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Herpes Simplex Keratitis

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141. Herpes Simplex Uveitis: A Clinical and Experimental Study (Full text)

Herpes Simplex Uveitis: A Clinical and Experimental Study 14032779 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Herpes simplex uveitis: a clinical and experimental study. 440-70 KIMURA S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 OM Herpes Simplex Humans Keratitis Keratitis, Dendritic Uveitis HERPES SIMPLEX KERATITIS, DENDRITIC UVEITIS 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish

1962 Transactions of the American Ophthalmological Society

142. VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION (Full text)

VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION Rapp, Fred (Baylor University College of Medicine, Houston, Tex.). Variants of herpes simplex virus: isolation, characterization, and factors influencing plaque formation. J. Bacteriol. 86:985-991. 1963.-Variants of herpes simplex virus were isolated which differed in plaque size and in virulence for rabbits and mice. Keratitis on the rabbit cornea and generalized disease were associated

1963 Journal of bacteriology

143. Corneal hypersensitivity to herpes simplex. (Full text)

Corneal hypersensitivity to herpes simplex. 4295044 1968 03 24 2018 11 13 0007-1161 51 12 1967 Dec The British journal of ophthalmology Br J Ophthalmol Corneal hypersensitivity to herpes simplex. 843-6 Swyers J S JS Lausch R N RN Kaufman H E HE eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Antigens IM Animals Antigens Chick Embryo Cornea Edema complications Guinea Pigs Hypersensitivity, Delayed complications Keratitis, Dendritic etiology Simplexvirus immunology 1967 12 1 1967

1967 The British journal of ophthalmology

144. Herpes simplex and zoster. (Full text)

Diseases, Male Herpes Simplex congenital drug therapy immunology Herpes Zoster drug therapy Humans Idoxuridine therapeutic use Immunologic Deficiency Syndromes complications Infant, Newborn Infant, Newborn, Diseases Keratitis, Dendritic Male Simplexvirus Steroids adverse effects Stomatitis 1973 2 17 1973 2 17 0 1 1973 2 17 0 0 ppublish 4347938 PMC1588333 Br Med J. 1964 Oct 17;2(5415):987-8 14185689 N Engl J Med. 1959 May 21;260(21):1062-5 13657339 J R Coll Gen Pract. 1970 Dec;20(101):323-7 5533234 J (...) Herpes simplex and zoster. 4347938 1973 05 04 2018 11 13 0007-1447 1 5850 1973 Feb 17 British medical journal Br Med J Herpes simplex and zoster. 406-10 Juel-Jensen B E BE eng Journal Article England Br Med J 0372673 0007-1447 0 Steroids 04079A1RDZ Cytarabine LGP81V5245 Idoxuridine YOW8V9698H Dimethyl Sulfoxide AIM IM Age Factors Central Nervous System Diseases Conjunctivitis Cytarabine therapeutic use Dimethyl Sulfoxide therapeutic use Eczema Female Fingers Genital Diseases, Female Genital

1973 British medical journal

145. Clinical evaluation of adenine arabinoside and idoxuridine in the treatment of ocular herpes simplex. (PubMed)

Clinical evaluation of adenine arabinoside and idoxuridine in the treatment of ocular herpes simplex. A Double-blind clinical study comparing idoxuridine (IDU) with adenine arabinoside (ara-A) in treating 54 routine herpetic ulcers, and an open ara-A therapy study of 58 herpetic ulcers in patients intolerant of or resistant to IDU, was carried out over a four-year period. There was no significant difference in healing time between IDU-treated eyes (11.5 days) and ara-A-treated eyes (12.4 days (...) and one was dropped from the study because his initial disease could not be distinguished from severe IDU-induced keratitis.

1975 American journal of ophthalmology Controlled trial quality: uncertain

146. Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty (Full text)

Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etiology has been unclear. Our cases

2016 Case reports in ophthalmological medicine

147. Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa (Full text)

hospitals in rural South Africa. Corneal swabs were tested for herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV) and adenovirus DNA by real-time polymerase chain reaction (PCR) and for bacteria and fungi by culture. Based on clinical history, disease characteristics and laboratory results, 29 (63 %) patients were diagnosed as viral keratitis, including 14 (48 %) viral keratitis cases complicated by bacterial superinfection, and 17 (37 %) as bacterial keratitis. VZV and HSV (...) -1 DNA was detected in 11 (24 %) and 5 (11 %) corneal swabs, respectively. Among clinically defined viral keratitis cases, a negative viral swab was predominantly (93 %) observed in cases with subepithelial inflammation and was significantly associated with an increased duration of symptoms (p = 0.003). The majority of bacteria cultured were Gram-positive (24/35), including Staphylococcus epidermidis and S. aureus. Viral aetiology was significantly associated with a history of herpes zoster

2016 European Journal of Clinical Microbiology & Infectious Diseases

148. Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. (Full text)

Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK

2016 Medicine

149. Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years

pain, epithelial defect, epithelial haze, pseudodendrites, and, most characteristically, radial keratoneuritis. The corneal infection of AK was first recognized in the mid 1970s. Since then, a growing number of AK cases were diagnosed, mainly resulting from improper use of soft contact lenses. Clinical diagnosis of AL is difficult, especially in the early phases of the disease, and it often is misdiagnosed and treated as a herpes simplex infection. It was reported a diagnostic delay of more than 18 (...) Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Retrospective

2016 Clinical Trials

150. Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis (Full text)

Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis The cornea is a complex tissue that must preserve its transparency to maintain optimal vision. However, in some circumstances, damage to the eye can result in neovascularization that impairs vision. This outcome can occur when herpes simplex virus type 1 (HSV-1) causes the immunoinflammatory lesion stromal keratitis (SK). Potentially useful measures to control the severity of SK are to target angiogenesis which with herpetic SK

2015 PloS one

151. Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. (Full text)

Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. The present study was designed to test the therapeutic value of soluble FasL (sFasL) in an acute model of herpetic stromal keratitis (HSK) and, more importantly, a recurrent model of HSK using BALB/c, BALB-lpr, and National Institutes of Health (NIH) mice.Mice were infected either acutely with the KOS strain of herpes simplex virus 1 (HSV-1) or latently with the McKrae strain of HSV-1

2015 Investigative Ophthalmology & Visual Science

152. Corneal Collagen Cross-Linking for Infectious Keratitis: A Systematic Review and Meta-Analysis. (PubMed)

to provide a valid proportion analysis). Treatment resulted in corneal melting and tectonic keratoplasty in both Herpes simplex virus cases.CXL seems promising in the management of infectious keratitis, excluding viral infections. However, more randomized controlled trials are required to assess its efficacy. (...) ulcer." Last search was on March 19, 2015. Extracted data from individual studies were summarized and summary proportions of eyes healed and complications for different subgroups were estimated.Twenty-five studies were included (2 randomized controlled trials, 13 case series, and 10 case reports) with a total of 210 eyes of 209 patients, of which 175 eyes underwent CXL. Causative microorganisms were bacteria, fungi, acanthamoeba, and Herpes simplex virus in 96, 32, 11, and 2 cases, respectively

2015 Cornea

153. Rapid and sensitive diagnosis of fungal keratitis using direct PCR without template DNA extraction. (Full text)

Rapid and sensitive diagnosis of fungal keratitis using direct PCR without template DNA extraction. This study was aimed at developing a direct PCR assay without template DNA extraction for the rapid and sensitive diagnosis of infectious keratitis. Eighty corneal scrapings from 67 consecutive patients with clinically suspected infectious keratitis were analysed prospectively. Direct PCR was performed with all scrapings, with specific primers for fungi, bacteria, herpes simplex virus-1 (HSV-1 (...) ) and Acanthamoeba simultaneously. The results were compared with those obtained from culture, smear, and confocal microscopy. Discrepant results were resolved according to the therapeutic effects of the corresponding antimicrobial drugs. The lowest detection limit of direct PCR was ten copies of each pathogen. Sixty-six scrapings yielded positive results with direct PCR, giving a total positive detection rate of 82.5% (66/80). For 34 patients with high suspicion of fungal keratitis, the positive detection rate

2014 Clinical Microbiology and Infection

154. Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. (PubMed)

rehabilitation. Thirty-seven (80.4%) patients in the keratoplasty group initially were misdiagnosed as having herpes simplex keratitis versus 59 (41.8%) patients who did not require a keratoplasty (P < 0.001). Final visual outcomes were significantly better in the optical group compared with the therapeutic group, with 13 (54.2%) achieving visual acuity of 20/30 or better versus 7 (26.9%), respectively. On multivariate analysis, beginning therapy at a hospital other than Moorfields and undergoing (...) Therapeutic and Optical Keratoplasty in the Management of Acanthamoeba Keratitis: Risk Factors, Outcomes, and Summary of the Literature. To report the risk factors for and outcomes of therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis (AK).Retrospective case series.A total of 50 eyes of 196 patients with retrievable medical records, diagnosed with AK at Moorfields Eye Hospital, London, underwent keratoplasty between January 1991 and April 2012.Patient demographics

2014 Ophthalmology

155. [Clinical assessment of oral ganciclovir capsules on the treatment of herpes simplex keratitis]. (PubMed)

[Clinical assessment of oral ganciclovir capsules on the treatment of herpes simplex keratitis]. To evaluate the clinical values of oral ganciclovir on the treatment of herpes simplex keratitis (HSK).A randomized, controlled, single-blind and prospective study was carried out from May in 2008 to June in 2009 at Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University. 60 patients (60 eyes) with HSK, including stromal keratitis and corneal endotheliitis, were enrolled (...) to relieve the symptoms and signs and shorten the pathogenesis of herpes simplex stromal keratitis and corneal endotheliitis. And short-term oral ganciclovir has confirmed good safety.

2010 [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Controlled trial quality: uncertain

156. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. (Full text)

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Eye disease due to herpes simplex virus (HSV) commonly presents as epithelial keratitis.To compare the relative effectiveness of antiviral agents, interferon, and corneal débridement in the treatment of acute HSV epithelial keratitis.We searched CENTRAL (The Cochrane Library 2010, Issue 4), MEDLINE (January 1950 to October 2010), EMBASE (January 1980 to October 2010), Latin American (...) Infrastructure (CNKI) with citations confirmed using China/Asia On Demand (COAD). There were no language or date restrictions in the search for trials. All databases except CNKI and COAD were last searched on 27 October 2010, CNKI and COAD were searched on 1 April 2010. We also searched literature digests, conference proceedings and reference lists.Of 152 eligible studies,106 comparative treatment trials involving 5872 eyes with dendritic or geographic epithelial keratitis were analysed for corneal healing

2010 Cochrane database of systematic reviews (Online)

157. SELECTIVE CHANGES IN HUMAN CORNEAL SENSATION ASSOCIATED WITH HERPES SIMPLEX VIRUS KERATITIS. (Full text)

SELECTIVE CHANGES IN HUMAN CORNEAL SENSATION ASSOCIATED WITH HERPES SIMPLEX VIRUS KERATITIS. To determine corneal sensitivity to selective mechanical, chemical, and thermal (heat and cold) stimulation in patients with a history of herpes simplex virus (HSV) keratitis.Corneal sensitivity to different modalities of stimulus was determined in both eyes of 16 patients with unilateral HSV keratitis diagnosed 1 to 12 months before the study. On slit lamp examination, 13 HSV-affected eyes showed (...) corneal scarring or opacities, and three had no signs of previous keratitis. Corneal sensitivity was determined with the Belmonte gas esthesiometer. Mechanical, chemical, heat, and cold stimuli were applied on the central cornea. Eyes from 10 healthy subjects served as controls.In all control and contralateral eyes, selective mechanical, chemical, heat, and cold stimulation evoked sensations of subjective intensity proportional to the magnitude of the applied stimulus. In one HSV patient, the affected

2010 Investigative Ophthalmology & Visual Science

158. Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. (PubMed)

Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Herpes Simplex Virus (HSV) keratitis is a leading cause of corneal blindness. Definitive laboratory diagnosis is essential for timely management. Collection of corneal scrapings in patients with advanced epithelial keratitis and corneal thinning poses perforation risks; tear fluid is a feasible and convenient alternative (...) but has not been widely evaluated for HSV detection.Tear fluid alone (229) or along with corneal scrapings (153) from patients of suspected herpetic keratitis was tested for HSV-1 antigen by indirect immunofluorescence assay, virus isolation in Hep 2 cells and PCR to amplify the 111bp region of the thymidine kinase (tk) coding gene and the 144bp region from the DNA polymerase coding gene of HSV.HSV 1 antigen was detected in 31/229 (13.53%) tear specimen and 35/153 (22.87%) corneal scrapings

2010 British Journal of Ophthalmology

159. Peripheral Ulcerative Keratitis (Overview)

, herpes simplex keratitis, fungal keratitis), and noninfectious local disorders (eg, Mooren ulcer, marginal keratitis) may also cause PUK. In summary, the major pathophysiologic mechanism of PUK is a result of degradation and tissue necrosis of corneal stroma produced by degradative enzymes, which are released primarily by neutrophils attracted into the area by diverse stimuli. Previous Next: Epidemiology Frequency United States Peripheral ulcerative keratitis (PUK) is uncommon. RA has been reported (...) Peripheral Ulcerative Keratitis (Overview) Peripheral Ulcerative Keratitis: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NTk4MC1vdmVydmlldw== processing > Peripheral

2014 eMedicine.com

160. Keratitis, Interstitial (Overview)

. Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. Cornea . 2018 Mar. 37 (3):375-378. . Media Gallery This photograph depicts a child with a bilateral eye condition known as interstitial keratitis (IK), a stigma related to congenital syphilis. Interstitial keratitis in a patient with ocular syphilis. Interstitial keratitis in a patient with ocular syphilis. Syphilis chorioretinitis in a 30-year-old patient who is mentally retarded. A 73-year-old woman (...) and collagen remodeling occur. The superficial vessels resorb, and the deeper vessels may constrict, resulting in the ghost vessels that are seen as a late finding of syphilitic interstitial keratitis. Previous Next: Epidemiology Interstitial keratitis is generally seen in the context of syphilis and, less commonly, in the context of herpes and Cogan syndrome. In various countries in which mycobacterial diseases (eg, , ) are endemic, these and other parasitic causes of interstitial keratitis may be seen

2014 eMedicine.com

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