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High Pressure Injection Wound

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21. Practice guideline: idiopathic normal pressure hydrocephalus: response to shunting and predictors of response

baseline. There were 3 subdural hematomas or effusions (5%), one requiring surgical evacuation. There also was one shunt infection, one superficial wound infection, and one pulmonary embolism (1 Class III study). A second prospective, nonrandomized trial with Class III evidence evaluated 33 patients with suspected iNPH as determined by clinical symptoms, ventriculomegaly, and ventricular stasis on a radionuclide CSF flow study (injection of radioisotope into the lumbar subarachnoid space with serial (...) of the assessments of other modalities. As demonstrated in , TTs, ELD, and perhaps CSF pulsatility in response to arterial pressure appear to have high sensitivity with variable but incomplete specificity. R o , measured in CSF-ITs in patients selected on the basis of only clinical and neuroimaging criteria, appears to add both sensitivity and specificity but still produces many false-negative results. Measuring aqueductal flow by MRI in patients preselected by TTs or infusion tests may provide some incremental

2015 American Academy of Neurology

22. Ceftaroline fosamil for injection (Teflaro)

Ceftaroline fosamil for injection (Teflaro) CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 200327 MEDICAL REVIEW(S) CLINICAL REVIEW Application Type NDA Application Number(s) 200327 Priority or Standard Standard Submit Date(s) December 29, 2009 Received Date(s) December 30, 2009 PDUFA Goal Date October 30, 2010 Division / Office Division of Anti-Infective and Ophthalmology Products Office of Antimicrobial Products Reviewer Name(s) Ariel Ramirez Porcalla, MD, MPH Neil Rellosa, MD (...) Review Completion Date October 29, 2010 Established Name Ceftaroline fosamil for injection (Proposed) Trade Name Teflaro Therapeutic Class Cephalosporin; ß-lactams Applicant Cerexa, Inc. Forest Laboratories, Inc. Formulation(s) 400 mg/vial and 600 mg/vial Intravenous Dosing Regimen 600 mg every 12 hours by IV infusion Indication(s) Acute Bacterial Skin and Skin Structure Infection (ABSSSI); Community-acquired Bacterial Pneumonia (CABP) Intended Population(s) Adults = 18 years of age Template Version

2010 FDA - Drug Approval Package

23. Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury

not be neuropathic. Static Mechanical Allodynia testing [ Time Frame: up to 12 weeks post--injection ] Mechanical allodynia is a characteristic of evoked pain in subjects with neuropathic pain. Static allodynia to mechanical stimuli will be defined as a sensation of pain evoked by the pressure of the end of a wooden stick. The end of a wooden stick will touch the affected region with enough pressure to indent the skin, for 10 seconds. Afterwards, the subject will be asked to rate the perceived pain on an 11 (...) Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2016 Clinical Trials

24. Cefepime for Injection USP and Dextrose Injection USP in the Duplex® Container

P, Drees, C, Chung S. Nonconvulsive status epilepticus. Epilepsy & Behavior 12 (2008) 572-586. Clinical Review Alma Davidson NDA 50-821 Cefepime for Injection and Dextrose Injection in Duplex ® Container 21 • Bresson J, Paugam Burtz C, Josserand J, Bardin C, Mantz J, Pease S. Cefepime overdosage with neurotoxicity recovered by high volume hemofiltration. J Antimicrob Chemother. 2008 Oct;62(4):849 50. Epub 2008 Jun 18. This article describes an adult male who was admitted to an intensive care (...) , but no evidence of epileptic discharges. Cefepime induced encephalopathy was suspected, and cefepime was stopped. Serum and CSF levels were measured by HPLC: on day 30, 3 h after the last injection, the serum cefepime level was 284 mg/L (usual levels are between 2.5 and 5.1 mg/L) and the CSF cefepime level was 18 mg/L. The antibiotic regimen was then switched to ertapenem 1 g/day once daily. Renal replacement therapy with high-volume continuous veno-venous hemofiltration was started to enhance cefepime

2009 FDA - Drug Approval Package

25. A systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression

A systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression http://wrap.warwick.ac.uk/ Original citation: Sutcliffe, Paul A., Connock, M., Shyangdan, Deepson S., Court, Rachel A., Kandala, Ngianga-Bakwin and Clarke, Aileen, 1955-. (2013) A systematic review of evidence on malignant spinal metastases : natural history and technologies for identifying patients at high risk (...) a systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression P Sutcliffe, M Connock, D Shyangdan, R Court, N-B Kandala and A Clarke Appendix 5 reasons for exclusion at full sift ( n = 305) Appendix 6 Quality assessment forms: extracted data for each study First author: bayley Year: 2001 ID: 107 reviewer(s): pS/MC – Agreed First author: bernat Year: 1983 ID: 108 reviewer(s): pS/MC

2013 NIHR HTA programme

26. Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery

and maintained throughout surgery. The target is to maintain systolic blood pressure at 110 mmHg or higher. Other Name: Norepinephrine Active Comparator: Routine blood-pressure management Phenylephrine (25-50 ug) is injected or vasopressors is infused only when necessary. The target is to maintain systolic blood pressure at 90 mmHg or higher during surgery. Drug: Routine blood-pressure management Phenylephrine (25-50 ug) is injected or vasopressors is infused only when necessary. The target is to maintain (...) Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

27. Wound Repair

for hemostasis management See See Identify functional loss prior to injecting anesthesia Evaluate muscle and tendon structures Evaluate nerve structures See See Evaluate vascular structures Evaluate underlying bone IV. Imaging Indications suspected See Modalities XRay V. Contraindications: Relative Contraindications to primary wound closure Infected and inflamed wounds or Serious crush wounds Primary repair time constraints above not met VI. Indications: Surgical Consultation Deep hand or s Full-thickness (...) concentration Nose/Ears: 1:200,000 concentration XIII. Protocol: Irrigation Wear a mask with eye shield during irrigation Saline is as effective as antiseptics (e.g. 1% betadine) for irrigation Antseptics should be avoided inside the wound due to tissue injury Tap water is as safe and effective as saline for irrigation (and more plentiful) Moderate pressure irrigation is the key Irrigation with syringe provides approximately 5-8 psi Irrigate with minimum of 250 to 500 cc, or 50-100 ml/cm wound length (use

2018 FP Notebook

28. Best practices for injections and related procedures toolkit

-stick or other puncture wounds caused by sharp objects. Needles, scalpels and other sharps should be handled with extreme caution. Note: This table provides information on glove use in relation to any type of injection. A table on glove use in general health-care settings is given in Annex A. 2.1.3 Other single-use personal protective equipment Masks, eye protection and other protective clothing ARE NOT indicated for the injection procedures covered by this document unless exposure to blood splashes (...) for injection 9 2.2.2 Medication Types of medication containers and recommendations on their use are given in Table 2.5. T able 2.5 Recommendations on medication containers Type of container Recommendations Reason Single-dose vial Preferred Low likelihood of contamination Multiple-dose vial Only if unavoidable High likelihood of contamination if aseptic technique is poor Ampoules Pop-open preferred Breaking a glass ampoule may result in particulate matter escaping from the vial, it may also injure

2010 World Health Organisation Guidelines

29. High Intensity Exercise in Incomplete SCI

High Intensity Exercise in Incomplete SCI High Intensity Exercise in Incomplete SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. High Intensity Exercise in Incomplete SCI The safety and scientific (...) Information provided by (Responsible Party): George Hornby, Indiana University Study Details Study Description Go to Brief Summary: The goal of this study is to identify the comparative efficacy of high-intensity walking training in individuals with chronic, motor incomplete spinal cord injury as compared to lower-intensity walking exercise. Condition or disease Intervention/treatment Phase Spinal Cord Injuries Procedure: Walking training Not Applicable Detailed Description: Background/Readiness

2018 Clinical Trials

30. Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury

Intermittent Hypoxia (AIH), during first screening visit Participants do NOT have to stop taking antispasticity medications to participate in the study. Must be tested for anemia with a value of at least 10g/dl (for both men and women). Patients will be recommended to their primary care physician to correct anemia if low levels are detected Blood pressure must fall within this range- high: 160/110mmHg low: 85/55 mmHg Must be asymptomatic (no dizziness, lightheadedness, etc) Exclusion Criteria: Medical (...) Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail

2018 Clinical Trials

31. Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Prostatic Adenocarcinoma

Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Prostatic Adenocarcinoma Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Metastatic Prostatic Adenocarcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Metastatic Prostatic Adenocarcinoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2018 Clinical Trials

32. Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia

Life expectancy < 6 months Patient determined to be nonsurgical candidate due to reasons such as High-risk medical conditions Unstable cardiac disease Stroke or transient ischemic attack leading to limitations in lower extremities or occurring within 180 days prior to the initial screening visit Severe arthritis or other musculoskeletal disorder. Systolic blood pressure (supine) ≤ 90 mmHg Resting heart rate > 100 bpm Poorly controlled diabetes mellitus (HgbA1c > 10%) Life‐threatening complications (...) Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2014 Clinical Trials

33. Therapeutic Injections for Pain Management (Follow-up)

reactions to LAs can result from high blood levels of the drug due to accidental intravenous (IV) infusion of all or part of the therapeutic dose, injection of an excessive amount of drug, or abnormal rates of absorption and biotransformation of the drug. Typically, these reactions demonstrate a combination of cardiovascular, respiratory, and central nervous system side effects that range from mild to severe. Mild reactions occur when systemic blood levels of LA rise above the usual physiologic levels (...) complications may result from systemic reactions or be due to specific procedures. For example, injuries to peripheral nerves may result from direct trauma including localized hematoma, compression by tourniquet, unintentional neural traction, compression due to positioning, or injection of an excessively high concentration of LA. Complications following subarachnoid or epidural injections can result from direct spinal cord or nerve root trauma, spinal cord compression by hematoma, or spinal cord ischemia

2014 eMedicine.com

34. Therapeutic Injections for Pain Management (Overview)

reactions to LAs can result from high blood levels of the drug due to accidental intravenous (IV) infusion of all or part of the therapeutic dose, injection of an excessive amount of drug, or abnormal rates of absorption and biotransformation of the drug. Typically, these reactions demonstrate a combination of cardiovascular, respiratory, and central nervous system side effects that range from mild to severe. Mild reactions occur when systemic blood levels of LA rise above the usual physiologic levels (...) complications may result from systemic reactions or be due to specific procedures. For example, injuries to peripheral nerves may result from direct trauma including localized hematoma, compression by tourniquet, unintentional neural traction, compression due to positioning, or injection of an excessively high concentration of LA. Complications following subarachnoid or epidural injections can result from direct spinal cord or nerve root trauma, spinal cord compression by hematoma, or spinal cord ischemia

2014 eMedicine.com

35. Therapeutic Injections for Pain Management (Treatment)

reactions to LAs can result from high blood levels of the drug due to accidental intravenous (IV) infusion of all or part of the therapeutic dose, injection of an excessive amount of drug, or abnormal rates of absorption and biotransformation of the drug. Typically, these reactions demonstrate a combination of cardiovascular, respiratory, and central nervous system side effects that range from mild to severe. Mild reactions occur when systemic blood levels of LA rise above the usual physiologic levels (...) complications may result from systemic reactions or be due to specific procedures. For example, injuries to peripheral nerves may result from direct trauma including localized hematoma, compression by tourniquet, unintentional neural traction, compression due to positioning, or injection of an excessively high concentration of LA. Complications following subarachnoid or epidural injections can result from direct spinal cord or nerve root trauma, spinal cord compression by hematoma, or spinal cord ischemia

2014 eMedicine.com

36. Hand, Injection Injuries

typically presents with an asymptomatic benign-appearing puncture wound at the injection site, and may delay seeking treatment. This may be accompanied by pallor, edema, and anesthesia, progressing to severe tenderness on palpation and gangrene if untreated, depending upon the chemical injected. Radiographic evaluation may reveal subcutaneous emphysema, paint, or both within the soft tissues. High-pressure injection of paint into a digit. Exploration revealed paint injection limited to the distal half (...) of the digit. The wound from a high pressure injection injury may appear deceptively benign, as the small puncture wound in this patient shows. Previous Next: Treatment & Management Prompt recognition of the injury and aggressive early treatment are essential to avoid a poor outcome. [ , , ] Tetanus toxoid should be administered if not up to date. The extensive amount of soft tissue necrosis resulting from the injury creates an environment that encourages the growth of bacteria. Prophylactic broad-spectrum

2014 eMedicine Surgery

37. Therapeutic Injections for Pain Management (Diagnosis)

reactions to LAs can result from high blood levels of the drug due to accidental intravenous (IV) infusion of all or part of the therapeutic dose, injection of an excessive amount of drug, or abnormal rates of absorption and biotransformation of the drug. Typically, these reactions demonstrate a combination of cardiovascular, respiratory, and central nervous system side effects that range from mild to severe. Mild reactions occur when systemic blood levels of LA rise above the usual physiologic levels (...) complications may result from systemic reactions or be due to specific procedures. For example, injuries to peripheral nerves may result from direct trauma including localized hematoma, compression by tourniquet, unintentional neural traction, compression due to positioning, or injection of an excessively high concentration of LA. Complications following subarachnoid or epidural injections can result from direct spinal cord or nerve root trauma, spinal cord compression by hematoma, or spinal cord ischemia

2014 eMedicine.com

38. Pressure Device in the Treatment of Ear Keloids

. Patients either undergo surgery using the "fillet technique" and intra-lesional injections of triamcinolone 10mg /ml every 4 to 6 weeks for 6 months, or they are additionally treated with a non-customized pressure device. Condition or disease Intervention/treatment Phase Keloid Ear Device: Pressure Device Procedure: Fillet Technique Drug: Triamcinolone Not Applicable Detailed Description: The prospective randomized controlled trial will be conducted at the Department of Otorhinolaryngology, Head (...) or magnifying glasses. The keloid is "peeled" out of the excessive skin pocket. If necessary skin trimming is performed and non-resorbable monofilament single sutures are placed. The first intracutaneous injection of triamcinolone 10mg/ml is given before wound dressing is placed. A blanching of the lesion marks the endpoint of injection. Cutaneous sutures are removed after approximately 7 days. Injection of triamcinolone is repeated every 4 to 6 weeks for a total of 6 months. When removing the sutures

2016 Clinical Trials

39. Wound Healing, Keloids

. The most frequently involved sites of keloids are areas of the body that are constantly subjected to high skin tension. Wounds on the anterior chest, shoulders, flexor surfaces of the extremities (eg, deltoid region), and anterior neck and wounds that cross skin tension lines are more susceptible to abnormal scar formation. The most important risk factor for the development of abnormal scars such as keloids is a wound healing by secondary intention, especially if healing time is greater than 3 weeks (...) in the treatment of keloids. The sheets can be worn for as long as 24 h/d for up to 1 year, with care to avoid contact dermatitis and skin breakdown. The silicone does not appear to enter the skin; therefore, the antikeloid effects appear to be secondary to both occlusion and hydration. Studies have demonstrated that silicone gel increases the temperature of the scar, possibly increasing collagenase activity. Increased pressure, hydration of the stratum corneum, and direct pressure on the wound also may

2014 eMedicine Surgery

40. Wound Healing, Widened and Hypertrophic Scars

in inflammation. Int Rev Connect Tissue Res . 1964. 2:301-25. . Stewart RJ, Duley JA, Dewdney J, et al. The wound fibroblast and macrophage. II: Their origin studied in a human after bone marrow transplantation. Br J Surg . 1981 Feb. 68(2):129-31. . Ahn ST, Monafo WW, Mustoe TA. Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch Surg . 1991 Apr. 126(4):499-504. . Sharp PA, Pan B, Yakuboff KP, Rothchild D. Development of a Best Evidence Statement for the Use of Pressure Therapy (...) /keloid scarring. Int J Oral Maxillofac Surg . 1994 Aug. 23(4):232-6. . Media Gallery This patient's neck wound developed a hypertrophic scar. It was revised with a fusiform excision and an intraoperative triamcinolone (Kenalog) injection. Postoperatively, the patient used silicone gel daily for 6 months and obtained a very satisfactory result. This patient underwent revision of her widened scar with a Millard 2-flap technique. The fusiform was incised around the deepithelialized scar. The wound edges

2014 eMedicine Surgery

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