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High Altitude Edema

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21. Managing High-Altitude Pulmonary Edema with Oxygen Alone.

Managing High-Altitude Pulmonary Edema with Oxygen Alone. Managing High-Altitude Pulmonary Edema with Oxygen Alone. – Less Is More Search for: Simpler & Better Medicine Menu / Summary: For healthy patients who experience high-altitude pulmonary edema (HAPE), treatment with only oxygen + bedrest may be associated with the same time to resolution of HAPE as treatment with oxygen + bedrest + nifedipine, and might be associated with a shorter time to resolution of HAPE than oxygen + bedrest

2017 Less Is More Blog

22. Is it time to revise the acclimatization schedule at high altitude? Evidence from a field trial in Western Himalayas. (Abstract)

rapidly by road to HAL in 4 days and prevalence of acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE) during the ascent was measured.Prevalence of AMS was found to be 1.56% and 1.59% in group 'A' and group 'B' respectively during the ascent with no cases of HAPE and HACE.At least on SH road, troops can be inducted rapidly to HAL from SLL in 4 days under pharmaco-prophylaxis with Acetazolamide with minimal occurrence of acute high altitude (...) Is it time to revise the acclimatization schedule at high altitude? Evidence from a field trial in Western Himalayas. In Western Himalayas, Indian Army soldiers take 11 days (6 days of acclimatization and 5 days of travel) on a sea-level to high altitude road (SH road) to reach a high altitude location (HAL) situated at an altitude of 11,500 feet from sea-level location (SLL) at an altitude of 1150 feet while following acclimatization schedule (AS). AS has an extra safety margin over

2019 Medical journal, Armed Forces India Controlled trial quality: uncertain

23. Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial. (Abstract)

Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial. Yanamandra, Uday, Velu Nair, Surinderpal Singh, Amul Gupta, Deepak Mulajkar, Sushma Yanamandra, Konchok Norgais, Ruchira Mukherjee, Vikrant Singh, Srinivasa A. Bhattachar, Sagarika Patyal, and Rajan Grewal. High-altitude pulmonary edema management: Is anything other than oxygen required? Results of a randomized controlled trial. High Alt Med Biol. 17:294-299, 2016.-Treatment strategies (...) for management of high-altitude pulmonary edema (HAPE) are mainly based on the observational studies with only two randomized controlled trials, thus the practice is very heterogeneous and individualized as per the choice of treating physician. To compare the response to different modalities of therapy in patients with HAPE in a randomized controlled manner. We conducted an open-label, randomized noninferiority trial to compare three modalities of therapy (Therapy 1: supplemental O2 with oral dexamethasone 8

2016 High altitude medicine & biology Controlled trial quality: uncertain

24. Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. Full Text available with Trip Pro

Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms behind these syndromes remain to be determined. We report a study in which 12 subjects were exposed to a FiO2 = 0.12 for 22 h and underwent serial magnetic resonance imaging sequences to enable measurement (...) ). Brain white matter volume increased over the 22-h period (574 ml to 587 ml; p < 0.001) and correlated with cumulative Lake Louise scores at 22 h (p < 0.05). We conclude that cerebral oxygen delivery was maintained by increased arterial inflow and this preceded the development of cerebral edema. Venous outflow restriction appeared to play a contributory role in the formation of cerebral edema, a novel feature that has not been observed previously.© The Author(s) 2016.

2016 Journal of Cerebral Blood Flow and Metabolism

25. Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers Full Text available with Trip Pro

Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP (...) levels, baseline hemodynamics and the response to hypoxia (FIo2 = 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p

2016 Scientific reports

26. Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema Full Text available with Trip Pro

Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema Introduction. Acute exposure to high altitude induces inflammation. However, the relationship between inflammation and high altitude related illness such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) is poorly understood. We tested if soluble urokinase-type plasminogen activator receptor (suPAR) plasma concentration, a prognostic (...) = 0.16, p = 0.24). Baseline suPAR plasma concentration was higher in the HAPE-s group (2.0 ± 0.4 versus 1.8 ± 0.4, p = 0.04); no difference was found for CRP and IL-6 and for subjects developing AMS. Conclusion. High altitude exposure leads to an increase in suPAR plasma concentration, with the missing correlation between suPAR and IL-6 suggesting a cytokine independent, leukocyte mediated mechanism of low grade inflammation. The correlation between IL-6 and PaO2 suggests a direct effect of hypoxia

2016 Mediators of inflammation Controlled trial quality: uncertain

27. Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers Full Text available with Trip Pro

Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers High altitude pulmonary edema (HAPE) susceptibility is associated with EGLN1 polymorphisms, we hypothesized that HAPE-susceptible (HAPE-S, had HAPE episode in past) subjects may exhibit abnormal HIF1α levels in normoxic conditions. We measured HIF1α levels in HAPE-S and HAPE resistant (HAPE-R, no HAPE episode) individuals with similar pulmonary functions. Hemodynamic responses were also measured before

2016 Scientific reports

28. Chemokines in High Altitude Pulmonary Edema Full Text available with Trip Pro

Chemokines in High Altitude Pulmonary Edema 27605749 2016 09 08 2018 11 13 0970-1915 31 4 2016 Oct Indian journal of clinical biochemistry : IJCB Indian J Clin Biochem Chemokines in High Altitude Pulmonary Edema. 483-4 10.1007/s12291-016-0581-x Bhattachar Srinivasa S Armed Forces Medical College, Pune, 411040 India. Sikri Gaurav G Armed Forces Medical College, Pune, 411040 India. eng Journal Article 2016 05 27 India Indian J Clin Biochem 8708303 0970-1915 2016 05 11 2016 05 17 2016 9 9 6 0 2016

2016 Indian Journal of Clinical Biochemistry

29. Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population Full Text available with Trip Pro

Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population Biomarkers are essential to unravel the locked pathophysiology of any disease. This study investigated the role of biomarkers and their interactions with each other and with the clinical parameters to study the physiology of high-altitude pulmonary edema (HAPE) in HAPE-patients (HAPE-p) against adapted highlanders (HLs

2016 Therapeutics and clinical risk management

30. Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk Full Text available with Trip Pro

Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk Previous studies demonstrated that Angiotensin II Receptor 1 (AGTR1) may play an important role in the development of high-altitude pulmonary edema. We envisaged a role for AGTR1 gene variants in the pathogenesis of HAPE and investigated their potential associations with HAPE in a Han Chinese population. We genotyped seven AGTR1 polymorphisms in 267 patients with diagnosed HAPE and 304 controls

2016 Oncotarget

31. ROCK2 and MYLK variants and high-altitude pulmonary edema Full Text available with Trip Pro

ROCK2 and MYLK variants and high-altitude pulmonary edema 27536156 2016 08 18 2018 11 13 1178-704X 9 2016 The application of clinical genetics Appl Clin Genet ROCK2 and MYLK variants and high-altitude pulmonary edema. 137-9 10.2147/TACG.S113924 Sikri Gaurav G Department of Physiology, Armed Forces Medical College, Pune, Maharashtra, India. Bhattachar Srinivasa S Department of Physiology, Armed Forces Medical College, Pune, Maharashtra, India. eng Journal Article 2016 08 02 New Zealand Appl Clin

2016 The application of clinical genetics

32. Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo)

altitude related diseases (AMS, high-altitude pulmonary edema (HAPE), etc.) based on previous experienced discomfort at altitudes. Exposure to an altitude >1500m for ≥3 nights during the last 4 weeks before the study participation Residence > 1000m above sea level Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, neurological or orthopedic problems with Walking disability Women who are pregnant or breast feeding Contacts and Locations Go (...) Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

33. Research advances in pathogenesis and prophylactic measures of acute high altitude illness. (Abstract)

Research advances in pathogenesis and prophylactic measures of acute high altitude illness. After ascent to high altitude (≥2500 m), the inability of the human body to adapt to the hypobaric and hypoxia environment can induce tissue hypoxia, then a series of high altitude illnesses including acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) would develop. Symptoms of AMS include headache, dizziness, nausea, and vomiting; HAPE (...) is characterized by orthopnea, breathlessness at rest, cough, pink frothy sputum, and results in obvious pulmonary edema that poses significant harm to people; HACE is characterized by ataxia and decreased consciousness, leading to coma and brain herniation which would be fatal if not treated promptly. This review article provides a current understanding of the pathophysiology of these three forms of high altitude illness and elaborates the current prevention and treatment measures of these diseases.Copyright

2018 Respiratory medicine

34. Response to: Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” Full Text available with Trip Pro

Response to: Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” 29853793 2018 11 14 1466-1861 2018 2018 Mediators of inflammation Mediators Inflamm. Response to: Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema". 8036759 10.1155/2018/8036759 Hilty Matthias Peter MP 0000-0002-2765-881X Medical (...) . 2017 Mar 1;595(5):1619-1626 27966225 High Alt Med Biol. 2016 Dec;17 (4):305-314 27754698 Mediators Inflamm. 2016;2016:1942460 27378823 JAMA. 2002 May 1;287(17 ):2228-35 11980523

2018 Mediators of inflammation

35. The STAR Data Reporting Guidelines for Clinical High Altitude Research Full Text available with Trip Pro

The STAR Data Reporting Guidelines for Clinical High Altitude Research Brodmann Maeder, Monika, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Baärtsch, Erik R. Swenson, Ken Zafren (STAR Core Group), and the STAR Delphi Expert Group. The STARdata reporting guidelines for clinical high altitude research. High AltMedBiol. 19:7-14, 2018.The goal of the STAR (STrengthening Altitude Research) initiative was to produce a uniform set of key (...) elements for research and reporting in clinical high-altitude (HA) medicine. The STAR initiative was inspired by research on treatment of cardiac arrest, in which the establishment of the Utstein Style, a uniform data reporting protocol, substantially contributed to improving data reporting and subsequently the quality of scientific evidence.The STAR core group used the Delphi method, in which a group of experts reaches a consensus over multiple rounds using a formal method. We selected experts

2018 High altitude medicine & biology

36. Central Corneal Thickness of Healthy Lowlanders at High Altitude: A Systematic Review and Meta-Analysis. (Abstract)

Central Corneal Thickness of Healthy Lowlanders at High Altitude: A Systematic Review and Meta-Analysis. Central corneal thickness, a marker of corneal hydration and metabolism, was reported to increase at high elevations. This study aimed to assess the effect of chronic high-altitude exposure on the central corneal thickness of healthy lowlanders with unoperated corneas, and determine if a relationship exists between exposure time and corneal edema formation.The PubMed, Embase, Scopus (...) a significant linear relation between high-altitude exposure time and corneal edema formation that exceeded 5% after 10 days.High-altitude exposure induces central corneal thickening with significant linear progression over time, whereas it takes over 10 days to reach clinical significance in healthy lowlanders with unoperated corneas, and changes in central corneal thickness are reversible after descent to lower elevations.

2018 Current eye research

37. The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. (Abstract)

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema. After suffering from severe acute respiratory distress syndrome, several patients show generalized brain alterations and atrophy. A distinctive morphologic pattern of cerebral injury, however, has not been found so far.We present the history of three patients who survived severe acute respiratory distress syndrome. In these patients, MRI of the brain showed multiple (...) microhemorrhages predominantly in the splenium of the corpus callosum. An identical pattern of microhemorrhages has previously been described in mountaineers who suffered from high-altitude cerebral edema.This report demonstrates that patients after treatment for acute respiratory distress syndrome and high-altitude cerebral edema show congruent cerebral injuries. Further investigation into the similarities of the causative conditions and neurologic consequences might reveal underlying pathophysiologic

2015 Critical Care Medicine

38. Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema Full Text available with Trip Pro

Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema 26766920 2016 01 15 2018 11 13 1179-1543 7 2016 Open access journal of sports medicine Open Access J Sports Med Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema. 1-3 10.2147/OAJSM.S99621 Sikri Gaurav G Department of Physiology, Armed Forces Medical College, Wanowarie, Pune, India. Bhattacharya Anirban A Department of Physiology, Armed Forces Medical College

2015 Open access journal of sports medicine

39. Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)

cerebral and spinal oedema. Condition or disease Intervention/treatment Phase High Altitude Cerebral Edema Drug: Dexamethasone Drug: Placebo Phase 1 Detailed Description: The exact mechanisms by which AMS develops remains poorly understood. Interestingly, brain and spinal cord swelling due to low oxygen levels can also occur in the period following surgery to treat thoracic and abdominal aortic aneurysms, dangerous swellings of the major blood vessel in the body. Therefore, if we find a therapeutic (...) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

40. Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” Full Text available with Trip Pro

Comment on “Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema” 28270701 2018 11 13 1466-1861 2017 2017 Mediators of inflammation Mediators Inflamm. Comment on "Soluble Urokinase-Type Plasminogen Activator Receptor Plasma Concentration May Predict Susceptibility to High Altitude Pulmonary Edema". 8546027 10.1155/2017/8546027 Sikri Gaurav G 0000-0002-5680-6252 Department of Physiology, Armed Forces Medical

2017 Mediators of inflammation

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