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High Altitude Edema

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121. Pulmonary Edema, Noncardiogenic

patients. Previous Next: Ultrasonography Lung ultrasound is a radiation-free, noninvasive tool available at the bedside that can provide useful information on ARDS diagnosis when radiography or CT is not available. [ ] In addition, use in prehospital assessment in extreme settings (war zones, natural disasters, and extreme sports settings in deserts, on mountains, and on water) has greatly increased. For example, ultrasonograhy has been used in the assessment of pulmonary edema (PE) in high-altitude (...) during lung injury reflects the state of neutrophil activation. FDG-PET scanning can depict pulmonary sequestration of activated neutrophils, even when alveolar neutrophilia are absent. [ ] Iodine-123 Iodine-123 meta-iodobenzylguanidine (MIBG) results can be considered indicators of pulmonary endothelial cell function. Koizumi and colleagues studied serial scintigraphic assessment of 123 I MIBG lung uptake in a patient with high-altitude pulmonary edema. [ ] The initial evaluation was performed 7

2014 eMedicine Radiology

122. Congestive Heart Failure and Pulmonary Edema (Treatment)

administration of a loop diuretic (ie, furosemide, bumetanide, torsemide) is preferred initially because of potentially poor absorption of the oral form in the presence of bowel edema. In patients with hypertensive heart failure who have mild fluid retention, thiazide diuretics may be preferred because of their more persistent antihypertensive effects. [ , ] Diuretics can be given by bolus or continuous infusion and in high or low doses. In a study of patients with acute decompensated heart failure, however (...) with medications Avoidance, or rapid treatment of, precipitating factors Precipitating factors include the following: Sleep apnea Pulmonary embolism Sepsis Arrhythmia Ischemia High altitude Anemia Hypoxemia Use of an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) is beneficial if RV failure is secondary to left ventricular (LV) failure; the efficacy of these agents in isolated RV failure is not known. The same recommendation applies for use of beta-blockers. The role

2014 eMedicine Emergency Medicine

123. Hypoxia-related altitude illnesses. (PubMed)

Hypoxia-related altitude illnesses. Millions of tourists and climbers visit high altitudes annually. Many unsuspecting and otherwise healthy individuals may get sick when sojourning to these high regions. Acute mountain sickness represents the most common illness, which is usually benign but can rapidly progress to the more severe and potentially fatal forms of high-altitude cerebral edema and high-altitude pulmonary edema.Data were identified by searches of Medline (1965 to May 2012 (...) ) and references from relevant articles and books. Studies, reviews, and books specifically pertaining to the epidemiology, prevention, and treatment of high-altitude illnesses in travelers were selected.This review provides information on geographical aspects, physiology/pathophysiology, clinical features, risk factors, and the prevalence of high-altitude illnesses and also state-of-the art recommendations for prevention and treatment of such illnesses.Given an increasing number of recreational activities

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2013 Journal of Travel Medicine

124. High-Field MRI Reveals a Drastic Increase of Hypoxia-Induced Microhemorrhages upon Tissue Reoxygenation in the Mouse Brain with Strong Predominance in the Olfactory Bulb (PubMed)

to normobaric hypoxia at 8% oxygen for 48 hours followed by rapid reoxygenation and incubation for further 24 h under normoxic conditions. T2*-, diffusion-weighted and T2-relaxometry MRI was performed before exposure, immediately after 48 hours of hypoxia and 24 hours after reoxygenation. Cerebral microhemorrhages, previously described in humans suffering from severe high altitude cerebral edema, were also detected in mice upon hypoxia-reoxygenation with a strong region-specific clustering in the olfactory (...) High-Field MRI Reveals a Drastic Increase of Hypoxia-Induced Microhemorrhages upon Tissue Reoxygenation in the Mouse Brain with Strong Predominance in the Olfactory Bulb Human pathophysiology of high altitude hypoxic brain injury is not well understood and research on the underlying mechanisms is hampered by the lack of well-characterized animal models. In this study, we explored the evolution of brain injury by magnetic resonance imaging (MRI) and histological methods in mice exposed

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2016 PloS one

125. NSAID RCT for Prevention of Altitude Sickness

: University of California, San Diego Information provided by (Responsible Party): Jeffrey Gertsch MD, Naval Health Research Center Study Details Study Description Go to Brief Summary: The proposed study is a prospective, randomized, double-blind, placebo-controlled clinical trial evaluating ibuprofen and placebo for the prevention of neurological forms of altitude illness [including high altitude headache (HAH), acute mountain sickness (AMS), high altitude cerebral edema (HACE), and an emerging concept (...) of High Altitude Anxiety]. The study will take place in the spring and summer of 2012 at the Marine Corps Mountain Warfare Training Center in the Eastern Sierras near Bridgeport, California. US Marines from near sea level will participate in battalion-level training exercises at between 8,500-11,500 Feet, where some altitude illness is expected. Concurrent measures used to determine objective markers of altitude illness, such that validated clinical scales, rapid cognitive screening tests, will inform

2012 Clinical Trials

126. Hemodynamic Changes in Altitude Adaptation

Stein, Goethe University Study Details Study Description Go to Brief Summary: We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of acclimatization on a expedition to Mount Aconcagua. Condition or disease Acute Mountain Sickness High Altitude Pulmonary Edema High Altitude Cerebral Edema Detailed Description: Several parameters (...) will be recorded to analyze their influence on the adaptation to high altitude. Such as, food composition, dietary supplements, water intake and output. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 12 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Hemodynamic Changes in Altitude Adaptation Study Start Date : August 2012 Estimated Primary Completion Date : December 2012 Estimated Study Completion Date : December

2012 Clinical Trials

127. Clinical Manifestations and Long-Term Follow-Up in Pediatric Patients Living at Altitude With Isolated Pulmonary Artery of Ductal Origin. (PubMed)

]). Fifteen children (88%) were symptomatic at presentation. High-altitude pulmonary edema was present in 2 patients (12%) at diagnosis, and only 1 patient had episodes of hemoptysis during follow-up. Fourteen patients (82%) demonstrated evidence of pulmonary arterial hypertension (PAH). Among 14 patients with PAH, 11 patients had surgical interventions. PAH resolved in 5 of 11 patients (45%) undergoing surgical rehabilitation. One patient died during follow-up, and 7 patients are receiving oral (...) Clinical Manifestations and Long-Term Follow-Up in Pediatric Patients Living at Altitude With Isolated Pulmonary Artery of Ductal Origin. This study's aim was to define the clinical manifestations and long-term outcome of pediatric patients living at altitude with isolated pulmonary artery (PA) of ductal origin (IPADO). This was a retrospective cohort study of 17 consecutive cases of IPADO at a single center. All patients lived at modest altitude (median 2050 m [range 1700 m to 3050 m

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2012 Pediatric Cardiology

128. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda (PubMed)

with patients suffering from high-altitude pulmonary edema, whereas it was present at a significantly lower frequency in Pitta and nearly absent in natives of high altitude. Analysis of Human Genome Diversity Panel-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) and Indian Genome Variation Consortium panels showed that disparate genetic lineages at high altitudes share the same ancestral allele (T) of rs480902 that is overrepresented in Pitta and positively correlated with altitude globally (P < 0.001 (...) ), including in India. Thus, EGLN1 polymorphisms are associated with high-altitude adaptation, and a genotype rare in highlanders but overrepresented in a subgroup of normal lowlanders discernable by Ayurveda may confer increased risk for high-altitude pulmonary edema.

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2010 Proceedings of the National Academy of Sciences of the United States of America

129. Shilajit: A panacea for high-altitude problems (PubMed)

Shilajit: A panacea for high-altitude problems High altitude problems like hypoxia, acute mountain sickness, high altitude cerebral edema, pulmonary edema, insomnia, tiredness, lethargy, lack of appetite, body pain, dementia, and depression may occur when a person or a soldier residing in a lower altitude ascends to high-altitude areas. These problems arise due to low atmospheric pressure, severe cold, high intensity of solar radiation, high wind velocity, and very high fluctuation of day (...) fatigue. Shilajit improves the ability to handle high altitudinal stresses and stimulates the immune system. Thus, Shilajit can be given as a supplement to people ascending to high-altitude areas so that it can act as a "health rejuvenator" and help to overcome high-altitude related problems.

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2010 International journal of Ayurveda research

130. New insights into changes in corneal thickness in healthy mountaineers during a very-high-altitude climb to Mount Muztagh Ata. (PubMed)

). The amount of decrease in SpO(2) paralleled the increase in CCT. There was no significant decrease in visual acuity. There was a significant correlation between CCT and cerebral acute mountain sickness score when controlled for SpO(2) and age.Corneal swelling during high-altitude climbs is promoted by low SpO(2). Systemic delivery of oxygen to the anterior chamber seems to play a greater role in corneal oxygenation than previously thought. Adhering to a slower ascent profile results in less corneal edema (...) New insights into changes in corneal thickness in healthy mountaineers during a very-high-altitude climb to Mount Muztagh Ata. To investigate the effect of very high altitude and different ascent profiles on central corneal thickness (CCT).Twenty-eight healthy mountaineers were randomly assigned to 2 different ascent profiles during a medical research expedition to Mount Muztagh Ata (7546 m) in western China. Group 1 was allotted a shorter acclimatization time prior to ascent to 6265 m

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2010 Archives of ophthalmology

131. High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. (PubMed)

High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. Globally, it is estimated that > 140 million people live at a high altitude (HA), defined as > 2,500 m (8,200 ft), and that countless others sojourn to the mountains for work, travel, and sport. The distribution of exposure to HA is worldwide, including 35 million in the Andes and > 80 million in Asia, including China and central Asia. HA stress primarily is due to the hypoxia of low atmospheric (...) pressure, but dry air, intense solar radiation, extreme cold, and exercise contribute to acute and chronic disorders. The acute disorders are acute mountain sickness (also known as soroche), HA cerebral edema, and HA pulmonary edema (HAPE). Of these, HAPE is highly correlated with acute pulmonary hypertension. The first chronic syndrome described in HA dwellers in Peru was chronic mountain sickness (Monge disease), which has a large component of relative hypoventilation and secondary erythrocytosis

2010 Chest

132. Altitude Diseases

manifestations; it may occur in recreational hikers and skiers and others traveling to high altitude. High-altitude cerebral edema (HACE) is a form of global encephalopathy, while high-altitude pulmonary edema (HAPE) is a form of noncardiogenic pulmonary edema causing severe dyspnea and hypoxemia. Diagnosis of AD is clinical. Treatment of mild AMS is with analgesics and acetazolamide or dexamethasone . Severe AMS may require descent and supplemental oxygen if available. Both HACE and HAPE are potentially (...) artery pressure which causes interstitial and alveolar pulmonary edema, resulting in impaired oxygenation. Small-vessel hypoxic vasoconstriction is patchy, causing elevated pressure, capillary wall damage, and capillary leakage in less constricted areas. Other factors, such as sympathetic overactivity, may also be involved. Long-time high-altitude residents can develop HAPE when they return after a brief stay at low altitude, a phenomenon referred to as reentry pulmonary edema. Acclimatization

2013 Merck Manual (19th Edition)

133. Altitude sickness

in the tissues of the body). At very high altitude, humans can get either (HAPE), or (HACE). The physiological cause of altitude-induced edema is not conclusively established. It is currently believed, however, that HACE is caused by local vasodilation of cerebral blood vessels in response to , resulting in greater blood flow and, consequently, greater capillary pressures. On the other hand, HAPE may be due to general vasoconstriction in the pulmonary circulation (normally a response to regional ventilation (...) number of people who ascend rapidly to these altitudes. Very high altitude [ ] At very high altitude, 3,500 to 5,500 metres (11,500 to 18,000 ft), maximum SaO 2 falls below 90% as the arterial PO 2 falls below 60mmHg. Extreme may occur during exercise, during sleep, and in the presence of high altitude pulmonary edema or other acute lung conditions. Severe altitude illness occurs most commonly in this range. Extreme altitude [ ] Above 5,500 metres (18,000 ft), marked hypoxemia

2012 Wikipedia

134. Going to altitude? Bring your vitamins! (PubMed)

Ascorbic Acid Pulmonary edema of mountaineers IM Altitude Sickness metabolism pathology Ascorbic Acid metabolism Endothelin-1 Humans Hypertension, Pulmonary metabolism pathology Nitric Oxide metabolism Oxidative Stress Vitamin E metabolism 2010 12 3 6 0 2010 12 3 6 0 2011 4 13 6 0 ppublish 21123200 588/23/4603 10.1113/jphysiol.2010.200899 PMC3010123 High Alt Med Biol. 2009 Spring;10(1):17-24 19326597 Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1283-92 19726713 J Appl Physiol (1985). 2005 (...) Going to altitude? Bring your vitamins! 21123200 2011 04 11 2018 11 13 1469-7793 588 Pt 23 2010 Dec 01 The Journal of physiology J. Physiol. (Lond.) Going to altitude? Bring your vitamins! 4603-4 10.1113/jphysiol.2010.200899 Lundby Carsten C Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, Switzerland. carsten.lundby@access.uzh.ch eng Journal Article England J Physiol 0266262 0022-3751 0 Endothelin-1 1406-18-4 Vitamin E 31C4KY9ESH Nitric Oxide PQ6CK8PD0R

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2010 The Journal of physiology

135. Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological (PubMed)

Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological Acute mountain sickness (AMS) is a neurological disorder that typically affects mountaineers who ascend to high altitude. The symptoms have traditionally been ascribed to intracranial hypertension caused by extracellular vasogenic edematous brain swelling subsequent to mechanical disruption of the blood-brain barrier in hypoxia. However, recent diffusion-weighted magnetic (...) resonance imaging studies have identified mild astrocytic swelling caused by a net redistribution of fluid from the "hypoxia-primed" extracellular space to the intracellular space without any evidence for further barrier disruption or additional increment in brain edema, swelling or pressure. These findings and the observation of minor vasogenic edema present in individuals with and without AMS suggest that the symptoms are not explained by cerebral edema. This has led to a re-evaluation of the relevant

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2009 Cellular and Molecular Life Sciences

136. Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. (PubMed)

Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. Whether pulmonary hypertension at high altitude limits exercise capacity remains uncertain.To gain further insight into the pathophysiology of hypoxia induced pulmonary hypertension and the resulting reduction in exercise capacity, we investigated if the reduction in hypoxic pulmonary vasoconstrictive response with corticosteroids or phosphodiesterase-5 inhibition improves exercise (...) capacity.A cardiopulmonary exercise test and echocardiography to estimate systolic pulmonary artery pressure were performed in 23 subjects with previous history of high altitude pulmonary edema, known to be associated with enhanced hypoxic vasoconstriction. Subjects were randomized to dexamethasone 8 mg twice a day, tadalafil 10 mg twice a day, or placebo (double-blinded), starting the day before ascent.Measurements were performed at low and high (i.e., 4,559 m) altitude. Altitude exposure decreased

2009 American journal of respiratory and critical care medicine

137. Cerebral edema

of this is P.R.E.S., or Posterior Reversible Encephalopathy Syndrome. Altered may cause brain cells to , and dilution of the may cause excess water to move into brain cells. Fast travel to high altitude without proper can cause . Types [ ] Four types of cerebral edema have been identified: Vasogenic [ ] Vasogenic edema occurs due to a breakdown of the that make up the blood–brain barrier. This allows intravascular proteins and fluid to penetrate into the parenchymal extracellular space. Once plasma constituents (...) , , , , and ). Subtypes of vasogenic edema include: Hydrostatic cerebral edema This form of cerebral edema is seen in acute malignant hypertension. It is thought to result from direct transmission of pressure to cerebral with of fluid from the into the . Cerebral edema from brain cancer Cancerous ( ) of the brain can increase secretion of (VEGF), which weakens the junctions of the . can be of benefit in reducing VEGF secretion. High altitude cerebral edema (HACE) is a severe and sometimes fatal form of that results

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2012 Wikipedia

139. CRACKCast E169 – Paediatric Respiratory Emergencies: Lower Airway Obstruction

failure (rales, murmur, gallop, hepatosplenomegaly, cardiomegaly or pulmonary vascular congestion on chest radiograph) Tracheoesophageal fistula (choking, coughing, cyanosis with feeds) Mediastinal mass (chest pain, mediastinal density on chest radiograph) Vascular ring (stridor, cyanosis, apnoea, high-pitched brassy cough, dysphagia) Acquired Foreign body aspiration (history of choking, toddler, asymmetric pulmonary exam, unilateral hyperinflation on chest radiograph) Anaphylaxis (abrupt onset (...) , urticarial rash, angioedema, history of allergies) [2] Outline the pathophysiology of asthma. “Asthma is a lower airway disease marked by bronchoconstriction, mucosal edema, and pulmonary secretions.” – Rosen’s 9 th ed. Often asthma is triggered by a viral URTI [3] What are the features of mild, moderate and severe asthma? mild exacerbation: ● alertness, ● slight tachypnea, ● expiratory wheezing only, ● mildly prolonged expiratory phase, ● minimal accessory muscle use, ● and oxygen saturation of greater

2018 CandiEM

140. CRACKCast E143 – Diving Injuries and Dysbarism

studies: suggesting that the PFO may only open at high ambient pressures Energy: Repetitive dives within several hours of each other Environment: Longer dive (>time) Deeper dive Almost never occurs with dives < 6 meters deep Cold ambient temperature High altitude diving Flying after diving The US Navy has developed dive tables – which are usually programed into dive “computers” – that set limits to prevent DCS. If these limits are exceeded a diver must do “decompression stops underwater” to off-gas (...) marmorata – patchy cyanotic marbling of the skin (trunk and torso) – may first show up as pruritus, then erythema, then mottling. This is due to venous stasis. Lymphatic obstruction presents with edema. Spinal cord at high risk – lumbar region: ● Limb weakness/paralysis ● Paresthesias – distal to proximal migration ● Numbness ● Low back/abdominal pain ● Bladder symptoms, fecal incontinence, priapism ● Patchy symptoms Cerebral symptoms: ● Headache, blurred vision, diplopia, dysarthria, fatigue, behaviour

2018 CandiEM

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