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High Pressure Injection Wound


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81. Urinary Incontinence

factors. Int Urogynecol J Pelvic Floor Dysfunct, 2007. 18: 397. 45. Milleman, M., et al. Post-void residual urine volume in women with overactive bladder symptoms. J Urol, 2004. 172: 1911. 46. Brostrom, S., et al. Short-term reproducibility of cystometry and pressure-flow micturition studies in healthy women. Neurourol Urodyn, 2002. 21: 457. 47. Broekhuis, S.R., et al. Reproducibility of same session repeated cystometry and pressure-flow studies in women with symptoms of urinary incontinence (...) . Neurourol Urodyn, 2010. 29: 428. 48. Schick, E., et al. Predictive value of maximum urethral closure pressure, urethral hypermobility and urethral incompetence in the diagnosis of clinically significant female genuine stress incontinence. J Urol, 2004. 171: 1871. 49. Dorflinger, A., et al. Urethral pressure profile: is it affected by position? Neurourol Urodyn, 2002. 21: 553. 50. Wang, A.C., et al. A comparison of urethral pressure profilometry using microtip and double-lumen perfusion catheters

2019 European Association of Urology

82. Muscle-invasive and Metastatic Bladder Cancer

. Chrouser, K., et al. Bladder cancer risk following primary and adjuvant external beam radiation for prostate cancer. J Urol, 2005. 174: 107. 26. Nieder, A.M., et al. Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population based cohort study. J Urol, 2008. 180: 2005. 27. Zelefsky, M.J., et al. Incidence of secondary cancer development after high-dose intensity-modulated radiotherapy and image-guided brachytherapy for the treatment of localized prostate (...) latero-montanal biopsies and urethral frozen sections during prostatocystectomy. Eur Urol, 1998. 33: 170. 81. Miladi, M., et al. The value of a second transurethral resection in evaluating patients with bladder tumours. Eur Urol, 2003. 43: 241. 82. Jakse, G., et al. A second-look TUR in T1 transitional cell carcinoma: why? Eur Urol, 2004. 45: 539. 83. Brauers, A., et al. Second resection and prognosis of primary high risk superficial bladder cancer: is cystectomy often too early? J Urol, 2001. 165

2019 European Association of Urology

83. Guidelines for crises in anaesthesia - Quick Reference Handbook

by the clinician in the light of the clinical data presented and the diagnostic and treatment options 3-11 High central neuraxial block v.1 • Can occur with deliberate or accidental injection of local anaesthetic drugs into the subarachnoid space. • Symptoms are – in sequence – hypotension and bradycardia – difficulty breathing – paralysis of the arms – impaired consciousness – apnoea and unconsciousness. • Progression through this sequence can be slow or fast. Box A: INDUCING ANAESTHESIA • Consider reduced (...) are commonly simultaneous 2-1 Cardiac arrest (v.1) 2-2 Hypoxia/desaturation/cyanosis (v.1) 2-3 Increased airway pressure (v.1) 2-4 Hypotension (v.1) 2-5 Hypertension (v.1) 2-6 Bradycardia (v.1) 2-7 Tachycardia (v.1) 2-8 Peri-operative hyperthermia (v.1) Section 3: ‘Knowns’ Guidelines for crises where a known or suspected event requires treatment 3-1 Anaphylaxis (v.3) 3-2 Massive blood loss (v.2) 3-3 Can't intubate, can’t oxygenate (CICO) (v.1) 3-4 Bronchospasm (v.2) 3-5 Circulatory embolus (v.1) 3-6

2019 Association of Anaesthetists of GB and Ireland

84. Treatment of Diabetes in Older Adults

65 to 85 years with diabetes, we recommend a target blood pressure of 140/90 mm Hg to decrease the risk of cardiovascular disease outcomes, stroke, and progressive chronic kidney disease. (1|⊕⊕⊕O) Technical remark: Patients in certain high-risk groups could be considered for lower blood pressure targets (130/80 mm Hg), such as those with previous stroke or progressing chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m 2 and/or albuminuria). If lower blood pressure (...) targets are selected, careful monitoring of such patients is needed to avoid orthostatic hypotension. Patients with high disease complexity (group 3, poor health, ) could be considered for higher blood pressure targets (145 to 160/90 mm Hg). Choosing a blood pressure target involves shared decision-making between the clinician and patient, with full discussion of the benefits and risks of each target. 5.2 In patients aged 65 years and older with diabetes and hypertension, we recommend

2019 The Endocrine Society

85. British Association of Dermatologists guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in children and young people

Supporting Information). Additional references relevant to the topic were also isolated from citations in reviewed literature. Evidence from the included studies was graded according to the GRADE system (high, moderate, low or very low quality). Recommendations are based on evidence drawn from systematic reviews of the literature pertaining to the clinical questions identified; tables Linking the Evidence To the Recommendations (LETR) (Appendix B; see Supporting Information), the summary of findings (...) recommendations and ratings were agreed upon unanimously by the core members of the GDG and patient representatives. For further information on the wording used for recommendations and strength of recommendation ratings see Section 2. The GDG is aware of the lack of high‐quality evidence for these recommendations, therefore strong recommendations with an asterisk (*) are based on available evidence and/or consensus within the GDG and specialist experience. Most of the recommendations are derived from

2019 British Association of Dermatologists

86. What is the evidence on the role of the arts in improving health and well-being? A scoping review

differences in society and the environment that can shape health) have been developed across higher- and lower-income countries, including in Canada (Quebec), Finland, Lithuania and Latin American countries. These have had a shared focus on using the arts to promote social inclusion, skills development, capacity-building and health promotion (84). For example, among children specifically identified as at risk (e.g. living in areas characterized by high levels of economic deprivation, substandard housing

2019 WHO Health Evidence Network

87. Treatment for Acute Pain: An Evidence Map

A. Nelson, M.Sc. Shellina Scheiner, PharmD, B.C.G.P. Mary L. Forte, Ph.D., D.C. Mary Butler, Ph.D., M.B.A. Sanket Nagarkar, D.D.S., M.P.H. Jayati Saha, Ph.D. Timothy J. Wilt, M.D., M.P.H. AHRQ Publication No. 19(20)-EHC022-EF Oct ober 2019 ii Key Messages Purpose of review The purpose of this evidence map is to provide a high-level overview of the current guidelines and systematic reviews on pharmacologic and nonpharmacologic treatments for acute pain. We map the evidence for several acute pain (...) treated in select settings (emergency departments; inpatient and outpatient surgical facilities; primary and specialty care clinics; and dental clinics and dental surgery centers)? a. How is acute pain for these conditions assessed and monitored? b. Which individual characteristics modify perceptions of pain severity, treatment options, and treatment response? 2. Which of these priority acute pain conditions have recent, high-quality guidelines that address acute pain treatments? 3. Which

2019 Effective Health Care Program (AHRQ)

88. Urological Trauma

Physician, 2001. 63: 1567. 261. Selikowitz, S.M. Penetrating high-velocity genitourinary injuries. Part I. Statistics mechanisms, and renal wounds. Urology, 1977. 9: 371. 262. Hudak, S.J., et al. Operative management of wartime genitourinary injuries at Balad Air Force Theater Hospital, 2005 to 2008. J Urol, 2009. 182: 180. 263. Cass, A.S., et al. Bilateral testicular injury from external trauma. J Urol, 1988. 140: 1435. 264. Michielsen, D., et al. Burns to the genitalia and the perineum. J Urol, 1998 (...) expectant (conservative) management of renal trauma--a systematic review. J Trauma, 2005. 59: 493. 29. Sujenthiran, A., et al. Is Nonoperative Management the Best First-line Option for High-grade Renal trauma? A Systematic Review. Eur Urol Focus, 2017. 30. Mingoli, A., et al. Operative and nonoperative management for renal trauma: comparison of outcomes. A systematic review and meta-analysis. Ther Clin Risk Manag, 2017. 13: 1127. 31. Bjurlin, M.A., et al. Comparison of nonoperative management

2019 European Association of Urology

89. Urological Infections

) in patients with chronic prostatitis syndrome. Andrologia, 2005. 37: 61. 256. Ohkawa, M., et al. Antimicrobial treatment for chronic prostatitis as a means of defining the role of Ureaplasma urealyticum. Urol Int, 1993. 51: 129. 257. Jimenez-Cruz, J.F., et al. Treatment of chronic prostatitis: intraprostatic antibiotic injections under echography control. J Urol, 1988. 139: 967. 258. Mayersak, J.S. Transrectal ultrasonography directed intraprostatic injection of gentamycin-xylocaine in the management (...) , and Vaginal Surgery: A Systematic Review. J Minim Invasive Gynecol, 2015. 22: 737. 294. Guenaga, K.F., et al. Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev, 2011: CD001544. 295. Dumville, J.C., et al. Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev, 2015: CD003949. 296. Webster, J., et al. Use of plastic adhesive drapes during surgery for preventing surgical site infection. Cochrane Database

2019 European Association of Urology

90. Renal Transplantation

uncontrolled donors after cardiac death. Transplant Proc, 2008. 40: 1023. 45. Jochmans, I., et al. Hypothermic machine perfusion of kidneys retrieved from standard and high-risk donors. Transpl Int, 2015. 28: 665. 46. Treckmann, J., et al. Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death. Transpl Int, 2011. 24: 548. 47. Gill, J., et al. Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants (...) , irrespective of donor type and cold ischemic time. Transplantation, 2014. 97: 668. 48. Matsuno, N., et al. Machine perfusion preservation for kidney grafts with a high creatinine from uncontrolled donation after cardiac death. Transplant Proc, 2010. 42: 155. 49. Jochmans, I., et al. Graft quality assessment in kidney transplantation: not an exact science yet! Curr Opin Organ Transplant, 2011. 16: 174. 50. Thuillier, R., et al. Benefits of active oxygenation during hypothermic machine perfusion of kidneys

2019 European Association of Urology

91. Diagnosis and Treatment of Non-Neurogenic Overactive Bladder (OAB) in Adults

of A (high), B (moderate), or C (low). Additional treatment information is provided as Clinical Principles and Expert Opinions when insufficient evidence existed. Following initial publication, this Guideline underwent amendment in 2014 and 2019 to pull in literature released since the initial publication of the Guideline. The current document reflects relevant literature published through October 2018. See text and algorithm for definitions and detailed diagnostic, management and treatment frameworks (...) /burdens. 3 Standards are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken based on Grade A (high level of certainty) or Grade B (moderate level of certainty) evidence. Recommendations are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken based on Grade C (low level of certainty) evidence. Options are non-directive statements

2019 American Urological Association

92. BSG consensus guidelines on the management of inflammatory bowel disease in adults

5.13.2 IBD-related cancer chemoprevention with mesalazine 168 5.13.3 IBD-related cancer chemoprevention with thiopurines 170 5.14 Anti-TNF, vedolizumab, ustekinumab and tofacitinib therapy during pregnancy 171 5.14.1 Fetal and infant exposure to anti-TNF drugs 171 5.14.2 Cessation of anti-TNF therapy in the second trimester in quiescent IBD 172 5.14.3 Continuation throughout pregnancy in IBD patients at high risk of flare 172 5.14.4 Risk to the fetus of continuing anti-TNF until delivery 172 5.14.5 (...) the Society.[1] The aim of this document is to provide high-quality disease management guidance for healthcare professionals managing IBD, to ensure that investigation, treatment and monitoring decisions are based on the best available evidence, and to promote and improve best accepted practice. Where appropriate the guidelines refer to relevant National Institute for Health and Care Excellence (NICE) documents, with attention drawn to how this guidance can be incorporated into the United Kingdom National

2019 British Society of Gastroenterology

93. Guideline regarding treatment of haemorrhoids

Injection sclerotherapy (SCL) 25 6.4 Evidence in the literature 25 6.4.1 Rubber Band Ligation (RBL) versus Infrared Coagulation (IRC)versus Sclerotherapy (SCL) 25 6.4.2 RBL versus DG-HAL versus SH versus Haemorrhoidectomy 29 6.5 Complications 31 6.5.1 Rubber Band Ligation (RBL) 31 6.5.2 Infrared Coagulation (IRC) 32 6.5.3 Sclerotherapy (SCL) 32 6.6 Relative effectiveness and ranking of the three options 32 6.7 Conclusions 33 6.8 GRADE 33 6.9 Recommendations for outpatient procedures 37 7 Surgical (...) be avoided (expert opinion, upgraded by guideline development group). ? The use of laxatives could be considered for symptom relief and to reduce bleeding (low level of evidence). ? Phlebotonics could contribute to symptom reduction (low level of evidence). 7 ? NSAIDs and non-opioids analgesics could be prescribed for pain (expert opinion). 1.3 Outpatient procedures ? Choice of the outpatient procedure (i.e. rubber band ligation, injection sclerotherapy and infrared coagulation) should be informed

2019 Palliative Care Evidence Review Service (PaCERS)

94. Prevention and Control of Methecillin-Resistant Staphylcoccus Aureus (MRSA)

been an in-patient in a hospital abroad during the previous 12 months. Grade C • Patients with non-intact skin, including wounds and ulcers and also exfoliative skin conditions, percutaneous endoscopic gastrostomy tubes, urinary catheters and central venous catheters. Grade C • Clients due to undergo elective high and medium risk surgery (e.g. cardiothoracic and vascular surgery, orthopaedic implant surgery). In addition, hospitals should assess which patient groups undergoing surgery have (...) a relatively high risk of MRSA infection and consider pre-operative screening for those particular patient sub-sets. For example, it may be appropriate for hospitals to screen emergency orthopaedic admissions as many of these patients are elderly and have frequent contact with the healthcare system. Grade C • Patients admitted to critical care areas, e.g. intensive care unit (ICU) and special care baby unit (SCBU) with at least weekly screening thereafter. Grade D • Patients requiring renal dialysis. Grade

2019 National Clinical Guidelines (Ireland)

95. Penetrating Trauma-Lower Abdomen and Pelvis.

with a traumatic rupture of the prostatomembranous urethra, with an average of 3.1 associated injuries per patient [4,6]. The degree of bladder distension with urine determines its shape and, to some degree, the injury it may sustain. Even relatively minor trauma can rupture the fully distended bladder [7]; the empty bladder is seldom injured, except by crushing or penetrating wounds. Gross hematuria indicates urologic trauma. The presence of gross blood at the urethral meatus strongly suggests urethral injury (...) and Stone [11], 90% of 103 patients with a pelvic fracture did not have a bladder rupture; therefore, the authors concluded that cystography may be safely reserved for patients with pelvic fractures who are considered to be at high risk for such an injury. They limited cystography in pelvic fracture to patients with significant pubic arch involvement, gross hematuria, and/or hemodynamic instability. Bladder Injury The Consensus Panel of the Société Internationale D’Urologie has classified bladder injury

2019 American College of Radiology

96. Integrated care for older people (?ICOPE)?: guidance for person-centred assessment and pathways in primary care

or currently under medical treatment (eg diabetes, high blood pressure) HEARING LOSS (Chapter 8) Hears whispers (whisper test) or Screening audiometry result is 35 dB or less or Passes automated app-based digits-in-noise test DEPRESSIVE SYMPTOMS (Chapter 9) Over the past two weeks, have you been bothered by feeling down, depressed or hopeless little interest or pleasure in doing things Wrong to either question or does not know Cannot recall all three words No Yes Yes Yes Yes Yes Fail TABLE 1. WHO ICOPE (...) CAPACITY CHANGE OVER THE LIFE COURSE? Figure 2 shows the typical pattern of intrinsic capacity and functional ability across adult life. Intrinsic capacity and functional ability decline with increasing age as a result of the ageing process as well as underlying diseases. This typical pattern can be divided into three common periods: a period of relatively high and stable capacity, a period of declining capacity and a period of signi?cant loss of capacity, characteried by dependence on care

2019 World Health Organisation Guidelines

97. Management of Pilonidal Disease

include a large area of tissue mobilization, increased risk of hematoma/ seroma formation, and wound dehiscence. 92 Although data from several randomized trials found low (0%–6%) overall rates of surgical site infections, 77,78,80 a recent ran- domized controlled trial shows a very high rate of wound dehiscence associated with this type of flap. 92 Although many of these dehiscences were minor, and the major- ity went on to heal without recurrence, they do require ongoing wound care. There are several (...) of Colon & Rectal Surgeons, Inc. Unauthorized reproduction of this article is prohibited. JOHNSON ET AL: MANAGEMENT OF PILONIDAL DISEASE 156 76. Biter LU, Beck GM, Mannaerts GH, Stok MM, van der Ham AC, Grotenhuis BA. The use of negative-pressure wound therapy in pilonidal sinus disease: a randomized controlled trial comparing negative-pressure wound therapy versus standard open wound care after surgical excision. Dis Colon Rectum. 2014;57:1406–1411. 77. Abu Galala KH, Salam IM, Abu Samaan KR, et al

2019 American Society of Colon and Rectal Surgeons

98. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

of Medicines ERA Environmental Risk Assessment EU European Union FAS Full Analysis Set Fpen market penetration factor GC Gas Chromatography GCP Good Clinical Practice HPLC high-pressure liquid chromatography HRQoL Health-Related Quality of Life ICH International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Ig Immunoglobulin IL Interleukin IOP Intraocular pressure IR Infrared LDPE Low Density Polyethylene LLNA Local Lymph Node Assay LLOD lower limit (...) , increase of intraocular pressure (IOP), induction and exacerbation of glaucoma, impaired wound healing, and increased susceptibility to infection including herpetic infection, is a major limitation of this treatment choice. Use of antihistamine/mast cell stabilisers as maintenance therapy and then pulse therapy with topical steroids during disease exacerbations is a common practice. With their ability to inhibit T-cell activation, hospital-compounded preparations of 0.5% to 2% ciclosporin A (CsA

2018 European Medicines Agency - EPARs

99. Adalimumab (Hyrimoz) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Crohn Disease, Papulosquamous Skin Diseases, Hidradenitis Suppurativa, Ankylosing Spondylitis, Uveitis

to report adverse reactions. 1. NAME OF THE MEDICINAL PRODUCT Hyrimoz 40 mg solution for injection in pre-filled syringe Hyrimoz 40 mg solution for injection in pre-filled pen 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Hyrimoz 40 mg solution for injection in pre-filled syringe: Each 0.8 ml single-dose pre-filled syringe contains 40 mg of adalimumab. Hyrimoz 40 mg solution for injection in pre-filled pen: Each 0.8 ml single-dose pre-filled pen contains 40 mg of adalimumab. Adalimumab is a recombinant (...) human monoclonal antibody produced in Chinese Hamster Ovary cells. For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Solution for injection (injection). Clear to slightly opalescent, colourless to slightly yellowish solution. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Rheumatoid arthritis Hyrimoz in combination with methotrexate, is indicated for: • the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease

2018 European Medicines Agency - EPARs

100. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

gene G-CSF granulocyte colony-stimulating factor GMP Good Manufacturing Practice GO gemtuzumab ozogamicin (Mylotarg) GOELAMS Groupe Ouest Est d'Etude des Leucémies aiguës et Autres Maladies du Sang HC Heavy chain HiDAC high-dose AraC HL-60 CD33-positive human leukaemia cell line HMBC heteronuclear multiple-bond correlation spectroscopy HPLC High-Performance Liquid Chromatography HR hazard ratio HSCT haematopoietic stem cell transplant ICD Informed Consent Document ICH International Conference (...) PSUR Periodic Safety Update Report PT Preferred Term PXRD Powder X-ray diffraction QoL Quality of Life R Arginine RBC red blood cell RFS relapse-free survival RP-HPLC Reverse Phase High-Performance Liquid Chromatography RSI Reference Safety Information SAE serious adverse event SCE Summary of Clinical Efficacy SCS Summary of Clinical Safety SD standard deviation SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis SEC size exclusion chromatography SMQ Standardised MedDRA Query SOC

2018 European Medicines Agency - EPARs

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