional JRF information on new vaccine

2016 Vaccine

149. Efficacy of VIUSID® Plus GLIZIGEN® in Patients With Papilloma Virus Esophageal

Consent Form (ICF) Clinical Study Report (CSR) Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Catalysis SL: Papillomavirus Viusid Glizigen Papilloma virus Esophageal Antioxidant Additional relevant MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Carcinoma, Verrucous Papilloma Virus Diseases Papillomavirus Infections Carcinoma Neoplasms, Glandular and Epithelial Neoplasms (...) of elimination of the virus than patients in the placebo group after treatment. The study will be conducted in the Superior Digestive Tract consultation of the Institute of Gastroenterology of Havana, Cuba. Condition or disease Intervention/treatment Phase Papilloma Viral Infection Papillomavirus Infections Esophageal Viral Wart Esophageal Verrucous Carcinoma Dietary Supplement: Viusid® Dietary Supplement: Glizigen® Dietary Supplement: Viusid Placebo Dietary Supplement: Glizigen Placebo Phase 2 Detailed

2018 Clinical Trials

150. Should Physicians Offer The HPV Vaccine To Men And Boys?

. BMJ. 2009:339:b3884. 11. Elbasha E, Dasbach E. Impact of vaccinating boys and men against HPV in the United States. Vaccine. 2010:28:6858-6867. 12.Vernon SD, Hart CE, Reeves WC, Icenogle JP. The HIV-1 tat protein enhances E2- dependent human papillomavirus 16 transcription. Virus Res. 1993;27(23):133-145. Share: | | 2 comments on “ Should Physicians Offer The HPV Vaccine To Men And Boys? ” on I support male vaccination against the Human Papilloma Virus. They are the carriers of the virus (...) , the FDA approved its use for the .[2] In 2009, the FDA approved its use in males and females from .[3] Human papilloma virus DNA can be detected in the cervical tissue of 27% of women, according to the National Health and Nutrition Examination Survey, .[4] In men, the prevalence varies depending on the site sampled, but ranges from 20 to 65%.[5] In a group of HIV-negative men who have sex with men (MSM), 48% were infected with HPV; the high-risk HPV types 16 and 18 (associated with malignancy) were

2012 Clinical Correlations

151. Cross sectional study investigating the differences in knowledge and behaviors about HPV between vaccinated and non-vaccinated girls Full Text available with Trip Pro

Cross sectional study investigating the differences in knowledge and behaviors about HPV between vaccinated and non-vaccinated girls The aim of the presents study was to compare the level of knowledge about Human Papilloma Virus (HPV) in vaccinated and non-vaccinated girls and to highlight the reasons why non-vaccinated girls refuse vaccination.A cross-sectional study was conducted from October 2012 to June 2013 in Turin (Piemonte Region, Italy). Questionnaires were administered to girls (...) attending secondary and high schools randomly selected.A total of 576 were compiled. The principle sources of information were parents and health workers. The main reported reasons for non-adherence to vaccination were the disagreement of the parents among the 11-12 years group (45.3%) and the lack of evidence on efficacy among the 18 years group (26.8%). By comparing the level of knowledge there was a statistically significant difference between groups: vaccinated girls reported higher score than

2016 Journal of preventive medicine and hygiene

152. Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials Full Text available with Trip Pro

Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials The human papilloma virus (HPV) infections were addressed with two FDA-approved HPV vaccines: quadrivalent and bivalent vaccine. The objective of this manuscript is to determine the safety of the HPV vaccine.A search of PubMed articles for "human papillomavirus vaccine" was used to identify all-type HPV clinical studies prior to October 2014. A refined search of clinical trials (...) , multicenter studies, and randomized studies were screened for only randomized controlled trials comparing HPV vaccine to controls (saline placebo or aluminum derivatives). Studies were limited to the two FDA-approved vaccines. Following PRISMA guidelines, the literature review rendered 13 publications that met inclusion/ exclusion criteria. Gender was limited to females in 10 studies and males in 1 study. Two studies included both males and females. Of the 11,189 individuals in 7 publications reporting

2016 Basic and Clinical Andrology

153. Reporting of adverse events following immunizations in Ghana – Using disproportionality analysis reporting ratios Full Text available with Trip Pro

and human papilloma virus vaccinations were used. All vaccinations occurred between January 2010 and December 2013. The ten most occurring events for each vaccination were captured and arranged using Medical Dictionary for Regulatory Authorities (MedDRA) Preferred Term (PT) and System Organ Classification (SOC) codes. Adverse event incidence rates were calculated for each vaccine type, and signals were generated using proportional reporting ratios (PRR).A total number of 5,141 reports were analysed (...) ranging from 33 (human papilloma virus) to 1958 (measles-rubella). Between 22% and 55% of all AEFIs per vaccine type were collected on the day of vaccination. For each vaccine type, at least 87% of all reported AEFIs occurred in the first 7 days post-vaccination. Multiple reports were received per vaccine type. For the MR vaccine, urticarial recorded the highest attack rate of 6.6 (95% CI 6.2, 7.1) per 100,000 vaccines. The AEFI with the highest PRR for both human papilloma and measles-rubella

2017 Human vaccines & immunotherapeutics

154. Engineered Immune Effectors Against Cervical Cancer

Description: Cervical cancer (CC) is a cancer arising from the cervix. Human papillomavirus (HPV) infection causes more than 90% of the cases. Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many sexual partners, but these are less important. Worldwide, CC is both the fourth-most common cause of cancer and the fourth-most common cause of death from cancer in women. The treatment of CC consists of surgical intervention, radiation (...) ; serum bilirubin ≤ 2×ULN; AST/ALT ≤ 2×ULN; ALKP ≤ 5×ULN; serum bilirubin. 2.0 is acceptable in the setting of known Gilbert's syndrome. Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) test negative. Exclusion Criteria: Patients with cervical benign lesions: cervical columnar epithelium ectopic, cervical polyps, cervical endometriosis and cervical tuberculous ulcers; cervical benign tumors: cervical submucous myoma, cervical cancer, cervical papilloma. Patients with evidence

2017 Clinical Trials

155. HPV Specific Immune Lymphocytes (HPV-CTLs) in the Treatment of HPV

: Shenzhen Geno-Immune Medical Institute Information provided by (Responsible Party): Lung-Ji Chang, Shenzhen Geno-Immune Medical Institute Study Details Study Description Go to Brief Summary: The purpose of this clinical trial is to evaluate the safety and efficacy of IV-infused autologous or allogenic HPV-CTLs. Condition or disease Intervention/treatment Phase Human Papilloma Virus Biological: HPV-CTLs Phase 1 Phase 2 Detailed Description: Human papilloma viruses (HPV) have been consistently implicated (...) a U.S. FDA-regulated Device Product: No Keywords provided by Lung-Ji Chang, Shenzhen Geno-Immune Medical Institute: Human papilloma virus Cytotoxic lymphocyte HPV-CTL Additional relevant MeSH terms: Layout table for MeSH terms Papilloma Neoplasms, Squamous Cell Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms

2017 Clinical Trials

156. Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data Full Text available with Trip Pro

expressed genes derived from control- vs drug-treated sample pairs, and the data from public databases including ImmGen and IRIS, which contain gene expression profiles of a variety of immune cells. By ICEPOP, we analysed cell responses induced by vaccine-adjuvants in the mouse spleen, and extended the analyses to human peripheral blood mononuclear cells and gut biopsy samples focusing on human papilloma virus vaccination and inflammatory bowel disease treatment with Infliximab. In both mouse and human (...) Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data Evaluation of immune responses in individual immune cell types is important for the development of new medicines. Here, we propose a computational method designated ICEPOP (Immune CEll POPulation) to estimate individual immune cell type responses from bulk tissue and organ samples. The relative gene responses are scored for each cell type by using the data from differentially

2017 Scientific reports

157. Protective cellular immunity generated by cross-presenting recombinant overlapping peptide proteins Full Text available with Trip Pro

) for cathepsin S, a protease found in the endosomes of DCs. We designed synthetic genes encoding ROPs derived from ovalbumin (OVA), tuberculosis protein (CFP10-ESAT6), human papilloma virus (HPV) protein (E7) and survivin, a protein commonly over-expressed in tumour cells. An epitope from ROP-OVA was cross-presented and detected by a CD8+ T cell receptor-like antibody (TCR like Ab). Human DCs pulsed with ROP-survivin activated CD8+ T cells. CD4-low PBMCs from HIV and TB co-infected patients recognized ROP (...) -CFP10-ESAT6 compared to a soluble form of the antigen. Immunization of mice with ROP-survivin or ROP-HPV-E7 generated specific cellular immune responses and protected mice from inoculation with melanoma B16 cells expressing survivin or HPV-E7 proteins. Together these data provide evidence to support ROP as a central component of a new platform for therapeutic vaccines and diagnostics.

2017 Oncotarget

158. Impaired immune function in children and adults with Fanconi anemia Full Text available with Trip Pro

) and candida (P = 0.019), were diminished in FA. Phytohemagglutinin responses and plasma cytokines were normal. Within FA subjects, adults and older children (≥10 years) exhibited higher CD8+ T cells than younger children (P = 0.004). Documented atypical infections were infrequent, although oral human papilloma virus (HPV) prevalence was higher (31% positive) in FA.Overall, these results demonstrate a high rate of significant humoral and cellular immune dysfunction. Continued longitudinal study of immune (...) Impaired immune function in children and adults with Fanconi anemia Fanconi anemia (FA) is a rare genetic disorder characterized by genome instability, bone marrow failure, and cancer predisposition. Previously, small studies have reported heterogeneous immune dysfunction in FA.We performed a detailed immunologic assessment in a large FA cohort who have not undergone bone marrow transplantation or developed malignancies. Comprehensive quantitative and functional immunologic assessment of 29 FA

2017 Pediatric blood & cancer

159. Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma Full Text available with Trip Pro

Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma The p16Ink4a is not a surrogate marker for high-risk human papilloma virus (HPV) genotypes but indicates better prognosis in vulvar squamous cell carcinoma patients. Our recent study confirmed substantial mismatch between p16Ink4a and high-risk HPV-status as well as revealed that p16Ink4a-overexpression itself is an independent prognostic factor for vulvar cancer.To determine significance (...) of the tumor infiltrating immune cells and p16Ink4a-status for better outcome of patients with vulvar cancer.Intraepithelial tumor infiltrating lymphocytes: CD8+, CD4+, FOXP3+, CD56+, tumor associated macrophages: CD68+, and GZB+ cells were calculated in 85 vulvar squamous cell carcinomas with previously defined p16Ink4a and high-risk HPV-status. Number of intraepithelial CD8+, CD4+, FOXP3+, CD56+, CD68+ and GZB+ cells were compared between tumors with different p16INK4a status and overlapping high-risk

2017 Oncotarget

160. Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis Full Text available with Trip Pro

differential immune profiles based on lymphoid and myeloid cell densities, correlating with human papilloma virus status and prognosis. Based on these results, we investigated 24 pancreatic ductal adenocarcinomas from patients who received neoadjuvant GVAX vaccination and revealed that response to therapy correlated with degree of mono-myelocytic cell density and percentages of CD8+ T cells expressing T cell exhaustion markers. These data highlight the utility of in situ immune monitoring for patient (...) Quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To validate this platform, we used tissue microarrays containing 38 archival head and neck squamous cell carcinomas and revealed

2017 Cell reports

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