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Herpes Simplex Keratitis

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101. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells Full Text available with Trip Pro

Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells Herpes Simplex Virus Type -1 (HSV-1) infections can cause serious complications such as keratitis and encephalitis. The goal of this study was to identify any changes in the concentrations of volatile organic compounds (VOCs) produced during HSV-1 infection of epithelial cells that could potentially be used

2016 PloS one

102. Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. (Abstract)

Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. Aciclovir (ACV) is the first-line drug for the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. Long-term administration of ACV for the treatment of severe infections in immunocompromised patients can lead to the development of drug resistance. Furthermore, the emergence of isolates resistant to ACV is increasingly recognized in immunocompetent (...) individuals with herpetic keratitis. This review describes the mechanisms involved in drug resistance for HSV and VZV, the laboratory diagnosis and management of patients with infections refractory to ACV therapy.Genotypic testing is more frequently performed for the diagnosis of infections caused by drug-resistant HSV or VZV isolates. Molecular biology-based systems for the generation of recombinant viruses have been developed to link unknown mutations with their drug phenotypes. Fast and sensitive

2016 Current Opinion in Infectious Diseases

103. IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection Full Text available with Trip Pro

IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection Herpes simplex virus type 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation because of damage to the corneal sensory fibers. We and others have reported regression of corneal nerves during acute HSV-1 infection. To determine whether denervation is caused directly by the virus or indirectly by the elicited immune response, mice were infected with HSV-1 (...) not affect viral contents at 4 and 8 days post infection. The elevated protein contents of chemokines and inflammatory cytokines on infection were greatly suppressed by DEX. Subconjunctival delivery of neutralizing antibody against IL-6 to infected mice resulted in partial preservation of corneal nerve structure and sensitivity. Our study supports a role for the immune response, but not local virus replication in the development of HSV-1-induced neurotrophic keratitis. IL-6 is one of the factors produced

2016 The American journal of pathology

104. Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure Full Text available with Trip Pro

occurring in neonates and patients with compromised immune systems. Severe pathologies from HSV include the blindness-inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex encephalitis, and generalized infections that can lead to herpes simplex virus-induced acute liver failure. While immune compromise is a known factor, the precise mechanisms that lead to generalized HSV infections are unknown. In this study, we used and developed a mouse model system in combination (...) Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes

2016 Journal of virology

105. High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. Full Text available with Trip Pro

High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. The "high-risk phenotype" of corneal graft recipients is considered to be related to preexisting vascularization such as that associated with herpes simplex virus-1 (HSV-1) keratitis (HSK). The purpose of this study was to investigate the immunologic mechanisms underlying accelerated corneal graft rejection using a mouse model of HSK.Herpes simplex virus type 1 keratitis was induced

2016 Investigative Ophthalmology & Visual Science

106. Loss of ICP22 in HSV-1 Elicits Immune Infiltration and Maintains Stromal Keratitis Despite Reduced Primary and Latent Virus Infectivity. Full Text available with Trip Pro

Loss of ICP22 in HSV-1 Elicits Immune Infiltration and Maintains Stromal Keratitis Despite Reduced Primary and Latent Virus Infectivity. We previously have reported that ICP22, an immediate early gene of herpes simplex virus type 1 (HSV-1), binds to the CD80 promoter to suppress CD80 expression in antigen-presenting cells, leading to reduced T-cell function and protection. In contrast, overexpression of CD80 exacerbates corneal scarring (CS) in ocularly infected mice. In this study we tested

2019 Investigative Ophthalmology & Visual Science

107. <i>Acanthamoeba</i> keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. (Abstract)

were associated with the presence of SIC, aged >34 years, corticosteroids used before giving AAT and symptom duration >37 days before AAT. The development of SIC was independently associated with aged >34 years, corticosteroids used before giving AAT and herpes simplex virus (HSV) keratitis treatment before AAT.The prompt diagnosis of AK, avoidance of a misdiagnosis of HSV keratitis and corticosteroid use before the exclusion of AK as a potential cause of keratitis are essential to the provision (...) Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined

2018 British Journal of Ophthalmology

108. Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid Full Text available with Trip Pro

is described. To control the disease, the patient was given rituximab therapy in combination with oral corticosteroids. He subsequently experienced an epithelial herpes simplex virus keratitis in one eye and 3 months later in his fellow eye. Topical treatment with ganciclovir resulted in prompt recovery.For the first time, a correlation between rituximab and bilateral epithelial herpes simplex virus keratitis is described.Although rituximab is a promising biologic agent for the treatment of autoimmune (...) diseases, it bears the risk of reactivation of viral infections, including the onset of herpes simplex virus keratitis.

2018 Journal of ophthalmic inflammation and infection

109. Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis Full Text available with Trip Pro

Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis Despite the clinical importance of herpes simplex virus (HSV)-induced ocular disease, the underlying pathophysiology of the disease remains poorly understood, in part due to the lack of adequate virus-natural-host models in which to study the cellular and viral factors involved in acute corneal infection. We developed an air-liquid canine corneal organ culture model (...) and evaluated its susceptibility to canine herpesvirus type 1 (CHV-1) in order to study ocular herpes in a physiologically relevant natural host model. Canine corneas were maintained in culture at an air-liquid interface for up to 25 days, and no degenerative changes were observed in the corneal epithelium during cultivation using histology for morphometric analyses, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays, and transmission electron microscopy (TEM). Next

2014 Journal of virology

110. Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis

of an ocular infection caused by viruses (herpes simplex virus [HSV]) or fungi. Subject treated with drugs having effects on Acanthamoeba cysts prior to study entry, including biguanides (PHMB, chlorhexidine) and diamidines (propamidine, hexamidine). Subjects requiring systemic immunosuppression for Acanthamoeba associated scleritis. Subjects requiring urgent surgical intervention for advanced Acanthamoeba keratitis in either eye (e.g., for advanced corneal thinning/melting etc.). Subject with known (...) Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2017 Clinical Trials

111. Update on the Management of Infectious Keratitis. Full Text available with Trip Pro

. The Herpetic Eye Disease Study (HEDS) I showed a significant benefit of topical corticosteroids and oral acyclovir for stromal keratitis. HEDS II showed that oral acyclovir decreased the recurrence of any type of herpes simplex virus keratitis by approximately half. Future strategies to reduce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuvant therapies aimed at modifying the immune response to infection holding the greatest potential to improve clinical (...) Update on the Management of Infectious Keratitis. Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms

2017 Ophthalmology

112. Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case Full Text available with Trip Pro

Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic (...) of Kocuria keratitis.Clinicians should be aware of Kocuria keratitis as a corneal complication of AKC, and that rapid diagnosis of Kocuria keratitis may improve visual prognosis.

2017 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

113. Non-contact lens related Acanthamoeba keratitis Full Text available with Trip Pro

. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases. Majority of cases present with diffuse infiltrate, mimicking herpes simplex or fungal keratitis. The diagnosis can be confirmed by microscopic examination of corneal scraping material and culture on nonnutrient agar with an overlay of Escherichia coli. Confocal microscopy (...) Non-contact lens related Acanthamoeba keratitis The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease

2017 Indian journal of ophthalmology

114. Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Full Text available with Trip Pro

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (...) (HSV) keratitis.In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration

2017 Journal of clinical and diagnostic research : JCDR

115. Corneal edema and keratitis following selective laser trabeculoplasty Full Text available with Trip Pro

reports of keratitis, it is imperative for ophthalmic surgeons to be aware of herpes simplex as a possible risk factor. Prompt treatment with antivirals and steroids can potentially prevent scarring and permanent damage to the cornea. (...) Corneal edema and keratitis following selective laser trabeculoplasty To describe three cases of keratitis following Selective Laser Trabeculoplasty (SLT).Three females with a history of glaucoma presented with corneal edema, keratitis (endothelial, epithelial) and decreased visual acuity shortly after SLT. There was variable resolution of symptoms after starting treatment with oral antiherpetics and topical steroids.With the increase in usage of SLT as a treatment for glaucoma and subsequent

2016 American journal of ophthalmology case reports

116. Tumor Necrosis Factor Alpha and Interleukin-6 Facilitate Corneal Lymphangiogenesis in Response to Herpes Simplex Virus 1 Infection Full Text available with Trip Pro

Tumor Necrosis Factor Alpha and Interleukin-6 Facilitate Corneal Lymphangiogenesis in Response to Herpes Simplex Virus 1 Infection Herpes simplex virus 1 (HSV-1) is a common human pathogen of clinical significance due to its association with vision impairment and encephalitis. In a mouse model of ocular neovascularization, we have previously shown that HSV-1 elicits the genesis of lymphatic vessels into the cornea proper through epithelial cell expression of vascular endothelial growth factor (...) at least two proinflammatory cytokines expressed locally that are involved in the genesis of lymphatic vessels in the normally avascular cornea in response to HSV-1 infection. This finding provides the basis to target IL-6 and TNF-α as additional proangiogenic factors in the cornea during the development of herpetic stromal keratitis as a means to alleviate further neovascularization and tissue pathology associated with the host immune response to the pathogen.Copyright © 2014, American Society

2014 Journal of virology

117. Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis

systemic disease, unstable medical disorders, life-threatening disease or current malignancies. Subjects with a current episode of herpes simplex labialis that has not completely healed. Presence of any facial skin condition or excessive facial hair that may interfere with diagnosis, assessment, and/or healing ability. History of herpes keratitis. Subject has a history of hypersensitivity or allergy to any ingredient in the drug product. History of unresponsiveness to topical acyclovir therapy (...) Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

118. Herpes simplex and herpes zoster keratouveitis: diagnosis and management. Full Text available with Trip Pro

Herpes simplex and herpes zoster keratouveitis: diagnosis and management. 302725 1977 11 25 2018 11 13 0028-7091 53 8 1977 Oct Bulletin of the New York Academy of Medicine Bull N Y Acad Med Herpes simplex and herpes zoster keratouveitis: diagnosis and management. 731-48 Pavan-Langston D D eng Journal Article Research Support, U.S. Gov't, P.H.S. United States Bull N Y Acad Med 7505398 0028-7091 9PHQ9Y1OLM Prednisolone LGP81V5245 Idoxuridine IM Herpes Zoster Ophthalmicus complications Humans (...) Idoxuridine therapeutic use Keratitis drug therapy etiology Prednisolone therapeutic use Recurrence Uveitis drug therapy etiology 1977 10 1 1977 10 1 0 1 1977 10 1 0 0 ppublish 302725 PMC1807398 Arch Intern Med. 1964 May;113:679-86 14120593 Lancet. 1964 Sep 19;2(7360):610-1 14186147 Arch Ophthalmol. 1963 Apr;69:468-72 14031372 Br Med J. 1957 Sep 28;2(5047):746-8 13460373 Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Sep-Oct;81(5):813-25 798369 Arch Ophthalmol. 1975 Sep;93(9):828-30 1235486

1977 Bulletin of the New York Academy of Medicine

119. Herpes Simplex (Overview)

Herpes Simplex (Overview) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes Simplex (...) Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable with aggressive

2014 eMedicine.com

120. Herpes Simplex (Overview)

, keratitis, acute retinal necrosis, Bell palsy, and encephalitis. Herpes simplex keratitis is characterized by ocular pain and is a common infectious cause of unilateral vision loss. [ ] Clinical manifestations of HSV-1 encephalitis include fever, headache, nausea, vomiting, seizures, confusion, and focal deficits. [ ] Approximately 15% of hospitalized patients die from HSV encephalitis, and survivors have long-term disability affecting cognitive function. [ ] The most common complication of primary HSV (...) , Mu EW, Orlow SJ. Characterization of Herpes Simplex Virus Infections Seen in the Pediatric Dermatology Office. Pediatr Dermatol . 2017 Jul. 34 (4):446-449. . Ng PP, Sun YJ, Tan HH, Tan SH. Detection of herpes simplex virus genomic DNA in various subsets of Erythema multiforme by polymerase chain reaction. Dermatology . 2003. 207 (4):349-53. . Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology . 2017 Nov. 124 (11):1678-1689. . Rabinstein AA

2014 eMedicine.com

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