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Herpes Simplex Keratitis

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121. Non-contact lens related Acanthamoeba keratitis (PubMed)

. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases. Majority of cases present with diffuse infiltrate, mimicking herpes simplex or fungal keratitis. The diagnosis can be confirmed by microscopic examination of corneal scraping material and culture on nonnutrient agar with an overlay of Escherichia coli. Confocal microscopy (...) Non-contact lens related Acanthamoeba keratitis The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease

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2017 Indian journal of ophthalmology

122. Corneal edema and keratitis following selective laser trabeculoplasty (PubMed)

reports of keratitis, it is imperative for ophthalmic surgeons to be aware of herpes simplex as a possible risk factor. Prompt treatment with antivirals and steroids can potentially prevent scarring and permanent damage to the cornea. (...) Corneal edema and keratitis following selective laser trabeculoplasty To describe three cases of keratitis following Selective Laser Trabeculoplasty (SLT).Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids.With the increase in usage of SLT as a treatment for glaucoma and subsequent

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2016 American journal of ophthalmology case reports

123. Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis

of an ocular infection caused by viruses (herpes simplex virus [HSV]) or fungi. Subject treated with drugs having effects on Acanthamoeba cysts prior to study entry, including biguanides (PHMB, chlorhexidine) and diamidines (propamidine, hexamidine). Subjects requiring systemic immunosuppression for Acanthamoeba associated scleritis. Subjects requiring urgent surgical intervention for advanced Acanthamoeba keratitis in either eye (e.g., for advanced corneal thinning/melting etc.). Subject with known (...) Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2017 Clinical Trials

124. Update on the Management of Infectious Keratitis. (PubMed)

. The Herpetic Eye Disease Study (HEDS) I showed a significant benefit of topical corticosteroids and oral acyclovir for stromal keratitis. HEDS II showed that oral acyclovir decreased the recurrence of any type of herpes simplex virus keratitis by approximately half. Future strategies to reduce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuvant therapies aimed at modifying the immune response to infection holding the greatest potential to improve clinical (...) Update on the Management of Infectious Keratitis. Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms

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2017 Ophthalmology

125. Neuroprotectin D1 reduces the severity of herpes simplex virus induced corneal immunopathology. (PubMed)

Neuroprotectin D1 reduces the severity of herpes simplex virus induced corneal immunopathology. Neuroprotectin D1 (NPD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3-polyunsaturated fatty acid docosahexaenoic acid (DHA). The purpose of this study is to test the therapeutic potential of NPD1 for the treatment of herpes simplex virus (HSV)-induced stromal keratitis (SK) using a mouse model.C57BL/6 mice were infected ocularly with HSV-1 strain RE

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2013 Investigative Ophthalmology & Visual Science

126. Tumor Necrosis Factor Alpha and Interleukin-6 Facilitate Corneal Lymphangiogenesis in Response to Herpes Simplex Virus 1 Infection (PubMed)

Tumor Necrosis Factor Alpha and Interleukin-6 Facilitate Corneal Lymphangiogenesis in Response to Herpes Simplex Virus 1 Infection Herpes simplex virus 1 (HSV-1) is a common human pathogen of clinical significance due to its association with vision impairment and encephalitis. In a mouse model of ocular neovascularization, we have previously shown that HSV-1 elicits the genesis of lymphatic vessels into the cornea proper through epithelial cell expression of vascular endothelial growth factor (...) at least two proinflammatory cytokines expressed locally that are involved in the genesis of lymphatic vessels in the normally avascular cornea in response to HSV-1 infection. This finding provides the basis to target IL-6 and TNF-α as additional proangiogenic factors in the cornea during the development of herpetic stromal keratitis as a means to alleviate further neovascularization and tissue pathology associated with the host immune response to the pathogen.Copyright © 2014, American Society

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2014 Journal of virology

127. Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis

systemic disease, unstable medical disorders, life-threatening disease or current malignancies. Subjects with a current episode of herpes simplex labialis that has not completely healed. Presence of any facial skin condition or excessive facial hair that may interfere with diagnosis, assessment, and/or healing ability. History of herpes keratitis. Subject has a history of hypersensitivity or allergy to any ingredient in the drug product. History of unresponsiveness to topical acyclovir therapy (...) Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

128. Herpes simplex and herpes zoster keratouveitis: diagnosis and management. (PubMed)

Herpes simplex and herpes zoster keratouveitis: diagnosis and management. 302725 1977 11 25 2018 11 13 0028-7091 53 8 1977 Oct Bulletin of the New York Academy of Medicine Bull N Y Acad Med Herpes simplex and herpes zoster keratouveitis: diagnosis and management. 731-48 Pavan-Langston D D eng Journal Article Research Support, U.S. Gov't, P.H.S. United States Bull N Y Acad Med 7505398 0028-7091 9PHQ9Y1OLM Prednisolone LGP81V5245 Idoxuridine IM Herpes Zoster Ophthalmicus complications Humans (...) Idoxuridine therapeutic use Keratitis drug therapy etiology Prednisolone therapeutic use Recurrence Uveitis drug therapy etiology 1977 10 1 1977 10 1 0 1 1977 10 1 0 0 ppublish 302725 PMC1807398 Arch Intern Med. 1964 May;113:679-86 14120593 Lancet. 1964 Sep 19;2(7360):610-1 14186147 Arch Ophthalmol. 1963 Apr;69:468-72 14031372 Br Med J. 1957 Sep 28;2(5047):746-8 13460373 Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Sep-Oct;81(5):813-25 798369 Arch Ophthalmol. 1975 Sep;93(9):828-30 1235486

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1977 Bulletin of the New York Academy of Medicine

129. Foreign body mimicking a herpes simplex dendritic ulcer in the cornea (PubMed)

Foreign body mimicking a herpes simplex dendritic ulcer in the cornea 23843417 2014 03 10 2016 05 19 1757-790X 2013 2013 Jul 09 BMJ case reports BMJ Case Rep Foreign body mimicking a herpes simplex dendritic ulcer in the cornea. 10.1136/bcr-2013-200143 bcr2013200143 Yeo Damien Chia Ming DC Department of Ophthalmology, Singleton Hospital, Swansea, UK. cm.yeo@doctors.org.uk eng Case Reports Journal Article 2013 07 09 England BMJ Case Rep 101526291 1757-790X IM Corneal Ulcer diagnosis virology (...) Diagnosis, Differential Eye Foreign Bodies diagnosis Female Humans Keratitis, Herpetic diagnosis Middle Aged 2013 7 12 6 0 2013 7 12 6 0 2014 3 13 6 0 epublish 23843417 bcr-2013-200143 10.1136/bcr-2013-200143 PMC3736634

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2013 BMJ case reports

130. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis - Eye Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Blurred Vision (...) SOCIAL MEDIA Add to Any Platform Loading , MD, FACS, Sidney Kimmel Medical College at Thomas Jefferson University Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Herpes simplex keratitis is corneal infection with herpes simplex virus. It may involve the iris. Symptoms and signs include foreign body sensation, lacrimation, photophobia, and conjunctival hyperemia. Recurrences are common and may lead to corneal hypoesthesia, ulceration, permanent

2013 Merck Manual (19th Edition)

131. Secretory Immunoglobulin A and Herpes Keratitis (PubMed)

Secretory Immunoglobulin A and Herpes Keratitis The sensitization of herpes simplex virus by immunoglobulin G (IgG) antibodies was studied. Although herpes simplex virus sensitized by IgG could not be neutralized by IgA antibodies known to neutralize a similar number of unsensitized viruses, this protection could be overcome by larger amounts of IgA antibodies. This suggests that the effective neutralization of herpes simplex virus in ocular tissue is dependent on the relative concentrations (...) of IgA and IgG antibodies. In vivo sensitized virus was isolated from chronically infected animals, and this may be the mechanism by which herpes simplex virus persists in animals with high titers of circulating antibodies in their serum.

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1970 Infection and immunity

132. Role of miR-132 in Angiogenesis after Ocular Infection with Herpes Simplex Virus (PubMed)

Role of miR-132 in Angiogenesis after Ocular Infection with Herpes Simplex Virus MicroRNAs (miRNAs) are small regulatory molecules that control diverse biological processes that include angiogenesis. Herpes simplex virus (HSV) causes a chronic immuno-inflammatory response in the eye that may result in corneal neovascularization during blinding immunopathological lesion stromal keratitis (SK). miR-132 is a highly conserved miRNA that is induced in endothelial cells in response to growth factors

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2012 The American journal of pathology

133. Sequence Variation in the Herpes Simplex Virus US1 Ocular Virulence Determinant. (PubMed)

Sequence Variation in the Herpes Simplex Virus US1 Ocular Virulence Determinant. The herpes simplex virus type 1 (HSV-1) U(S)1 gene encodes host-range and ocular virulence determinants. Mutations in U(S)1 affecting virulence are known in strain OD4, but the genomic variation across several strains is not known. The goal was to determine the degree of sequence variation in the gene from several ocular HSV isolates.The U(S)1 gene from six ocular HSV-1 isolates, as well as strains KOS and F, were (...) in the central core. Consensus-binding motifs for cyclin-dependent kinases and pocket proteins were also identified.These results suggest that significant sequence variation exists in the U(S)1 gene, that the α22 protein contains a conserved central core region with structurally variable regions at the amino- and carboxyl termini, that 10 amino acids are conserved in α-herpes U(S)1 homologs, and that additional host proteins may interact with the HSV-1 U(S)1 and U(S)1.5 proteins. This information

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2011 Investigative Ophthalmology & Visual Science

134. Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability and SNP Distribution. (PubMed)

Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability and SNP Distribution. Little is known about the role of sequence variation in the pathology of HSV-1 keratitis virus. The goal was to show that a multiplex, high-throughput genome-sequencing approach is feasible for simultaneously sequencing seven HSV-1 ocular strains.A genome sequencer was used to sequence the HSV-1 ocular isolates TFT401, 134, CJ311, CJ360, CJ394, CJ970, and OD4

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2011 Investigative Ophthalmology & Visual Science

135. Immunity to Ocular and Genital Herpes Simplex Viruses Infections (PubMed)

Immunity to Ocular and Genital Herpes Simplex Viruses Infections 23326289 2013 08 12 2016 10 25 1740-2530 2012 2012 Clinical & developmental immunology Clin. Dev. Immunol. Immunity to ocular and genital herpes simplex viruses infections. 732546 10.1155/2012/732546 Chentoufi Aziz Alami AA BenMohamed Lbachir L Van De Perre Philippe P Ashkar Ali A AA eng R01 EY014900 EY NEI NIH HHS United States R01 EY019896 EY NEI NIH HHS United States Editorial 2012 12 26 Egypt Clin Dev Immunol 101183692 1740 (...) -2522 IM Animals Herpes Genitalis genetics immunology metabolism virology Humans Immunity immunology Keratitis, Herpetic genetics immunology metabolism virology Mice Simplexvirus immunology 2012 11 20 2012 11 20 2013 1 18 6 0 2013 1 18 6 0 2013 8 13 6 0 ppublish 23326289 10.1155/2012/732546 PMC3541643

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2012 Clinical and Developmental Immunology

136. Management of ocular herpes simplex. (PubMed)

Management of ocular herpes simplex. 6029236 1967 09 12 2013 11 21 0007-1161 51 7 1967 Jul The British journal of ophthalmology Br J Ophthalmol Management of ocular herpes simplex. 494-5 Patterson A A eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Mydriatics 0 Steroids LGP81V5245 Idoxuridine IM Bandages Cautery Humans Idoxuridine therapeutic use Keratitis, Dendritic therapy Mydriatics therapeutic use Steroids therapeutic use 1967 7 1 1967 7 1 0 1 1967 7 1 0 0 ppublish 6029236

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1967 The British journal of ophthalmology

137. Corneal hypersensitivity to herpes simplex. (PubMed)

Corneal hypersensitivity to herpes simplex. 4295044 1968 03 24 2018 11 13 0007-1161 51 12 1967 Dec The British journal of ophthalmology Br J Ophthalmol Corneal hypersensitivity to herpes simplex. 843-6 Swyers J S JS Lausch R N RN Kaufman H E HE eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Antigens IM Animals Antigens Chick Embryo Cornea Edema complications Guinea Pigs Hypersensitivity, Delayed complications Keratitis, Dendritic etiology Simplexvirus immunology 1967 12 1 1967

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1967 The British journal of ophthalmology

138. Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections (PubMed)

Phosphonoacetic Acid in the Treatment of Experimental Ocular Herpes Simplex Infections Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically

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1976 Antimicrobial Agents and Chemotherapy

139. Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus (PubMed)

" was observed with high concentrations of drug, causing less inhibition of deoxyribonucleic acid synthesis than was observed with lower concentrations. Herpes simplex virus type 1 was inactivated also by the 8-hydroxyquinolines and their copper complexes. No intracellular inhibition of plaque formation was observed. Treatment with 8-hydroxyquinoline sulfate had no effect on the resolution of herpetic keratitis in rabbits. Some 8-hydroxyquinolines bind to deoxyribonucleic acid in the presence of copper (...) Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus 8-Hydroxyquinoline and several of its derivatives inactivate the transforming ability of Rous sarcoma virus and inhibit its ribonucleic acid-dependent deoxyribonucleic acid polymerase activity. The copper complex of these metal-binding ligands is as active as the free ligand. The activity of the 8-hydroxyquinolines is approximately 50-fold more

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1976 Antimicrobial Agents and Chemotherapy

140. Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London. (PubMed)

of antiherpes simplex virus antibody in their blood. No adenovirus was isolated from these patients, but complement fixation test for adenovirus was positive in 1 patient with cultural test positive for herpes simplex virus. Most patients were between 20 and 35 years old and the ratio of males to females was 12 to 13. At the initial visit the clinical features of disease were moderate to severe conjunctival papillary and follicular reasons with epithelial and subepithelial punctate keratitis but little (...) Acute follicular conjunctivitis and keratoconjunctivitis due to herpes simplex virus in London. During the 18 months January 1975 to June 1976, 25 cases of acute herpetic follicular conjunctivitis and keratoconjunctivitis resembling adenovirus ocular infection presented in the External Eye Disease Clinic, Moorfields Eye Hospital, City Road, London. Herpes simplex virus was isolated in HEp2 cells in 22 patients, and the remaining 3 patients were identified by a minimum 4-fold rise in the level

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1978 The British journal of ophthalmology

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