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High Pressure Injection Wound

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161. Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radological Society of Europe and the Canadian Association for

site/wound infections incurred during surgery, the in- fectious complications in IR are most likely the result of bacterial inocu- lation into the bloodstream. Common mechanisms include (i) contamination of a needle, catheter, or wire by contact with a nonsterile surface or residual skin ?ora during vascular access (8);(ii) traversal of small vessels located along the trajectory of a needle creating channels of communication for bacteria to enter the bloodstream (9);(iii) intravasation (...) to aseptic technique, and an emphasis on hand hygiene (8,11). PROCEDURE CLASSIFICATION Although the pathogenesis behind infectious complications in IR is differentthaninsurgery,IRprocedureshaveinthepastbeencategorizedby usingde?nitionsestablishedbytheNationalAcademyofSciences/National Research Council surgical wound classi?cation originally de?ned in 1964 (12). More recent studies have found that the de?nitions used in this classi?cation schemeto describeinfectiousadverseevents,includingsepsis

2019 Society of Interventional Radiology

162. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

gene G-CSF granulocyte colony-stimulating factor GMP Good Manufacturing Practice GO gemtuzumab ozogamicin (Mylotarg) GOELAMS Groupe Ouest Est d'Etude des Leucémies aiguës et Autres Maladies du Sang HC Heavy chain HiDAC high-dose AraC HL-60 CD33-positive human leukaemia cell line HMBC heteronuclear multiple-bond correlation spectroscopy HPLC High-Performance Liquid Chromatography HR hazard ratio HSCT haematopoietic stem cell transplant ICD Informed Consent Document ICH International Conference (...) PSUR Periodic Safety Update Report PT Preferred Term PXRD Powder X-ray diffraction QoL Quality of Life R Arginine RBC red blood cell RFS relapse-free survival RP-HPLC Reverse Phase High-Performance Liquid Chromatography RSI Reference Safety Information SAE serious adverse event SCE Summary of Clinical Efficacy SCS Summary of Clinical Safety SD standard deviation SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis SEC size exclusion chromatography SMQ Standardised MedDRA Query SOC

2018 European Medicines Agency - EPARs

163. Promethazine

of high-risk patients administered prophylactic ondansetron. All subjects enrolled were identified as high risk for PONV, administered general 2009 7. Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine 22346617 2012 02 20 2012 07 09 2017 02 20 1424-8220 11 1 2011 Sensors (Basel, Switzerland) Sensors (Basel) Ionophore-based potentiometric sensors for the flow-injection determination of promethazine (...) wanted the latest trusted evidence on promethazine or other clinical topics then use Trip today. This page lists the very latest high quality evidence on promethazine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip

2018 Trip Latest and Greatest

164. Side effects

pressure, osteoporosis, and development of diabetes mellitus. However (...) , whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied. OBJECTIVES: To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes). SEARCH METHODS: We searched MEDLINE, Embase (...) of evidence. If you wanted the latest trusted evidence on side effects or other clinical topics then use Trip today. This page lists the very latest high quality evidence on side effects and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice

2018 Trip Latest and Greatest

165. Nitroglycerin

of evidence. If you wanted the latest trusted evidence on nitroglycerin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on nitroglycerin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice (...) of STEMI prior to NTG administration. We sought to determine if NTG administration is more likely to be associated (...) with hypotension (systolic blood pressure < 90 mmHg) in inferior STEMI compared to non-inferior STEMI. We conducted a retrospective chart review of prehospital patients with chest pain of suspected cardiac origin and computer-interpreted prehospital ECGs indicating "ACUTE MI." We included all local STEMI cases identified as part of our STEMI registry. Univariate analysis was used

2018 Trip Latest and Greatest

166. Hip fracture

of evidence. If you wanted the latest trusted evidence on hip fracture or other clinical topics then use Trip today. This page lists the very latest high quality evidence on hip fracture and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice (...) in older persons: an update Jenson C S Mak, Ian D Cameron and Lyn M March Med J Aust 2010; 192 (1): 37-41. Abstract (...) . Recommendations for time to surgery, thromboprophylaxis, anaesthesia, analgesia, prophylactic antibiotics, surgical fixation of fractures , nutritional status, mobilisation and rehabilitation have been updated. Also, recommendations regarding surgical wound closure, management of postoperative delirium, osteoporosis treatment and hip protectors have been added. The guidelines

2018 Trip Latest and Greatest

167. Guidelines For Professional Ultrasound Practice

3 Foreword 5 Revision 1, December 2016 6 Revision 2, December 2017 Introduction 7 Section 1 General information 1.1 Explanation of the professional title ‘sonographer’ 9 1.2 Registration for sonographers 10 1.3 Professional Indemnity Insurance 11 1.4 Profession vs tool 11 1.5 Safety of medical ultrasound 12 1.6 Medico-legal issues 13 1.7 Transducer cleaning and disinfection 14 1.8 Screening examinations using ultrasound 15 1.9 Ergonomic practice including managing the high BMI patient 17 1.10 (...) should be performed and are based on best available evidence. They help ultrasound practitioners in their work but they do not replace their knowledge and skills’. Protocol: An agreement, preferably based on research, between practitioners to ensure the delivery of high quality standardised ultrasound examinations. The title of this 2015 edition ‘Guidelines for Professional Ultrasound Practice’ reflects the above definitions. These Guidelines, which are not prescriptive, are made available to be used

2018 British Medical Ultrasound Society

168. Bevacizumab (Mvasi) - Cancer, colon, breast, lung, kidney, ovary, cervix

EMA/798844/2017 Page 4/91 ELISA enzyme-linked immunosorbent assay EOI event of interest ESI-TOF-MS electrospray ionization time-of-flight mass spectrometry EU endotoxin units Fc fragment crystallizable FcR fragment crystallizable receptor FcRn neonatal Fc receptor FDA Food and Drug Administration (US) FTIR fourier-transformed infrared spectroscopy GCP good clinical practice GFR glomerular filtration rate GI gastrointestinal HC heavy chain HCP host cell protein HIAC high accuracy light obscuration (...) particle counting HIC hydrophobic interaction chromatography HPLC high-performance liquid chromatography HUVEC human umbilical vein endothelial cells HWP high molecular weight ICF informed consent form ICH International Conference on Harmonisation IEC Independent Ethics Committee Ig immunoglobulin IP investigational product IPC in-process control IRB Institutional Review Board ITT intent-to-treat IV intravenous IXRS interactive voice and web response system KM Kaplan-Meier LC light chain LC-MS/MS

2018 European Medicines Agency - EPARs

169. Guidelines for Living Donor Kidney Transplantation

10.1 Long-Term Outcome Following Living Kidney Donation 248 10.2 Arrangements for Follow-up 251 10.3 The Unsuitable Donor 255 10.4 Pregnancy following Kidney Donation 256 BTS/RA Living Donor Kidney Transplantation Guidelines 2018 4 11 RECIPIENT OUTCOME AFTER LIVING DONOR KIDNEY TRANSPLANTATION IN ADULTS 260 11.1 Living versus Deceased Donor Transplantation 261 11.2 Extended Criteria Living Donors 261 11.3 Transplantation versus Dialysis 262 11.4 High Risk Recipients 263 12 RECURRENT RENAL DISEASE (...) to living donor kidney transplantation and reflects a growing body of evidence, incorporating aspects of clinical practice that are relevant to both adult and paediatric settings. These include the ethical and medico-legal aspects of donor selection, medical and pre-operative donor evaluation, identification of high risk donors, the management of complications, and expected outcome. Scenarios that present an increased level of risk to the potential recipient, such as antibody incompatible

2018 Renal Association

170. Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines

of Evidence: Lumbar Disc Injections: Based on the available evidence regarding the use of platelet-rich plasma (PRP), including one high-quality randomized controlled trial (RCT), multiple moderate-quality observational studies, a single-arm meta-analysis and evidence from a systematic review, the qualitative evidence has been assessed as Level III (on a scale of Level I through V) using a qualitative modified approach to the grading of evidence based on best-evidence synthesis. Based on the available (...) , Ricardo Vallejo, MD, PhD 24 , Art Watanabe, MD 25 , Douglas Beall, MD 26 , Todd P. Stitik, MD 27 , Patrick M. Foye, MD 28 , Erik M. Helander, MBBS 29 , and Joshua A. Hirsch, MD 30 www.painphysicianjournal.com Pain Physician 2019; 22:S1-S74 • ISSN 1533-3159on best evidence synthesis. Lumbar Epidural Injections Based on one high-quality RCT, multiple relevant moderate-quality observational studies and a single-arm meta-analysis, the qualitative evidence has been assessed as Level IV (on a scale of Level

2019 American Society of Interventional Pain Physicians

171. Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines

and antithrombotic therapy was conducted. Data sources included relevant literature identified through searches of EMBASE and PubMed from 1966 through August 2018 and manual searches of the bibliographies of known primary and review articles. Results: 1. There is good evidence for risk stratification by categorizing multiple interventional techniques into low-risk, moderate-risk, and high-risk. Also, their risk should be up- graded based on other risk factors. 2. There is good evidence for the risk (...) of thromboembolic events in patients who inter- rupt antithrombotic therapy. 3. There is good evidence supporting discontinuation of low dose aspirin for high risk and moderate risk procedures for at least 3 days, and there is moderate evidence that these may be continued for low risk or some intermediate risk procedures. Guidelines Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians

2019 American Society of Interventional Pain Physicians

172. Management of diabetes mellitus-tuberculosis - a guide to the essential practice

-TB 75 8.1 Quarterly cohort report of TB patients being screened for DM 77 8.2 Quarterly cohort report of new DM patients being screened for TB 79 10.1 Quarterly cohort report of DM screening in TB patients 89 10.2 Quarterly cohort report of TB screening in DM patients 91 Figures 1.1 Natural history of TB 16 4.1 Algorithm for the diagnosis of DM among TB patients 41 5.1 Algorithm for TB screening amongst persons with newly diagnosed DM in countries with high prevalence of TB (>100 cases per (...) glucose and, if resources are available, HbA1c are the preferred diagnostic tests for DM in patients with TB. Although the oral glucose tolerance test is the gold standard for diagnosing DM, it is too cumbersome for routine use in busy TB clinics. • DM patients should be offered systematic screening for TB only in high-TB burden countries where TB prevalence is greater than 100 per 100,000 people. • In persons newly diagnosed with DM, systematic TB screening should be performed actively (i.e

2019 International Union Against TB and Lung Disease

173. Complex regional pain syndrome in adults (2nd edition)

of Clinical Neurophysiology. Patients with complex regional pain syndrome (CRPS) and their relatives contributed to the development process. Published with:ii © Royal College of Physicians 2018 The Royal College of Physicians The Royal College of Physicians (RCP) plays a leading role in the delivery of high-quality patient care by setting standards of medical practice and promoting clinical excellence. The RCP provides physicians in over 30 medical specialties with education, training and support (...) of the categories C) The patient reports at least one symptom in three or more of the categories D) No other diagnosis can better explain the signs and symptoms ? ? ? ? Category Sign (you can see or feel a problem) Symptom (the patient reports a problem) 1 ‘Sensory’ Allodynia (to light touch and/or temperature sensation and/or deep somatic pressure and/or hyperalgesia (to pinprick) ? Hyperesthesia does also qualify as a symptom ? 2 ‘Vasomotor’ Temperature asymmetry and/or skin colour changes and/or skin colour

2018 Royal College of Physicians

174. ETA Guidelines for the Treatment and Follow-Up of Advanced Radioiodine-Refractory Thyroid Cancer Full Text available with Trip Pro

[ ]. The histopathological diagnostic criteria for PDTC are defined in the Turin Consensus proposal: (1) malignant thyroid follicular cell neoplasm (presence of invasion and/or metastasis); (2) solid, trabecular, or insular growth pattern; (3) absence of the conventional nuclear features of PTC; (4) at least one of the following three features: convoluted nuclei (defined as a small round hyperchromatic nuclei with convolutions of the nuclear membrane), 3 or more than 3 mitoses per 10 high-power fields, and tumour (...) of dedifferentiation in nuclei, in the growth pattern, a high mitotic activity, and necrosis in the recurrent or metastatic lesion of a patient with primary diagnosis of DTC [ , , ]. The molecular pattern of DTCs is often characterized by mutations in the MAPK and PI3K pathways, prevalently BRAF and RAS mutations in PTC and RAS and PAX8/PPARγ mutations in FTC [ ]. During the dedifferentiation process, DTCs acquire subsequent mutations, and they frequently harbour, as PDTC, multiple somatic genetic alterations

2019 European Thyroid Association

175. The EAU – EANM – ESTRO – ESUR – SIOG Guidelines on Prostate Cancer

-Lapierre, A., et al. Metabolic syndrome and prostate cancer risk in a population-based case-control study in Montreal, Canada. BMC Public Health, 2015. 15: 913. 33. Preston, M.A., et al. Metformin use and prostate cancer risk. Eur Urol, 2014. 66: 1012. 34. Freedland, S.J., et al. Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study. Prostate Cancer Prostatic Dis, 2013. 16: 254. 35. James, N.D., et al. Abiraterone for Prostate Cancer Not Previously Treated (...) with Hormone Therapy. N Engl J Med, 2017. 377: 338. 36. YuPeng, L., et al. Cholesterol Levels in Blood and the Risk of Prostate Cancer: A Meta-analysis of 14 Prospective Studies. Cancer Epidemiol Biomarkers Prev, 2015. 24: 1086. 37. Vidal, A.C., et al. Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study. Cancer Epidemiol Biomarkers Prev, 2014. 23: 2936. 38. Davies, N.M., et al. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian

2020 European Association of Nuclear Medicine

176. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up

meningitis may be present. Risk factors include concurrent craniospinal radiotherapy and frequent injections via the lumbar route. Prevention and treatment No evidence based preventive measure is established. For treatment, steroids injected slowly via lumbar route might be considered, although sufficient data are limited [V, C] [53]. Treatment with high-dose folate metabolites in patients with MTX- induced myelopathy may be worth a try [V, C] [66]. In general, recovery is variable; the majority (...) paraesthesia, as reported among 1409 long-term Norwegian survivors of testicular cancer [7]. There have been many attempts to identify genetic markers carrying a high risk of developing CIPN. However, none of the individual single nucleotide polymorphisms (SNPs) identified so far has sufficient prognostic value for use in clinical practice [8]. In cases with severe neurotoxicity, for instance motor involvement due to vincristine- induced CIPN, relevant predisposing neurological diseases such as axonal

2020 European Society for Medical Oncology

177. Dental Management of Pediatric Patients Receiving Chemotherapy, Hematopoietic Cell Transplantation, and/or Radiation Therapy

be gently flossed daily. If pain or exces - sive bleeding occurs, the patient should avoid the affected area, but floss the other teeth. 1 Patients with poor oral hygiene and/or periodontal disease may use chlorhexidine rinses daily until the tissue health improves or mucositis develops. 13 The high alcohol content of commercially-available chlorhexidine mouthwash may cause discomfort and dehydrate the tissues in patients with mucositis; thus, an alcohol-free chlorhexidine solution is indicated (...) in this situation. Diet: Dental practitioners should discuss the importance of a healthy diet to maintain nutritional status with an empha- sis on foods that do not promote caries. Patients and parents should be advised about the high cariogenic potential of di- etary supplements rich in carbohydrates and oral pediatric medications rich in sucrose. 6 They should also be instructed that sharp, crunchy, spicy, and highly acidic foods and alcohol should be avoided during chemotherapy, radiation, and HCT. 1

2018 American Academy of Pediatric Dentistry

178. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada

, London, ON Jean-Marie Ekoé MD CSPQ PD Professor of Medicine, Endocrinology, Metabolism and Nutrition Service of Endocrinology and Metabolism, CHUM, Department of Medicine and Nutrition, University of Montreal, Montréal, QC John Embil BSc(Hon) MD FRCPC FACP Professor Max Rady College of Medicine, University of Manitoba, Director, Health Science Centre Infection Prevention and Control Unit, Coordinator, Diabetic Foot and Complicated Wound Clinic, Winnipeg, MB Dean T. Eurich PhD Professor School

2018 Diabetes Canada

179. VAAFT for treating anal fistulae

that they should only be used with special arrangements for clinical governance, consent and audit or research. Fibrin glue can be injected into the fistula tract in an attempt to seal it. Evidence for this procedure reports initial success rates of 50%, but long-term findings indicate that it may be associated with a high rate of recurrence (Cirocchi et al. 2009). NICE is unaware of any CE-marked technologies which fulfil a similar function to VAAFT. VAAFT for treating anal fistulae (MIB102) © NICE 2018. All (...) patients (34.15%) had discharge from the wound. 13 patients (15.85%) had a recurrence during 6 month follow- up. Anal manometry showed that there were no statistically significant changes in the mean resting anal pressures and mean anal squeeze pressures before and after the procedure. None of the patients reported any problems with faecal continence. People with Crohn's disease and existing faecal incontinence were excluded from the study. MRI scans were done for all participants. Faecal continence

2017 National Institute for Health and Clinical Excellence - Advice

180. Scleroderma Morphea

Forced vital capacity GBCA Gadolinium-based contrast agents GFR Glomerular filtration rate HR-CT High-resolution computed tomography ILD Interstitial lung disease IVIg Intravenous immunoglobulin LFT Lung function test LoSCAT Localized Scleroderma Cutaneous Assessment Tool LoSDI Modified Localized Scleroderma Skin Severity Index LS Localized scleroderma MCTD Mixed connective tissue disease mLoSSI Modified Localized Scleroderma Skin Severity Index MMF Mycophenolate mofetil MMP Matrix metalloproteinases (...) much is known about the early inflammatory phase and the molecular mechanisms involved in the fibroblastic reaction of LS, little is known about the potential triggers of the disease. Among infectious agents, Borrelia organisms have been extensively studied on both sides of the Atlantic. Whereas high rates of Borrelia infections, some of which were detected using highly sensitive new detection techniques such as focus-floating microscopy, have been reported in LS patients from Europe, a variety

2018 European Dermatology Forum

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