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81. Bariatric surgery: an HTA report on the efficacy, safety and cost-effectiveness

the presence of (pre- )diabetes, hypertension, a low HDL-cholesterol, high triglycerides, and/or a high waist-circumference might indicate a higher associated risk, as is also the presence of non-alcoholic steato-hepatitis. Insulin resistance and metabolic syndrome are more prevalent in people with visceral adiposity. Obesity clearly does imply risks, may lead to physical and psychological symptoms, can cause functional limitation, the development of co- morbidities and complications, and cause psycho (...) A study in 20 European countries found an overall prevalence rate of overweight and obesity of 53% with the highest prevalence rates in Eastern European countries. For obesity (BMI =30 kg/m²), Slovenia (20.8%), Estonia (19.7%) and the UK (19.2%) had the highest rates. 17 While the increase in some countries plateaus (at a high level), there is still a general increase in the prevalence of obesity observed around the globe, even in countries with historically low prevalence rates. 6, 16, 18 The burden

2019 Belgian Health Care Knowledge Centre

82. Iron Deficiency and Anaemia in Adults

>500 to 1000mg 250ml 15 minutes Note: For stability reasons, dilutions to concentrations less than 2mg iron/ml are not permissible. Ferinject must not be administered by the subcutaneous or intramuscular route. Minimum observation is required (pulse and blood pressure should be checked before and after infusion). Facilities for cardiorespiratory resuscitation and equipment for handling acute anaphylactic/anaphylactoid reactions should be available, including an injectable 1:1000 adrenaline solution (...) or irregular heartbeat. • Pounding or ‘whooshing’ in the ears. • Headache. • Cold hands or feet. • Pale skin. • Chest pain. • Lack of concentration. • Mouth ulcers or cracks at the corners of the mouth. • Slow or poor wound healing. • Tinnitus. (Arnott et al., 2013) Important questions to ask To determine the underlying cause of anaemia, questions about an individual’s lifestyle and medical history should be asked. These questions should cover the following areas. Diet Certain types of food preferences

2018 Royal College of Nursing

83. ESC/EACTS Guidelines on Myocardial Revascularization Full Text available with Trip Pro

contribution of the European Association for Percutaneous Cardiovascular Interventions (EAPCI) Table of contents Abbreviations and acronyms 90 1 Preamble 93 2 Introduction 94 2.1 What is new in the 2018 Guidelines? 95 3 Diagnostic tools to guide myocardial revascularization 96 3.1 Non-invasive diagnostic tools 96 3.1.1 Assessment of myocardial ischaemia 96 3.1.2 Assessment of myocardial viability in patients with heart failure and coronary artery disease 96 3.2 Invasive diagnostic tools 96 3.2.1 Pressure (...) -derived fractional flow reserve 96 3.2.1.1 Use of fractional flow reserve in patients with intermediate-grade coronary stenosis including left main stenosis 96 3.2.1.2 Use of fractional flow reserve to identify lesions requiring revascularization in patients with multivessel coronary artery disease undergoing percutaneous coronary intervention 97 3.2.1.3 Fractional flow reserve-guided management vs. medical therapy in patients with coronary artery disease 97 3.2.2 Other pressure-derived indices 97

2018 European Society of Cardiology

84. Hip fracture

of evidence. If you wanted the latest trusted evidence on hip fracture or other clinical topics then use Trip today. This page lists the very latest high quality evidence on hip fracture and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice (...) in older persons: an update Jenson C S Mak, Ian D Cameron and Lyn M March Med J Aust 2010; 192 (1): 37-41. Abstract (...) . Recommendations for time to surgery, thromboprophylaxis, anaesthesia, analgesia, prophylactic antibiotics, surgical fixation of fractures , nutritional status, mobilisation and rehabilitation have been updated. Also, recommendations regarding surgical wound closure, management of postoperative delirium, osteoporosis treatment and hip protectors have been added. The guidelines

2018 Trip Latest and Greatest

85. Adalimumab (Hyrimoz) - Juvenile Rheumatoid Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Crohn Disease, Papulosquamous Skin Diseases, Hidradenitis Suppurativa, Ankylosing Spondylitis, Uveitis

to report adverse reactions. 1. NAME OF THE MEDICINAL PRODUCT Hyrimoz 40 mg solution for injection in pre-filled syringe Hyrimoz 40 mg solution for injection in pre-filled pen 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Hyrimoz 40 mg solution for injection in pre-filled syringe: Each 0.8 ml single-dose pre-filled syringe contains 40 mg of adalimumab. Hyrimoz 40 mg solution for injection in pre-filled pen: Each 0.8 ml single-dose pre-filled pen contains 40 mg of adalimumab. Adalimumab is a recombinant (...) human monoclonal antibody produced in Chinese Hamster Ovary cells. For the full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Solution for injection (injection). Clear to slightly opalescent, colourless to slightly yellowish solution. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Rheumatoid arthritis Hyrimoz in combination with methotrexate, is indicated for: • the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease

2018 European Medicines Agency - EPARs

86. Nitroglycerin

of evidence. If you wanted the latest trusted evidence on nitroglycerin or other clinical topics then use Trip today. This page lists the very latest high quality evidence on nitroglycerin and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice (...) of STEMI prior to NTG administration. We sought to determine if NTG administration is more likely to be associated (...) with hypotension (systolic blood pressure < 90 mmHg) in inferior STEMI compared to non-inferior STEMI. We conducted a retrospective chart review of prehospital patients with chest pain of suspected cardiac origin and computer-interpreted prehospital ECGs indicating "ACUTE MI." We included all local STEMI cases identified as part of our STEMI registry. Univariate analysis was used

2018 Trip Latest and Greatest

87. Side effects

pressure, osteoporosis, and development of diabetes mellitus. However (...) , whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied. OBJECTIVES: To assess the effects of a steroid load of dexamethasone on postoperative systemic or wound infection, delayed wound healing, and blood glucose change in adult surgical patients (with planned subgroup analysis of patients with and without diabetes). SEARCH METHODS: We searched MEDLINE, Embase (...) of evidence. If you wanted the latest trusted evidence on side effects or other clinical topics then use Trip today. This page lists the very latest high quality evidence on side effects and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice

2018 Trip Latest and Greatest

88. Promethazine

of high-risk patients administered prophylactic ondansetron. All subjects enrolled were identified as high risk for PONV, administered general 2009 7. Ionophore-Based Potentiometric Sensors for the Flow-Injection Determination of Promethazine Hydrochloride in Pharmaceutical Formulations and Human Urine 22346617 2012 02 20 2012 07 09 2017 02 20 1424-8220 11 1 2011 Sensors (Basel, Switzerland) Sensors (Basel) Ionophore-based potentiometric sensors for the flow-injection determination of promethazine (...) wanted the latest trusted evidence on promethazine or other clinical topics then use Trip today. This page lists the very latest high quality evidence on promethazine and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months. What is Trip? Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care. Trip

2018 Trip Latest and Greatest

89. Ciclosporin (Verkazia) - Conjunctivitis, Keratitis

of Medicines ERA Environmental Risk Assessment EU European Union FAS Full Analysis Set Fpen market penetration factor GC Gas Chromatography GCP Good Clinical Practice HPLC high-pressure liquid chromatography HRQoL Health-Related Quality of Life ICH International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Ig Immunoglobulin IL Interleukin IOP Intraocular pressure IR Infrared LDPE Low Density Polyethylene LLNA Local Lymph Node Assay LLOD lower limit (...) , increase of intraocular pressure (IOP), induction and exacerbation of glaucoma, impaired wound healing, and increased susceptibility to infection including herpetic infection, is a major limitation of this treatment choice. Use of antihistamine/mast cell stabilisers as maintenance therapy and then pulse therapy with topical steroids during disease exacerbations is a common practice. With their ability to inhibit T-cell activation, hospital-compounded preparations of 0.5% to 2% ciclosporin A (CsA

2018 European Medicines Agency - EPARs

90. Bevacizumab (Mvasi) - Cancer, colon, breast, lung, kidney, ovary, cervix

EMA/798844/2017 Page 4/91 ELISA enzyme-linked immunosorbent assay EOI event of interest ESI-TOF-MS electrospray ionization time-of-flight mass spectrometry EU endotoxin units Fc fragment crystallizable FcR fragment crystallizable receptor FcRn neonatal Fc receptor FDA Food and Drug Administration (US) FTIR fourier-transformed infrared spectroscopy GCP good clinical practice GFR glomerular filtration rate GI gastrointestinal HC heavy chain HCP host cell protein HIAC high accuracy light obscuration (...) particle counting HIC hydrophobic interaction chromatography HPLC high-performance liquid chromatography HUVEC human umbilical vein endothelial cells HWP high molecular weight ICF informed consent form ICH International Conference on Harmonisation IEC Independent Ethics Committee Ig immunoglobulin IP investigational product IPC in-process control IRB Institutional Review Board ITT intent-to-treat IV intravenous IXRS interactive voice and web response system KM Kaplan-Meier LC light chain LC-MS/MS

2018 European Medicines Agency - EPARs

91. Guidelines For Professional Ultrasound Practice

3 Foreword 5 Revision 1, December 2016 6 Revision 2, December 2017 Introduction 7 Section 1 General information 1.1 Explanation of the professional title ‘sonographer’ 9 1.2 Registration for sonographers 10 1.3 Professional Indemnity Insurance 11 1.4 Profession vs tool 11 1.5 Safety of medical ultrasound 12 1.6 Medico-legal issues 13 1.7 Transducer cleaning and disinfection 14 1.8 Screening examinations using ultrasound 15 1.9 Ergonomic practice including managing the high BMI patient 17 1.10 (...) should be performed and are based on best available evidence. They help ultrasound practitioners in their work but they do not replace their knowledge and skills’. Protocol: An agreement, preferably based on research, between practitioners to ensure the delivery of high quality standardised ultrasound examinations. The title of this 2015 edition ‘Guidelines for Professional Ultrasound Practice’ reflects the above definitions. These Guidelines, which are not prescriptive, are made available to be used

2018 British Medical Ultrasound Society

92. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

gene G-CSF granulocyte colony-stimulating factor GMP Good Manufacturing Practice GO gemtuzumab ozogamicin (Mylotarg) GOELAMS Groupe Ouest Est d'Etude des Leucémies aiguës et Autres Maladies du Sang HC Heavy chain HiDAC high-dose AraC HL-60 CD33-positive human leukaemia cell line HMBC heteronuclear multiple-bond correlation spectroscopy HPLC High-Performance Liquid Chromatography HR hazard ratio HSCT haematopoietic stem cell transplant ICD Informed Consent Document ICH International Conference (...) PSUR Periodic Safety Update Report PT Preferred Term PXRD Powder X-ray diffraction QoL Quality of Life R Arginine RBC red blood cell RFS relapse-free survival RP-HPLC Reverse Phase High-Performance Liquid Chromatography RSI Reference Safety Information SAE serious adverse event SCE Summary of Clinical Efficacy SCS Summary of Clinical Safety SD standard deviation SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis SEC size exclusion chromatography SMQ Standardised MedDRA Query SOC

2018 European Medicines Agency - EPARs

93. Care around stillbirth and neonatal death

and provide appropriate assistance to parents. The guideline is not intended to be prescriptive, but is designed to provide reliable, up-to-date information enabling integration of best evidence, clinicians’ judgement and individual choice in arriving at decisions about care. Clinical practice guidelines may be considered as generally recommended practice. Inevitably, given the nature and sensitivity of the subject and the lack of high quality studies, some contentious issues remain. The Working Party (...) . Please refer to Appendix T – Australian and New Zealand definitions of perinatal mortality for a summary of definitions across the jurisdictions. Rates and causes of stillbirth and neonatal death Australia and New Zealand have one of the lowest perinatal mortality rates in the world, however areas for further improvement are clear; notably the slow progress in reducing the rates of stillbirth - similar to many high income countries 9 . Stillbirths make up the majority of perinatal deaths and have

2019 Centre of Research Excellence in Stillbirth

94. Prevention and Control of Methecillin-Resistant Staphylcoccus Aureus (MRSA)

been an in-patient in a hospital abroad during the previous 12 months. Grade C • Patients with non-intact skin, including wounds and ulcers and also exfoliative skin conditions, percutaneous endoscopic gastrostomy tubes, urinary catheters and central venous catheters. Grade C • Clients due to undergo elective high and medium risk surgery (e.g. cardiothoracic and vascular surgery, orthopaedic implant surgery). In addition, hospitals should assess which patient groups undergoing surgery have (...) a relatively high risk of MRSA infection and consider pre-operative screening for those particular patient sub-sets. For example, it may be appropriate for hospitals to screen emergency orthopaedic admissions as many of these patients are elderly and have frequent contact with the healthcare system. Grade C • Patients admitted to critical care areas, e.g. intensive care unit (ICU) and special care baby unit (SCBU) with at least weekly screening thereafter. Grade D • Patients requiring renal dialysis. Grade

2019 National Clinical Guidelines (Ireland)

95. Guidelines for crises in anaesthesia - Quick Reference Handbook

by the clinician in the light of the clinical data presented and the diagnostic and treatment options 3-11 High central neuraxial block v.1 • Can occur with deliberate or accidental injection of local anaesthetic drugs into the subarachnoid space. • Symptoms are – in sequence – hypotension and bradycardia – difficulty breathing – paralysis of the arms – impaired consciousness – apnoea and unconsciousness. • Progression through this sequence can be slow or fast. Box A: INDUCING ANAESTHESIA • Consider reduced (...) are commonly simultaneous 2-1 Cardiac arrest (v.1) 2-2 Hypoxia/desaturation/cyanosis (v.1) 2-3 Increased airway pressure (v.1) 2-4 Hypotension (v.1) 2-5 Hypertension (v.1) 2-6 Bradycardia (v.1) 2-7 Tachycardia (v.1) 2-8 Peri-operative hyperthermia (v.1) Section 3: ‘Knowns’ Guidelines for crises where a known or suspected event requires treatment 3-1 Anaphylaxis (v.3) 3-2 Massive blood loss (v.2) 3-3 Can't intubate, can’t oxygenate (CICO) (v.1) 3-4 Bronchospasm (v.2) 3-5 Circulatory embolus (v.1) 3-6

2019 Association of Anaesthetists of GB and Ireland

96. Integrated care for older people (?ICOPE)?: guidance for person-centred assessment and pathways in primary care

or currently under medical treatment (eg diabetes, high blood pressure) HEARING LOSS (Chapter 8) Hears whispers (whisper test) or Screening audiometry result is 35 dB or less or Passes automated app-based digits-in-noise test DEPRESSIVE SYMPTOMS (Chapter 9) Over the past two weeks, have you been bothered by feeling down, depressed or hopeless little interest or pleasure in doing things Wrong to either question or does not know Cannot recall all three words No Yes Yes Yes Yes Yes Fail TABLE 1. WHO ICOPE (...) CAPACITY CHANGE OVER THE LIFE COURSE? Figure 2 shows the typical pattern of intrinsic capacity and functional ability across adult life. Intrinsic capacity and functional ability decline with increasing age as a result of the ageing process as well as underlying diseases. This typical pattern can be divided into three common periods: a period of relatively high and stable capacity, a period of declining capacity and a period of signi?cant loss of capacity, characteried by dependence on care

2019 World Health Organisation Guidelines

97. WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

122 95 116 89 112 122 98 92 112 123 77 4.4 Combating sexually transmitted infections (including HIV), reproductive tract infections, cervical cancer and other gynaecological morbidities 4.3 Eliminating unsafe abortion 4.2 Providing high- quality services for family planning, including infertility services 4.1 Improving antenatal care, delivery, postpartum and newborn care 5.1 Overview 6.1 Research on self-care contributing to WHO’s “triple billion” goals 7.1 Dissemination 5.4 Training needs (...) / AIDS [UNAIDS]), Lucinda O’Hanlon (Office of the United Nations High Commissioner for Human Rights [OHCHR]), Shaffiq Essajee (United Nations Children’s Fund [UNICEF]), Kenechukwu Esom (United Nations Development Programme [UNDP]), Ayman Abdelmohsen, Petra ten Hoope-Bender and Tim Sladden (United Nations Population Fund [UNFPA]) and David Wilson (World Bank). The following WHO staff members contributed as members of the WHO Guideline Steering Group (SG), which managed the guideline development

2019 World Health Organisation Guidelines

98. Diagnosis and Treatment of Non-Neurogenic Overactive Bladder (OAB) in Adults

of A (high), B (moderate), or C (low). Additional treatment information is provided as Clinical Principles and Expert Opinions when insufficient evidence existed. Following initial publication, this Guideline underwent amendment in 2014 and 2019 to pull in literature released since the initial publication of the Guideline. The current document reflects relevant literature published through October 2018. See text and algorithm for definitions and detailed diagnostic, management and treatment frameworks (...) /burdens. 3 Standards are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken based on Grade A (high level of certainty) or Grade B (moderate level of certainty) evidence. Recommendations are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken based on Grade C (low level of certainty) evidence. Options are non-directive statements

2019 American Urological Association

99. Global Vascular Guidelines for patients with chronic limb-threatening ischemia Full Text available with Trip Pro

CLTI should be referred urgently to a vascular specialist. Accurately staging the severity of limb threat is fundamental, and the Society for Vascular Surgery Threatened Limb Classification system, based on grading of Wounds, Ischemia, and foot Infection (WIfI) is endorsed. Objective hemodynamic testing, including toe pressures as the preferred measure, is required to assess CLTI. Evidence-based revascularization (EBR) hinges on three independent axes: Patient risk, Limb severity, and ANatomic (...) controlled trial SCS Spinal cord stimulation SF-12 12-Item Short-Form Health Survey SFA Superficial femoral artery SLI severe limb ischemia SCLI subcritical limb ischemia SVS Society for Vascular Surgery SYNTAX [System for coronary disease] TAP Target arterial path TBI Toe-brachial index TcP o 2 Transcutaneous oximetry TKA Through-knee amputation TP Toe pressure VascuQoL Vascular Quality of Life tool WFVS World Federation of Vascular Societies WIfI Wound, Ischemia, foot Infection Introduction Rationale

2019 Society for Vascular Surgery

100. Darvadstrocel (Alofisel) - non-active / mildly active luminal Crohn’s disease

Darvadstrocel (Alofisel) - non-active / mildly active luminal Crohn’s disease 1 Published 8 July 2019 1 SMC2115 darvadstrocel 30 million cells/6mL suspension for injection (Alofisel®) Takeda UK Ltd 7 December 2018 (Issued June 2019) The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission (...) to the administration of darvadstrocel, if setons are in place, they must be removed and the fistula tracts should be conditioned as follows: - identify the location of the internal openings. For this, it is recommended to inject sodium chloride 9mg/mL (0.9%) solution through the external openings until it gets through the internal openings. - perform a vigorous curettage of all fistula tracts, with special emphasis in the internal openings areas, using a metallic curette. - suture the internal openings to close

2019 Scottish Medicines Consortium

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