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High Altitude Edema

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81. [Bundle program of treatment for acute severe type high altitude disease]. (Abstract)

[Bundle program of treatment for acute severe type high altitude disease]. To discuss Bundle treatment of the acute severe type high altitude disease.The prospective and randomized controlled trial was conducted. Two hundred and three patients with high altitude pulmonary edema (HAPE) or high altitude cerebral edema (HACE) met inclusion criteria were included, and were randomly divided into Bundle treatment group (n = 125) and conventional treatment control group (n = 78). Critical patients

2013 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Controlled trial quality: uncertain

82. From The Archives: Does Acetazolamide Prevent Altitude Sickness?

away from poorly oxygenated areas, and vasodilation in other organs, namely in the brain, to improve delivery of oxygen. The body compensates with an increase in minute ventilation. In cases of altitude related illness it is not well understood what goes wrong but, essentially, these normal adaptations are inadequate or maladaptive. The term mountain sickness includes a spectrum of illnesses, namely the following entities: acute mountain sickness (AMS), high altitude cerebral edema (HACE), and high (...) Diamox before going trekking in the Himalayas. You work at Bellevue in New York City: who climbs mountains here? What do you say? Why do illnesses develop from changes in altitude? The essential culprit is the fall in atmospheric pressure with an increase in altitude. While at sea level, barometric pressure (Pb) is ~760mm Hg (1atm), whereas at the summit of Mount Everest (~8800 meters high), this pressure drops to ~250mm Hg. The fraction of inspired oxygen remains constant (21% of air is made

2011 Clinical Correlations

83. Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization

and/or the ability to participate in strenuous exercise Evidence of apnea or other sleeping disorders Evidence of prior high altitude pulmonary edema or high altitude cerebral edema diagnosis Allergies or intolerance to foods (including but not limited to lactose intolerance/milk allergy), vegetarian practices, or medications (including, but not limited to, lidocaine or phenylalanine) to be utilized in the study History of complications with lidocaine Taking medications that interfere with oxygen delivery (...) Posted : April 7, 2016 Last Update Posted : November 6, 2017 Sponsor: United States Army Research Institute of Environmental Medicine Collaborator: Eastern Michigan University Information provided by (Responsible Party): United States Army Research Institute of Environmental Medicine Study Details Study Description Go to Brief Summary: This research will evaluate nutrition requirements for missions at high altitude (i.e. >7800 feet above sea level) and the information obtained can be used to optimize

2016 Clinical Trials

84. Concise Clinical Review: High Altitude Medicine. (Abstract)

of responses to cellular hypoxia. HIFs constitute a master switch determining the general response of the body to oxygen deprivation. The recent discovery of genetic changes in Tibetans has opened up an exciting area of research. The two major human populations that have adapted well to high altitude, the Tibetans and Andeans, have strikingly different phenotypes. Diseases of lowlanders going to high altitude include acute mountain sickness, high-altitude pulmonary edema, and high-altitude cerebral edema (...) Concise Clinical Review: High Altitude Medicine. Medical problems occur at high altitude because of the low inspired Po(2), which is caused by the reduced barometric pressure. The classical physiological responses to high altitude include hyperventilation, polycythemia, hypoxic pulmonary vasoconstriction-increased intracellular oxidative enzymes, and increased capillary density in muscle. However, with the discovery of hypoxia-inducible factors (HIFs), it is apparent that there is a multitude

2012 American Journal of Respiratory and Critical Care Medicine

85. Sleep and Cerebral Responses to High Altitude

for 7 days in order to better describe sleep and cerebral responses. The investigators hypothesized that sleep and cerebral disturbances play a critical role for the developement of acute mountain sickness and for exercise performance limitation during acute high-altitude exposure. Condition or disease Acute Mountain Sickness High Altitude Pulmonary Edema High Altitude Cerebral Edema Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 12 participants (...) Sleep and Cerebral Responses to High Altitude Sleep and Cerebral Responses to High Altitude - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sleep and Cerebral Responses to High Altitude (VALLOT 2011

2012 Clinical Trials

86. Pik Lenin High Altitude Research Expedition 2009

altitude illnesses are specified by three different entities: acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE). Prevalence of AMS is known to be between 10 to 20% for altitudes between 4000 and 5000m, increasing significantly in higher altitude. The prevalence depends on the ascent rate, individual susceptibility and physical exhaustion. Although mechanisms leading to high altitude illnesses are not yet completely clear some progress has been (...) Pik Lenin High Altitude Research Expedition 2009 Pik Lenin High Altitude Research Expedition 2009 - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pik Lenin High Altitude Research Expedition 2009 (PLHARE

2012 Clinical Trials

87. Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude

(> 200 meters over the previous 24 hours) Must be willing to stay 2 nights in Manang, Nepal Healthy adults, age 18-65 Self-report of new difficulty sleeping over the previous two days Exclusion Criteria: Recent (< 2 weeks) high altitude exposure (higher than 11, 500 feet or 3500 meters) Current acute illness Moderate to Severe Acute Mountain Sickness (Lake Louise AMS score > 4) High Altitude Cerebral Edema High Altitude Pulmonary Edema Any pre-existing sleep disorders or sleep related condition (...) Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2012 Clinical Trials

88. [Bundle program of treatment for acute severe type high altitude disease]. (Abstract)

[Bundle program of treatment for acute severe type high altitude disease]. To discuss Bundle treatment of the acute severe type high altitude disease.The prospective and randomized controlled trial was conducted. Two hundred and three patients with high altitude pulmonary edema (HAPE) or high altitude cerebral edema (HACE) met inclusion criteria were included, and were randomly divided into Bundle treatment group (n = 125) and conventional treatment control group (n = 78). Critical patients

2012 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

89. Effect of morphine on pulmonary blood volume in convalescents from high altitude pulmonary oedema. Full Text available with Trip Pro

Effect of morphine on pulmonary blood volume in convalescents from high altitude pulmonary oedema. 5858108 1966 04 10 2018 11 13 0007-0769 27 6 1965 Nov British heart journal Br Heart J Effect of morphine on pulmonary blood volume in convalescents from high altitude pulmonary oedema. 876-8 Roy S B SB Singh I I Bhatia M L ML Khanna P K PK eng Case Reports Journal Article England Br Heart J 0370634 0007-0769 76I7G6D29C Morphine AIM IM Altitude Blood Volume Humans Male Morphine therapeutic use (...) Pulmonary Circulation Pulmonary Edema drug therapy 1965 11 1 1965 11 1 0 1 1965 11 1 0 0 ppublish 5858108 PMC490115 Am Heart J. 1957 Nov;54(5):753-65 13469744 Circulation. 1964 Mar;29:393-408 14131411 Lancet. 1965 Jan 30;1(7379):229-34 14238062

1965 British Heart Journal

90. Augmentation of frusemide diuresis by morphine in high altitude pulmonary oedema. Full Text available with Trip Pro

Augmentation of frusemide diuresis by morphine in high altitude pulmonary oedema. 6039165 1967 10 31 2018 11 13 0007-0769 29 5 1967 Sep British heart journal Br Heart J Augmentation of frusemide diuresis by morphine in high altitude pulmonary oedema. 709-13 Singh I I Lal M M Khanna P K PK Mathew N T NT eng Journal Article England Br Heart J 0370634 0007-0769 76I7G6D29C Morphine 7LXU5N7ZO5 Furosemide AIM IM Adolescent Adult Altitude Diuresis Furosemide therapeutic use Humans Injections (...) , Intravenous Male Morphine therapeutic use Pulmonary Edema etiology therapy 1967 9 1 1967 9 1 0 1 1967 9 1 0 0 ppublish 6039165 PMC459180 Br Heart J. 1965 Nov;27(6):876-8 5858108 Proc Soc Exp Biol Med. 1965 Feb;118:333-6 14268614 Circ Res. 1956 Jan;4(1):85-90 13277115 Prog Cardiovasc Dis. 1961 Jul;4:1-26 13703962 J Physiol. 1929 Aug 28;68(1):39-44 16994049 Endocrinology. 1955 Aug;57(2):205-19 13251225 Lancet. 1965 Jan 30;1(7379):229-34 14238062

1967 British Heart Journal

91. The heart at high altitude. Full Text available with Trip Pro

The heart at high altitude. 5651242 1968 07 10 2018 11 13 0007-0769 30 3 1968 May British heart journal Br Heart J The heart at high altitude. 291-4 Jackson F F eng Journal Article England Br Heart J 0370634 0007-0769 AIM IM S Adaptation, Physiological Altitude Coronary Disease etiology Electrocardiography Heart physiology Humans Hypoxia etiology Mountaineering Pulmonary Edema etiology 68242952 1968 5 1 1968 5 1 0 1 1968 5 1 0 0 ppublish 5651242 PMC487619 Br Heart J. 1963 May;25(3):291-8

1968 British Heart Journal

92. Haemodynamic studies in high altitude pulmonary oedema. Full Text available with Trip Pro

Haemodynamic studies in high altitude pulmonary oedema. 5764965 1969 04 01 2018 11 13 0007-0769 31 1 1969 Jan British heart journal Br Heart J Haemodynamic studies in high altitude pulmonary oedema. 52-8 Roy S B SB Guleria J S JS Khanna P K PK Manchanda S C SC Pande J N JN Subba P S PS eng Journal Article England Br Heart J 0370634 0007-0769 142M471B3J Carbon Dioxide S88TT14065 Oxygen AIM IM Adult Altitude Carbon Dioxide blood Hemodynamics Humans Hypertension, Pulmonary complications Male (...) Oxygen blood Pulmonary Artery physiopathology Pulmonary Edema complications etiology physiopathology Respiration 1969 1 1 1969 1 1 0 1 1969 1 1 0 0 ppublish 5764965 PMC487443 Am Heart J. 1957 Nov;54(5):753-65 13469744 N Engl J Med. 1965 Jul 8;273:66-73 14301200 Br Heart J. 1967 May;29(3):428-31 6023736 Br Heart J. 1965 Nov;27(6):876-8 5858108 Am J Pathol. 1964 Sep;45:381-91 14212805 Circulation. 1964 Mar;29:393-408 14131411 Indian Heart J. 1966 Jul;18(3):203-6 5946426 J Clin Invest. 1937 May;16(3

1969 British Heart Journal

93. Editorial: High altitude retinal haemorrhage. Full Text available with Trip Pro

Editorial: High altitude retinal haemorrhage. 1174848 1975 12 23 2018 11 13 0007-1447 3 5985 1975 Sep 20 British medical journal Br Med J Editorial: High altitude retinal haemorrhage. 663-4 eng Journal Article England Br Med J 0372673 0007-1447 AIM IM S Altitude Altitude Sickness complications Brain Edema complications Humans Intracranial Pressure Mountaineering Oliguria etiology Retinal Hemorrhage etiology 76019988 1975 9 20 1975 9 20 0 1 1975 9 20 0 0 ppublish 1174848 PMC1674546 J Neurosurg

1975 British medical journal

94. FURTHER STUDIES OF HIGH ALTITUDE PULMONARY Å’DEMA Full Text available with Trip Pro

FURTHER STUDIES OF HIGH ALTITUDE PULMONARY Å’DEMA 14449930 1998 11 01 2018 12 01 0007-0769 24 1962 Jan British heart journal Br Heart J Further studies of high altitude pulmonary oedema. 95-102 HULTGREN H H SPICKARD W W LOPEZ C C eng Case Reports Journal Article England Br Heart J 0370634 0007-0769 Pulmonary edema of mountaineers OM Altitude Altitude Sickness Humans Hypertension, Pulmonary Medical Records Pulmonary Edema ALTITUDE PULMONARY EDEMA/case reports 1962 1 1 1962 1 1 0 1 1962 1 1 0 0

1962 British Heart Journal

95. Ultrastructure of high altitude pulmonary oedema Full Text available with Trip Pro

Ultrastructure of high altitude pulmonary oedema 4787981 1974 06 14 2018 11 13 0040-6376 28 6 1973 Nov Thorax Thorax Ultrastructure of high altitude pulmonary oedema. 694-700 Heath D D Moosavi H H Smith P P eng Journal Article England Thorax 0417353 0040-6376 IM Altitude Animals Capillaries pathology Female Lung pathology Male Microscopy, Electron Pinocytosis Pulmonary Alveoli pathology Pulmonary Edema pathology Rats 1973 11 1 1973 11 1 0 1 1973 11 1 0 0 ppublish 4787981 PMC470103 Thorax. 1969

1973 Thorax

96. High-altitude oedema presenting as coma. Full Text available with Trip Pro

High-altitude oedema presenting as coma. 4723483 1973 10 11 2018 11 13 0007-1447 3 5874 1973 Aug 04 British medical journal Br Med J High-altitude oedema presenting as coma. 294-5 Radford P P eng Journal Article England Br Med J 0372673 0007-1447 AIM IM S Adult Altitude Brain Edema etiology Coma etiology Humans Hypoxia complications Male Mountaineering Pulmonary Edema etiology 73232328 1973 8 4 1973 8 4 0 1 1973 8 4 0 0 ppublish 4723483 PMC1586706 Lancet. 1965 Jan 30;1(7379):229-34 14238062

1973 British medical journal

97. High Altitude Medical Problems Full Text available with Trip Pro

. Serious and potentially fatal problems, such as high altitude pulmonary edema or cerebral edema, occur in approximately 0.5 percent to 1.0 percent of visitors to elevations above 10,000 feet-especially with heavy physical exertion on arrival, such as climbing or skiing. Early recognition, high flow oxygen therapy and prompt descent are crucially important in management. Our knowledge of the causes of these and other high altitude problems, such as retinal hemorrhage, systemic edema and pulmonary (...) High Altitude Medical Problems Increased travel to high altitude areas by mountaineers and nonclimbing tourists has emphasized the clinical problems associated with rapid ascent. Acute mountain sickness affects most sojourners at elevations above 10,000 feet. Symptoms are usually worse on the second or third day after arrival. Gradual ascent, spending one to three days at an intermediate altitude, and the use of acetazolamide (Diamox) will prevent or ameliorate symptoms in most instances

1979 Western Journal of Medicine

98. Solnatide demonstrates profound therapeutic activity in a rat model of pulmonary edema induced by acute hypobaric hypoxia and exercise. Full Text available with Trip Pro

hemorrhage and disruption of the alveolar-capillary barrier than those of high-altitude control animals. Occludin expression was significantly higher in solnatide-treated animals, compared with high-altitude control, dexamethasone-, and aminophylline-treated animals.Solnatide reduced pulmonary edema, increased occludin expression, and improved gas-blood barrier function during acute hypobaric hypoxia and exercise in rats. These results provide a rationale for the clinical application of solnatide (...) to patients with pulmonary edema and exposure to a high-altitude hypoxic environment.Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

2016 Chest

99. Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia Full Text available with Trip Pro

Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the exact mechanisms underlying the HACE are not fully understood.Human volunteers ascended to high altitude (3860 m, 2 days), and rats were exposed to hypoxia in a hypobaric chamber (5000 m, 2 days). Human acute mountain sickness (...) levels in human and rats, which positively correlated with AMS. A single LPS injection (ip, 4 mg/kg, 12 h) into rats increased TNF-α and IL-1β levels in the serum and cortex, and AQP4 and AQP4 mRNA expression in cortex and astrocytes, and astrocyte water permeability but did not cause brain edema. However, LPS treatment 11 h prior to 1 h hypoxia (elevation, 7000 m) challenge caused cerebral edema, which was associated with activation of NF-κB and MAPKs, hypoxia-reduced Na(+)-K(+)-ATPase activity

2016 Journal of neuroinflammation

100. Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m. Full Text available with Trip Pro

Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559 m. We have previously demonstrated that prophylactic intake of dexamethasone improves maximal oxygen uptake (Vo(2)max) in high altitude pulmonary edema (HAPE) susceptible subjects 4 to 6 h after a 2-day climb to 4559 m. However, since with this ascent protocol HAPE usually develops after the first night at 4559 m or later, we hypothesized that a continued dexamethasone (...) prophylaxis would result in an even more pronounced improvement of Vo(2)max after an additional night at high altitude. Vo(2)max of 24 HAPE susceptibles was evaluated on a bicycle ergometer at an altitude of 490 m and at 24 h after rapid ascent to 4559 m. Subjects were divided into two groups: The control group (n=14) performed both tests without dexamethasone, whereas the dexamethasone group (n=10) received dexamethasone 8 mg twice a day (b.i.d), starting 24 h prior to ascent. At 4559 m, Vo(2)max was 61

2011 High altitude medicine & biology Controlled trial quality: uncertain

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