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Herpes Simplex Keratitis

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121. Herpes Simplex (Diagnosis)

, keratitis, acute retinal necrosis, Bell palsy, and encephalitis. Herpes simplex keratitis is characterized by ocular pain and is a common infectious cause of unilateral vision loss. [ ] Clinical manifestations of HSV-1 encephalitis include fever, headache, nausea, vomiting, seizures, confusion, and focal deficits. [ ] Approximately 15% of hospitalized patients die from HSV encephalitis, and survivors have long-term disability affecting cognitive function. [ ] The most common complication of primary HSV (...) , Mu EW, Orlow SJ. Characterization of Herpes Simplex Virus Infections Seen in the Pediatric Dermatology Office. Pediatr Dermatol . 2017 Jul. 34 (4):446-449. . Ng PP, Sun YJ, Tan HH, Tan SH. Detection of herpes simplex virus genomic DNA in various subsets of Erythema multiforme by polymerase chain reaction. Dermatology . 2003. 207 (4):349-53. . Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology . 2017 Nov. 124 (11):1678-1689. . Rabinstein AA

2014 eMedicine.com

122. Herpes Simplex Encephalitis (Diagnosis)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Diagnosis) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine.com

123. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

124. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Herpes Simplex Follow-up: Deterrence/Prevention, Complications, Patient Education Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjE4NTgwLWZvbGxvd3Vw processing > Herpes Simplex Follow (...) -up Updated: Mar 01, 2018 Author: Folusakin O Ayoade, MD; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Herpes Simplex Follow-up Deterrence/Prevention Because of the ubiquitous and cosmopolitan nature of herpes simplex virus (HSV), avoiding contact with individuals who (often asymptomatically) are excreting the virus in saliva or genital secretions is difficult. Daily antiviral therapy can be given to reduce episodes of asymptomatic genital shedding

2014 eMedicine.com

125. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Dermatologic Manifestations of Herpes Simplex Treatment & Management: Approach Considerations, Medical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEzMjM1MS10cmVhdG1lbnQ= processing > Dermatologic Manifestations of Herpes Simplex Treatment & Management Updated: Feb 16, 2018 Author: Sean P McGregor, DO, PharmD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Herpes Simplex Treatment Approach Considerations Most herpes simplex virus (HSV) infections are self-limited and treatment is not always indicated or necessary. However, antiviral therapy shortens the course of the symptoms and may prevent

2014 eMedicine.com

126. Herpes Simplex (Treatment)

transmitted infections. Urol Clin North Am . 2008 Feb. 35(1):33-46; vi. . Bucher J, Koyfman A. What Is the Most Effective Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical (...) Herpes Simplex (Treatment) Herpes Simplex in Emergency Medicine Treatment & Management: Emergency Department Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLXRyZWF0bWVudA

2014 eMedicine Emergency Medicine

127. Herpes Simplex (Overview)

Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis. J Am Acad Dermatol . 1999 Dec. 41 (6):996-1001. . [Guideline] Workowski KA (...) Herpes Simplex (Overview) Herpes Simplex in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLW92ZXJ2aWV3 processing > Herpes Simplex

2014 eMedicine Emergency Medicine

128. Herpes Simplex Encephalitis (Overview)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Overview) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine Emergency Medicine

129. Herpes Simplex (Diagnosis)

Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis. J Am Acad Dermatol . 1999 Dec. 41 (6):996-1001. . [Guideline] Workowski KA (...) Herpes Simplex (Diagnosis) Herpes Simplex in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLW92ZXJ2aWV3 processing > Herpes Simplex

2014 eMedicine Emergency Medicine

130. Herpes Simplex Encephalitis (Diagnosis)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Diagnosis) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine Emergency Medicine

131. Herpes Simplex (Follow-up)

and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep . 2015 Jun 5. 64 (RR-03):1-137. . Gnann JW Jr, Whitley RJ. CLINICAL PRACTICE. Genital Herpes. N Engl J Med . 2016 Aug 18. 375 (7):666-74. . Frenkl TL, Potts J. Sexually transmitted infections. Urol Clin North Am . 2008 Feb. 35(1):33-46; vi. . Bucher J, Koyfman A. What Is the Most Effective Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir (...) Herpes Simplex (Follow-up) Herpes Simplex in Emergency Medicine Follow-up: Further Outpatient Care, Further Inpatient Care, Deterrence/Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLWZvbGxvd3Vw

2014 eMedicine Emergency Medicine

132. Foreign body mimicking a herpes simplex dendritic ulcer in the cornea Full Text available with Trip Pro

Foreign body mimicking a herpes simplex dendritic ulcer in the cornea 23843417 2014 03 10 2016 05 19 1757-790X 2013 2013 Jul 09 BMJ case reports BMJ Case Rep Foreign body mimicking a herpes simplex dendritic ulcer in the cornea. 10.1136/bcr-2013-200143 bcr2013200143 Yeo Damien Chia Ming DC Department of Ophthalmology, Singleton Hospital, Swansea, UK. cm.yeo@doctors.org.uk eng Case Reports Journal Article 2013 07 09 England BMJ Case Rep 101526291 1757-790X IM Corneal Ulcer diagnosis virology (...) Diagnosis, Differential Eye Foreign Bodies diagnosis Female Humans Keratitis, Herpetic diagnosis Middle Aged 2013 7 12 6 0 2013 7 12 6 0 2014 3 13 6 0 epublish 23843417 bcr-2013-200143 10.1136/bcr-2013-200143 PMC3736634

2013 BMJ case reports

133. Neuroprotectin D1 reduces the severity of herpes simplex virus induced corneal immunopathology. Full Text available with Trip Pro

Neuroprotectin D1 reduces the severity of herpes simplex virus induced corneal immunopathology. Neuroprotectin D1 (NPD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3-polyunsaturated fatty acid docosahexaenoic acid (DHA). The purpose of this study is to test the therapeutic potential of NPD1 for the treatment of herpes simplex virus (HSV)-induced stromal keratitis (SK) using a mouse model.C57BL/6 mice were infected ocularly with HSV-1 strain RE

2013 Investigative Ophthalmology & Visual Science

134. VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION Full Text available with Trip Pro

VARIANTS OF HERPES SIMPLEX VIRUS: ISOLATION, CHARACTERIZATION, AND FACTORS INFLUENCING PLAQUE FORMATION Rapp, Fred (Baylor University College of Medicine, Houston, Tex.). Variants of herpes simplex virus: isolation, characterization, and factors influencing plaque formation. J. Bacteriol. 86:985-991. 1963.-Variants of herpes simplex virus were isolated which differed in plaque size and in virulence for rabbits and mice. Keratitis on the rabbit cornea and generalized disease were associated

1963 Journal of bacteriology

135. Corneal hypersensitivity to herpes simplex. Full Text available with Trip Pro

Corneal hypersensitivity to herpes simplex. 4295044 1968 03 24 2018 11 13 0007-1161 51 12 1967 Dec The British journal of ophthalmology Br J Ophthalmol Corneal hypersensitivity to herpes simplex. 843-6 Swyers J S JS Lausch R N RN Kaufman H E HE eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Antigens IM Animals Antigens Chick Embryo Cornea Edema complications Guinea Pigs Hypersensitivity, Delayed complications Keratitis, Dendritic etiology Simplexvirus immunology 1967 12 1 1967

1967 The British journal of ophthalmology

136. Management of ocular herpes simplex. Full Text available with Trip Pro

Management of ocular herpes simplex. 6029236 1967 09 12 2013 11 21 0007-1161 51 7 1967 Jul The British journal of ophthalmology Br J Ophthalmol Management of ocular herpes simplex. 494-5 Patterson A A eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Mydriatics 0 Steroids LGP81V5245 Idoxuridine IM Bandages Cautery Humans Idoxuridine therapeutic use Keratitis, Dendritic therapy Mydriatics therapeutic use Steroids therapeutic use 1967 7 1 1967 7 1 0 1 1967 7 1 0 0 ppublish 6029236

1967 The British journal of ophthalmology

137. Experimental and Clinical Use of Aureomycin in Herpes Simplex Full Text available with Trip Pro

Experimental and Clinical Use of Aureomycin in Herpes Simplex 15418604 2004 09 30 2018 12 01 0065-9533 47 1949 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Experimental and clinical use of aureomycin in herpes simplex. 335-48 BRALEY A E AE ALEXANDER R C RC eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 WCK1KIQ23Q Chlortetracycline OM Chlortetracycline Cornea Herpes Simplex Keratitis 5019:8463:18:56:130 AUREOMYCIN CORNEA KERATITIS

1949 Transactions of the American Ophthalmological Society

138. Herpes Simplex Uveitis: A Clinical and Experimental Study Full Text available with Trip Pro

Herpes Simplex Uveitis: A Clinical and Experimental Study 14032779 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Herpes simplex uveitis: a clinical and experimental study. 440-70 KIMURA S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 OM Herpes Simplex Humans Keratitis Keratitis, Dendritic Uveitis HERPES SIMPLEX KERATITIS, DENDRITIC UVEITIS 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish

1962 Transactions of the American Ophthalmological Society

139. Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections Full Text available with Trip Pro

Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically

1976 Antimicrobial Agents and Chemotherapy

140. Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus Full Text available with Trip Pro

" was observed with high concentrations of drug, causing less inhibition of deoxyribonucleic acid synthesis than was observed with lower concentrations. Herpes simplex virus type 1 was inactivated also by the 8-hydroxyquinolines and their copper complexes. No intracellular inhibition of plaque formation was observed. Treatment with 8-hydroxyquinoline sulfate had no effect on the resolution of herpetic keratitis in rabbits. Some 8-hydroxyquinolines bind to deoxyribonucleic acid in the presence of copper (...) Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus 8-Hydroxyquinoline and several of its derivatives inactivate the transforming ability of Rous sarcoma virus and inhibit its ribonucleic acid-dependent deoxyribonucleic acid polymerase activity. The copper complex of these metal-binding ligands is as active as the free ligand. The activity of the 8-hydroxyquinolines is approximately 50-fold more

1976 Antimicrobial Agents and Chemotherapy

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