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High Altitude Edema

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21. Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk (PubMed)

Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk Previous studies demonstrated that Angiotensin II Receptor 1 (AGTR1) may play an important role in the development of high-altitude pulmonary edema. We envisaged a role for AGTR1 gene variants in the pathogenesis of HAPE and investigated their potential associations with HAPE in a Han Chinese population. We genotyped seven AGTR1 polymorphisms in 267 patients with diagnosed HAPE and 304 controls

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2016 Oncotarget

22. Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial. (PubMed)

Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial. Yanamandra, Uday, Velu Nair, Surinderpal Singh, Amul Gupta, Deepak Mulajkar, Sushma Yanamandra, Konchok Norgais, Ruchira Mukherjee, Vikrant Singh, Srinivasa A. Bhattachar, Sagarika Patyal, and Rajan Grewal. High-altitude pulmonary edema management: Is anything other than oxygen required? Results of a randomized controlled trial. High Alt Med Biol. 17:294-299, 2016.-Treatment strategies (...) for management of high-altitude pulmonary edema (HAPE) are mainly based on the observational studies with only two randomized controlled trials, thus the practice is very heterogeneous and individualized as per the choice of treating physician. To compare the response to different modalities of therapy in patients with HAPE in a randomized controlled manner. We conducted an open-label, randomized noninferiority trial to compare three modalities of therapy (Therapy 1: supplemental O2 with oral dexamethasone 8

2016 High altitude medicine & biology

23. Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers (PubMed)

Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP (...) levels, baseline hemodynamics and the response to hypoxia (FIo2 = 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p

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2016 Scientific reports

24. High Altitude Pulmonary Edema

High Altitude Pulmonary Edema High Altitude Pulmonary Edema Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 High Altitude Pulmonary (...) Edema High Altitude Pulmonary Edema Aka: High Altitude Pulmonary Edema , HAPE From Related Chapters II. Epidemiology : 4% in travel above 15000 feet (4600 meters) Most common cause of death from high altitude illness Onset: 1-4 days after rapid ascent above 8000 feet (2400 meters) III. Pathophysiology Hypoxic pulmonary striction results in increased pulmonary capillary pressure Results in non-inflammatory fluid extravasation into alveoli May occur in the absence of IV. Risk Factors Same as with V

2018 FP Notebook

25. High Altitude Cerebral Edema

High Altitude Cerebral Edema High Altitude Cerebral Edema Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 High Altitude Cerebral Edema (...) High Altitude Cerebral Edema Aka: High Altitude Cerebral Edema , HACE From Related Chapters II. Pathophysiology End-stage Course from mild to death can occur within hours III. Symptoms See IV. Signs Screening: Heal-toe walking in a straight line V. Diagnosis Criteria 1 Mental status changes OR and criteria Criteria 2 Mental status changes AND Without criteria VI. Management See Descend Immediately Initial: 4-8 mg IM/IV/PO Later: 4 mg q6h IM/IV/PO High flow Intubation and if patient comatose VII

2018 FP Notebook

26. High Altitude Edema

High Altitude Edema High Altitude Edema Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 High Altitude Edema High Altitude Edema Aka (...) : High Altitude Edema From Related Chapters II. Definition on ascending to altitudes over 2400 meters III. Related Conditions ( ) ( ) IV. Epidemiology More common in women V. Signs Facial and Provoked by high salt diet Resolves with diuresis on altitude descent Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "High Altitude Edema." Click on the image (or right click) to open the source website in a new browser window. Related

2018 FP Notebook

27. Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. (PubMed)

Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms behind these syndromes remain to be determined. We report a study in which 12 subjects were exposed to a FiO2 = 0.12 for 22 h and underwent serial magnetic resonance imaging sequences to enable measurement (...) ). Brain white matter volume increased over the 22-h period (574 ml to 587 ml; p < 0.001) and correlated with cumulative Lake Louise scores at 22 h (p < 0.05). We conclude that cerebral oxygen delivery was maintained by increased arterial inflow and this preceded the development of cerebral edema. Venous outflow restriction appeared to play a contributory role in the formation of cerebral edema, a novel feature that has not been observed previously.© The Author(s) 2016.

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2016 Journal of Cerebral Blood Flow and Metabolism

28. Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers (PubMed)

Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers High altitude pulmonary edema (HAPE) susceptibility is associated with EGLN1 polymorphisms, we hypothesized that HAPE-susceptible (HAPE-S, had HAPE episode in past) subjects may exhibit abnormal HIF1α levels in normoxic conditions. We measured HIF1α levels in HAPE-S and HAPE resistant (HAPE-R, no HAPE episode) individuals with similar pulmonary functions. Hemodynamic responses were also measured before

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2016 Scientific reports

29. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema (PubMed)

Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema Introduction. Acute exposure to high altitude induces inflammation. However, the relationship between inflammation and high altitude related illness such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) is poorly understood. We tested if soluble urokinase-type plasminogen activator receptor (suPAR) plasma concentration, a prognostic (...) = 0.16, p = 0.24). Baseline suPAR plasma concentration was higher in the HAPE-s group (2.0 ± 0.4 versus 1.8 ± 0.4, p = 0.04); no difference was found for CRP and IL-6 and for subjects developing AMS. Conclusion. High altitude exposure leads to an increase in suPAR plasma concentration, with the missing correlation between suPAR and IL-6 suggesting a cytokine independent, leukocyte mediated mechanism of low grade inflammation. The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia

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2016 Mediators of inflammation

30. Chemokines in High Altitude Pulmonary Edema (PubMed)

Chemokines in High Altitude Pulmonary Edema 27605749 2016 09 08 2018 11 13 0970-1915 31 4 2016 Oct Indian journal of clinical biochemistry : IJCB Indian J Clin Biochem Chemokines in High Altitude Pulmonary Edema. 483-4 10.1007/s12291-016-0581-x Bhattachar Srinivasa S Armed Forces Medical College, Pune, 411040 India. Sikri Gaurav G Armed Forces Medical College, Pune, 411040 India. eng Journal Article 2016 05 27 India Indian J Clin Biochem 8708303 0970-1915 2016 05 11 2016 05 17 2016 9 9 6 0 2016

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2016 Indian Journal of Clinical Biochemistry

31. Lung Ultrasound Is Accurate for the Diagnosis of High-Altitude Pulmonary Edema: A Prospective Study (PubMed)

Lung Ultrasound Is Accurate for the Diagnosis of High-Altitude Pulmonary Edema: A Prospective Study The aim of this study was to assess the diagnostic accuracy of lung ultrasonography (LUS) for high-altitude pulmonary edema (HAPE).LUS has proven to be a reliable tool for the diagnosis of pulmonary diseases, including pneumonia, acute respiratory distress syndrome (ARDS), and pneumothorax. LUS also has potential for the diagnosis of HAPE. However, the actual diagnostic value of LUS for HAPE (...) CXR (0.98 vs. 0.93, P < 0.05 using the McNemar test). After treatment, LUS was consistent with CXR in 96.55% of HAPE patients, and the concordance between LUS and CXR was high (k statistic = 0.483 P ≤ 0.001; 95% CI -0.021 to -0.853).The results indicate that LUS is a reliable method for the diagnosis and surveillance of HAPE. This trial is registered with Chinese Clinical Trial Registry (No. ChiCTR-DDD-16009841).

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2018 Canadian respiratory journal

32. Central Corneal Thickness of Healthy Lowlanders at High Altitude: A Systematic Review and Meta-Analysis.

Central Corneal Thickness of Healthy Lowlanders at High Altitude: A Systematic Review and Meta-Analysis. Central corneal thickness, a marker of corneal hydration and metabolism, was reported to increase at high elevations. This study aimed to assess the effect of chronic high-altitude exposure on the central corneal thickness of healthy lowlanders with unoperated corneas, and determine if a relationship exists between exposure time and corneal edema formation.The PubMed, Embase, Scopus (...) a significant linear relation between high-altitude exposure time and corneal edema formation that exceeded 5% after 10 days.High-altitude exposure induces central corneal thickening with significant linear progression over time, whereas it takes over 10 days to reach clinical significance in healthy lowlanders with unoperated corneas, and changes in central corneal thickness are reversible after descent to lower elevations.

2018 Current eye research

33. Response to: Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” (PubMed)

Response to: Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” 29853793 2018 11 14 1466-1861 2018 2018 Mediators of inflammation Mediators Inflamm. Response to: Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema". 8036759 10.1155/2018/8036759 Hilty Matthias Peter MP 0000-0002-2765-881X Medical (...) . 2017 Mar 1;595(5):1619-1626 27966225 High Alt Med Biol. 2016 Dec;17 (4):305-314 27754698 Mediators Inflamm. 2016;2016:1942460 27378823 JAMA. 2002 May 1;287(17 ):2228-35 11980523

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2018 Mediators of inflammation

34. Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo)

altitude related diseases (AMS, high-altitude pulmonary edema (HAPE), etc.) based on previous experienced discomfort at altitudes. Exposure to an altitude >1500m for ≥3 nights during the last 4 weeks before the study participation Residence > 1000m above sea level Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with Walking disability Women who are pregnant or breast feeding Contacts and Locations Go (...) Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

35. The STAR Data Reporting Guidelines for Clinical High Altitude Research (PubMed)

The STAR Data Reporting Guidelines for Clinical High Altitude Research Brodmann Maeder, Monika, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Baärtsch, Erik R. Swenson, Ken Zafren (STAR Core Group), and the STAR Delphi Expert Group. The STARdata reporting guidelines for clinical high altitude research. High AltMedBiol. 19:7-14, 2018.The goal of the STAR (STrengthening Altitude Research) initiative was to produce a uniform set of key (...) elements for research and reporting in clinical high-altitude (HA) medicine. The STAR initiative was inspired by research on treatment of cardiac arrest, in which the establishment of the Utstein Style, a uniform data reporting protocol, substantially contributed to improving data reporting and subsequently the quality of scientific evidence.The STAR core group used the Delphi method, in which a group of experts reaches a consensus over multiple rounds using a formal method. We selected experts

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2018 High altitude medicine & biology

36. Research advances in pathogenesis and prophylactic measures of acute high altitude illness. (PubMed)

Research advances in pathogenesis and prophylactic measures of acute high altitude illness. After ascent to high altitude (≥2500 m), the inability of the human body to adapt to the hypobaric and hypoxia environment can induce tissue hypoxia, then a series of high altitude illnesses including acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) would develop. Symptoms of AMS include headache, dizziness, nausea, and vomiting; HAPE (...) is characterized by orthopnea, breathlessness at rest, cough, pink frothy sputum, and results in obvious pulmonary edema that poses significant harm to people; HACE is characterized by ataxia and decreased consciousness, leading to coma and brain herniation which would be fatal if not treated promptly. This review article provides a current understanding of the pathophysiology of these three forms of high altitude illness and elaborates the current prevention and treatment measures of these diseases.Copyright

2018 Respiratory medicine

37. Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema (PubMed)

Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema 26766920 2016 01 15 2018 11 13 1179-1543 7 2016 Open access journal of sports medicine Open Access J Sports Med Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema. 1-3 10.2147/OAJSM.S99621 Sikri Gaurav G Department of Physiology, Armed Forces Medical College, Wanowarie, Pune, India. Bhattacharya Anirban A Department of Physiology, Armed Forces Medical College

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2015 Open access journal of sports medicine

38. The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. (PubMed)

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. After suffering from severe acute respiratory distress syndrome, several patients show generalized brain alterations and atrophy. A distinctive morphologic pattern of cerebral injury, however, has not been found so far.We present the history of three patients who survived severe acute respiratory distress syndrome. In these patients, MRI of the brain showed multiple (...) microhemorrhages predominantly in the splenium of the corpus callosum. An identical pattern of microhemorrhages has previously been described in mountaineers who suffered from high-altitude cerebral edema.This report demonstrates that patients after treatment for acute respiratory distress syndrome and high-altitude cerebral edema show congruent cerebral injuries. Further investigation into the similarities of the causative conditions and neurologic consequences might reveal underlying pathophysiologic

2015 Critical Care Medicine

39. Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)

cerebral and spinal oedema. Condition or disease Intervention/treatment Phase High Altitude Cerebral Edema Drug: Dexamethasone Drug: Placebo Phase 1 Detailed Description: The exact mechanisms by which AMS develops remains poorly understood. Interestingly, brain and spinal cord swelling due to low oxygen levels can also occur in the period following surgery to treat thoracic and abdominal aortic aneurysms, dangerous swellings of the major blood vessel in the body. Therefore, if we find a therapeutic (...) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

40. Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” (PubMed)

Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” 28270701 2018 11 13 1466-1861 2017 2017 Mediators of inflammation Mediators Inflamm. Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema". 8546027 10.1155/2017/8546027 Sikri Gaurav G 0000-0002-5680-6252 Department of Physiology, Armed Forces Medical

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2017 Mediators of inflammation

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