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, or Diamox, is the standard medical prophylaxis agent for highaltitude illness. The medication is effective in preventing acute mountain sickness (AMS), highaltitude pulmonary edema (HAPE), and highaltitude cerebral edema (HACE). Its mechanism is via inhibition of the carbonic anhydrase enzyme which counteracts the respiratory alkalosis which occurs during ascent to altitude. It facilitates the excretion of bicarbonate in the urine. As a result, acetazolamide hastens acclimatization and helps prevent (...) Acetazolamide for the Prevention of HighAltitude Illness: a Comparison of Dosing Acetazolamide for the Prevention of HighAltitude Illness: a Comparison of Dosing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding
disease Subjects with diabetes mellitus type I or II Regular intake of beta-blockers, ACE-inhibitors, nitrates and calcium antagonists as well as corticosteroids or anti-inflammatory medication Subjects who developed highaltitude pulmonary edema after a rapid ascent (< 3 nights) at altitudes below 3500m Subjects who developed severe acute mountain sickness and/or highaltitude cerebral edema after rapid ascent to altitudes below 3500m Contacts and Locations Go to Information from the National Library (...) HighAltitude Medical Research Expedition Himlung 2013 HighAltitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. High
Investigation of whole-brain white matter identifies altered water mobility in the pathogenesis of high-altitude headache. Elevated brain water is a common finding in individuals with severe forms of altitude illness. However, the location, nature, and a causative link between brain edema and symptoms of acute mountain sickness such as headache remains unknown. We examined indices of brain white matter water mobility in 13 participants after 2 and 10 hours in normoxia (21% O2) and hypoxia (12 (...) , with headache score after 10 hours in hypoxia. Region of interest-based analyses generally confirmed these results. These data indicate that acute periods of hypoxemia cause a shift of water into the intracellular space within the cerebral white matter, whereas no evidence of brain edema (a volumetric enlargement) is identifiable. Furthermore, these changes in brain water mobility are related to the intensity of high-altitude headache.
measures of aqueous outflow structures remained consistent with no significant changes in AOD or ACA. Incidence of AMS on day 1 was 64% followed by a decrease in AMS scores over time spent at highaltitude; while AMS correlated significantly with stromal edema formation just after arrival (r = 0.71; P = 0.01), no correlation was found on day 3 (r = 0.05; P = 0.87); no correlations were found for vital parameters.Significant stromal edema was found during exposure to highaltitude in healthy subjects (...) Impact of Acute Exposure to HighAltitude on Anterior Chamber Geometry. This study aimed to quantify the impact of exposure to highaltitude on individual layers of the cornea in regard to central corneal thickness (CCT) and the geometry of the anterior chamber angle (ACA). This work is related to the Tübingen HighAltitude Ophthalmology study.Anterior segment spectral domain optical coherence tomography was used to quantify changes in individual corneal layers and to study ACA and angle
Short-term responses of the kidney to highaltitude in mountain climbers. In high-altitude climbers, the kidneys play a crucial role in acclimatization and in mountain sickness syndromes [acute mountain sickness (AMS), high-altitude cerebral edema, high-altitude pulmonary edema] through their roles in regulating body fluids, electrolyte and acid-base homeostasis. Here, we discuss renal responses to several high-altitude-related stresses, including changes in systemic volume status, renal plasma (...) flow and clearance, and altered acid-base and electrolyte status. Volume regulation is considered central both to high-altitude adaptation and to maladaptive development of mountain sickness. The rapid and powerful diuretic response to the hypobaric hypoxic stimulus of altitude integrates decreased circulating concentrations of antidiuretic hormone, renin and aldosterone, increased levels of natriuretic hormones, plasma and urinary epinephrine, norepinephrine, endothelin and urinary adrenomedullin
for 7 days in order to better describe sleep and cerebral responses. The investigators hypothesized that sleep and cerebral disturbances play a critical role for the developement of acute mountain sickness and for exercise performance limitation during acute high-altitude exposure. Condition or disease Acute Mountain Sickness HighAltitude Pulmonary EdemaHighAltitude Cerebral Edema Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 12 participants (...) Sleep and Cerebral Responses to HighAltitude Sleep and Cerebral Responses to HighAltitude - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sleep and Cerebral Responses to HighAltitude (VALLOT 2011
altitude illnesses are specified by three different entities: acute mountain sickness (AMS), highaltitude pulmonary edema (HAPE) and highaltitude cerebral edema (HACE). Prevalence of AMS is known to be between 10 to 20% for altitudes between 4000 and 5000m, increasing significantly in higher altitude. The prevalence depends on the ascent rate, individual susceptibility and physical exhaustion. Although mechanisms leading to highaltitude illnesses are not yet completely clear some progress has been (...) Pik Lenin HighAltitude Research Expedition 2009 Pik Lenin HighAltitude Research Expedition 2009 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pik Lenin HighAltitude Research Expedition 2009 (PLHARE
(> 200 meters over the previous 24 hours) Must be willing to stay 2 nights in Manang, Nepal Healthy adults, age 18-65 Self-report of new difficulty sleeping over the previous two days Exclusion Criteria: Recent (< 2 weeks) highaltitude exposure (higher than 11, 500 feet or 3500 meters) Current acute illness Moderate to Severe Acute Mountain Sickness (Lake Louise AMS score > 4) HighAltitude Cerebral EdemaHighAltitude Pulmonary Edema Any pre-existing sleep disorders or sleep related condition (...) Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at HighAltitude Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at HighAltitude - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies
[Bundle program of treatment for acute severe type highaltitude disease]. To discuss Bundle treatment of the acute severe type highaltitude disease.The prospective and randomized controlled trial was conducted. Two hundred and three patients with highaltitude pulmonary edema (HAPE) or highaltitude cerebral edema (HACE) met inclusion criteria were included, and were randomly divided into Bundle treatment group (n = 125) and conventional treatment control group (n = 78). Critical patients
of responses to cellular hypoxia. HIFs constitute a master switch determining the general response of the body to oxygen deprivation. The recent discovery of genetic changes in Tibetans has opened up an exciting area of research. The two major human populations that have adapted well to highaltitude, the Tibetans and Andeans, have strikingly different phenotypes. Diseases of lowlanders going to highaltitude include acute mountain sickness, high-altitude pulmonary edema, and high-altitude cerebral edema (...) Concise Clinical Review: HighAltitude Medicine. Medical problems occur at highaltitude because of the low inspired Po(2), which is caused by the reduced barometric pressure. The classical physiological responses to highaltitude include hyperventilation, polycythemia, hypoxic pulmonary vasoconstriction-increased intracellular oxidative enzymes, and increased capillary density in muscle. However, with the discovery of hypoxia-inducible factors (HIFs), it is apparent that there is a multitude
: University of Giessen Collaborator: MVZ für Laboratoriumsmedizin Koblenz Information provided by (Responsible Party): Andree Hillebrecht, University of Giessen Study Details Study Description Go to Brief Summary: In this investigation the researchers explore whether different types of breathing procedures can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain sickness or a highaltitude pulmonary edema. Condition or disease Intervention/treatment Phase Acute Mountain (...) in pressure and lowering partial pressure of oxygen during increasing altitude. The direct consequence of those changes is a hypoxic pulmonary vasoconstriction (Euler-Lijestrand-mechanism). In addition a rise in pulmonary blood pressure (Hypertonia) can occur so that there is a higher risk of developing a highaltitude pulmonary edema (HAPE). In this investigation the investigators are exploring whether different types of breathing procedures can improve the peripheral oxygen saturation. We are comparing
Sildenafil citrate for the prevention of highaltitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial. Exaggerated hypoxic pulmonary vasoconstriction is a key factor in the development of highaltitude pulmonary edema (HAPE). Due to its effectiveness as a pulmonary vasodilator, sildenafil has been proposed as a prophylactic agent against HAPE. By conducting a parallel-group double blind, randomized, placebo-controlled trial, we investigated the effect (...) of chronic sildenafil administration on pulmonary artery systolic pressure (PASP) and symptoms of acute mountain sickness (AMS) during acclimatization to highaltitude. Sixty-two healthy lowland volunteers (36 male; median age 21 years, range 18 to 31) on the Apex 2 research expedition were flown to La Paz, Bolivia (3650 m), and after 4-5 days acclimatization ascended over 90 min to 5200 m. The treatment group (n=20) received 50 mg sildenafil citrate three times daily. PASP was recorded
HIGH-ALTITUDE RETINOPATHY AFTER CLIMBING MOUNT ACONCAGUA IN A GROUP OF EXPERIENCED CLIMBERS. Visual disturbances after high-altitude exposure were first reported in 1969. Manifestations may include retinal hemorrhage, papilledema, and vitreous hemorrhage.We observed a group of 6 experienced climbers who ascended Mt Aconcagua to an altitude of 6,962 m in February 2007. Visual acuity study, intraocular pressure study, visual field study, nerve fiber layer analysis, eye Doppler, laboratory studies (...) , fundus photography, and intravenous fluorescein angiography were performed on the climbers before and after their exposures to high altitude.In all six study subjects, retinal vascular engorgement and tortuosity were present in varying degrees in both eyes. One of the climbers had both retinal hemorrhage and pulmonary edema. Of the two subjects who had visual field defects, one had severe nerve fiber layer defects of both eyes. Furthermore, laboratory studies of this climber showed a high level
. They were then monitored up at highaltitude and classified as suffering from severe high-altitude illness (SHAI) or not. Analysis was stratified according to acetazolamide use.Severe acute mountain sickness occurred in 314 (23.7%), high-altitude pulmonary edema in 22 (1.7%), and high-altitude cerebral edema in 13 (0.98%) patients. Among nonacetazolamide users (n = 917), main factors independently associated with SHAI were previous history of SHAI (adjusted odds ratios [aOR], 12.82; 95% confidence (...) Physiological Risk Factors of Severe HighAltitude Illness: A Prospective Cohort Study. An increasing number of persons, exposed to highaltitude for leisure, sport, or work, may suffer from severe high-altitude illness.To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a risk prediction model.A total of 1,326 persons went through a hypoxic exercise test before a sojourn above 4,000 m
Reducing Pulmonary Injury by Hyperbaric Oxygen Preconditioning During Simulated HighAltitude Exposure in Rats. Hyperbaric oxygen preconditioning (HBO₂P + HAE) has been found to be beneficial in preventing the occurrence of ischemic damage to brain, spinal cord, heart, and liver in several disease models. In addition, pulmonary inflammation and edema are associated with a marked reduction in the expression levels of both aquaporin (AQP) 1 and AQP5 in the lung. Here, the aims of this study (...) are first to ascertain whether acute lung injury can be induced by simulated highaltitude in rats and second to assess whether HBO2P + HAE is able to prevent the occurrence of the proposed highaltitude-induced ALI.Rats were randomly divided into the following three groups: the normobaric air (NBA; 21% O₂ at 1 ATA) group, the HBO₂P + highaltitude exposure (HAE) group, and the NBA + HAE group. In HBO₂P + HAE group, animals received 100% O₂ at 2.0 ATA for 1 hour per day, for five consecutive days
=0.001 and Environmental Symptoms Cerebral Symptoms: +0.6±0.9 points, P=0.0003 versus sea level). Inverse relationships were observed between the sea-level autoregulation index score and the high-altitude-induced increases in the Lake Louise (r=-0.62, P=0.007) and Environmental Symptoms Cerebral Symptoms (r=-0.78, P=0.01) scores. One subject with a history of high-altitude pulmonary and cerebral edema presented with the lowest sea-level autoregulation index score (3.7 versus group: 6.2±1.0 points (...) ) and later developed high-altitude cerebral edema at 4800 m during the summit bid.These findings suggest that a lower baseline autoregulation index may be considered a potential risk factor for AMS. This laboratory measurement may prove a useful screening tool for the expedition doctor when considering targeted pharmacological prophylaxis in individuals deemed "AMS-susceptible."
. Serious and potentially fatal problems, such as highaltitude pulmonary edema or cerebral edema, occur in approximately 0.5 percent to 1.0 percent of visitors to elevations above 10,000 feet-especially with heavy physical exertion on arrival, such as climbing or skiing. Early recognition, high flow oxygen therapy and prompt descent are crucially important in management. Our knowledge of the causes of these and other highaltitude problems, such as retinal hemorrhage, systemic edema and pulmonary (...) HighAltitude Medical Problems Increased travel to highaltitude areas by mountaineers and nonclimbing tourists has emphasized the clinical problems associated with rapid ascent. Acute mountain sickness affects most sojourners at elevations above 10,000 feet. Symptoms are usually worse on the second or third day after arrival. Gradual ascent, spending one to three days at an intermediate altitude, and the use of acetazolamide (Diamox) will prevent or ameliorate symptoms in most instances
FURTHER STUDIES OF HIGHALTITUDE PULMONARY Å’DEMA 14449930 1998 11 01 2018 12 01 0007-0769 24 1962 Jan British heart journal Br Heart J Further studies of highaltitude pulmonary oedema. 95-102 HULTGREN H H SPICKARD W W LOPEZ C C eng Case Reports Journal Article England Br Heart J 0370634 0007-0769 Pulmonary edema of mountaineers OM AltitudeAltitude Sickness Humans Hypertension, Pulmonary Medical Records Pulmonary EdemaALTITUDE PULMONARY EDEMA/case reports 1962 1 1 1962 1 1 0 1 1962 1 1 0 0