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Herpes Simplex Keratitis

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141. Role of miR-132 in Angiogenesis after Ocular Infection with Herpes Simplex Virus Full Text available with Trip Pro

Role of miR-132 in Angiogenesis after Ocular Infection with Herpes Simplex Virus MicroRNAs (miRNAs) are small regulatory molecules that control diverse biological processes that include angiogenesis. Herpes simplex virus (HSV) causes a chronic immuno-inflammatory response in the eye that may result in corneal neovascularization during blinding immunopathological lesion stromal keratitis (SK). miR-132 is a highly conserved miRNA that is induced in endothelial cells in response to growth factors

2012 The American journal of pathology

142. Clinical evaluation of adenine arabinoside and idoxuridine in the treatment of ocular herpes simplex. (Abstract)

Clinical evaluation of adenine arabinoside and idoxuridine in the treatment of ocular herpes simplex. A Double-blind clinical study comparing idoxuridine (IDU) with adenine arabinoside (ara-A) in treating 54 routine herpetic ulcers, and an open ara-A therapy study of 58 herpetic ulcers in patients intolerant of or resistant to IDU, was carried out over a four-year period. There was no significant difference in healing time between IDU-treated eyes (11.5 days) and ara-A-treated eyes (12.4 days (...) and one was dropped from the study because his initial disease could not be distinguished from severe IDU-induced keratitis.

1975 American journal of ophthalmology Controlled trial quality: uncertain

143. Management of ocular herpes simplex. Full Text available with Trip Pro

Management of ocular herpes simplex. 6029236 1967 09 12 2013 11 21 0007-1161 51 7 1967 Jul The British journal of ophthalmology Br J Ophthalmol Management of ocular herpes simplex. 494-5 Patterson A A eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Mydriatics 0 Steroids LGP81V5245 Idoxuridine IM Bandages Cautery Humans Idoxuridine therapeutic use Keratitis, Dendritic therapy Mydriatics therapeutic use Steroids therapeutic use 1967 7 1 1967 7 1 0 1 1967 7 1 0 0 ppublish 6029236

1967 The British journal of ophthalmology

144. Corneal hypersensitivity to herpes simplex. Full Text available with Trip Pro

Corneal hypersensitivity to herpes simplex. 4295044 1968 03 24 2018 11 13 0007-1161 51 12 1967 Dec The British journal of ophthalmology Br J Ophthalmol Corneal hypersensitivity to herpes simplex. 843-6 Swyers J S JS Lausch R N RN Kaufman H E HE eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Antigens IM Animals Antigens Chick Embryo Cornea Edema complications Guinea Pigs Hypersensitivity, Delayed complications Keratitis, Dendritic etiology Simplexvirus immunology 1967 12 1 1967

1967 The British journal of ophthalmology

145. Herpes simplex and zoster. Full Text available with Trip Pro

Diseases, Male Herpes Simplex congenital drug therapy immunology Herpes Zoster drug therapy Humans Idoxuridine therapeutic use Immunologic Deficiency Syndromes complications Infant, Newborn Infant, Newborn, Diseases Keratitis, Dendritic Male Simplexvirus Steroids adverse effects Stomatitis 1973 2 17 1973 2 17 0 1 1973 2 17 0 0 ppublish 4347938 PMC1588333 Br Med J. 1964 Oct 17;2(5415):987-8 14185689 N Engl J Med. 1959 May 21;260(21):1062-5 13657339 J R Coll Gen Pract. 1970 Dec;20(101):323-7 5533234 J (...) Herpes simplex and zoster. 4347938 1973 05 04 2018 11 13 0007-1447 1 5850 1973 Feb 17 British medical journal Br Med J Herpes simplex and zoster. 406-10 Juel-Jensen B E BE eng Journal Article England Br Med J 0372673 0007-1447 0 Steroids 04079A1RDZ Cytarabine LGP81V5245 Idoxuridine YOW8V9698H Dimethyl Sulfoxide AIM IM Age Factors Central Nervous System Diseases Conjunctivitis Cytarabine therapeutic use Dimethyl Sulfoxide therapeutic use Eczema Female Fingers Genital Diseases, Female Genital

1973 British medical journal

146. Herpes Simplex Uveitis: A Clinical and Experimental Study Full Text available with Trip Pro

Herpes Simplex Uveitis: A Clinical and Experimental Study 14032779 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Herpes simplex uveitis: a clinical and experimental study. 440-70 KIMURA S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 OM Herpes Simplex Humans Keratitis Keratitis, Dendritic Uveitis HERPES SIMPLEX KERATITIS, DENDRITIC UVEITIS 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish

1962 Transactions of the American Ophthalmological Society

147. VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION Full Text available with Trip Pro

VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION Rapp, Fred (Baylor University College of Medicine, Houston, Tex.). Variants of herpes simplex virus: isolation, characterization, and factors influencing plaque formation. J. Bacteriol. 86:985-991. 1963.-Variants of herpes simplex virus were isolated which differed in plaque size and in virulence for rabbits and mice. Keratitis on the rabbit cornea and generalized disease were associated

1963 Journal of bacteriology

148. Experimental and Clinical Use of Aureomycin in Herpes Simplex Full Text available with Trip Pro

Experimental and Clinical Use of Aureomycin in Herpes Simplex 15418604 2004 09 30 2018 12 01 0065-9533 47 1949 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Experimental and clinical use of aureomycin in herpes simplex. 335-48 BRALEY A E AE ALEXANDER R C RC eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 WCK1KIQ23Q Chlortetracycline OM Chlortetracycline Cornea Herpes Simplex Keratitis 5019:8463:18:56:130 AUREOMYCIN CORNEA KERATITIS

1949 Transactions of the American Ophthalmological Society

149. Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections Full Text available with Trip Pro

Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically

1976 Antimicrobial Agents and Chemotherapy

150. Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus Full Text available with Trip Pro

" was observed with high concentrations of drug, causing less inhibition of deoxyribonucleic acid synthesis than was observed with lower concentrations. Herpes simplex virus type 1 was inactivated also by the 8-hydroxyquinolines and their copper complexes. No intracellular inhibition of plaque formation was observed. Treatment with 8-hydroxyquinoline sulfate had no effect on the resolution of herpetic keratitis in rabbits. Some 8-hydroxyquinolines bind to deoxyribonucleic acid in the presence of copper (...) Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus 8-Hydroxyquinoline and several of its derivatives inactivate the transforming ability of Rous sarcoma virus and inhibit its ribonucleic acid-dependent deoxyribonucleic acid polymerase activity. The copper complex of these metal-binding ligands is as active as the free ligand. The activity of the 8-hydroxyquinolines is approximately 50-fold more

1976 Antimicrobial Agents and Chemotherapy

151. Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London. Full Text available with Trip Pro

of antiherpes simplex virus antibody in their blood. No adenovirus was isolated from these patients, but complement fixation test for adenovirus was positive in 1 patient with cultural test positive for herpes simplex virus. Most patients were between 20 and 35 years old and the ratio of males to females was 12 to 13. At the initial visit the clinical features of disease were moderate to severe conjunctival papillary and follicular reasons with epithelial and subepithelial punctate keratitis but little (...) Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London. During the 18 months January 1975 to June 1976, 25 cases of acute herpetic follicular conjunctivitis and keratoconjunctivitis resembling adenovirus ocular infection presented in the External Eye Disease Clinic, Moorfields Eye Hospital, City Road, London. Herpes simplex virus was isolated in HEp2 cells in 22 patients, and the remaining 3 patients were identified by a minimum 4-fold rise in the level

1978 The British journal of ophthalmology

152. Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty Full Text available with Trip Pro

Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etiology has been unclear. Our cases

2016 Case reports in ophthalmological medicine

153. Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa Full Text available with Trip Pro

hospitals in rural South Africa. Corneal swabs were tested for herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV) and adenovirus DNA by real-time polymerase chain reaction (PCR) and for bacteria and fungi by culture. Based on clinical history, disease characteristics and laboratory results, 29 (63 %) patients were diagnosed as viral keratitis, including 14 (48 %) viral keratitis cases complicated by bacterial superinfection, and 17 (37 %) as bacterial keratitis. VZV and HSV (...) -1 DNA was detected in 11 (24 %) and 5 (11 %) corneal swabs, respectively. Among clinically defined viral keratitis cases, a negative viral swab was predominantly (93 %) observed in cases with subepithelial inflammation and was significantly associated with an increased duration of symptoms (p = 0.003). The majority of bacteria cultured were Gram-positive (24/35), including Staphylococcus epidermidis and S. aureus. Viral aetiology was significantly associated with a history of herpes zoster

2016 European Journal of Clinical Microbiology & Infectious Diseases

154. Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. Full Text available with Trip Pro

Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK

2016 Medicine

155. Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years

pain, epithelial defect, epithelial haze, pseudodendrites, and, most characteristically, radial keratoneuritis. The corneal infection of AK was first recognized in the mid 1970s. Since then, a growing number of AK cases were diagnosed, mainly resulting from improper use of soft contact lenses. Clinical diagnosis of AL is difficult, especially in the early phases of the disease, and it often is misdiagnosed and treated as a herpes simplex infection. It was reported a diagnostic delay of more than 18 (...) Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Retrospective

2016 Clinical Trials

156. Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. Full Text available with Trip Pro

Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. The present study was designed to test the therapeutic value of soluble FasL (sFasL) in an acute model of herpetic stromal keratitis (HSK) and, more importantly, a recurrent model of HSK using BALB/c, BALB-lpr, and National Institutes of Health (NIH) mice.Mice were infected either acutely with the KOS strain of herpes simplex virus 1 (HSV-1) or latently with the McKrae strain of HSV-1

2015 Investigative Ophthalmology & Visual Science

157. Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis Full Text available with Trip Pro

Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis The cornea is a complex tissue that must preserve its transparency to maintain optimal vision. However, in some circumstances, damage to the eye can result in neovascularization that impairs vision. This outcome can occur when herpes simplex virus type 1 (HSV-1) causes the immunoinflammatory lesion stromal keratitis (SK). Potentially useful measures to control the severity of SK are to target angiogenesis which with herpetic SK

2015 PloS one

158. Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. (Abstract)

Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. To compare long-term outcomes of full-bed deep lamellar keratoplasty (DLK) with penetrating keratoplasty (PK) for treating corneal leucoma caused by herpes simplex keratitis (HSK).Retrospective, comparative, interventional case series.setting: Institutional. patients: Inclusion criteria were patients with corneal scarring induced exclusively (...) which recurrent epithelial keratitis amounted to 13 episodes in the PK group, remarkably more frequent than the 1 episode in the full-bed DLK group. Twenty-six eyes (41.3%) encountered rejection episodes in the PK group, but no rejection episode was found in the full-bed DLK group (P < .001). In 14 eyes in the PK group, graft failure developed because of graft rejection, recurrence of HSK, or both, whereas only in 1 eye in the full-bed DLK group did graft failure develop because of recurrence of HSK

2011 American Journal of Ophthalmology

159. Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection

the year prior to Day 0. A history of HSV infection of the eye (e.g., herpes simplex interstitial keratitis or uveitis). A history of herpes gladiatorum, herpetic whitlow or eczema herpeticum. A history of lesions caused by HSV on either arm. A history of herpes-associated erythema multiforme. A history of a clinically significant autoimmune disorder. Known or suspected congenital or acquired immunodeficiency Receipt of anti-cancer chemotherapy or radiation therapy within the preceding 6 months (...) Institute of Allergy and Infectious Diseases (NIAID) Collaborator: Sanofi Pasteur, a Sanofi Company Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ) Study Details Study Description Go to Brief Summary: Background: - Herpes simplex virus type 2 (HSV-2) is a major cause of genital herpes. It can also cause serious infection in newborns and in people with weakened immune systems. It increases

2013 Clinical Trials

160. Curative effect assessment of bandage contact lens in neurogenic keratitis. Full Text available with Trip Pro

group (drug therapy, n=10). In experimental group patients wore silicone hydrogel bandage soft contact lens. Both groups used the following eyedrops: 0.5% levofloxacin TID; 0.5% Sodium carboxymethyl cellulose QID; fibroblast growth factor BID; ganciclovir BID [cases complicated with herpes simplex virus (HSV)]; compound tropicamide BID (cases concurrent hypopyon). The healing time of corneal ulcer and complication rates were observed in the two groups.The healing time of corneal ulcer (...) Curative effect assessment of bandage contact lens in neurogenic keratitis. To observe the curative effect of bandage contact lens in neurogenic keratitis.Twenty cases of neurogenic keratitis were studied at the Department of Ophthalmology, the first Affiliated Hospital of China Medical University, between October 2012 and June 2013. These included 13 males and 7 females, aged from 35 to 88y. Patients were voluntarily divided into an experimental group (lens wearing group, n=10) and control

2014 International journal of ophthalmology Controlled trial quality: uncertain

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