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Herpes Simplex Keratitis

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101. Herpes Simplex (Diagnosis)

Herpes Simplex (Diagnosis) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes Simplex (...) Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable with aggressive

2014 eMedicine.com

102. Herpes Simplex (Treatment)

Herpes Simplex (Treatment) Dermatologic Manifestations of Herpes Simplex Treatment & Management: Approach Considerations, Medical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEzMjM1MS10cmVhdG1lbnQ= processing > Dermatologic Manifestations of Herpes Simplex Treatment & Management Updated: Feb 16, 2018 Author: Sean P McGregor, DO, PharmD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Herpes Simplex Treatment Approach Considerations Most herpes simplex virus (HSV) infections are self-limited and treatment is not always indicated or necessary. However, antiviral therapy shortens the course of the symptoms and may prevent

2014 eMedicine.com

103. Herpes Simplex (Overview)

, keratitis, acute retinal necrosis, Bell palsy, and encephalitis. Herpes simplex keratitis is characterized by ocular pain and is a common infectious cause of unilateral vision loss. [ ] Clinical manifestations of HSV-1 encephalitis include fever, headache, nausea, vomiting, seizures, confusion, and focal deficits. [ ] Approximately 15% of hospitalized patients die from HSV encephalitis, and survivors have long-term disability affecting cognitive function. [ ] The most common complication of primary HSV (...) , Mu EW, Orlow SJ. Characterization of Herpes Simplex Virus Infections Seen in the Pediatric Dermatology Office. Pediatr Dermatol . 2017 Jul. 34 (4):446-449. . Ng PP, Sun YJ, Tan HH, Tan SH. Detection of herpes simplex virus genomic DNA in various subsets of Erythema multiforme by polymerase chain reaction. Dermatology . 2003. 207 (4):349-53. . Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology . 2017 Nov. 124 (11):1678-1689. . Rabinstein AA

2014 eMedicine.com

104. Herpes Simplex Encephalitis (Overview)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Overview) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine.com

105. Herpes Simplex (Overview)

Herpes Simplex (Overview) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes Simplex (...) Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable with aggressive

2014 eMedicine.com

106. Herpes Simplex (Treatment)

Herpes Simplex (Treatment) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

107. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Dermatologic Manifestations of Herpes Simplex Treatment & Management: Approach Considerations, Medical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEzMjM1MS10cmVhdG1lbnQ= processing > Dermatologic Manifestations of Herpes Simplex Treatment & Management Updated: Feb 16, 2018 Author: Sean P McGregor, DO, PharmD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Herpes Simplex Treatment Approach Considerations Most herpes simplex virus (HSV) infections are self-limited and treatment is not always indicated or necessary. However, antiviral therapy shortens the course of the symptoms and may prevent

2014 eMedicine.com

108. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

109. Herpes Simplex (Follow-up)

Herpes Simplex (Follow-up) Herpes Simplex Follow-up: Deterrence/Prevention, Complications, Patient Education Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjE4NTgwLWZvbGxvd3Vw processing > Herpes Simplex Follow (...) -up Updated: Mar 01, 2018 Author: Folusakin O Ayoade, MD; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Herpes Simplex Follow-up Deterrence/Prevention Because of the ubiquitous and cosmopolitan nature of herpes simplex virus (HSV), avoiding contact with individuals who (often asymptomatically) are excreting the virus in saliva or genital secretions is difficult. Daily antiviral therapy can be given to reduce episodes of asymptomatic genital shedding

2014 eMedicine.com

110. Herpes Simplex (Treatment)

transmitted infections. Urol Clin North Am . 2008 Feb. 35(1):33-46; vi. . Bucher J, Koyfman A. What Is the Most Effective Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical (...) Herpes Simplex (Treatment) Herpes Simplex in Emergency Medicine Treatment & Management: Emergency Department Care, Consultations, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLXRyZWF0bWVudA

2014 eMedicine Emergency Medicine

111. Herpes Simplex (Overview)

Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis. J Am Acad Dermatol . 1999 Dec. 41 (6):996-1001. . [Guideline] Workowski KA (...) Herpes Simplex (Overview) Herpes Simplex in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLW92ZXJ2aWV3 processing > Herpes Simplex

2014 eMedicine Emergency Medicine

112. Herpes Simplex Encephalitis (Overview)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Overview) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine Emergency Medicine

113. Herpes Simplex (Follow-up)

and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep . 2015 Jun 5. 64 (RR-03):1-137. . Gnann JW Jr, Whitley RJ. CLINICAL PRACTICE. Genital Herpes. N Engl J Med . 2016 Aug 18. 375 (7):666-74. . Frenkl TL, Potts J. Sexually transmitted infections. Urol Clin North Am . 2008 Feb. 35(1):33-46; vi. . Bucher J, Koyfman A. What Is the Most Effective Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir (...) Herpes Simplex (Follow-up) Herpes Simplex in Emergency Medicine Follow-up: Further Outpatient Care, Further Inpatient Care, Deterrence/Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLWZvbGxvd3Vw

2014 eMedicine Emergency Medicine

114. Herpes Simplex (Diagnosis)

, keratitis, acute retinal necrosis, Bell palsy, and encephalitis. Herpes simplex keratitis is characterized by ocular pain and is a common infectious cause of unilateral vision loss. [ ] Clinical manifestations of HSV-1 encephalitis include fever, headache, nausea, vomiting, seizures, confusion, and focal deficits. [ ] Approximately 15% of hospitalized patients die from HSV encephalitis, and survivors have long-term disability affecting cognitive function. [ ] The most common complication of primary HSV (...) , Mu EW, Orlow SJ. Characterization of Herpes Simplex Virus Infections Seen in the Pediatric Dermatology Office. Pediatr Dermatol . 2017 Jul. 34 (4):446-449. . Ng PP, Sun YJ, Tan HH, Tan SH. Detection of herpes simplex virus genomic DNA in various subsets of Erythema multiforme by polymerase chain reaction. Dermatology . 2003. 207 (4):349-53. . Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology . 2017 Nov. 124 (11):1678-1689. . Rabinstein AA

2014 eMedicine.com

115. Herpes Simplex Encephalitis (Diagnosis)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Diagnosis) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine Emergency Medicine

116. Herpes Simplex (Diagnosis)

Treatment of Herpes Simplex Keratitis?. Ann Emerg Med . 2016 Jul. 68 (1):26-7. . Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA . 2010 Aug 25. 304(8):859-66. . Kaminester LH, Pariser RJ, Pariser DM, Weiss JS, Shavin JS, Landsman L, et al. A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis. J Am Acad Dermatol . 1999 Dec. 41 (6):996-1001. . [Guideline] Workowski KA (...) Herpes Simplex (Diagnosis) Herpes Simplex in Emergency Medicine: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNzgzMTEzLW92ZXJ2aWV3 processing > Herpes Simplex

2014 eMedicine Emergency Medicine

117. Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid (Full text)

is described. To control the disease, the patient was given rituximab therapy in combination with oral corticosteroids. He subsequently experienced an epithelial herpes simplex virus keratitis in one eye and 3 months later in his fellow eye. Topical treatment with ganciclovir resulted in prompt recovery.For the first time, a correlation between rituximab and bilateral epithelial herpes simplex virus keratitis is described.Although rituximab is a promising biologic agent for the treatment of autoimmune (...) diseases, it bears the risk of reactivation of viral infections, including the onset of herpes simplex virus keratitis.

2018 Journal of ophthalmic inflammation and infection

118. <i>Acanthamoeba</i> keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. (PubMed)

were associated with the presence of SIC, aged >34 years, corticosteroids used before giving AAT and symptom duration >37 days before AAT. The development of SIC was independently associated with aged >34 years, corticosteroids used before giving AAT and herpes simplex virus (HSV) keratitis treatment before AAT.The prompt diagnosis of AK, avoidance of a misdiagnosis of HSV keratitis and corticosteroid use before the exclusion of AK as a potential cause of keratitis are essential to the provision (...) Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined

2018 British Journal of Ophthalmology

119. Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis (Full text)

Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis Despite the clinical importance of herpes simplex virus (HSV)-induced ocular disease, the underlying pathophysiology of the disease remains poorly understood, in part due to the lack of adequate virus-natural-host models in which to study the cellular and viral factors involved in acute corneal infection. We developed an air-liquid canine corneal organ culture model (...) and evaluated its susceptibility to canine herpesvirus type 1 (CHV-1) in order to study ocular herpes in a physiologically relevant natural host model. Canine corneas were maintained in culture at an air-liquid interface for up to 25 days, and no degenerative changes were observed in the corneal epithelium during cultivation using histology for morphometric analyses, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays, and transmission electron microscopy (TEM). Next

2014 Journal of virology

120. Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case (Full text)

Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic (...) of Kocuria keratitis.Clinicians should be aware of Kocuria keratitis as a corneal complication of AKC, and that rapid diagnosis of Kocuria keratitis may improve visual prognosis.

2017 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

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