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Herpes Simplex Keratitis

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81. IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS Full Text available with Trip Pro

IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS 14249189 1996 12 01 2018 12 01 0007-1161 48 1964 Dec The British journal of ophthalmology Br J Ophthalmol IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS. 678-83 DAVIDSON S I SI EVANS P J PJ eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 gamma-Globulins 1C4QK22F9J Potassium Iodide 9679TC07X4 Iodine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Iodine Keratitis Keratitis, Dendritic Keratitis, Herpetic (...) Potassium Iodide gamma-Globulins CLINICAL RESEARCH DRUG THERAPY GAMMA GLOBULIN IDOXURIDINE IODINE KERATITIS, DENDRITIC POTASSIUM IODIDE 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14249189 PMC506041 Br Med J. 1962 Aug 4;2(5300):304-5 13881470 AMA Arch Ophthalmol. 1956 Sep;56(3):375-88 13361612 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Am J Ophthalmol. 1963 Feb;55:237-8 13934060 Br J Ophthalmol. 1963 Aug;47:449-56 14189714 Am J Ophthalmol. 1963 Feb;55:234-7 13961073 Arch Ophthalmol. 1963 Sep;70:381

1964 The British journal of ophthalmology

82. CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS Full Text available with Trip Pro

CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS 14255597 1996 12 01 2018 12 01 0007-1161 49 1965 Jan The British journal of ophthalmology Br J Ophthalmol CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS. 37-9 KRWAWICZ T T eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Cryosurgery Humans Keratitis Keratitis, Dendritic Keratitis, Herpetic CRYOGENIC SURGERY KERATITIS, DENDRITIC 1965 1 1 1965 1 1 0 1 1965 1 1 0 0 ppublish 14255597 PMC506057 Arch Ophthalmol. 1962 Aug;68:235-9

1965 The British journal of ophthalmology

83. The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis Full Text available with Trip Pro

The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis 13945859 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc The effectiveness of 5-iodo-2-deoxyuridine in the treatment of herpes simplex keratitis. 243-59 FURGIUELE F P FP PENTECOST G F GF KLEIN M M McGAVIC J S JS eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Antimetabolites 0 Nucleosides 14259-58-6 5'-deoxy-5 (...) '-iodouridine LGP81V5245 Idoxuridine OM Antimetabolites Humans Idoxuridine Keratitis, Dendritic Keratitis, Herpetic Nucleosides ANTIMETABOLITES KERATITIS, DENDRITIC NUCLEOSIDES 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish 13945859 PMC1316491

1962 Transactions of the American Ophthalmological Society

84. TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE Full Text available with Trip Pro

TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE 14189714 1996 12 01 2018 12 01 0007-1161 47 1963 Aug The British journal of ophthalmology Br J Ophthalmol TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5-IODO-2'-DEOXYURIDINE. 449-56 LUNTZ M H MH MACCALLUM F O FO eng Journal Article England Br J Ophthalmol 0421041 0007-1161 14259-58-6 5'-deoxy-5'-iodouridine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Keratitis Keratitis, Dendritic Keratitis (...) , Herpetic Virus Cultivation CLINICAL RESEARCH DRUG THERAPY IDOXURIDINE KERATITIS, DENDRITIC VIRUS CULTIVATION 1963 8 1 1963 8 1 0 1 1963 8 1 0 0 ppublish 14189714 PMC505831 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Br Med J. 1962 Aug 4;2(5300):304-5 13881470

1963 The British journal of ophthalmology

85. Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. (Abstract)

Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. A double controlled clinical study comparing idoxuridine (IDU) and vidarabine (ara-A) in the treatment of uncomplicated herpes simplex keratitis was carried out with 10 patients. No statistically significant differences occurred in the healing time between IDU (6.8 days) and ara-A (8.0 days). Two moderately adverse reactions to IDU were observed, but no demonstrable ocular toxicity was noted with ara-A.

1978 Annals of ophthalmology Controlled trial quality: uncertain

86. Cryotherapy of herpes simplex keratitis. (Abstract)

Cryotherapy of herpes simplex keratitis. Twenty-one cases of epithelial herpetic keratitis were treated with cryotherapy and 14 cases were treated with Iodoxouridine (IDU). Cryotherapy was found statistically superior to IDU. The average healing time was 2.4 days for cryotherapy and 6.2 days for IDU. The advantages of cryotherapy are emphasized.

1978 Annals of ophthalmology Controlled trial quality: uncertain

87. Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. Full Text available with Trip Pro

(7.9%, 2.5%, respectively, P = 0.012) in the epithelial defect group was higher than in the non-defects group. Multivariate logistic regression revealed that male sex (P = 0.001), age ≥ 60 years (P = 0.024), graft diameter >9mm (P = 0.001), bacterial (P = 0.039) and herpes simplex keratitis (P = 0.008), rheumatism (P = 0.031) and cancer treated with chemo- or radiotherapy (P = 0.032) were independent risk factors for epithelial defects. Graft clarity after epithelial defects were significantly (...) Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008

2018 PLoS ONE

88. High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. Full Text available with Trip Pro

High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. The "high-risk phenotype" of corneal graft recipients is considered to be related to preexisting vascularization such as that associated with herpes simplex virus-1 (HSV-1) keratitis (HSK). The purpose of this study was to investigate the immunologic mechanisms underlying accelerated corneal graft rejection using a mouse model of HSK.Herpes simplex virus type 1 keratitis was induced

2016 Investigative Ophthalmology & Visual Science

89. A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Full Text available with Trip Pro

of infection, including necrotizing stromal keratitis and herpes simplex encephalitis. The present study was undertaken to evaluate a novel vaccine to ocular HSV-1 infection not only for resistance to viral replication and spread but also for maintenance of the visual axis. The results underscore the necessity to reconsider strategies that utilize attenuated live virus as opposed to subunit vaccines against ocular HSV-1 infection.Copyright © 2016, American Society for Microbiology. All Rights Reserved. (...) A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Correlates of immunologic protection requisite for an efficacious herpes simplex virus 1 (HSV-1) vaccine remain unclear with respect to viral pathogenesis and clinical disease. In the present study, mice were vaccinated with a novel avirulent, live attenuated virus (0ΔNLS) or an adjuvanted glycoprotein D subunit (gD-2) similar to that used in several human

2016 Journal of virology

90. IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection Full Text available with Trip Pro

IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection Herpes simplex virus type 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation because of damage to the corneal sensory fibers. We and others have reported regression of corneal nerves during acute HSV-1 infection. To determine whether denervation is caused directly by the virus or indirectly by the elicited immune response, mice were infected with HSV-1 (...) not affect viral contents at 4 and 8 days post infection. The elevated protein contents of chemokines and inflammatory cytokines on infection were greatly suppressed by DEX. Subconjunctival delivery of neutralizing antibody against IL-6 to infected mice resulted in partial preservation of corneal nerve structure and sensitivity. Our study supports a role for the immune response, but not local virus replication in the development of HSV-1-induced neurotrophic keratitis. IL-6 is one of the factors produced

2016 The American journal of pathology

91. Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure Full Text available with Trip Pro

occurring in neonates and patients with compromised immune systems. Severe pathologies from HSV include the blindness-inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex encephalitis, and generalized infections that can lead to herpes simplex virus-induced acute liver failure. While immune compromise is a known factor, the precise mechanisms that lead to generalized HSV infections are unknown. In this study, we used and developed a mouse model system in combination (...) Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes

2016 Journal of virology

92. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells Full Text available with Trip Pro

Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells Herpes Simplex Virus Type -1 (HSV-1) infections can cause serious complications such as keratitis and encephalitis. The goal of this study was to identify any changes in the concentrations of volatile organic compounds (VOCs) produced during HSV-1 infection of epithelial cells that could potentially be used

2016 PloS one

93. Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. (Abstract)

Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. Aciclovir (ACV) is the first-line drug for the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. Long-term administration of ACV for the treatment of severe infections in immunocompromised patients can lead to the development of drug resistance. Furthermore, the emergence of isolates resistant to ACV is increasingly recognized in immunocompetent (...) individuals with herpetic keratitis. This review describes the mechanisms involved in drug resistance for HSV and VZV, the laboratory diagnosis and management of patients with infections refractory to ACV therapy.Genotypic testing is more frequently performed for the diagnosis of infections caused by drug-resistant HSV or VZV isolates. Molecular biology-based systems for the generation of recombinant viruses have been developed to link unknown mutations with their drug phenotypes. Fast and sensitive

2016 Current Opinion in Infectious Diseases

94. Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid Full Text available with Trip Pro

is described. To control the disease, the patient was given rituximab therapy in combination with oral corticosteroids. He subsequently experienced an epithelial herpes simplex virus keratitis in one eye and 3 months later in his fellow eye. Topical treatment with ganciclovir resulted in prompt recovery.For the first time, a correlation between rituximab and bilateral epithelial herpes simplex virus keratitis is described.Although rituximab is a promising biologic agent for the treatment of autoimmune (...) diseases, it bears the risk of reactivation of viral infections, including the onset of herpes simplex virus keratitis.

2018 Journal of ophthalmic inflammation and infection

95. <i>Acanthamoeba</i> keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. (Abstract)

were associated with the presence of SIC, aged >34 years, corticosteroids used before giving AAT and symptom duration >37 days before AAT. The development of SIC was independently associated with aged >34 years, corticosteroids used before giving AAT and herpes simplex virus (HSV) keratitis treatment before AAT.The prompt diagnosis of AK, avoidance of a misdiagnosis of HSV keratitis and corticosteroid use before the exclusion of AK as a potential cause of keratitis are essential to the provision (...) Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined

2018 British Journal of Ophthalmology

96. Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis Full Text available with Trip Pro

Establishment and Characterization of an Air-Liquid Canine Corneal Organ Culture Model To Study Acute Herpes Keratitis Despite the clinical importance of herpes simplex virus (HSV)-induced ocular disease, the underlying pathophysiology of the disease remains poorly understood, in part due to the lack of adequate virus-natural-host models in which to study the cellular and viral factors involved in acute corneal infection. We developed an air-liquid canine corneal organ culture model (...) and evaluated its susceptibility to canine herpesvirus type 1 (CHV-1) in order to study ocular herpes in a physiologically relevant natural host model. Canine corneas were maintained in culture at an air-liquid interface for up to 25 days, and no degenerative changes were observed in the corneal epithelium during cultivation using histology for morphometric analyses, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assays, and transmission electron microscopy (TEM). Next

2014 Journal of virology

97. Update on the Management of Infectious Keratitis. Full Text available with Trip Pro

. The Herpetic Eye Disease Study (HEDS) I showed a significant benefit of topical corticosteroids and oral acyclovir for stromal keratitis. HEDS II showed that oral acyclovir decreased the recurrence of any type of herpes simplex virus keratitis by approximately half. Future strategies to reduce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuvant therapies aimed at modifying the immune response to infection holding the greatest potential to improve clinical (...) Update on the Management of Infectious Keratitis. Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms

2017 Ophthalmology

98. Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case Full Text available with Trip Pro

Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic (...) of Kocuria keratitis.Clinicians should be aware of Kocuria keratitis as a corneal complication of AKC, and that rapid diagnosis of Kocuria keratitis may improve visual prognosis.

2017 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

99. Non-contact lens related Acanthamoeba keratitis Full Text available with Trip Pro

. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases. Majority of cases present with diffuse infiltrate, mimicking herpes simplex or fungal keratitis. The diagnosis can be confirmed by microscopic examination of corneal scraping material and culture on nonnutrient agar with an overlay of Escherichia coli. Confocal microscopy (...) Non-contact lens related Acanthamoeba keratitis The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease

2017 Indian journal of ophthalmology

100. Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Full Text available with Trip Pro

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (...) (HSV) keratitis.In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration

2017 Journal of clinical and diagnostic research : JCDR

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