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Higher Integrative Function

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1. Higher levels of trait emotional awareness are associated with more efficient global information integration throughout the brain: a graph-theoretic analysis of resting state functional connectivity (PubMed)

Higher levels of trait emotional awareness are associated with more efficient global information integration throughout the brain: a graph-theoretic analysis of resting state functional connectivity Previous studies have suggested that trait differences in emotional awareness (tEA) are clinically relevant, and associated with differences in neural structure/function. While multiple leading theories suggest that conscious awareness requires widespread information integration across the brain (...) , no study has yet tested the hypothesis that higher tEA corresponds to more efficient brain-wide information exchange. Twenty-six healthy volunteers (13 females) underwent a resting state functional magnetic resonance imaging scan, and completed the Levels of Emotional Awareness Scale (LEAS; a measure of tEA) and the Wechsler Abbreviated Scale of Intelligence (WASI-II; a measure of general intelligence quotient [IQ]). Using a whole-brain (functionally defined) region of interest (ROI) atlas, we computed

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2018 Social cognitive and affective neuroscience

2. Higher Integrative Function

Higher Integrative Function Higher Integrative Function Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Higher Integrative Function (...) Higher Integrative Function Aka: Higher Integrative Function , Cognitive Function Testing , Executive Function Disturbance , Executive Function , Intellectual Function II. Pathophysiology See See See See III. Exam: Intellectual Functioning Fund of knowledge Number of weeks in a year? How many nickels in $1.15? Name the last 5 presidents? (impacted by educational status) Calculations Subtract 7 from 100, then from 93, 86, 79, 72, 65, 58, 51, 44, 37, 30... Subtract 3 from 20, then from 17, 14, 11, 8, 5

2018 FP Notebook

3. Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions (PubMed)

Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions ARL2 is among the most highly conserved proteins, predicted to be present in the last eukaryotic common ancestor, and ubiquitously expressed. Genetic screens in multiple model organisms identified ARL2, and its cytosolic binding partner cofactor D (TBCD), as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize (...) -talk or coordination of cell regulation, termed higher order signaling, based upon the use of a common GTPase in disparate cell functions.

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2016 Small GTPases

4. Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries

Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries 1 Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries SYSTEMATIC REVIEW, APRIL 2019 i The authors of this report are: H Elizabeth Peters (Urban Institute, Washington, DC (...) This report should be cited as: Peters HE, Irvin-Erickson Y, Adelstein S, Malik A, Derrick-Mills T, Valido A, Esplage D (2019) Qualitative evidence on barriers to and facilitators of women’s participation in higher or growing productivity and male-dominated labour market sectors in low- and middle-income countries. London: EPPI Centre, Social Science Research Unit, UCL Institute of Education, University College London. ii © Copyright Authors of the systematic reviews on the EPPI-Centre website (http

2019 EPPI Centre

5. Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England

Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England Making sense of integrated care systems, integrated care partnerships and accountable care organisations in the NHS in England | The King's Fund Main navigation Health and care services Leadership, systems and organisations Patients, people and society Policy, finance and performance Search term Apply Making sense of integrated care systems, integrated care partnerships (...) and accountable care organisations in the NHS in England This content relates to the following topics: Share this content Authors NHS England has recently changed the name of accountable care systems to integrated care systems, which describes more accurately the work being done in the 10 areas of England operating in this way. Our updated long read looks at work under way in these systems and at NHS England’s proposals for an accountable care organisation contract. Why is change needed? Constraints on NHS

2018 The King's Fund

6. The effects of the integration of dynamic weight shifting training into treadmill training on walking function of children with cerebral palsy– a randomized controlled study (PubMed)

The effects of the integration of dynamic weight shifting training into treadmill training on walking function of children with cerebral palsy– a randomized controlled study The aim of the study was to determine whether applying an assistance force to the pelvis and legs during treadmill training can improve walking function in children with cerebral palsy.Twenty-three children with cerebral palsy were randomly assigned to the robotic or treadmill only group. For participants who were (...) assigned to the robotic group, a controlled force was applied to the pelvis and legs during treadmill walking. For participants who were assigned to the treadmill only group, manual assistance was provided as needed. Each participant trained 3 times/wk for 6 wks. Outcome measures included walking speed, 6-min walking distance, and clinical assessment of motor function, which were evaluated before, after training, and 8 wks after the end of training, and were compared between two groups.Significant

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2017 American journal of physical medicine & rehabilitation

7. Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. (PubMed)

Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. Cholecystokinin (CCK) is a satiety hormone that is highly expressed in brain regions like the hippocampus. CCK is integral for maintaining or enhancing memory and thus may be a useful marker of cognitive and neural integrity in participants with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD). Cerebrospinal fluid (CSF) CCK levels were examined in 287 (...) subjects from the Alzheimer's Disease Neuroimaging Initiative. Linear or voxelwise regression was used to examine associations between CCK, regional gray matter, CSF AD biomarkers, and cognitive outcomes. Briefly, higher CCK was related to a decreased likelihood of having mild cognitive impairment or AD, better global and memory scores, and more gray matter volume primarily spanning posterior cingulate cortex, parahippocampal gyrus, and medial prefrontal cortex. CSF CCK was also strongly related

2019 Neurobiology of Aging

8. Comparing the effectiveness of Integrating Ergonomics and Motor Control to conventional treatment for pain and functional recovery of work-related neck-shoulder pain: A randomized trial. (PubMed)

differences were found (p > 0.05). Significantly higher rating in global recovery score was reported in EM group at 1-year follow-up (p < 0.05).Intervention integrating ergonomic advice/modification with motor control exercise was found to be equally effective as pain relief and general exercise for pain and functional recovery. However, at 1-year follow-up, such integrated approach resulted in significantly better global recovery perceived by people with WRNSP.Integrating ergonomic intervention and motor (...) Comparing the effectiveness of Integrating Ergonomics and Motor Control to conventional treatment for pain and functional recovery of work-related neck-shoulder pain: A randomized trial. Work-related neck and shoulder pain (WRNSP) is highly prevalent among patients who seek physiotherapy treatment. Clinicians may tend to focus on teaching home exercises and provide general advice about workplace improvement. The present study investigates the short- and long-term impact of an intervention

2019 European Journal of Pain

9. Impact of higher-order heme degradation products on hepatic function and hemodynamics. (PubMed)

Impact of higher-order heme degradation products on hepatic function and hemodynamics. Biliverdin and bilirubin were previously considered end products of heme catabolism; now, however, there is evidence for further degradation to diverse bioactive products. Z-BOX A and Z-BOX B arise upon oxidation with unknown implications for hepatocellular function and integrity. We studied the impact of Z-BOX A and B on hepatic functions and explored their alterations in health and cholestatic (...) , affected the glutathione redox state, and differentially modulated activity of Rev-erbα and Rev-erbβ. Moreover, BOXes-triggered remodeling of the hepatocellular cytoskeleton.Our data provide evidence that higher-order heme degradation products, namely Z-BOX A and B, impair hepatocellular integrity and might mediate intra- and extrahepatic cytotoxic effects previously attributed to hyperbilirubinemia.Degradation of the blood pigment heme yields the bile pigment bilirubin and the oxidation products Z-BOX

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2017 Journal of Hepatology

10. Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema (PubMed)

Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema To respectively evaluate macular morphological features and functional parameters by using spectral-domain optical coherence tomography (SD-OCT) and macular integrity assessment (MAIA) in patients with diabetic macular edema (DME).This prospective, non-controlled, open study included 61 eyes of 38 consecutive patients with DME. All patients underwent best (...) ) and morphological parameters (retinal thickness) were significantly associated with an intact IS/OS. Local photoreceptor integrity was a strong predictor of local visual function throughout the retina. MI revealed the functional status in DME, reflecting the IS/OS juction status in the macula.

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2018 International journal of ophthalmology

11. Pilot of a Group-based Program on Lifestyle-integrated Functional Exercise (LiFE) in Older Persons

Pilot of a Group-based Program on Lifestyle-integrated Functional Exercise (LiFE) in Older Persons Pilot of a Group-based Program on Lifestyle-integrated Functional Exercise (LiFE) in Older Persons - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Pilot of a Group-based Program on Lifestyle-integrated Functional Exercise (LiFE) in Older Persons The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03412123 Recruitment Status : Completed First Posted : January 26, 2018 Last Update Posted : March 13, 2018

2018 Clinical Trials

12. Sonographic assessment of the subscapularis after reverse shoulder arthroplasty: impact of tendon integrity on shoulder function. (PubMed)

Sonographic assessment of the subscapularis after reverse shoulder arthroplasty: impact of tendon integrity on shoulder function. The deltopectoral approach for reverse shoulder arthroplasty (RSA) requires subscapularis tenotomy or lesser tuberosity osteotomy. Whether the subscapularis should be repaired at the conclusion of the procedure remains controversial. The present study sonographically assessed the subscapularis after RSA and evaluated the effect of tendon integrity on functional (...) outcome.All patients who had undergone RSA in the Gold Coast University Hospital between 2005 and 2016 were included. Sonography was performed by a blinded examiner. Function was assessed using the Disabilities of the Arm, Shoulder and Hand, the Constant-Murley, and Oxford Shoulder scores. Internal rotation ability was recorded on a 6-point scale.The study included 43 patients (48 shoulders). Median length of follow-up was 19 months (range, 4-132 months). On sonography, the subscapularis was graded intact

2018 Journal of Shoulder and Elbow Surgery

13. Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing (PubMed)

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.In this study, we integrated (...) AS events derived from RNA-seq with H3K79me2 ChIP-seq data across 34 different normal and cancer cell types and found the higher enrichment of H3K79me2 in two AS types, skipping exon (SE) and alternative 3' splice site (A3SS).Interestingly, by applying self-organizing map (SOM) clustering, we unveiled two clusters mainly comprised of blood cancer cell types with a strong correlation between H3K79me2 and SE. Remarkably, the expression of transcripts associated with SE was not significantly different from

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2018 Genome medicine

14. Aerobic Exercise Intervention Alters Executive Function and White Matter Integrity in Deaf Children: A Randomized Controlled Study (PubMed)

Aerobic Exercise Intervention Alters Executive Function and White Matter Integrity in Deaf Children: A Randomized Controlled Study This study examined the effects of an 11-week aerobic exercise intervention on executive function (EF) and white matter integrity (WMI). In total, 28 deaf children (aged 9-13 years) were randomly assigned to either an 11-week exercise intervention or the control group. All the children had behavioral assessment and diffusion tensor imaging prior to and following (...) the exercise intervention. The behavioral performance results demonstrated that EF was enhanced by exercise. Relative to the control group, WMI of the exercise intervention group showed (1) lower fractional anisotropy (FA) in the pontine crossing tract (PCT) and right cingulum (hippocampus) (CH), genu of the corpus callosum (gCC), right inferior cerebellar peduncle (ICP), left superior corona radiata (SCR), and left superior frontooccipital fasciculus (SFOF); (2) higher mean diffusivity (MD) in the gCC

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2018 Neural plasticity

15. An Integrated Native Mass Spectrometry and Top-Down Proteomics Method that Connects Sequence to Structure and Function of Macromolecular Complexes (PubMed)

An Integrated Native Mass Spectrometry and Top-Down Proteomics Method that Connects Sequence to Structure and Function of Macromolecular Complexes Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification. These two techniques are usually performed separately without taking advantage of the synergies between them. Here we describe (...) the development of an integrated native MS and top-down proteomics method using Fourier-transform ion cyclotron resonance (FTICR) to analyse macromolecular protein complexes in a single experiment. We address previous concerns of employing FTICR MS to measure large macromolecular complexes by demonstrating the detection of complexes up to 1.8 MDa, and we demonstrate the efficacy of this technique for direct acquirement of sequence to higher-order structural information with several large complexes. We

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2018 Nature chemistry

16. Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program

Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Lifestyle Integrated Functional Exercise for People With Dementia: a Home-based Physical Activity Program (LiFE4D) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

17. Intra-colonial diversity in the scleractinian coral, Acropora millepora: identifying the nutritional gradients underlying physiological integration and compartmentalised functioning (PubMed)

Intra-colonial diversity in the scleractinian coral, Acropora millepora: identifying the nutritional gradients underlying physiological integration and compartmentalised functioning Scleractinian corals are colonial organisms comprising multiple physiologically integrated polyps and branches. Colonialism in corals is highly beneficial, and allows a single colony to undergo several life processes at once through physiological integration and compartmentalised functioning. Elucidating differences (...) scleractinian, Acropora millepora. For smaller colonies, branches were sampled at three locations: the colony centre (S-centre), 50% of the longitudinal radius length (LRL) (S-50), and the colony edge (S-edge). For larger colonies, four locations were sampled: the colony centre (L-centre), 33.3% of the LRL (L-33), 66.6% of the LRL (L-66), and the edge (L-edge). Results demonstrate significant branch position effects, with the edge regions containing higher protein, likely due to increased tissue synthesis

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2018 PeerJ

18. Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant (PubMed)

Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant Gene regulatory networks (GRNs) consist of different molecular interactions that closely work together to establish proper gene expression in time and space. Especially in higher eukaryotes, many questions remain on how these interactions collectively coordinate gene regulation. We study high quality GRNs consisting of undirected protein-protein, genetic and homologous interactions (...) , and directed protein-DNA, regulatory and miRNA-mRNA interactions in the worm Caenorhabditis elegans and the plant Arabidopsis thaliana. Our data-integration framework integrates interactions in composite network motifs, clusters these in biologically relevant, higher-order topological network motif modules, overlays these with gene expression profiles and discovers novel connections between modules and regulators. Similar modules exist in the integrated GRNs of worm and plant. We show how experimental

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2018 Nucleic acids research

19. Molecular chaperoning helps safeguarding mitochondrial integrity and motor functions in the Sahara silver ant Cataglyphis bombycina (PubMed)

in preserving mitochondrial integrity and energy production. The joined induction of small heat-shock proteins likely depicts the higher requirement of this insect for proper motor function in response to extreme burst of heat-stresses. We discuss how those physiological adaptations may effectively help workers resist and survive the scorching heat and burning ground of the midday Sahara Desert. (...) Molecular chaperoning helps safeguarding mitochondrial integrity and motor functions in the Sahara silver ant Cataglyphis bombycina The Sahara silver ant Cataglyphis bombycina is one of the world's most thermotolerant animals. Workers forage for heat-stricken arthropods during the hottest part of the day, when temperatures exceed 50 °C. However, the physiological adaptations needed to cope with such harsh conditions remain poorly studied in this desert species. Using transcriptomics, we

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2018 Scientific reports

20. Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats (PubMed)

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated synaptic transmission in the medial prefrontal (...) . Interestingly, in the stress-resilient animals, we found higher number of neuropeptide Y-positive neurons in the entire mPFC. The electrophysiological analysis revealed reduced frequencies of spontaneous and miniature IPSCs in the anhedonic rats and decreased release probability of perisomatic-targeting GABAergic synapses and alterations in GABAB receptor mediated signaling. In turn, pyramidal neurons showed higher excitability. Anhedonic rats were also significantly impaired in the object-place paired

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2018 Frontiers in cellular neuroscience

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