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Herpes Simplex Keratitis

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81. Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis (Full text)

Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis 18748204 2010 06 30 2010 06 30 0093-0415 128 5 1978 May The Western journal of medicine West. J. Med. Ophthalmology-epitomes of progress: herpes simplex keratitis. 428-9 O'Connor G R GR eng Journal Article United States West J Med 0410504 0093-0415 1978 5 1 0 0 1978 5 1 0 1 1978 5 1 0 0 ppublish 18748204 PMC1238157

1978 Western Journal of Medicine

82. Treatment of experimental herpes simplex keratitis with acycloguanosine. (Full text)

Treatment of experimental herpes simplex keratitis with acycloguanosine. Acycloguanosine, a recently developed compound with high inhibitory activity against viruses belonging to the herpes group, has been evaluated in experimental herpes simplex keratitis in rabbits in comparison with trifluorothymidine and preparations of idoxuridine and vidarabine at present in clinical use. All compunds were used in the form of ophthalmic ointments which were applied 5 times a day at intervals of 2 hours

1979 The British journal of ophthalmology

83. Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. (Full text)

Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. Scanning electron microscopy of the endothelium of experimental disciform keratitis revealed corneal endothelial changes which distinguished disciform oedema from the more progressive stages of disciform keratitis. The endothelium of corneas with disciform oedema were wholly intact and characterised by subtle morphological alterations. In contrast, the more progressive stages of disciform keratitis were

1978 The British journal of ophthalmology

84. NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX (Full text)

NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX 18169905 2008 01 11 2008 11 20 0007-1161 27 2 1943 Feb The British journal of ophthalmology Br J Ophthalmol NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX. 80-7 Hamilton J B JB A.A.M.C. Abroad. eng Journal Article England Br J Ophthalmol 0421041 0007-1161 1943 2 1 0 0 1943 2 1 0 1 1943 2 1 0 0 ppublish 18169905 PMC510308

1943 The British journal of ophthalmology

85. The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis (Full text)

The Effectiveness of 5-Iodo-2-Deoxyuridine in the Treatment of Herpes Simplex Keratitis 13945859 1998 11 01 2018 12 01 0065-9533 60 1962 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc The effectiveness of 5-iodo-2-deoxyuridine in the treatment of herpes simplex keratitis. 243-59 FURGIUELE F P FP PENTECOST G F GF KLEIN M M McGAVIC J S JS eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Antimetabolites 0 Nucleosides 14259-58-6 5'-deoxy-5 (...) '-iodouridine LGP81V5245 Idoxuridine OM Antimetabolites Humans Idoxuridine Keratitis, Dendritic Keratitis, Herpetic Nucleosides ANTIMETABOLITES KERATITIS, DENDRITIC NUCLEOSIDES 1962 1 1 1962 1 1 0 1 1962 1 1 0 0 ppublish 13945859 PMC1316491

1962 Transactions of the American Ophthalmological Society

86. TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE (Full text)

TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5–IODO–2′–DEOXYURIDINE 14189714 1996 12 01 2018 12 01 0007-1161 47 1963 Aug The British journal of ophthalmology Br J Ophthalmol TREATMENT OF HERPES SIMPLEX KERATITIS WITH 5-IODO-2'-DEOXYURIDINE. 449-56 LUNTZ M H MH MACCALLUM F O FO eng Journal Article England Br J Ophthalmol 0421041 0007-1161 14259-58-6 5'-deoxy-5'-iodouridine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Keratitis Keratitis, Dendritic Keratitis (...) , Herpetic Virus Cultivation CLINICAL RESEARCH DRUG THERAPY IDOXURIDINE KERATITIS, DENDRITIC VIRUS CULTIVATION 1963 8 1 1963 8 1 0 1 1963 8 1 0 0 ppublish 14189714 PMC505831 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Br Med J. 1962 Aug 4;2(5300):304-5 13881470

1963 The British journal of ophthalmology

87. CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS (Full text)

CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS 14255597 1996 12 01 2018 12 01 0007-1161 49 1965 Jan The British journal of ophthalmology Br J Ophthalmol CRYOGENIC TREATMENT OF HERPES SIMPLEX KERATITIS. 37-9 KRWAWICZ T T eng Journal Article England Br J Ophthalmol 0421041 0007-1161 OM Cryosurgery Humans Keratitis Keratitis, Dendritic Keratitis, Herpetic CRYOGENIC SURGERY KERATITIS, DENDRITIC 1965 1 1 1965 1 1 0 1 1965 1 1 0 0 ppublish 14255597 PMC506057 Arch Ophthalmol. 1962 Aug;68:235-9

1965 The British journal of ophthalmology

88. IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS (Full text)

IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS 14249189 1996 12 01 2018 12 01 0007-1161 48 1964 Dec The British journal of ophthalmology Br J Ophthalmol IDU AND THE TREATMENT OF HERPES SIMPLEX KERATITIS. 678-83 DAVIDSON S I SI EVANS P J PJ eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 gamma-Globulins 1C4QK22F9J Potassium Iodide 9679TC07X4 Iodine LGP81V5245 Idoxuridine OM Biomedical Research Drug Therapy Idoxuridine Iodine Keratitis Keratitis, Dendritic Keratitis, Herpetic (...) Potassium Iodide gamma-Globulins CLINICAL RESEARCH DRUG THERAPY GAMMA GLOBULIN IDOXURIDINE IODINE KERATITIS, DENDRITIC POTASSIUM IODIDE 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14249189 PMC506041 Br Med J. 1962 Aug 4;2(5300):304-5 13881470 AMA Arch Ophthalmol. 1956 Sep;56(3):375-88 13361612 Arch Ophthalmol. 1962 Aug;68:235-9 14454436 Am J Ophthalmol. 1963 Feb;55:237-8 13934060 Br J Ophthalmol. 1963 Aug;47:449-56 14189714 Am J Ophthalmol. 1963 Feb;55:234-7 13961073 Arch Ophthalmol. 1963 Sep;70:381

1964 The British journal of ophthalmology

89. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. (Full text)

Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 5662199 1968 09 05 2018 11 13 0035-9157 61 6 1968 Jun Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 541-2 Starr P A PA eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Fluoresceins IM Aqueous Humor metabolism Biological Transport Cell Membrane Permeability Cornea Fluoresceins Humans (...) Keratitis, Dendritic pathology 1968 6 1 1968 6 1 0 1 1968 6 1 0 0 ppublish 5662199 PMC1902596 Exp Eye Res. 1963 Jan;2:33-8 13934003

1968 Proceedings of the Royal Society of Medicine

90. Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. (Full text)

Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 4351680 1973 08 31 2018 11 13 0007-1161 57 5 1973 May The British journal of ophthalmology Br J Ophthalmol Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 336-8 Thomas J V JV Dunlap W A WA Rich A M AM eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Aniline Compounds 0 Coloring Agents IM Aniline Compounds Animals Coloring Agents Keratitis, Dendritic therapy

1973 The British journal of ophthalmology

91. Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. (PubMed)

Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double-blind study. A double controlled clinical study comparing idoxuridine (IDU) and vidarabine (ara-A) in the treatment of uncomplicated herpes simplex keratitis was carried out with 10 patients. No statistically significant differences occurred in the healing time between IDU (6.8 days) and ara-A (8.0 days). Two moderately adverse reactions to IDU were observed, but no demonstrable ocular toxicity was noted with ara-A.

1978 Annals of ophthalmology Controlled trial quality: uncertain

92. Cryotherapy of herpes simplex keratitis. (PubMed)

Cryotherapy of herpes simplex keratitis. Twenty-one cases of epithelial herpetic keratitis were treated with cryotherapy and 14 cases were treated with Iodoxouridine (IDU). Cryotherapy was found statistically superior to IDU. The average healing time was 2.4 days for cryotherapy and 6.2 days for IDU. The advantages of cryotherapy are emphasized.

1978 Annals of ophthalmology Controlled trial quality: uncertain

93. A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity (Full text)

of infection, including necrotizing stromal keratitis and herpes simplex encephalitis. The present study was undertaken to evaluate a novel vaccine to ocular HSV-1 infection not only for resistance to viral replication and spread but also for maintenance of the visual axis. The results underscore the necessity to reconsider strategies that utilize attenuated live virus as opposed to subunit vaccines against ocular HSV-1 infection.Copyright © 2016, American Society for Microbiology. All Rights Reserved. (...) A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity Correlates of immunologic protection requisite for an efficacious herpes simplex virus 1 (HSV-1) vaccine remain unclear with respect to viral pathogenesis and clinical disease. In the present study, mice were vaccinated with a novel avirulent, live attenuated virus (0ΔNLS) or an adjuvanted glycoprotein D subunit (gD-2) similar to that used in several human

2016 Journal of virology

94. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells (Full text)

Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells Herpes Simplex Virus Type -1 (HSV-1) infections can cause serious complications such as keratitis and encephalitis. The goal of this study was to identify any changes in the concentrations of volatile organic compounds (VOCs) produced during HSV-1 infection of epithelial cells that could potentially be used

2016 PloS one

95. IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection (Full text)

IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection Herpes simplex virus type 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation because of damage to the corneal sensory fibers. We and others have reported regression of corneal nerves during acute HSV-1 infection. To determine whether denervation is caused directly by the virus or indirectly by the elicited immune response, mice were infected with HSV-1 (...) not affect viral contents at 4 and 8 days post infection. The elevated protein contents of chemokines and inflammatory cytokines on infection were greatly suppressed by DEX. Subconjunctival delivery of neutralizing antibody against IL-6 to infected mice resulted in partial preservation of corneal nerve structure and sensitivity. Our study supports a role for the immune response, but not local virus replication in the development of HSV-1-induced neurotrophic keratitis. IL-6 is one of the factors produced

2016 The American journal of pathology

96. Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure (Full text)

occurring in neonates and patients with compromised immune systems. Severe pathologies from HSV include the blindness-inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex encephalitis, and generalized infections that can lead to herpes simplex virus-induced acute liver failure. While immune compromise is a known factor, the precise mechanisms that lead to generalized HSV infections are unknown. In this study, we used and developed a mouse model system in combination (...) Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes

2016 Journal of virology

97. High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. (Full text)

High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection. The "high-risk phenotype" of corneal graft recipients is considered to be related to preexisting vascularization such as that associated with herpes simplex virus-1 (HSV-1) keratitis (HSK). The purpose of this study was to investigate the immunologic mechanisms underlying accelerated corneal graft rejection using a mouse model of HSK.Herpes simplex virus type 1 keratitis was induced

2016 Investigative Ophthalmology & Visual Science

98. Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. (PubMed)

Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management. Aciclovir (ACV) is the first-line drug for the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. Long-term administration of ACV for the treatment of severe infections in immunocompromised patients can lead to the development of drug resistance. Furthermore, the emergence of isolates resistant to ACV is increasingly recognized in immunocompetent (...) individuals with herpetic keratitis. This review describes the mechanisms involved in drug resistance for HSV and VZV, the laboratory diagnosis and management of patients with infections refractory to ACV therapy.Genotypic testing is more frequently performed for the diagnosis of infections caused by drug-resistant HSV or VZV isolates. Molecular biology-based systems for the generation of recombinant viruses have been developed to link unknown mutations with their drug phenotypes. Fast and sensitive

2016 Current Opinion in Infectious Diseases

99. Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis

systemic disease, unstable medical disorders, life-threatening disease or current malignancies. Subjects with a current episode of herpes simplex labialis that has not completely healed. Presence of any facial skin condition or excessive facial hair that may interfere with diagnosis, assessment, and/or healing ability. History of herpes keratitis. Subject has a history of hypersensitivity or allergy to any ingredient in the drug product. History of unresponsiveness to topical acyclovir therapy (...) Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

100. Herpes Simplex Encephalitis (Diagnosis)

. Like other forms of , herpes simplex meningitis usually has a benign course and is not discussed in this article. Patients with HSV may require long-term antiviral treatment if they have recurrent lesions or if other organ systems are involved (as in herpes simplex keratitis). HSV remains dormant in the nervous system; rarely, it presents as encephalitis, possibly by direct transmission through peripheral nerves to the central nervous system (CNS). This encephalitis is a neurologic emergency (...) Herpes Simplex Encephalitis (Diagnosis) Herpes Simplex Encephalitis: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE2NTE4My1vdmVydmlldw== processing > Herpes

2014 eMedicine.com

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