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Human Granulocytic Anaplasmosis

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1. Acute Kidney Injury Associated With Human Granulocytic Anaplasmosis: A Case Report. (Abstract)

Acute Kidney Injury Associated With Human Granulocytic Anaplasmosis: A Case Report. Tick-borne illnesses are a growing problem in the United States. Human granulocytic anaplasmosis (HGA), carried by the Ixodes scapularis tick, is caused by Anaplasma phagocytophilum. While the clinical manifestations of HGA may be protean, ranging from asymptomatic infection to life-threatening multiorgan failure, renal involvement is uncommon. We report a case of a 64-year-old man presenting with a febrile

2019 American Journal of Kidney Diseases

2. Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France. Full Text available with Trip Pro

Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France. We prospectively examined the effectiveness of diagnostic tests for anaplasmosis using patients with suspected diagnoses in France. PCR (sensitivity 0.74, specificity 1) was the best-suited test. Serology had a lower specificity but higher sensitivity when testing acute and convalescent samples. PCR and serology should be used in combination for anaplasmosis diagnosis.

2019 Emerging Infectious Diseases

3. Severe Human Granulocytic Anaplasmosis With Significantly Elevated Ferritin Levels in an Immunocompetent Host in Pennsylvania: A Case Report Full Text available with Trip Pro

Severe Human Granulocytic Anaplasmosis With Significantly Elevated Ferritin Levels in an Immunocompetent Host in Pennsylvania: A Case Report Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by Anaplasma phagocytophilum that generally presents with nonspecific symptoms such as fever, chills, headache, malaise, and myalgia. If not treated immediately, HGA can cause hemophagocytic lymphohistiocytosis (HLH), a well-documented but underrecognized sequela of severe HGA

2018 Journal of investigative medicine high impact case reports

4. Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of Human Granulocytic Anaplasmosis. Full Text available with Trip Pro

Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of Human Granulocytic Anaplasmosis. Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by Anaplasma phagocytophilum, an obligate intracellular bacterium. Until now, the utility of tick-bite site samples for HGA diagnosis has not been reported. Using a patient's buffy coat and tick-bite site crust samples, we performed polymerase chain reaction (PCR) testing using Ehrlichia

2017 American Journal of Tropical Medicine & Hygiene

5. Human Granulocytic Anaplasmosis as a Cause of Febrile Illness in Korea Since At Least 2006. Full Text available with Trip Pro

Human Granulocytic Anaplasmosis as a Cause of Febrile Illness in Korea Since At Least 2006. AbstractHuman granulocytic anaplasmosis (HGA) is a tick-borne rickettsial zoonosis with fever, thrombocytopenia, and leukopenia. HGA has been reported in Korea in 2013 but it is uncertain how long it has existed. A retrospective study was conducted on patients who underwent bone marrow examination due to fever and cytopenia, with no clear hematologic or microbiologic causes, from 2003 through 2012

2017 American Journal of Tropical Medicine & Hygiene

6. Human Granulocytic Anaplasmosis

Human Granulocytic Anaplasmosis Human Granulocytic Anaplasmosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Human Granulocytic (...) Anaplasmosis Human Granulocytic Anaplasmosis Aka: Human Granulocytic Anaplasmosis , HGA , Anaplasma phagocytophila , Human Granulocytic Ehrlichiosis , Ehrlichia equi , Ehrlichia phagocytophila , Human Anaplasmosis , Anaplasmosis From Related Chapters II. Epidemiology : 1832 reported cases in U.S. in 2014 Majority of cases occur l to September Tick Carriers ( ) Dog tick (Dermacentor variabilis) United States endemic areas (similar distribution to ) Upper Midwest including. Minnesota Wyoming Northeast

2018 FP Notebook

7. First molecular evidence of Equine Granulocytic Anaplasmosis in Pakistan. (Abstract)

First molecular evidence of Equine Granulocytic Anaplasmosis in Pakistan. Anaplasma phagocytophilum (A. phagocytophilum) is an obligate intracellular bacterium that causes equine granulocytic anaplasmosis (EGA) disease in equines. This pathogen has zoonotic potential, which makes it very important to be detected and controlled as early as possible. This study was aimed to assess the molecular prevalence, associated risk factors of EGA along with its effects on various hematological parameters (...) . This study revealed an overall 10.67% prevalence in equine. Horses showed highest prevalence followed by mules and donkeys presenting 11.86, 10.53 and 9.43% prevalence, respectively. The samples were confirmed for anaplasmosis through sequencing. The BLAST queries confirmed very high homology of our isolates with Chinese and Japanese isolates of A. phagocytophilum (Accession no's; KX505303, KY242456 and LC002836). The phylogenetic analysis found the study isolates clustered with each other

2018 Acta Tropica

8. Ehrlichiosis and anaplasmosis

bacteria from the Anaplasmataceae family: Ehrlichia ewingii , E chaffeensis , and Anaplasma phagocytophilum . Ehrlichia muris -like agent (EMLA) also causes symptomatic infection and is the most recently recognised form of human ehrlichiosis. The type of infection that develops depends on the infecting bacteria and includes human monocytotropic/monocytic ehrlichiosis (HME), human granulocytotropic/granulocytic anaplasmosis (HGA), and human ewingii ehrlichiosis (HEE). The clinical manifestations of each (...) Ehrlichiosis and anaplasmosis Ehrlichiosis and anaplasmosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Ehrlichiosis and anaplasmosis Last reviewed: February 2019 Last updated: August 2018 Summary All types of human ehrlichioses and anaplasmosis are nationally notifiable diseases. Seasonality is due to higher likelihood of tick exposure/bite when people spend more time outdoors in warmer months. Presumptive

2018 BMJ Best Practice

9. Accuracy of Diagnosis of Human Granulocytic Anaplasmosis in China. Full Text available with Trip Pro

Accuracy of Diagnosis of Human Granulocytic Anaplasmosis in China. In 2008, human granulocytic anaplasmosis (HGA) was reported from China. However, the clinical and laboratory findings, including reports of nosocomial transmission, were inconsistent with those reported for HGA in the United States. In 2012, it was demonstrated that the patients described in the 2008 report had all been infected with a newly discovered bunyavirus, severe fever with thrombocytopenia syndrome virus, which causes

2016 Emerging Infectious Diseases

10. Human Granulocytic Anaplasmosis in the United States from 2008 to 2012: A Summary of National Surveillance Data. Full Text available with Trip Pro

Human Granulocytic Anaplasmosis in the United States from 2008 to 2012: A Summary of National Surveillance Data. Human granulocytic anaplasmosis is an acute, febrile illness transmitted by the ticks Ixodes scapularis and Ixodes pacificus in the United States. We present a summary of passive surveillance data for cases of anaplasmosis with onset during 2008-2012. The overall reported incidence rate (IR) was 6.3 cases per million person-years. Cases were reported from 38 states and from New York (...) of anaplasmosis appears to have increased since 2000-2007. Our findings are consistent with previous case series and recent reports of the expanding range of the tick vector I. scapularis. © The American Society of Tropical Medicine and Hygiene.

2015 American Journal of Tropical Medicine & Hygiene

11. Clinical and laboratory features parameters of human granulocytic anaplasmosis (HGA) in patients admitted to hospital in Guangdong Province, China. (Abstract)

Clinical and laboratory features parameters of human granulocytic anaplasmosis (HGA) in patients admitted to hospital in Guangdong Province, China. Human granulocytic anaplasmosis (HGA) is an acute tick-borne infectious disease with increasing morbidity and mortality, but is rarely considered in clinical practice. Because human-to-human transfusion or nosocomial transmission can occur, diagnosis is difficult when the history of tick bites is not clear.We present clinical features and laboratory

2015 Tropical Doctor

12. Human Granulocytic Anaplasmosis Acquired in Scotland, 2013 Full Text available with Trip Pro

Human Granulocytic Anaplasmosis Acquired in Scotland, 2013 24857681 2015 01 06 2018 11 13 1080-6059 20 6 2014 Jun Emerging infectious diseases Emerging Infect. Dis. Human granulocytic anaplasmosis acquired in Scotland, 2013. 1079-81 10.3201/eid2006.131849 Hagedorn Peter P Imhoff Maren M Fischer Christian C Domingo Cristina C Niedrig Matthias M eng Case Reports Letter Research Support, Non-U.S. Gov't United States Emerg Infect Dis 9508155 1080-6040 0 Antibodies, Bacterial IM Adult Anaplasma (...) phagocytophilum genetics immunology isolation & purification Anaplasmosis blood diagnosis microbiology Animals Antibodies, Bacterial blood Humans Male Polymerase Chain Reaction Scotland Ticks virology Anaplasma phagocytophilum Human granulocytic anaplasmosis Scotland bacteria vector-borne infections 2014 5 27 6 0 2014 5 27 6 0 2015 1 7 6 0 ppublish 24857681 10.3201/eid2006.131849 PMC4036789 Vet Parasitol. 2010 Feb 10;167(2-4):108-22 19811878 Clin Infect Dis. 2001 Mar 15;32(6):862-70 11247709 Clin Microbiol

2014 Emerging Infectious Diseases

13. High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands Full Text available with Trip Pro

High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands Substantial exposure to Borrelia miyamotoi occurs through bites from Ixodes ricinus ticks in the Netherlands, which also transmit Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum. Direct evidence for B. miyamotoi infection in European populations is scarce. A flu-like illness with high fever, resembling human granulocytic (...) granulocytic anaplasmosis was 14.6% (9.0-21.8%); these were significantly higher compared with the seroprevalence in blood donors. Our findings indicate that infections with B. miyamotoi occur in tick-exposed individuals in the Netherlands. In addition, B. miyamotoi infections should be considered in patients reporting tick bites and febrile illness with unresolved aetiology in the Netherlands, and other countries where I. ricinus ticks are endemic.

2014 New Microbes and New Infections

14. Diagnosis of human granulocytic anaplasmosis in Belgium by combining molecular and serological methods Full Text available with Trip Pro

Diagnosis of human granulocytic anaplasmosis in Belgium by combining molecular and serological methods We report here one new, hospitalized case of Anaplasma phagocytophilum in Belgium. The clinical presentation of anaplasmosis, its treatment and the molecular and serological relevant laboratory methods are briefly developed.

2014 New Microbes and New Infections

15. Do leukoreduction filters passively reduce the transmission risk of human granulocytic anaplasmosis? (Abstract)

Do leukoreduction filters passively reduce the transmission risk of human granulocytic anaplasmosis? Human granulocytic anaplasmosis, caused by Anaplasma phagocytophilum, poses an increasing public health risk in the United States. Since 2000, case reports have increased annually; 2782 cases were reported in 2013. Despite the increasing frequency of clinical cases, only eight cases of transfusion-transmitted anaplasmosis (TTA) have been reported. We investigated if current leukoreduction

2014 Transfusion

16. Human granulocytic anaplasmosis, South Korea, 2013. Full Text available with Trip Pro

Human granulocytic anaplasmosis, South Korea, 2013. We report a patient with human granulocytic anaplasmosis in South Korea. The patient had fever and thrombocytopenia. Human granulocytic anaplasmosis was confirmed by seroconversion, PCR, and sequence analysis for Anaplasma phagocytophilum. Morulae were observed in the cultured HL-60 cells inoculated with blood from the patient.

2014 Emerging Infectious Diseases

17. Manifestation of anaplasmosis as cerebral infarction: a case report. Full Text available with Trip Pro

Manifestation of anaplasmosis as cerebral infarction: a case report. Human granulocytic anaplasmosis is a tick-borne zoonotic disease caused by Anaplasma phagocytophilum, an obligate intracellular granulocytotropic bacterium.A 70-year-old female patient was admitted with the clinical signs of fever and an altered state of consciousness 1 week after experiencing a tick bite while planting lawn grass. Magnetic resonance imaging, performed at the time of admission, indicated cerebral infarction (...) in the left basal ganglia, whereas increasing immunofluorescence assay antibody titers for A. phagocytophilum were also documented. A. phagocytophilum was identified using groEL and ankA targeted polymerase chain reaction and sequencing. Because of severe thrombocytopenia, only doxycycline was administered, without any antiplatelet agents. Subsequently, the symptoms improved without any focal neurologic sequela.This is the first reported case of cerebral infarction occurrence in an anaplasmosis patient.

2018 BMC Infectious Diseases

18. Human Granulocytic Anaplasmosis

Human Granulocytic Anaplasmosis Human Granulocytic Anaplasmosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Human Granulocytic (...) Anaplasmosis Human Granulocytic Anaplasmosis Aka: Human Granulocytic Anaplasmosis , HGA , Anaplasma phagocytophila , Human Granulocytic Ehrlichiosis , Ehrlichia equi , Ehrlichia phagocytophila , Human Anaplasmosis , Anaplasmosis From Related Chapters II. Epidemiology : 1832 reported cases in U.S. in 2014 Majority of cases occur l to September Tick Carriers ( ) Dog tick (Dermacentor variabilis) United States endemic areas (similar distribution to ) Upper Midwest including. Minnesota Wyoming Northeast

2016 FP Notebook

19. Human Granulocytic Anaplasmosis

Human Granulocytic Anaplasmosis Human Granulocytic Anaplasmosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 '); } document.write (...) (' '); //]]> Human Granulocytic Anaplasmosis Human Granulocytic Anaplasmosis Aka: Human Granulocytic Anaplasmosis , HGA , Anaplasma phagocytophila , Human Granulocytic Ehrlichiosis , Ehrlichia equi , Ehrlichia phagocytophila , Ehrlichiosis , Human anaplasmosis , Human ehrlichiosis From Related Chapters I. See also II. Pathophysiology Transmission: Small gram-negative organisms Pleomorphic Obligate intracellular organisms Disease: Human Granulocytic Anaplasmosis (HGA) Previously known as: Human Granulocytic

2015 FP Notebook

20. Epidemiology and control of human granulocytic anaplasmosis: a systematic review. (Abstract)

Epidemiology and control of human granulocytic anaplasmosis: a systematic review. Granulocytic anaplasmosis caused by Anaplasma phagocytophilum is an emerging tick-borne zoonosis worldwide. The obligate intracellular pathogen is transmitted by Ixodes ticks and infects neutrophils in humans and animals, resulting in clinical symptoms ranging from asymptomatic seroconversion to mild, severe, or fatal disease. Since the initial description of human granulocytic anaplasmosis (HGA) in the United

2012 Vector borne and zoonotic diseases (Larchmont, N.Y.)

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