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High Pressure Injection Wound

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121. Management of Surgical Site Infections

: Strong Description: Evidence from two or more “High” strength studies with consistent findings for recommending for or against the intervention. C-REACTIVE PROTEIN Strong evidence supports that C-reactive Protein is a strong rule-in and rule-out marker for patients with suspected surgical site infections. Strength of Recommendation: Strong Description: Evidence from two or more “High” strength studies with consistent findings for recommending for or against the intervention. ERYTHROCYTE SEDIMENTATION (...) . CLINICAL EXAM FOR THE DIAGNOSIS OF SURGICAL SITE INFECTIONS Moderate strength evidence supports that clinical exam (i.e. pain, drainage, fever) is a moderate to strong rule-in test (i.e. high probability of presence of infection, if test is positive) for patients with suspected surgical site infections, but a weak rule-out test. Strength of Recommendation: Moderate Description: Evidence from two or more “Moderate” quality studies with consistent findings, or evidence from a single “High” quality study

2018 American Academy of Orthopaedic Surgeons

122. ILCOR Scientific Knowledge Gaps and Clinical Research Priorities for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: A Consensus Statement

pressure associated with high-quality pediatric CPR, as well as with improved outcomes. Vasopressors During Cardiac Arrest The efficacy of vasopressor administration during adult OHCA has been questioned because of the results of several prospective randomized trials and associated meta-analyses. , However, no human studies have compared epinephrine or combinations of vasopressors with controls for pediatric OHCA, although a small case series suggested that the use of epinephrine could be harmful (...) of treatment recommendations supported by high-quality science. , To promote transparency, each systematic review was accompanied by a list of knowledge gaps identified by the task forces as they wrote treatment recommendations that were frequently qualified as weak on the basis of low-quality evidence. When insufficient or conflicting evidence prohibited formulation of a treatment recommendation, the following language was used: “The confidence in effect estimates is so low that the panel feels

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2018 American Heart Association

123. 2018 IDSA Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy

for effective monitoring for vascular access complications and antimicrobial adverse events (weak recommendation, low-quality evidence) . III. Can persons who inject drugs (PWID) be treated with OPAT at home? No recommendation can be made about whether PWID may be treated with OPAT at home (no recommendation, low-quality evidence) . Decisions should be made on a case-by-case basis. IV. Should elderly patients be allowed to be treated with OPAT at home? Elderly patients should be allowed to be treated (...) OPAT have laboratory test monitoring while on therapy? If so, which tests should be done and how often? Serial laboratory testing should be monitored in patients receiving OPAT (strong recommendation, high-quality evidence) . Data are insufficient to make evidence-based recommendations about specific tests and specific frequencies of monitoring for individual antimicrobials used in OPAT. XV. For patients receiving vancomycin as part of OPAT, should vancomycin serum levels be measured regularly

2018 Infectious Diseases Society of America

124. Imaging Guidelines

, but exceptions can be made for patients with difficult access, as is often the case in seriously injured patients. 17 When a large bore peripheral IV catheter cannot be obtained, a pressure rated central venous catheter designed to accommodate high-pressure injection (consult the package insert for each brand for further clarification) is a safe alternative. 17 A central 9 Fr venous catheter is commonly placed in such patients and can be used, although many currently available products are not yet pressure (...) of approximately 0.26 to 0.7 percent. 14-16 Significant morbidity is infrequent, with most adverse events occurring in patients with severe cachexia or impaired venous or lymphatic drainage. 16 Most cases do not require significant intervention, with 97.4 percent having minimal to no adverse effects. 15 IV contrast is most frequently administered through a pressure injector for optimal diagnostic clarity. Antecubital or large forearm venous injection sites are preferred to reduce risk of contrast extravasation

2018 American College of Surgeons

125. 2018 guidelines for the early management of patients with acute ischemic stroke

limited data exist demonstrating the urgent need for continued research on treatment of acute ischemic stroke. New high-quality evidence has produced major changes in the evidence-based treatment of patients with acute ischemic stroke (AIS) since the publication of the most recent “Guidelines for the Early Management of Patients With Acute Ischemic Stroke” in 2013. Much of this new evidence has been incorporated into American Heart Association (AHA) focused updates, guidelines, or scientific (...) stroke ARD Absolute risk difference ASCVD Atherosclerotic cardiovascular disease ASPECTS Alberta Stroke Program Early Computed Tomography Score BP Blood pressure CEA Carotid endarterectomy CeAD Cervical artery dissection CI Confidence interval CMB Cerebral microbleed COR Class of recommendation CS Conscious sedation CT Computed tomography CTA Computed tomographic angiography CTP Computed tomographic perfusion DTN Door-to-needle DVT Deep vein thrombosis DW-MRI Diffusion-weighted magnetic resonance

2018 American Academy of Neurology

126. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

. Conclusions— These guidelines are based on the best evidence currently available. In many instances, however, only limited data exist demonstrating the urgent need for continued research on treatment of acute ischemic stroke. New high-quality evidence has produced major changes in the evidence-based treatment of patients with acute ischemic stroke (AIS) since the publication of the most recent “Guidelines for the Early Management of Patients With Acute Ischemic Stroke” in 2013. Much of this new evidence (...) ACC American College of Cardiology AHA American Heart Association AIS Acute ischemic stroke ARD Absolute risk difference ASCVD Atherosclerotic cardiovascular disease ASPECTS Alberta Stroke Program Early Computed Tomography Score BP Blood pressure CEA Carotid endarterectomy CeAD Cervical artery dissection CI Confidence interval CMB Cerebral microbleed COR Class of recommendation CS Conscious sedation CT Computed tomography CTA Computed tomographic angiography CTP Computed tomographic perfusion DTN

2018 American Heart Association

127. Regorafenib (Stivarga) indicated as monotherapy for the treatment of adult patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib treatment

- ment, incorrect statistical analysis). For each domain, assessors were expected to judge the risk of bias (‘low risk’, ‘high risk’, or ‘un- clear’) on the basis of the information retrieved from the paper and from the CSR. The results of the risk of bias assessment at both study and outcome level are presented in Table A8 and Table A9 in Appendix 1. The external validity of the included trial was assessed using the EUnetHTA guideline on applica- bility of evidence in the context of a relative (...) by the addition of one fluorine atom. Although regorafenib is a targeted therapy, there is no relevant predictive biomarker identified. Pharmacodynamics/Kinetics Absorption: a high-fat meal increased the mean area under the curve (AUC) of the drug by 48% compared with the fasted state and decreased the mean AUC of the active metabolites M-2 (N- oxide) by 20% and M-5 (N-oxide and N-desmethyl) by 51%. A low-fat meal increased the mean AUC of regorafenib by 36%, M-2 by 40%, and M-5 by 23%, compared

2018 EUnetHTA

128. Paediatric Urology

., et al. Correction of congenital penile curvature using modified tunical plication with absorbable sutures: the long-term outcome and patient satisfaction. Eur Urol, 2007. 52: 261. 271. Sasso, F., et al. Penile curvature: an update for management from 20 years experience in a high volume centre. Urologia, 2016. 83: 130. 272. Gittes, R.F., et al. Injection technique to induce penile erection. Urology, 1974. 4: 473. 273. Schultheiss, D., et al. Congenital and acquired penile deviation treated (...) therapy with LHRH and HCG in cryptorchid infants. Eur J Pediatr, 1993. 152 Suppl 2: S31. 66. Forest, M.G., et al. Effects of human chorionic gonadotropin, androgens, adrenocorticotropin hormone, dexamethasone and hyperprolactinemia on plasma sex steroid-binding protein. Ann N Y Acad Sci, 1988. 538: 214. 67. Aycan, Z., et al. Evaluation of low-dose hCG treatment for cryptorchidism. Turk J Pediatr, 2006. 48: 228. 68. Hesse, V., et al. Three injections of human chorionic gonadotropin are as effective

2018 European Association of Urology

129. Urological Trauma

Physician, 2001. 63: 1567. 261. Selikowitz, S.M. Penetrating high-velocity genitourinary injuries. Part I. Statistics mechanisms, and renal wounds. Urology, 1977. 9: 371. 262. Hudak, S.J., et al. Operative management of wartime genitourinary injuries at Balad Air Force Theater Hospital, 2005 to 2008. J Urol, 2009. 182: 180. 263. Cass, A.S., et al. Bilateral testicular injury from external trauma. J Urol, 1988. 140: 1435. 264. Michielsen, D., et al. Burns to the genitalia and the perineum. J Urol, 1998 (...) expectant (conservative) management of renal trauma--a systematic review. J Trauma, 2005. 59: 493. 29. Sujenthiran, A., et al. Is Nonoperative Management the Best First-line Option for High-grade Renal trauma? A Systematic Review. Eur Urol Focus, 2017. 30. Mingoli, A., et al. Operative and nonoperative management for renal trauma: comparison of outcomes. A systematic review and meta-analysis. Ther Clin Risk Manag, 2017. 13: 1127. 31. Bjurlin, M.A., et al. Comparison of nonoperative management

2018 European Association of Urology

130. Urological Infections

) in patients with chronic prostatitis syndrome. Andrologia, 2005. 37: 61. 256. Ohkawa, M., et al. Antimicrobial treatment for chronic prostatitis as a means of defining the role of Ureaplasma urealyticum. Urol Int, 1993. 51: 129. 257. Jimenez-Cruz, J.F., et al. Treatment of chronic prostatitis: intraprostatic antibiotic injections under echography control. J Urol, 1988. 139: 967. 258. Mayersak, J.S. Transrectal ultrasonography directed intraprostatic injection of gentamycin-xylocaine in the management (...) , and Vaginal Surgery: A Systematic Review. J Minim Invasive Gynecol, 2015. 22: 737. 294. Guenaga, K.F., et al. Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev, 2011: CD001544. 295. Dumville, J.C., et al. Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev, 2015: CD003949. 296. Webster, J., et al. Use of plastic adhesive drapes during surgery for preventing surgical site infection. Cochrane Database

2018 European Association of Urology

131. Male Sexual Dysfunction

(penile rehabilitation) in the patient after brachytherapy for prostate cancer. Brachytherapy, 2012. 11: 87. 82. Cordeiro, E.R., et al. High-intensity focused ultrasound (HIFU) for definitive treatment of prostate cancer. BJU Int, 2012. 110: 1228. 83. Williams, S.B., et al. Comparative effectiveness of cryotherapy vs brachytherapy for localised prostate cancer. BJU Int, 2012. 110: E92. 84. Hatzichristou, D., et al. Diagnosing Sexual Dysfunction in Men and Women: Sexual History Taking and the Role (...) : reproducibility, evaluation criteria and the effect of sexual intercourse. J Urol, 1998. 159: 1921. 110. Hatzichristou, D.G., et al. Hemodynamic characterization of a functional erection. Arterial and corporeal veno-occlusive function in patients with a positive intracavernosal injection test. Eur Urol, 1999. 36: 60. 111. Sikka, S.C., et al. Standardization of vascular assessment of erectile dysfunction: standard operating procedures for duplex ultrasound. J Sex Med, 2013. 10: 120. 112. Pathak, R.A., et al

2018 European Association of Urology

132. Penile Cancer

in Five Continents Vol. VIII. IARC Scientific Publication No. 155. Vol. Vol III. 2002, The International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon CEDEX 08, France. 16. Parkin, D.M., et al. Chapter 2: The burden of HPV-related cancers. Vaccine, 2006. 24 Suppl 3: S3/11. 17. Baldur-Felskov, B., et al. Increased incidence of penile cancer and high-grade penile intraepithelial neoplasia in Denmark 1978-2008: a nationwide population-based study. Cancer Causes Control, 2012. 23: 273 (...) carcinoma of the penis. Scand J Urol Nephrol Suppl, 2000: 189. 22. Maden, C., et al. History of circumcision, medical conditions, and sexual activity and risk of penile cancer. J Natl Cancer Inst, 1993. 85: 19. 23. Tsen, H.F., et al. Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). Cancer Causes Control, 2001. 12: 267. 24. Afonso, L.A., et al. High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients

2018 European Association of Urology

133. Urinary Incontinence

factors. Int Urogynecol J Pelvic Floor Dysfunct, 2007. 18: 397. 45. Milleman, M., et al. Post-void residual urine volume in women with overactive bladder symptoms. J Urol, 2004. 172: 1911. 46. Brostrom, S., et al. Short-term reproducibility of cystometry and pressure-flow micturition studies in healthy women. Neurourol Urodyn, 2002. 21: 457. 47. Broekhuis, S.R., et al. Reproducibility of same session repeated cystometry and pressure-flow studies in women with symptoms of urinary incontinence (...) . Neurourol Urodyn, 2010. 29: 428. 48. Schick, E., et al. Predictive value of maximum urethral closure pressure, urethral hypermobility and urethral incompetence in the diagnosis of clinically significant female genuine stress incontinence. J Urol, 2004. 171: 1871. 49. Dorflinger, A., et al. Urethral pressure profile: is it affected by position? Neurourol Urodyn, 2002. 21: 553. 50. Wang, A.C., et al. A comparison of urethral pressure profilometry using microtip and double-lumen perfusion catheters

2018 European Association of Urology

134. Muscle-invasive and Metastatic Bladder Cancer

. Chrouser, K., et al. Bladder cancer risk following primary and adjuvant external beam radiation for prostate cancer. J Urol, 2005. 174: 107. 26. Nieder, A.M., et al. Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population based cohort study. J Urol, 2008. 180: 2005. 27. Zelefsky, M.J., et al. Incidence of secondary cancer development after high-dose intensity-modulated radiotherapy and image-guided brachytherapy for the treatment of localized prostate (...) latero-montanal biopsies and urethral frozen sections during prostatocystectomy. Eur Urol, 1998. 33: 170. 81. Miladi, M., et al. The value of a second transurethral resection in evaluating patients with bladder tumours. Eur Urol, 2003. 43: 241. 82. Jakse, G., et al. A second-look TUR in T1 transitional cell carcinoma: why? Eur Urol, 2004. 45: 539. 83. Brauers, A., et al. Second resection and prognosis of primary high risk superficial bladder cancer: is cystectomy often too early? J Urol, 2001. 165

2018 European Association of Urology

135. Prostate Cancer

Broeck T., et al. A systematic review of oncological effectiveness and harms of primary local interventions for high-risk localized and locally advanced prostate cancer. PROSPERO International prospective register of systematic reviews, 2017. CRD42017078862 8. Willemse, P.M., et al. Systematic review of deferred treatment with curative intent for localised prostate cancer to explore heterogeneity of definitions, thresholds and criteria and clinical effectiveness. PROSPERO International prospective (...) . 29. Esposito, K., et al. Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis. J Endocrinol Invest, 2013. 36: 132. 30. Blanc-Lapierre, A., et al. Metabolic syndrome and prostate cancer risk in a population-based case-control study in Montreal, Canada. BMC Public Health, 2015. 15: 913. 31. Preston, M.A., et al. Metformin use and prostate cancer risk. Eur Urol, 2014. 66: 1012. 32. Freedland, S.J., et al. Statin use and risk of prostate cancer and high-grade

2018 European Association of Urology

136. Adult Type 1 diabetes mellitus

, high-risk activities). • Advise adults with type 1 diabetes to aim for: - a fasting plasma glucose level of 5–7 mmol/litre on waking and - a plasma glucose level of 4–7 mmol/litre before meals at other times of the day. _________________________ 1 Refer to section 2.9 for a description on the strength of recommendations made10 | Adult type 1 diabetes mellitus | A National Clinical Guideline Insulin therapy • Offer multiple daily injection basal–bolus insulin regimens, rather than twice-daily mixed (...) in ensuring that patients get the best outcomes from their care. The Department of Health is of the view that supporting evidence-based practice, through the clinical effectiveness framework, is a critical element of the health service to deliver safe and high quality care. The National Clinical Effectiveness Committee (NCEC) is a Ministerial committee set up in 2010 as a key recommendation of the report of the Commission on Patient Safety and Quality Assurance (2008). The establishment of the Commission

2018 National Clinical Guidelines (Ireland)

137. National Clinical Guideline on Adult type 1 diabetes mellitus

- evident that safe, effective care and treatment are important in ensuring that patients get the best outcomes from their care. The Department of Health is of the view that supporting evidence-based practice, through the clinical effectiveness framework, is a critical element of the health service to deliver safe and high quality care. The National Clinical Effectiveness Committee (NCEC) is a Ministerial committee set up in 2010 as a key recommendation of the report of the Commission on Patient Safety (...) and Quality Assurance (2008). The establishment of the Commission was prompted by an increasing awareness of patient safety issues in general and high profile health service system failures at home and abroad. The NCEC on behalf of the Department of Health has embarked on a quality assured National Clinical Guideline development process linked to service delivery priorities. Furthermore, implementing National Clinical Guidelines sets a standard nationally, to enable healthcare professionals to deliver

2018 HIQA Guidelines

138. Renal Transplantation

uncontrolled donors after cardiac death. Transplant Proc, 2008. 40: 1023. 45. Jochmans, I., et al. Hypothermic machine perfusion of kidneys retrieved from standard and high-risk donors. Transpl Int, 2015. 28: 665. 46. Treckmann, J., et al. Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death. Transpl Int, 2011. 24: 548. 47. Gill, J., et al. Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants (...) , irrespective of donor type and cold ischemic time. Transplantation, 2014. 97: 668. 48. Matsuno, N., et al. Machine perfusion preservation for kidney grafts with a high creatinine from uncontrolled donation after cardiac death. Transplant Proc, 2010. 42: 155. 49. Jochmans, I., et al. Graft quality assessment in kidney transplantation: not an exact science yet! Curr Opin Organ Transplant, 2011. 16: 174. 50. Thuillier, R., et al. Benefits of active oxygenation during hypothermic machine perfusion of kidneys

2018 European Association of Urology

139. Low back pain and radicular pain: development of a clinical pathway

LIST OF ABBREVIATIONS 7 ? SCIENTIFIC REPORT 12 1 INTRODUCTION 12 1.1 BACKGROUND: A FREQUENT PROBLEM WITH HIGH SOCIETAL IMPACT 12 1.2 STUDY OBJECTIVES AND RESEARCH QUESTIONS 13 1.3 DEFINITION OF CONCEPTS 13 1.3.1 Definition of low back and radicular pain 13 1.3.2 Definition of clinical pathway 14 1.4 STUDY PROCESS 14 2 A SYSTEMATIC REVIEW OF LITERATURE 15 2.1 RESEARCH OBJECTIVE 15 2.2 METHODS 15 2.3 RESULTS 16 2.4 LIMITATIONS 22 3 INTERNATIONAL COMPARISON OF PATHWAYS 22 3.1 RESEARCH OBJECTIVE 22 3.2 (...) WIV – ISP Wetenschappelijk Instituut Volksgezondheid – Institut Scientifique de Santé Publique wk(s) Week(s) WVV Wetenschappelijke Vereniging voor Verzekeringsgeneeskunde WVVK Wetenschappelijke vereniging van Vlaamse kinesitherapeuten yrs Years ZNA Ziekenhuis Netwerk Antwerpen ZOL Ziekenhuis Oost-Limburg 12 Low back pain and radicular pain: development of a clinical pathway KCE Report 295 ? SCIENTIFIC REPORT 1 INTRODUCTION 1.1 Background: a frequent problem with high societal impact Low back pain

2017 Belgian Health Care Knowledge Centre

140. Prescribing patterns of dependence forming medicines

medication supply from iGen and Braeburn and also discussions with various companies about medications potentially applicable in the treatment of addictions and related problems. This includes exploration of the potential for - and consideration of research trials of - improved medications with less abuse liability, longer duration of action (e.g. implant or depot formulations) and also novel non-injectable emergency medications. JS works with the charity Action on Addiction, and also with the Pilgrim (...) or by whether patients live in high or low deprivation neighbourhoods. Characteristics of patients by average prescribing period Some types of DFM tend to be prescribed on average for longer periods in more deprived neighbourhoods. • While local area-level deprivation was not significantly associated with whether or not DFM prescribing periods exceeded 30 days, it was associated with the mean average length of prescriptions. Mean average length is affected by the overall distribution in prescribing periods

2017 Public Health Research Consortium

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