How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

821 results for

Herpes Simplex Keratitis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. (Abstract)

Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. A double controlled clinical study comparing idoxuridine (IDU) and vidarabine (ara-A) in the treatment of uncomplicated herpes simplex keratitis was carried out with 10 patients. No statistically significant differences occurred in the healing time between IDU (6.8 days) and ara-A (8.0 days). Two moderately adverse reactions to IDU were observed, but no demonstrable ocular toxicity was noted with ara-A.

1978 Annals of ophthalmology Controlled trial quality: uncertain

82. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. Full Text available with Trip Pro

Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 5662199 1968 09 05 2018 11 13 0035-9157 61 6 1968 Jun Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 541-2 Starr P A PA eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Fluoresceins IM Aqueous Humor metabolism Biological Transport Cell Membrane Permeability Cornea Fluoresceins Humans (...) Keratitis, Dendritic pathology 1968 6 1 1968 6 1 0 1 1968 6 1 0 0 ppublish 5662199 PMC1902596 Exp Eye Res. 1963 Jan;2:33-8 13934003

1968 Proceedings of the Royal Society of Medicine

83. Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. Full Text available with Trip Pro

Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 4351680 1973 08 31 2018 11 13 0007-1161 57 5 1973 May The British journal of ophthalmology Br J Ophthalmol Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 336-8 Thomas J V JV Dunlap W A WA Rich A M AM eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Aniline Compounds 0 Coloring Agents IM Aniline Compounds Animals Coloring Agents Keratitis, Dendritic therapy

1973 The British journal of ophthalmology

84. The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis Full Text available with Trip Pro

The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis 13945859 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc The effectiveness of 5-iodo-2-deoxyuridine in the treatment of herpes simplex keratitis. 243-59 FURGIUELE F P FP PENTECOST G F GF KLEIN M M McGAVIC J S JS eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Antimetabolites 0 Nucleosides 14259-58-6 5'-deoxy-5 (...) '-iodouridine LGP81V5245 Idoxuridine OM Antimetabolites Humans Idoxuridine Keratitis, Dendritic Keratitis, Herpetic Nucleosides ANTIMETABOLITES KERATITIS, DENDRITIC NUCLEOSIDES 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish 13945859 PMC1316491

1962 Transactions of the American Ophthalmological Society

85. CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS Full Text available with Trip Pro

CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS 14255597 1996 12 01 2018 12 01 0007-1161 49 1965 Jan The British journal of ophthalmology Br J Ophthalmol CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS. 37-9 KRWAWICZ T T eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Cryosurgery Humans Keratitis Keratitis, Dendritic Keratitis, Herpetic CRYOGENIC SURGERY KERATITIS, DENDRITIC 1965 1 1 1965 1 1 0 1 1965 1 1 0 0 ppublish 14255597 PMC506057 Arch Ophthalmol. 1962 Aug;68:235-9

1965 The British journal of ophthalmology

86. IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS Full Text available with Trip Pro

IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS 14249189 1996 12 01 2018 12 01 0007-1161 48 1964 Dec The British journal of ophthalmology Br J Ophthalmol IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS. 678-83 DAVIDSON S I SI EVANS P J PJ eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 gamma-Globulins 1C4QK22F9J Potassium Iodide 9679TC07X4 Iodine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Iodine Keratitis Keratitis, Dendritic Keratitis, Herpetic (...) Potassium Iodide gamma-Globulins CLINICAL RESEARCH DRUG THERAPY GAMMA GLOBULIN IDOXURIDINE IODINE KERATITIS, DENDRITIC POTASSIUM IODIDE 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14249189 PMC506041 Br Med J. 1962 Aug 4;2(5300):304-5 13881470 AMA Arch Ophthalmol. 1956 Sep;56(3):375-88 13361612 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Am J Ophthalmol. 1963 Feb;55:237-8 13934060 Br J Ophthalmol. 1963 Aug;47:449-56 14189714 Am J Ophthalmol. 1963 Feb;55:234-7 13961073 Arch Ophthalmol. 1963 Sep;70:381

1964 The British journal of ophthalmology

87. TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE Full Text available with Trip Pro

TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE 14189714 1996 12 01 2018 12 01 0007-1161 47 1963 Aug The British journal of ophthalmology Br J Ophthalmol TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5-IODO-2'-DEOXYURIDINE. 449-56 LUNTZ M H MH MACCALLUM F O FO eng Journal Article England Br J Ophthalmol 0421041 0007-1161 14259-58-6 5'-deoxy-5'-iodouridine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Keratitis Keratitis, Dendritic Keratitis (...) , Herpetic Virus Cultivation CLINICAL RESEARCH DRUG THERAPY IDOXURIDINE KERATITIS, DENDRITIC VIRUS CULTIVATION 1963 8 1 1963 8 1 0 1 1963 8 1 0 0 ppublish 14189714 PMC505831 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Br Med J. 1962 Aug 4;2(5300):304-5 13881470

1963 The British journal of ophthalmology

88. NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX Full Text available with Trip Pro

NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX 18169905 2008 01 11 2008 11 20 0007-1161 27 2 1943 Feb The British journal of ophthalmology Br J Ophthalmol NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX. 80-7 Hamilton J B JB A.A.M.C. Abroad. eng Journal Article England Br J Ophthalmol 0421041 0007-1161 1943 2 1 0 0 1943 2 1 0 1 1943 2 1 0 0 ppublish 18169905 PMC510308

1943 The British journal of ophthalmology

89. Experimental stromal herpes simplex keratitis in rabbits. Full Text available with Trip Pro

Experimental stromal herpes simplex keratitis in rabbits. 4295148 1968 03 30 2018 11 13 0065-9533 65 1967 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Experimental stromal herpes simplex keratitis in rabbits. 189-210 Irvine A R AR Kimura S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 IM Animals Anterior Chamber pathology Antibody Formation Blood Cell Count Cornea pathology Hypersensitivity Iritis immunology Keratitis

1967 Transactions of the American Ophthalmological Society

90. Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis Full Text available with Trip Pro

Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

1975 Antimicrobial Agents and Chemotherapy

91. Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid Full Text available with Trip Pro

Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid Fifty strains of herpes simplex virus, isolated from patients with herpetic keratitis, were examined in vitro for susceptibility to polyinosinic acid-polycytidylic acid [poly(I:C)] in the presence of a constant concentration of diethylaminoethyl-dextran. The minimal inhibitory concentration of poly(I:C) for 44 of these strains ranged from 0.0001 to 0.1 mug/ml; for the remaining

1977 Antimicrobial Agents and Chemotherapy

92. Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. Full Text available with Trip Pro

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest (...) that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.

1977 The British journal of ophthalmology

93. Histopathology of human superficial herpes simplex keratitis. Full Text available with Trip Pro

Histopathology of human superficial herpes simplex keratitis. In vivo corneal replicas were made in 20 cases of patients with superficial dendritic ulcers of the cornea. Histopathological study of the replicas and superficial epithelial cells showed that the dendrites are composed of rounded epithelial cells and variable sized syncytia containing bizarre shaped nuclei. Pseudopodia-like processes containing DNA and some RNA extend from the syncytia into the surrounding epithelial cells, which

1978 The British journal of ophthalmology

94. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. Full Text available with Trip Pro

Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte

1977 Infection and immunity

95. Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis Full Text available with Trip Pro

Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis Treatment of established experimental keratitis caused by herpes simplex virus with 9-beta-d-arabinofuranosyladenine 5'-monophosphate (Ara-AMP) or 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP (...) showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.

1976 Antimicrobial Agents and Chemotherapy

96. Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis Full Text available with Trip Pro

Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis 18748204 2010 06 30 2010 06 30 0093-0415 128 5 1978 May The Western journal of medicine West. J. Med. Ophthalmology-epitomes of progress: herpes simplex keratitis. 428-9 O'Connor G R GR eng Journal Article United States West J Med 0410504 0093-0415 1978 5 1 0 0 1978 5 1 0 1 1978 5 1 0 0 ppublish 18748204 PMC1238157

1978 Western Journal of Medicine

97. Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. Full Text available with Trip Pro

Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. Scanning electron microscopy of the endothelium of experimental disciform keratitis revealed corneal endothelial changes which distinguished disciform oedema from the more progressive stages of disciform keratitis. The endothelium of corneas with disciform oedema were wholly intact and characterised by subtle morphological alterations. In contrast, the more progressive stages of disciform keratitis were

1978 The British journal of ophthalmology

98. Treatment of experimental herpes simplex keratitis with acycloguanosine. Full Text available with Trip Pro

Treatment of experimental herpes simplex keratitis with acycloguanosine. Acycloguanosine, a recently developed compound with high inhibitory activity against viruses belonging to the herpes group, has been evaluated in experimental herpes simplex keratitis in rabbits in comparison with trifluorothymidine and preparations of idoxuridine and vidarabine at present in clinical use. All compunds were used in the form of ophthalmic ointments which were applied 5 times a day at intervals of 2 hours

1979 The British journal of ophthalmology

99. Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. Full Text available with Trip Pro

(7.9%, 2.5%, respectively, P = 0.012) in the epithelial defect group was higher than in the non-defects group. Multivariate logistic regression revealed that male sex (P = 0.001), age ≥ 60 years (P = 0.024), graft diameter >9mm (P = 0.001), bacterial (P = 0.039) and herpes simplex keratitis (P = 0.008), rheumatism (P = 0.031) and cancer treated with chemo- or radiotherapy (P = 0.032) were independent risk factors for epithelial defects. Graft clarity after epithelial defects were significantly (...) Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008

2018 PLoS ONE

100. A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Full Text available with Trip Pro

of infection, including necrotizing stromal keratitis and herpes simplex encephalitis. The present study was undertaken to evaluate a novel vaccine to ocular HSV-1 infection not only for resistance to viral replication and spread but also for maintenance of the visual axis. The results underscore the necessity to reconsider strategies that utilize attenuated live virus as opposed to subunit vaccines against ocular HSV-1 infection.Copyright © 2016, American Society for Microbiology. All Rights Reserved. (...) A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Correlates of immunologic protection requisite for an efficacious herpes simplex virus 1 (HSV-1) vaccine remain unclear with respect to viral pathogenesis and clinical disease. In the present study, mice were vaccinated with a novel avirulent, live attenuated virus (0ΔNLS) or an adjuvanted glycoprotein D subunit (gD-2) similar to that used in several human

2016 Journal of virology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>