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Higher Integrative Function

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1. Higher levels of trait emotional awareness are associated with more efficient global information integration throughout the brain: a graph-theoretic analysis of resting state functional connectivity Full Text available with Trip Pro

Higher levels of trait emotional awareness are associated with more efficient global information integration throughout the brain: a graph-theoretic analysis of resting state functional connectivity Previous studies have suggested that trait differences in emotional awareness (tEA) are clinically relevant, and associated with differences in neural structure/function. While multiple leading theories suggest that conscious awareness requires widespread information integration across the brain (...) , no study has yet tested the hypothesis that higher tEA corresponds to more efficient brain-wide information exchange. Twenty-six healthy volunteers (13 females) underwent a resting state functional magnetic resonance imaging scan, and completed the Levels of Emotional Awareness Scale (LEAS; a measure of tEA) and the Wechsler Abbreviated Scale of Intelligence (WASI-II; a measure of general intelligence quotient [IQ]). Using a whole-brain (functionally defined) region of interest (ROI) atlas, we computed

2018 Social cognitive and affective neuroscience

2. Higher Integrative Function

Higher Integrative Function Higher Integrative Function Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Higher Integrative Function (...) Higher Integrative Function Aka: Higher Integrative Function , Cognitive Function Testing , Executive Function Disturbance , Executive Function , Intellectual Function II. Pathophysiology See See See See III. Exam: Intellectual Functioning Fund of knowledge Number of weeks in a year? How many nickels in $1.15? Name the last 5 presidents? (impacted by educational status) Calculations Subtract 7 from 100, then from 93, 86, 79, 72, 65, 58, 51, 44, 37, 30... Subtract 3 from 20, then from 17, 14, 11, 8, 5

2018 FP Notebook

3. Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England

Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England | The King's Fund Main navigation Health and care services Leadership, systems and organisations Patients, people and society Policy, finance and performance Search term Apply Making sense of integrated care systems, integrated care partnerships (...) and accountable care organisations in the NHS in England This content relates to the following topics: Share this content Authors NHS England has recently changed the name of accountable care systems to integrated care systems, which describes more accurately the work being done in the 10 areas of England operating in this way. Our updated long read looks at work under way in these systems and at NHS England’s proposals for an accountable care organisation contract. Why is change needed? Constraints on NHS

2018 The King's Fund

4. Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries

Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries 1 Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries SYSTEMATIC REVIEW, APRIL 2019 i The authors of this report are: H Elizabeth Peters (Urban Institute, Washington, DC (...) This report should be cited as: Peters HE, Irvin-Erickson Y, Adelstein S, Malik A, Derrick-Mills T, Valido A, Esplage D (2019) Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries. London: EPPI Centre, Social Science Research Unit, UCL Institute of Education, University College London. ii © Copyright Authors of the systematic reviews on the EPPI-Centre website (http

2019 EPPI Centre

5. The effects of the integration of dynamic weight shifting training into treadmill training on walking function of children with cerebral palsy– a randomized controlled study Full Text available with Trip Pro

The effects of the integration of dynamic weight shifting training into treadmill training on walking function of children with cerebral palsy– a randomized controlled study The aim of the study was to determine whether applying an assistance force to the pelvis and legs during treadmill training can improve walking function in children with cerebral palsy.Twenty-three children with cerebral palsy were randomly assigned to the robotic or treadmill only group. For participants who were (...) assigned to the robotic group, a controlled force was applied to the pelvis and legs during treadmill walking. For participants who were assigned to the treadmill only group, manual assistance was provided as needed. Each participant trained 3 times/wk for 6 wks. Outcome measures included walking speed, 6-min walking distance, and clinical assessment of motor function, which were evaluated before, after training, and 8 wks after the end of training, and were compared between two groups.Significant

2017 American journal of physical medicine & rehabilitation Controlled trial quality: uncertain

6. Transforming health through innovation: Integrating the NHS and academia

that is protected for research (formal pilot to be run in selected hospitals). Establish similar pilots in time across other healthcare professions. 5. Ring-fence and reinvest funding income from research into research endeavours, including backfilling time dedicated to research in NHS and public health organisations. 6. Establish an integrated R&D office function with affiliated higher education institution, in view of providing a single function. University Vice- Chancellors 1. Offer honorary academic (...) undergraduate degrees offer a research component, and opportunities for students to learn about and participate in research. 5. Work with professional bodies to provide postgraduate healthcare trainees with a sustainable infrastructure for research and clear, flexible clinical academic career pathways. 6. Establish an integrated R&D office function with affiliated NHS Trust or Health Board, in view of providing a single function. Research funders 1. Develop funding schemes that encourage greater mobility

2020 Academy of Medical Sciences

7. Transforming health through innovation: Integrating the NHS and academia - supporting case studies

Transforming health through innovation: Integrating the NHS and academia - supporting case studies Transforming health through innovation: Integrating the NHS and academia - supporting case studies www.acmedsci.ac.uk 1 The UK’s NHS was launched on 5 July 1948. Since then, the UK has made many significant contributions to medical science resulting in ground-breaking advances in patient care. The case studies in the timeline below present a selection of some of the UK’s most significant research (...) Children at Great Ormond Street Hospital and adults at UCLH have been the first in Europe to receive this ground-breaking treatment. 83 First gene therapy trials for children without an immune system Pioneering work undertaken by scientists at the UCL Institute of Child Health has led to the development of the first gene therapy for children born with Severe Combined Immunodeficiency (SCID), a previously lethal condition in which children are born without a functioning immune system. 84,85 Over 50 SCID

2020 Academy of Medical Sciences

8. Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions Full Text available with Trip Pro

Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions ARL2 is among the most highly conserved proteins, predicted to be present in the last eukaryotic common ancestor, and ubiquitously expressed. Genetic screens in multiple model organisms identified ARL2, and its cytosolic binding partner cofactor D (TBCD), as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize (...) -talk or coordination of cell regulation, termed higher order signaling, based upon the use of a common GTPase in disparate cell functions.

2016 Small GTPases

9. Impact of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, and systemic endotoxin and inflammatory profile. (Abstract)

Impact of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, and systemic endotoxin and inflammatory profile. It is commonly believed that gastrointestinal issues during exercise are exacerbated by hypohydration. This study aimed to determine the effect of exercise-induced hypohydration on gastrointestinal integrity, function, symptoms, and systemic endotoxin and inflammatory profiles. In a randomized crossover design, male endurance runners (n = 11) performed 2 h (...) leukocytosis (overall pre- to postexercise: 5.9 × 109/l to 12.1 × 109/l) was similar on both trials. Depressed in vitro neutrophil function was observed during recovery on HypoH (-36%) but not on EUH (+6%). A pre- to postexercise increase (P < 0.05) was observed for circulating cytokine concentrations but not endotoxin values. Hypohydration during 2 h of running modestly perturbs gastrointestinal integrity and function and increases GIS incidence but does not affect systemic endotoxemia and cytokinemia

2019 Journal of applied physiology (Bethesda, Md. : 1985) Controlled trial quality: uncertain

10. Does adding an integrated physical therapy and neuromuscular electrical stimulation therapy to standard rehabilitation improve functional outcome in elderly patients with pneumonia? A randomised controlled trial. (Abstract)

. 0.58 (0.61)) and total score (5.91 (3.61) vs. 4.15 (3.15)). The intervention group showed better performance than the control group in both cases. Fatigue (32.04 (18.58) vs. 46.22 (8.90)) and cough (18.84 (2.47) vs. 17.40 (3.67)) showed higher improvement in the intervention group, and significant differences were observed between the groups.An integrated programme of physical and electrical therapy during hospitalization improves physical and functional performance in patients with pneumonia. (...) Does adding an integrated physical therapy and neuromuscular electrical stimulation therapy to standard rehabilitation improve functional outcome in elderly patients with pneumonia? A randomised controlled trial. To compare the effects of an integrated programme of physical and electrical therapy to standard rehabilitation to improve physical and functional performance in elderly patients with pneumonia.Randomized clinical trial. The study was registered in the ClinicalTrial.gov website

2019 Clinical rehabilitation Controlled trial quality: predicted high

11. Comparing the effectiveness of Integrating Ergonomics and Motor Control to conventional treatment for pain and functional recovery of work-related neck-shoulder pain: A randomized trial. (Abstract)

differences were found (p > 0.05). Significantly higher rating in global recovery score was reported in EM group at 1-year follow-up (p < 0.05).Intervention integrating ergonomic advice/modification with motor control exercise was found to be equally effective as pain relief and general exercise for pain and functional recovery. However, at 1-year follow-up, such integrated approach resulted in significantly better global recovery perceived by people with WRNSP.Integrating ergonomic intervention and motor (...) Comparing the effectiveness of Integrating Ergonomics and Motor Control to conventional treatment for pain and functional recovery of work-related neck-shoulder pain: A randomized trial. Work-related neck and shoulder pain (WRNSP) is highly prevalent among patients who seek physiotherapy treatment. Clinicians may tend to focus on teaching home exercises and provide general advice about workplace improvement. The present study investigates the short- and long-term impact of an intervention

2019 European Journal of Pain Controlled trial quality: uncertain

12. Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. (Abstract)

Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. Cholecystokinin (CCK) is a satiety hormone that is highly expressed in brain regions like the hippocampus. CCK is integral for maintaining or enhancing memory and thus may be a useful marker of cognitive and neural integrity in participants with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD). Cerebrospinal fluid (CSF) CCK levels were examined in 287 (...) subjects from the Alzheimer's Disease Neuroimaging Initiative. Linear or voxelwise regression was used to examine associations between CCK, regional gray matter, CSF AD biomarkers, and cognitive outcomes. Briefly, higher CCK was related to a decreased likelihood of having mild cognitive impairment or AD, better global and memory scores, and more gray matter volume primarily spanning posterior cingulate cortex, parahippocampal gyrus, and medial prefrontal cortex. CSF CCK was also strongly related

2019 Neurobiology of Aging

13. Towards integrated antenatal care for low-risk pregnancy

are free to ask a higher tariff. Figure 2 – Proportion of low-risk pregnant women who attended at least one consultation during their pregnancy by healthcare professional, in 2016 20 Towards integrated antenatal care for low-risk pregnancy KCE Report 326 Figure 3 – Number of ANC consultations (2016) for clinical follow-up by provider per region (n= 87 436 pregnant women) Gynaecologists Midwives GP Gynaecologists and midwives Gynaecologists, GP and midwives Note. Only women with at least one (...) Towards integrated antenatal care for low-risk pregnancy 2019 www.kce.fgov.be KCE REPORT 326 TOWARDS INTEGRATED ANTENATAL CARE FOR LOW-RISK PREGNANCY 2019 www.kce.fgov.be KCE REPORT 326 HEALTH SERVICES RESEARCH TOWARDS INTEGRATED ANTENATAL CARE FOR LOW-RISK PREGNANCY NADIA BENAHMED, MÉLANIE LEFÈVRE, WENDY CHRISTIAENS, CARL DEVOS, SABINE STORDEUR COLOPHON Title : Towards integrated antenatal care for low-risk pregnancy Authors : Nadia Benahmed (KCE), Mélanie Lefèvre (KCE), Wendy Christiaens (KCE

2020 Belgian Health Care Knowledge Centre

14. Effects of the combination therapy of tilt sensor functional electrical stimulation and integrated volitional control electrical stimulation on brain activity during the subacute phase following stroke: a feasibility study. Full Text available with Trip Pro

Effects of the combination therapy of tilt sensor functional electrical stimulation and integrated volitional control electrical stimulation on brain activity during the subacute phase following stroke: a feasibility study. [Purpose] The aim of this study was to investigate whether the combination of integrated volitional control functional electrical stimulation and tilt sensor functional electrical stimulation training affected brain activation during the subacute phase following a stroke (...) . [Participant and Methods] The patient was a 60-year-old male with right hemiparesis, secondary to stroke in the left thalamus. Conventional intervention was performed for 60 minutes per day during the first two weeks of treatment (the control condition). Functional electrical stimulation intervention, including integrated volitional control functional electrical stimulation and tilt sensor functional electrical stimulation training, was then performed for 60 minutes per day for two weeks (the experimental

2018 Journal of physical therapy science Controlled trial quality: uncertain

15. Protein Intake and Functional Integrity in Aging: The Framingham Heart Study Offspring. Full Text available with Trip Pro

Protein Intake and Functional Integrity in Aging: The Framingham Heart Study Offspring. Higher protein intake is linked to maintenance of muscle mass and strength, but few studies have related protein to physical function and disability in aging.In participants of the Framingham Heart Study Offspring, we examined associations between protein intake (g/d), estimated from food frequency questionnaires, and maintenance of functional integrity, as a functional integrity score based on responses (...) to 17 questions from Katz Activities of Daily Living, Nagi, and Rosow-Breslau questionnaires, repeated up to five times (1991/1995-2011/2014) over 23 years of follow-up. Cox proportional hazard models were used to estimate risk of incident loss of functional integrity (functional integrity score ≤ 15th percentile).In 2,917 participants (age 54.5 [9.8] years), baseline protein intake was 77.2 (15.6) g/d. The functional integrity score (baseline, mean 98.9, range 82.4-100.0) was associated

2018 Biological Sciences and Medical Sciences

16. Integrative Bayesian Analysis of Brain Functional Networks Incorporating Anatomical Knowledge Full Text available with Trip Pro

Integrative Bayesian Analysis of Brain Functional Networks Incorporating Anatomical Knowledge Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization by integrating information on both brain structure and function. In particular, incorporating anatomical knowledge leads to desirable outcomes such as increased accuracy in brain network estimates and greater reproducibility of topological features across scanning sessions. Despite the clear (...) advantages, major challenges persist in integrative analyses including an incomplete understanding of the structure-function relationship and inaccuracies in mapping anatomical structures due to inherent deficiencies in existing imaging technology. This calls for the development of advanced network modeling tools that appropriately incorporate anatomical structure in constructing brain functional networks. We propose a hierarchical Bayesian Gaussian graphical modeling approach which models the brain

2018 NeuroImage

17. Differential Functions of Two Metalloproteases, Mrmep1 and Mrmep2, in Growth, Sporulation, Cell Wall Integrity, and Virulence in the Filamentous Fungus Metarhizium robertsii Full Text available with Trip Pro

Differential Functions of Two Metalloproteases, Mrmep1 and Mrmep2, in Growth, Sporulation, Cell Wall Integrity, and Virulence in the Filamentous Fungus Metarhizium robertsii The Metarhizium genus of filamentous entomopathogenic fungi plays a pivotal role in regulating insect populations. Metalloproteases (MEPs) are a widely distributed and diverse family of hydrolytic enzymes that are important toxicity factors in the interactions between fungi and their hosts. Herein, we characterized two MEPs (...) levels of gallerimycin gene were 1.2-fold, 2.18-fold, and 2.5-fold higher in insects infected with the ΔMrmep1, ΔMrmep2, or ΔMrmep1ΔMrmep2 mutant than those infected with the WT strain, respectively. Our findings suggest that Mrmep1 and Mrmep2 are differentially contributed to the growth, sporulation, cell wall integrity, and virulence of M. robertsii.

2018 Frontiers in microbiology

18. Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing Full Text available with Trip Pro

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.In this study, we integrated (...) AS events derived from RNA-seq with H3K79me2 ChIP-seq data across 34 different normal and cancer cell types and found the higher enrichment of H3K79me2 in two AS types, skipping exon (SE) and alternative 3' splice site (A3SS).Interestingly, by applying self-organizing map (SOM) clustering, we unveiled two clusters mainly comprised of blood cancer cell types with a strong correlation between H3K79me2 and SE. Remarkably, the expression of transcripts associated with SE was not significantly different from

2018 Genome medicine

19. Studying the integrated functional cognitive basis of sustained attention with a Primed Subjective-Illusory-Contour Attention Task Full Text available with Trip Pro

Studying the integrated functional cognitive basis of sustained attention with a Primed Subjective-Illusory-Contour Attention Task Sustained attention plays an important role in everyday life, for work, learning, or when affected by attention disorders. Studies of the neural correlates of attention commonly treat sustained attention as an isolated construct, measured with computerized continuous performance tests. However, in any ecological context, sustained attention interacts with other (...) executive functions and depends on lower level perceptual processing. Such interactions occur, for example, in inhibition of interference, and processing of complex hierarchical stimuli; both of which are important for successful ecological attention. Motivated by the need for more studies on neural correlates of higher cognition, I present an experiment to investigate these interactions of attention in 17 healthy participants measured with high-resolution electroencephalography. Participants perform

2018 Scientific reports

20. Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema Full Text available with Trip Pro

Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema To respectively evaluate macular morphological features and functional parameters by using spectral-domain optical coherence tomography (SD-OCT) and macular integrity assessment (MAIA) in patients with diabetic macular edema (DME).This prospective, non-controlled, open study included 61 eyes of 38 consecutive patients with DME. All patients underwent best (...) ) and morphological parameters (retinal thickness) were significantly associated with an intact IS/OS. Local photoreceptor integrity was a strong predictor of local visual function throughout the retina. MI revealed the functional status in DME, reflecting the IS/OS juction status in the macula.

2018 International journal of ophthalmology

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