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Herpes Simplex Keratitis

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141. Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty Full Text available with Trip Pro

Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etiology has been unclear. Our cases

2016 Case reports in ophthalmological medicine

142. Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years

pain, epithelial defect, epithelial haze, pseudodendrites, and, most characteristically, radial keratoneuritis. The corneal infection of AK was first recognized in the mid 1970s. Since then, a growing number of AK cases were diagnosed, mainly resulting from improper use of soft contact lenses. Clinical diagnosis of AL is difficult, especially in the early phases of the disease, and it often is misdiagnosed and treated as a herpes simplex infection. It was reported a diagnostic delay of more than 18 (...) Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Retrospective

2016 Clinical Trials

143. Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. Full Text available with Trip Pro

Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. The present study was designed to test the therapeutic value of soluble FasL (sFasL) in an acute model of herpetic stromal keratitis (HSK) and, more importantly, a recurrent model of HSK using BALB/c, BALB-lpr, and National Institutes of Health (NIH) mice.Mice were infected either acutely with the KOS strain of herpes simplex virus 1 (HSV-1) or latently with the McKrae strain of HSV-1

2015 Investigative Ophthalmology & Visual Science

144. Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis Full Text available with Trip Pro

Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis The cornea is a complex tissue that must preserve its transparency to maintain optimal vision. However, in some circumstances, damage to the eye can result in neovascularization that impairs vision. This outcome can occur when herpes simplex virus type 1 (HSV-1) causes the immunoinflammatory lesion stromal keratitis (SK). Potentially useful measures to control the severity of SK are to target angiogenesis which with herpetic SK

2015 PloS one

145. Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. (Abstract)

Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. To compare long-term outcomes of full-bed deep lamellar keratoplasty (DLK) with penetrating keratoplasty (PK) for treating corneal leucoma caused by herpes simplex keratitis (HSK).Retrospective, comparative, interventional case series.setting: Institutional. patients: Inclusion criteria were patients with corneal scarring induced exclusively (...) which recurrent epithelial keratitis amounted to 13 episodes in the PK group, remarkably more frequent than the 1 episode in the full-bed DLK group. Twenty-six eyes (41.3%) encountered rejection episodes in the PK group, but no rejection episode was found in the full-bed DLK group (P < .001). In 14 eyes in the PK group, graft failure developed because of graft rejection, recurrence of HSK, or both, whereas only in 1 eye in the full-bed DLK group did graft failure develop because of recurrence of HSK

2011 American Journal of Ophthalmology

146. Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection

the year prior to Day 0. A history of HSV infection of the eye (e.g., herpes simplex interstitial keratitis or uveitis). A history of herpes gladiatorum, herpetic whitlow or eczema herpeticum. A history of lesions caused by HSV on either arm. A history of herpes-associated erythema multiforme. A history of a clinically significant autoimmune disorder. Known or suspected congenital or acquired immunodeficiency Receipt of anti-cancer chemotherapy or radiation therapy within the preceding 6 months (...) Institute of Allergy and Infectious Diseases (NIAID) Collaborator: Sanofi Pasteur, a Sanofi Company Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ) Study Details Study Description Go to Brief Summary: Background: - Herpes simplex virus type 2 (HSV-2) is a major cause of genital herpes. It can also cause serious infection in newborns and in people with weakened immune systems. It increases

2013 Clinical Trials

147. Curative effect assessment of bandage contact lens in neurogenic keratitis. Full Text available with Trip Pro

group (drug therapy, n=10). In experimental group patients wore silicone hydrogel bandage soft contact lens. Both groups used the following eyedrops: 0.5% levofloxacin TID; 0.5% Sodium carboxymethyl cellulose QID; fibroblast growth factor BID; ganciclovir BID [cases complicated with herpes simplex virus (HSV)]; compound tropicamide BID (cases concurrent hypopyon). The healing time of corneal ulcer and complication rates were observed in the two groups.The healing time of corneal ulcer (...) Curative effect assessment of bandage contact lens in neurogenic keratitis. To observe the curative effect of bandage contact lens in neurogenic keratitis.Twenty cases of neurogenic keratitis were studied at the Department of Ophthalmology, the first Affiliated Hospital of China Medical University, between October 2012 and June 2013. These included 13 males and 7 females, aged from 35 to 88y. Patients were voluntarily divided into an experimental group (lens wearing group, n=10) and control

2014 International journal of ophthalmology Controlled trial quality: uncertain

148. Rapid and sensitive diagnosis of fungal keratitis using direct PCR without template DNA extraction. Full Text available with Trip Pro

Rapid and sensitive diagnosis of fungal keratitis using direct PCR without template DNA extraction. This study was aimed at developing a direct PCR assay without template DNA extraction for the rapid and sensitive diagnosis of infectious keratitis. Eighty corneal scrapings from 67 consecutive patients with clinically suspected infectious keratitis were analysed prospectively. Direct PCR was performed with all scrapings, with specific primers for fungi, bacteria, herpes simplex virus-1 (HSV-1 (...) ) and Acanthamoeba simultaneously. The results were compared with those obtained from culture, smear, and confocal microscopy. Discrepant results were resolved according to the therapeutic effects of the corresponding antimicrobial drugs. The lowest detection limit of direct PCR was ten copies of each pathogen. Sixty-six scrapings yielded positive results with direct PCR, giving a total positive detection rate of 82.5% (66/80). For 34 patients with high suspicion of fungal keratitis, the positive detection rate

2014 Clinical Microbiology and Infection

149. Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. (Abstract)

rehabilitation. Thirty-seven (80.4%) patients in the keratoplasty group initially were misdiagnosed as having herpes simplex keratitis versus 59 (41.8%) patients who did not require a keratoplasty (P < 0.001). Final visual outcomes were significantly better in the optical group compared with the therapeutic group, with 13 (54.2%) achieving visual acuity of 20/30 or better versus 7 (26.9%), respectively. On multivariate analysis, beginning therapy at a hospital other than Moorfields and undergoing (...) Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. To report the risk factors for and outcomes of therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis (AK).Retrospective case series.A total of 50 eyes of 196 patients with retrievable medical records, diagnosed with AK at Moorfields Eye Hospital, London, underwent keratoplasty between January 1991 and April 2012.Patient demographics

2014 Ophthalmology

150. Herpes Simplex Virus (HSV) Infections

. Herpes simplex keratitis (HSV infection of the corneal epithelium) causes pain, tearing, photophobia, and corneal ulcers that often have a branching pattern. Herpetic whitlow Herpetic Whitlow DR P. MARAZZI/SCIENCE PHOTO LIBRARY , a swollen, painful, erythematous lesion of the distal phalanx, results from inoculation of HSV through the skin and is most common among health care practitioners. Neonatal herpes simplex develops in neonates, including those whose mothers have no suggestion of current (...) simplex keratitis involves topical antivirals, such as trifluridine , and should be supervised by an ophthalmologist. Neonatal herpes simplex Acyclovir 20 mg/kg IV q 8 h for 14 to 21 days should be used if renal function is normal. A dose of 20 mg/kg IV q 8 h for at least 21 days is indicated for CNS and disseminated HSV disease. CNS infection Encephalitis is treated with acyclovir 10 mg/kg IV q 8 h for 14 to 21 days if renal function is normal. Treatment for 14 to 21 days is preferred to prevent

2013 Merck Manual (19th Edition)

151. Peripheral Ulcerative Keratitis (Diagnosis)

) or local (eg, herpes simplex keratitis, fungal keratitis), and noninfectious local disorders (eg, Mooren ulcer, marginal keratitis) may also cause PUK. In summary, the major pathophysiologic mechanism of PUK is a result of degradation and tissue necrosis of corneal stroma produced by degradative enzymes, which are released primarily by neutrophils attracted into the area by diverse stimuli. Previous Next: Epidemiology Frequency United States Peripheral ulcerative keratitis (PUK) is uncommon. RA has (...) Peripheral Ulcerative Keratitis (Diagnosis) Peripheral Ulcerative Keratitis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NTk4MC1vdmVydmlldw== processing

2014 eMedicine.com

152. Keratitis, Interstitial (Diagnosis)

. Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. Cornea . 2018 Mar. 37 (3):375-378. . Media Gallery This photograph depicts a child with a bilateral eye condition known as interstitial keratitis (IK), a stigma related to congenital syphilis. Interstitial keratitis in a patient with ocular syphilis. Interstitial keratitis in a patient with ocular syphilis. Syphilis chorioretinitis in a 30-year-old patient who is mentally retarded. A 73-year-old woman (...) and collagen remodeling occur. The superficial vessels resorb, and the deeper vessels may constrict, resulting in the ghost vessels that are seen as a late finding of syphilitic interstitial keratitis. Previous Next: Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome. In various countries in which mycobacterial diseases (eg, , ) are endemic, these and other parasitic causes of interstitial keratitis may be seen

2014 eMedicine.com

153. Keratitis, Interstitial (Overview)

. Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. Cornea . 2018 Mar. 37 (3):375-378. . Media Gallery This photograph depicts a child with a bilateral eye condition known as interstitial keratitis (IK), a stigma related to congenital syphilis. Interstitial keratitis in a patient with ocular syphilis. Interstitial keratitis in a patient with ocular syphilis. Syphilis chorioretinitis in a 30-year-old patient who is mentally retarded. A 73-year-old woman (...) and collagen remodeling occur. The superficial vessels resorb, and the deeper vessels may constrict, resulting in the ghost vessels that are seen as a late finding of syphilitic interstitial keratitis. Previous Next: Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome. In various countries in which mycobacterial diseases (eg, , ) are endemic, these and other parasitic causes of interstitial keratitis may be seen

2014 eMedicine.com

154. Keratitis, Interstitial (Treatment)

. Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. Cornea . 2018 Mar. 37 (3):375-378. . Media Gallery This photograph depicts a child with a bilateral eye condition known as interstitial keratitis (IK), a stigma related to congenital syphilis. Interstitial keratitis in a patient with ocular syphilis. Interstitial keratitis in a patient with ocular syphilis. Syphilis chorioretinitis in a 30-year-old patient who is mentally retarded. A 73-year-old woman (...) and collagen remodeling occur. The superficial vessels resorb, and the deeper vessels may constrict, resulting in the ghost vessels that are seen as a late finding of syphilitic interstitial keratitis. Previous Next: Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome. In various countries in which mycobacterial diseases (eg, , ) are endemic, these and other parasitic causes of interstitial keratitis may be seen

2014 eMedicine.com

155. Peripheral Ulcerative Keratitis (Overview)

, herpes simplex keratitis, fungal keratitis), and noninfectious local disorders (eg, Mooren ulcer, marginal keratitis) may also cause PUK. In summary, the major pathophysiologic mechanism of PUK is a result of degradation and tissue necrosis of corneal stroma produced by degradative enzymes, which are released primarily by neutrophils attracted into the area by diverse stimuli. Previous Next: Epidemiology Frequency United States Peripheral ulcerative keratitis (PUK) is uncommon. RA has been reported (...) Peripheral Ulcerative Keratitis (Overview) Peripheral Ulcerative Keratitis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NTk4MC1vdmVydmlldw== processing > Peripheral

2014 eMedicine.com

156. Keratitis, Interstitial (Follow-up)

. Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. Cornea . 2018 Mar. 37 (3):375-378. . Media Gallery This photograph depicts a child with a bilateral eye condition known as interstitial keratitis (IK), a stigma related to congenital syphilis. Interstitial keratitis in a patient with ocular syphilis. Interstitial keratitis in a patient with ocular syphilis. Syphilis chorioretinitis in a 30-year-old patient who is mentally retarded. A 73-year-old woman (...) and collagen remodeling occur. The superficial vessels resorb, and the deeper vessels may constrict, resulting in the ghost vessels that are seen as a late finding of syphilitic interstitial keratitis. Previous Next: Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome. In various countries in which mycobacterial diseases (eg, , ) are endemic, these and other parasitic causes of interstitial keratitis may be seen

2014 eMedicine.com

157. Corneal Ulceration and Ulcerative Keratitis (Diagnosis)

Ophtalmol . 2005. 7-15. . Zaher SS, Sandinha T, Roberts F, et al. Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. Cornea . 2005 Nov. 24(8):1015-7. . Media Gallery Peripheral ulcerative keratitis in the right eye of a patient with rheumatoid arthritis. Glue has been placed. of 1 Tables Contributor Information and Disclosures Author Jesse Borke, MD, FACEP, FAAEM Associate Medical Director, Department of Emergency Medicine, Los Alamitos Medical Center (...) Corneal Ulceration and Ulcerative Keratitis (Diagnosis) Corneal Ulcer and Ulcerative Keratitis in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Emergency Medicine

158. Corneal Ulceration and Ulcerative Keratitis (Follow-up)

, Van Looveren J, et al. Clinical, epidemiological and cost aspects of contact lens related infectious keratitis in Belgium: results of a seven-year retrospective study. Bull Soc Belge Ophtalmol . 2005. 7-15. . Zaher SS, Sandinha T, Roberts F, et al. Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. Cornea . 2005 Nov. 24(8):1015-7. . Media Gallery Peripheral ulcerative keratitis in the right eye of a patient with rheumatoid arthritis. Glue has (...) . Previous References Jeng BH, Gritz DC, Kumar AB, et al. Epidemiology of ulcerative keratitis in Northern California. Arch Ophthalmol . 2010 Aug. 128(8):1022-8. . Kosker M, Duman F, Suri K, Hammersmith KM, Nagra PK, Rapuano CJ. Long-term Results of Keratoplasty in Patients With Herpes Zoster Ophthalmicus. Cornea . 2013 Mar 27. . French DD, Margo CE. Demographic patterns of ED patients diagnosed as having corneal ulcer. Am J Emerg Med . 2013 May 17. . Morgan PB, Efron N, Brennan NA, et al. Risk factors

2014 eMedicine Emergency Medicine

159. Corneal Ulceration and Ulcerative Keratitis (Treatment)

, Van Looveren J, et al. Clinical, epidemiological and cost aspects of contact lens related infectious keratitis in Belgium: results of a seven-year retrospective study. Bull Soc Belge Ophtalmol . 2005. 7-15. . Zaher SS, Sandinha T, Roberts F, et al. Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. Cornea . 2005 Nov. 24(8):1015-7. . Media Gallery Peripheral ulcerative keratitis in the right eye of a patient with rheumatoid arthritis. Glue has (...) . Previous References Jeng BH, Gritz DC, Kumar AB, et al. Epidemiology of ulcerative keratitis in Northern California. Arch Ophthalmol . 2010 Aug. 128(8):1022-8. . Kosker M, Duman F, Suri K, Hammersmith KM, Nagra PK, Rapuano CJ. Long-term Results of Keratoplasty in Patients With Herpes Zoster Ophthalmicus. Cornea . 2013 Mar 27. . French DD, Margo CE. Demographic patterns of ED patients diagnosed as having corneal ulcer. Am J Emerg Med . 2013 May 17. . Morgan PB, Efron N, Brennan NA, et al. Risk factors

2014 eMedicine Emergency Medicine

160. Corneal Ulceration and Ulcerative Keratitis (Overview)

Ophtalmol . 2005. 7-15. . Zaher SS, Sandinha T, Roberts F, et al. Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. Cornea . 2005 Nov. 24(8):1015-7. . Media Gallery Peripheral ulcerative keratitis in the right eye of a patient with rheumatoid arthritis. Glue has been placed. of 1 Tables Contributor Information and Disclosures Author Jesse Borke, MD, FACEP, FAAEM Associate Medical Director, Department of Emergency Medicine, Los Alamitos Medical Center (...) Corneal Ulceration and Ulcerative Keratitis (Overview) Corneal Ulcer and Ulcerative Keratitis in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Emergency Medicine

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