How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

481 results for

High Altitude Edema

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. The Incidence of Subclinical High-altitude Pulmonary Oedema at High Altitude

Sickness Subclinical High Altitude Pulmonary Edema Detailed Description: The high-altitude pulmonary edema (HAPE) is the leading cause of death from high altitude sickness. At moderate altitude (2500-4500m) the incidence (0.2-6%) may be underestimated because only clinical HAPE leads to symptoms and motivates the patient to seek medical advice. Cremona et al. [Cremona et al. Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study. Lancet 2002;359:303-09] suggested (...) twodimensional technology and has been applied in extreme, out-of-hospital setting, showing in recreational climbers a high prevalence of clinically silent interstitial pulmonary edema at high-altitude [Pratali L et al. Frequent subclinical high-altitude pulmonary edema detected by chest sonography as ultrasound lung comets in recreational climbers. Crit Care Med 2010;38:1818-23]. However, data for moderate altitude remain scarce, despite that mountaineers are increasing in age and comorbidities and could

2013 Clinical Trials

62. The Influence of CO2 and Exercise on Hypobaric Hypoxia Induced Pulmonary Edema in Rats Full Text available with Trip Pro

The Influence of CO2 and Exercise on Hypobaric Hypoxia Induced Pulmonary Edema in Rats Introduction: Individuals with a known susceptibility to high altitude pulmonary edema (HAPE) demonstrate a reduced ventilation response and increased pulmonary vasoconstriction when exposed to hypoxia. It is unknown whether reduced sensitivity to hypercapnia is correlated with increased incidence and/or severity of HAPE, and while acute exercise at altitude is known to exacerbate symptoms the effect (...) training nor chronic intermittent hypercapnia affect HH- induced pulmonary edema.

2018 Frontiers in physiology

63. Decompression Tables for Diving at Altitude

by breathing 100% O2 for 120 minutes at 1.3 ATA. This will simulate, for example, a 2 hour dive at 12,000 ft to 65 fsw breathing 50% O2. The diver will then return to 15,000 ft and remain at that altitude for 24 hours to allow for AMS symptoms to recur (if indeed they do). Lake Louise AMS scores will be collected every 8 hours. AMS symptoms will be treated with acetaminophen, NSAIDs and anti-emetics as needed. Subjects will be assessed clinically every 12 hours for high altitude pulmonary edema (HAPE (...) ) and high altitude cerebral edema (HACE). Occurrence of either HAPE or HACE will require that the subject be returned immediately to 1 ATA and treated appropriately. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 72 participants Intervention Model: Sequential Assignment Intervention Model Description: This design is a two factor, incomplete block design - three altitudes (8,000, 10,000, and 12,000 feet) and 2 breathing gases (air

2017 Clinical Trials

64. Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.

), diabetes medications and birth control pills. A psychiatric disorder, other than mild depression; e.g. schizophrenia, bipolar disorder, major depression, panic or anxiety disorders. Substantial alcohol (>3oz/day) or use of illicit drugs. Previous occurrence of high altitude pulmonary or cerebral edema. Recent exposure to altitude (>8000ft) in the last month or having slept at an altitude >6000ft in the last month. Inability to provide written informed consent or able to complete the experiment. Non (...) mounting evidence that even in populations of people that live at high altitudes and are considered adapted, low oxygen contributes to reductions in learning and memory. Therefore there is a serious need for treatments which may improve sleep, control of breathing and mental function during low oxygen. Melatonin is a hormone produced in the brain during the night which regulates sleep patterns with strong antioxidant and anti-inflammatory properties. A study previously reported that melatonin taken 90

2017 Clinical Trials

65. Viagra Helps Mountaineers Perform at Altitude

sickness, but it carries the risk for hypotension. There is evidence that sildenafil can be used to prevent high altitude pulmonary edema (HAPE), and given its excellent safety profile, may prove to be a viable alternative. What is the usefulness of sildenafil in the prevention of HAPE and the improvement of aerobic capacity in young healthy adults at high altitudes? Methods: An exhaustive search of available literature was conducted using the search terms: [sildenafil or PDE or phosphodiesterase (...) Viagra Helps Mountaineers Perform at Altitude "Viagra Helps Mountaineers Perform at Altitude" by Philip Van Peursem < > > > > > Title Author Date of Graduation 12-11-2012 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Many people work and play at higher altitudes where hypoxia can cause altitude sickness and hamper one’s ability to carry out physical tasks. Nifedipine is currently the adjunct drug of choice for altitude

2012 Pacific University EBM Capstone Project

66. High Altitude Illnesses in Hawai‘i Full Text available with Trip Pro

High Altitude Illnesses in Hawai‘i High Altitude Headache (HAH), Acute Mountain Sickness (AMS), and High Altitude Cerebral Edema (HACE) are all high altitude related illnesses in order of severity from the mildly symptomatic to the potentially life-threatening. High altitude illnesses occur when travelers ascend to high altitudes too rapidly, which does not allow enough time for the body to adjust. Slow graded ascent to the desired altitude and termination of ascent if AMS symptoms present (...) are keys to illness prevention. Early recognition and rapid intervention of AMS can halt progression to HACE. Pharmacologic prophylaxis with acetazolamide is a proven method of prevention and treatment of high altitude illness. If prevention fails then treatment modalities include supplemental oxygen, supportive therapy, hyperbaric treatment, and dexamethasone. Given the multitude of visitors to the mountains of Hawai'i, high altitude illness will continue to persist as a prevalent local condition

2014 Hawai'i Journal of Medicine & Public Health

67. High-Altitude Cardiopulmonary Diseases (Overview)

), a spectrum that, in its severest form, can manifest as high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema. Fortunately, for most individuals, the symptoms are annoying but not incapacitating. The duration of these symptoms is brief, usually only several days. The development of AMS is directly related to the speed and height of the ascent and inversely related to age, as AMS is most common in the young. Symptoms observed in preverbal children include increased fussiness, decreased (...) appetite, poor sleep patterns, and decreased playfulness. High-altitude pulmonary edema Healthy children and active young adults exposed to moderate altitudes are at risk for HAPE. This is an unusual form of noncardiogenic pulmonary edema that develops after an ascent to altitudes generally above 8000 ft (2438 m). The ascent is often rapid and is accomplished by means of either automobile or aircraft. In this situation, exposure to high altitude typically lasts several hours, most commonly after

2014 eMedicine Pediatrics

68. High-Altitude Cardiopulmonary Diseases (Treatment)

), a spectrum that, in its severest form, can manifest as high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema. Fortunately, for most individuals, the symptoms are annoying but not incapacitating. The duration of these symptoms is brief, usually only several days. The development of AMS is directly related to the speed and height of the ascent and inversely related to age, as AMS is most common in the young. Symptoms observed in preverbal children include increased fussiness, decreased (...) appetite, poor sleep patterns, and decreased playfulness. High-altitude pulmonary edema Healthy children and active young adults exposed to moderate altitudes are at risk for HAPE. This is an unusual form of noncardiogenic pulmonary edema that develops after an ascent to altitudes generally above 8000 ft (2438 m). The ascent is often rapid and is accomplished by means of either automobile or aircraft. In this situation, exposure to high altitude typically lasts several hours, most commonly after

2014 eMedicine Pediatrics

69. High-Altitude Cardiopulmonary Diseases (Follow-up)

), a spectrum that, in its severest form, can manifest as high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema. Fortunately, for most individuals, the symptoms are annoying but not incapacitating. The duration of these symptoms is brief, usually only several days. The development of AMS is directly related to the speed and height of the ascent and inversely related to age, as AMS is most common in the young. Symptoms observed in preverbal children include increased fussiness, decreased (...) appetite, poor sleep patterns, and decreased playfulness. High-altitude pulmonary edema Healthy children and active young adults exposed to moderate altitudes are at risk for HAPE. This is an unusual form of noncardiogenic pulmonary edema that develops after an ascent to altitudes generally above 8000 ft (2438 m). The ascent is often rapid and is accomplished by means of either automobile or aircraft. In this situation, exposure to high altitude typically lasts several hours, most commonly after

2014 eMedicine Pediatrics

70. Pulmonary Hypertension, High Altitude (Overview)

enzyme (ACE) gene. Genetic susceptibility to high-altitude pulmonary edema (HAPE) has been attributed to variants of the endothelial nitric oxide synthetase gene ( NOS3 ). Individuals with a genetic risk for increased thrombosis may be at increased risk for HAPE. Chronic hypoxia, pulmonary venous hypertension, and increased pulmonary blood flow can markedly increase pulmonary pressures in many genetically susceptible individuals; these factors may be additive. At sea level, 25%-30% of adults (...) evidence to determine the effects of nonpharmacologic and pharmacologic interventions in treating high-altitude illness and indicated high-quality research is needed. [ ] The investigators noted low-quality evidence for dexamethasone and acetazolamide suggested these agents may reduce acute mountain sickness score relative to placebo, but their clinical benefits and harms remain unclear. High-altitude pulmonary edema High-altitude pulmonary edema (HAPE) is an unusual form of noncardiogenic pulmonary

2014 eMedicine Pediatrics

71. Pulmonary Hypertension, High Altitude (Diagnosis)

enzyme (ACE) gene. Genetic susceptibility to high-altitude pulmonary edema (HAPE) has been attributed to variants of the endothelial nitric oxide synthetase gene ( NOS3 ). Individuals with a genetic risk for increased thrombosis may be at increased risk for HAPE. Chronic hypoxia, pulmonary venous hypertension, and increased pulmonary blood flow can markedly increase pulmonary pressures in many genetically susceptible individuals; these factors may be additive. At sea level, 25%-30% of adults (...) evidence to determine the effects of nonpharmacologic and pharmacologic interventions in treating high-altitude illness and indicated high-quality research is needed. [ ] The investigators noted low-quality evidence for dexamethasone and acetazolamide suggested these agents may reduce acute mountain sickness score relative to placebo, but their clinical benefits and harms remain unclear. High-altitude pulmonary edema High-altitude pulmonary edema (HAPE) is an unusual form of noncardiogenic pulmonary

2014 eMedicine Pediatrics

72. Pulmonary Hypertension, High Altitude (Follow-up)

enzyme (ACE) gene. Genetic susceptibility to high-altitude pulmonary edema (HAPE) has been attributed to variants of the endothelial nitric oxide synthetase gene ( NOS3 ). Individuals with a genetic risk for increased thrombosis may be at increased risk for HAPE. Chronic hypoxia, pulmonary venous hypertension, and increased pulmonary blood flow can markedly increase pulmonary pressures in many genetically susceptible individuals; these factors may be additive. At sea level, 25%-30% of adults (...) evidence to determine the effects of nonpharmacologic and pharmacologic interventions in treating high-altitude illness and indicated high-quality research is needed. [ ] The investigators noted low-quality evidence for dexamethasone and acetazolamide suggested these agents may reduce acute mountain sickness score relative to placebo, but their clinical benefits and harms remain unclear. High-altitude pulmonary edema High-altitude pulmonary edema (HAPE) is an unusual form of noncardiogenic pulmonary

2014 eMedicine Pediatrics

73. High-Altitude Cardiopulmonary Diseases (Diagnosis)

), a spectrum that, in its severest form, can manifest as high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema. Fortunately, for most individuals, the symptoms are annoying but not incapacitating. The duration of these symptoms is brief, usually only several days. The development of AMS is directly related to the speed and height of the ascent and inversely related to age, as AMS is most common in the young. Symptoms observed in preverbal children include increased fussiness, decreased (...) appetite, poor sleep patterns, and decreased playfulness. High-altitude pulmonary edema Healthy children and active young adults exposed to moderate altitudes are at risk for HAPE. This is an unusual form of noncardiogenic pulmonary edema that develops after an ascent to altitudes generally above 8000 ft (2438 m). The ascent is often rapid and is accomplished by means of either automobile or aircraft. In this situation, exposure to high altitude typically lasts several hours, most commonly after

2014 eMedicine Pediatrics

74. Investigation of whole-brain white matter identifies altered water mobility in the pathogenesis of high-altitude headache. Full Text available with Trip Pro

Investigation of whole-brain white matter identifies altered water mobility in the pathogenesis of high-altitude headache. Elevated brain water is a common finding in individuals with severe forms of altitude illness. However, the location, nature, and a causative link between brain edema and symptoms of acute mountain sickness such as headache remains unknown. We examined indices of brain white matter water mobility in 13 participants after 2 and 10 hours in normoxia (21% O2) and hypoxia (12 (...) , with headache score after 10 hours in hypoxia. Region of interest-based analyses generally confirmed these results. These data indicate that acute periods of hypoxemia cause a shift of water into the intracellular space within the cerebral white matter, whereas no evidence of brain edema (a volumetric enlargement) is identifiable. Furthermore, these changes in brain water mobility are related to the intensity of high-altitude headache.

2013 Journal of Cerebral Blood Flow and Metabolism

75. Impact of Acute Exposure to High Altitude on Anterior Chamber Geometry. Full Text available with Trip Pro

measures of aqueous outflow structures remained consistent with no significant changes in AOD or ACA. Incidence of AMS on day 1 was 64% followed by a decrease in AMS scores over time spent at high altitude; while AMS correlated significantly with stromal edema formation just after arrival (r = 0.71; P = 0.01), no correlation was found on day 3 (r = 0.05; P = 0.87); no correlations were found for vital parameters.Significant stromal edema was found during exposure to high altitude in healthy subjects (...) Impact of Acute Exposure to High Altitude on Anterior Chamber Geometry. This study aimed to quantify the impact of exposure to high altitude on individual layers of the cornea in regard to central corneal thickness (CCT) and the geometry of the anterior chamber angle (ACA). This work is related to the Tübingen High Altitude Ophthalmology study.Anterior segment spectral domain optical coherence tomography was used to quantify changes in individual corneal layers and to study ACA and angle

2013 Investigative Ophthalmology & Visual Science

76. Short-term responses of the kidney to high altitude in mountain climbers. Full Text available with Trip Pro

Short-term responses of the kidney to high altitude in mountain climbers. In high-altitude climbers, the kidneys play a crucial role in acclimatization and in mountain sickness syndromes [acute mountain sickness (AMS), high-altitude cerebral edema, high-altitude pulmonary edema] through their roles in regulating body fluids, electrolyte and acid-base homeostasis. Here, we discuss renal responses to several high-altitude-related stresses, including changes in systemic volume status, renal plasma (...) flow and clearance, and altered acid-base and electrolyte status. Volume regulation is considered central both to high-altitude adaptation and to maladaptive development of mountain sickness. The rapid and powerful diuretic response to the hypobaric hypoxic stimulus of altitude integrates decreased circulating concentrations of antidiuretic hormone, renin and aldosterone, increased levels of natriuretic hormones, plasma and urinary epinephrine, norepinephrine, endothelin and urinary adrenomedullin

2013 Transplantation

77. Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

31, 2013 Results First Posted : April 12, 2017 Last Update Posted : April 12, 2017 Sponsor: Richard Moon Information provided by (Responsible Party): Richard Moon, Duke University Study Details Study Description Go to Brief Summary: During ascent to high altitude there is a physiologic response to hypoxia that results in an elevated pulmonary arterial pressure associated with decreased exercise performance, altitude-induced pulmonary hypertension, and high altitude pulmonary edema (HAPE (...) Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2013 Clinical Trials

78. Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing

, or Diamox, is the standard medical prophylaxis agent for high altitude illness. The medication is effective in preventing acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE). Its mechanism is via inhibition of the carbonic anhydrase enzyme which counteracts the respiratory alkalosis which occurs during ascent to altitude. It facilitates the excretion of bicarbonate in the urine. As a result, acetazolamide hastens acclimatization and helps prevent (...) Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2013 Clinical Trials

79. High Altitude Medical Research Expedition Himlung 2013

disease Subjects with diabetes mellitus type I or II Regular intake of beta-blockers, ACE-inhibitors, nitrates and calcium antagonists as well as corticosteroids or anti-inflammatory medication Subjects who developed high altitude pulmonary edema after a rapid ascent (< 3 nights) at altitudes below 3500m Subjects who developed severe acute mountain sickness and/or high altitude cerebral edema after rapid ascent to altitudes below 3500m Contacts and Locations Go to Information from the National Library (...) High Altitude Medical Research Expedition Himlung 2013 High Altitude Medical Research Expedition Himlung 2013 - a Study of Human Adaption to Hypoxia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. High

2013 Clinical Trials

80. [Bundle program of treatment for acute severe type high altitude disease]. (Abstract)

[Bundle program of treatment for acute severe type high altitude disease]. To discuss Bundle treatment of the acute severe type high altitude disease.The prospective and randomized controlled trial was conducted. Two hundred and three patients with high altitude pulmonary edema (HAPE) or high altitude cerebral edema (HACE) met inclusion criteria were included, and were randomly divided into Bundle treatment group (n = 125) and conventional treatment control group (n = 78). Critical patients

2013 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>