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Herpes Simplex Keratitis

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801. A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis. (Abstract)

A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis. Thirty patients randomized to the Acyclovir (ACV) group (26 with dendritic lesions, 4 geographic lesions) and 34 patients randomized to the idoxuridine (IDU) treatment group (26 dendritic lesions, 8 geographic lesions) with epithelial herpetic keratitis were evaluated for efficacy and adverse reactions in a multi-center, double-masked, randomized, stratified trial (...) . Patients were treated with either 3% acyclovir ophthalmic ointment or 0.5% idoxuridine ophthalmic ointment five times a day for 14 days. The results of the trial indicated no significant difference between ACV and IDU as antiviral agents in the treatment of epithelial herpetic keratitis. The overall healing patterns of ACV and IDU adjusted for lesion type and prognostic factors, including presenting condition (initial or recurrent disease), duration of symptoms, prior ophthalmic steroid use

1982 Ophthalmology Controlled trial quality: uncertain

802. Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis. (Abstract)

Acyclovir for the treatment and prevention of recurrent infectious herpes simplex keratitis. To evaluate the role of acyclovir in treatment and prevention of herpes simplex keratitis (HSK).A total of 105 patients with HSK were divided into 4 groups. Group 1 consisted of 79 patients with HSV epithelial keratitis. Group 2 consisted of 20 patients with interstitial keratitis. Group 3 consisted of 6 patients with necrotizing keratitis. Group 4 consisted of 4 necrotizing keratitis patients (...) in the prophylaxis group and 14 cases in the control group, showing a statistically significant difference. One case of stromal HSK recurred in the prophylaxis group and 4 recurred in the control group.Long term and low dose oral acyclovir for prophylaxis of recurrent epithelial herpes simplex infection and therapeutic doses of oral acyclovir reduce both the rate and duration of recurrences of infectious herpes simplex keratitis.

2002 Chinese medical journal Controlled trial quality: uncertain

803. Herpes simplex keratitis in children. Full Text available with Trip Pro

Herpes simplex keratitis in children. Ophthalmic findings are reported in 31 eyes of 28 children with herpes simplex keratitis. Twenty two had dendritic ulcers, and nine had geographic ulcers or disciform stromal keratitis. After resolution of keratitis, 80% (19/22) of children with dendritic ulcers achieved corrected visual acuity of 6/9 or better, 50% (11/22) had induced astigmatism, 45% (9/22) had one to five recurrences. In the group with geographic or disciform lesions, 89% (8/9) had

1994 The British journal of ophthalmology

804. Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis. Full Text available with Trip Pro

Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis. Trifluorothymidine (TFT) and adenine arabinoside (ara-A) are effective antiviral drugs with a very low toxicity for the cornea. In our study no difference between these 2 drugs in antiviral activity was noted. The average healing time for TFT was 11-14 days and for ara-A 10-54 days. These data differ markedly from those of other studies. This was the result of the use of additional criteria for healing

1980 The British journal of ophthalmology

805. Two laboratory methods for diagnosis of herpes simplex keratitis. Full Text available with Trip Pro

Two laboratory methods for diagnosis of herpes simplex keratitis. Two techniques are described which enable a rapid diagnosis of herpes simplex keratitis to be made. The tests, antibody/antigen reactions, were shown to be accurate and sensitive in the 119 patients examined. A result is available within four hours with the indirect peroxidase-antiperoxidase method and within one hour with the direct method. The techniques are relatively inexpensive, though labour intensive. Negative reactions

1987 The British journal of ophthalmology

806. Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis Full Text available with Trip Pro

Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis To report a case of atypical herpes simplex keratitis initially diagnosed as bacterial keratitis, in a contact lens wearer.Case report of an 18-year-old woman using contact lenses who presented with pain, redness and gradual decrease in vision in the right eye. Examination revealed (...) a paracentral large stromal infiltrate with a central 2-mm perforation. Corneal and conjunctival scrapings were collected for microbiological investigations. Corneal tissue was obtained following penetrating keratoplasty. Corneal scraping revealed no microorganisms. Giemsa stained smear showed multinucleated giant cells. Conjunctival, corneal scrapings and tissue were positive for herpes simplex virus - 1 (HSV) antigen. Corneal tissue was positive for HSV DNA by PCR.Atypical HSV keratitis can occur

2001 BMC ophthalmology

807. Herpes simplex virus bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma: an unusual presentation Full Text available with Trip Pro

Herpes simplex virus bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma: an unusual presentation To report an unusual case of herpetic bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma.A retrospective analysis of the case record of a 60-year-old man who had earlier undergone bilateral cataract surgery, was done. He presented with a complaint of decrease in vision in the right eye of 20 days (...) duration. On examination, cornea showed epithelial bullae all over the surface with stromal and epithelial edema. Intraocular pressure was 30 mm of Hg in RE. He was treated with anti-glaucoma medications. Two dendritic lesions were seen in the cornea during a subsequent visit four days later. Virological investigations confirmed a diagnosis of Herpes simplex keratitis. He was treated with topical acyclovir.This case highlights the fact that herpes simplex keratitis can present initially as a more

2001 BMC ophthalmology

808. Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis Full Text available with Trip Pro

Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis 11914228 2002 05 22 2018 11 13 0007-1161 86 4 2002 Apr The British journal of ophthalmology Br J Ophthalmol Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. 478-9 Siverio C D CD Jr Whitcher J P JP eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Adult Corneal Ulcer virology Haemophilus Infections (...) complications Haemophilus influenzae Humans Keratitis, Dendritic complications Keratoconjunctivitis, Infectious virology Male 2002 3 27 10 0 2002 5 25 10 1 2002 3 27 10 0 ppublish 11914228 PMC1771094 Am J Ophthalmol. 1980 Jul;90(1):38-47 7395957 Arch Ophthalmol. 1982 Jan;100(1):77-80 6173033 Br J Ophthalmol. 1982 Jun;66(6):357-60 7082605 CLAO J. 1996 Jul;22(3):213-4 8828940 Br J Ophthalmol. 1985 Dec;69(12):920-6 3936534 Am J Ophthalmol. 1991 Jan 15;111(1):92-9 1985498 Am J Ophthalmol. 1991 Apr 15;111(4):466

2002 The British journal of ophthalmology

809. Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers Full Text available with Trip Pro

Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV x C57BL/6)F(2) mice were generated and examined for their disease susceptibility in terms of clinical

2002 Journal of virology

810. Herpes simplex keratitis in renal transplant recipients. Full Text available with Trip Pro

Herpes simplex keratitis in renal transplant recipients. Herpes simplex epithelial keratitis developed in four renal transplant recipients while they were receiving high-dose systemic corticosteroid and immunosuppressive therapy. In all cases the presentation was atypical, and in two cases the course was protracted, leading to some visual loss from corneal scarring and opacification. With the immunocompromised patient it is important to seek early ophthalmologic consultation when even minor

1981 Canadian Medical Association Journal

811. Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine. Full Text available with Trip Pro

Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine. Systemic vaccination of rabbits with an inactivated type 1 virus subunit vaccine induced humoral and cell-mediated immune responses. Following ocular infection with type 1 herpes virus corneal ulceration and virus excretion were reduced in the vaccinated rabbits.

1981 The British journal of ophthalmology

812. Herpes simplex keratitis in renal transplant patients. Full Text available with Trip Pro

Herpes simplex keratitis in renal transplant patients. Five out of 430 patients (1.16%) undergoing kidney transplantation developed an atypical clinical picture of herpetic dendritic keratitis within four weeks after surgery. It was manifested by multiple dendrites, located mainly in the corneal periphery or the limbus, developing in relatively uninflamed eyes. The response to acyclovir therapy was prolonged and took at least three weeks. Additionally, subepithelial infiltrates with ultimate

1991 The British journal of ophthalmology

813. Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. Full Text available with Trip Pro

Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. 7908153 1994 04 26 2018 11 13 0065-9533 91 1993 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. 325-48; discussion 349-50 Foster C S CS Hilles Immunology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston. Rodriguez Garcia A A Pedroza-Seres M M Berra (...) A A Heiligenhaus A A Soukiasian S S Jayaraman S S eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Lymphokines 0 Receptors, Antigen, T-Cell, alpha-beta 0 Viral Envelope Proteins 0 glycoprotein D, Human herpesvirus 1 IM Animals CD4-Positive T-Lymphocytes immunology Cell Line Clone Cells Corneal Stroma microbiology Disease Models, Animal Female Herpesvirus 1, Human immunology Immunoenzyme Techniques Immunophenotyping Immunotherapy, Adoptive Incidence Keratitis, Herpetic immunology

1993 Transactions of the American Ophthalmological Society

814. Herpes simplex keratitis in renal transplant patients. Full Text available with Trip Pro

Herpes simplex keratitis in renal transplant patients. 1751473 1992 01 28 2018 11 13 0007-1161 75 11 1991 Nov The British journal of ophthalmology Br J Ophthalmol Herpes simplex keratitis in renal transplant patients. 704 Robin J B JB eng Comment Letter England Br J Ophthalmol 0421041 0007-1161 IM X Br J Ophthalmol. 1991 Feb;75(2):94-6 1995052 Acquired Immunodeficiency Syndrome complications Cornea pathology Humans Keratitis, Herpetic complications Kidney Transplantation Postoperative

1991 The British journal of ophthalmology

815. Oral antiviral drugs in experimental herpes simplex keratitis. Full Text available with Trip Pro

Oral antiviral drugs in experimental herpes simplex keratitis. Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears.

1983 Antimicrobial Agents and Chemotherapy

816. Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. Full Text available with Trip Pro

Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. 6288065 1982 12 03 2018 11 13 0007-1161 66 10 1982 Oct The British journal of ophthalmology Br J Ophthalmol Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. 643-7 Shimeld C C Tullo A B AB Easty D L DL Thomsitt J J eng Case Reports Journal Article Research Support, Non-U.S. Gov't England Br J Ophthalmol 0421041 0007-1161 IM Adult Cornea microbiology ultrastructure Female Humans (...) Keratitis microbiology pathology Male Microscopy, Electron Middle Aged Simplexvirus isolation & purification ultrastructure 1982 10 1 1982 10 1 0 1 1982 10 1 0 0 ppublish 6288065 PMC1039889 Trans Ophthalmol Soc U K. 1977 Jul;97(2):305-13 345532 Arch Ophthalmol. 1972 Oct;88(4):412-7 4342439 Lancet. 1976 Dec 18;2(7999):1364-5 63844 Med Microbiol Immunol. 1981;169(2):91-6 6261108 Surv Ophthalmol. 1976 Sep-Oct;21(2):121-35 988644 Am J Ophthalmol. 1964 Apr;57:551-64 14141470 Arch Ophthalmol. 1968 Jun;79(6

1982 The British journal of ophthalmology

817. Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation. Full Text available with Trip Pro

Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation. To report promoted healing of acute ulcerative and necrotising herpetic keratitis after amniotic membrane transplantation (AMT).Retrospective, non-comparative case series of seven patients with acute ulcerative and necrotising herpetic stromal keratitis. Single or multilayer AMT with epithelial side facing up was performed. The main outcome measures were wound healing (...) of patients, these findings indicate that the AMT shows promise in selected cases for the restoration of ocular surface integrity, reduction of stromal inflammation, and improvement of vision in acute ulcerative and necrotising herpetic keratitis.

2003 British Journal of Ophthalmology

818. Restricted T cell receptor beta-chain variable region protein use by cornea-derived CD4+ and CD8+ herpes simplex virus-specific T cells in patients with herpetic stromal keratitis. Full Text available with Trip Pro

Restricted T cell receptor beta-chain variable region protein use by cornea-derived CD4+ and CD8+ herpes simplex virus-specific T cells in patients with herpetic stromal keratitis. Herpetic stromal keratitis (HSK) is a T helper type 1 cell-mediated inflammatory disease triggered by herpes simplex virus (HSV) infection of the cornea. In contrast to animal models of HSK, little is known about the role of T cells in human HSK. The phenotypes and repertoires of HSV-specific T cells recovered from

2003 Journal of Infectious Diseases

819. Secretory IgA specific for herpes simplex virus in lacrimal fluid from patients with herpes keratitis--a possible diagnostic parameter. Full Text available with Trip Pro

Secretory IgA specific for herpes simplex virus in lacrimal fluid from patients with herpes keratitis--a possible diagnostic parameter. In the present study a solid-phase radioimmune assay was used for the demonstration of herpes simplex virus-specific IgG and secretory IgA antibodies in the lacrimal fluid from patients with active recurrent herpes keratitis. The method was quantitative and made it possible to test specifically for the production of secretory IgA antibodies produced during (...) an active herpes simplex virus infection. The production of secretory IgA was followed in 2 patients with fresh recurrent lesions. The HSV-specific secretory IgA could be demonstrated during the first 10 days of infection, where the maximal concentration was reached 3-5 days after the first symptoms occurred. The secretory antibodies were locally produced, and it is shown for the first time that herpes virus-specific secretory antibodies were of diagnostic value.

1982 The British journal of ophthalmology

820. Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (Abstract)

Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. To investigate the effect of oral acyclovir therapy for recurrences of herpes simplex virus (HSV) epithelial keratitis and stromal keratitis and to determine if certain patients derive differential benefit.This randomized, double-masked clinical trial enrolled 703 immunocompetent patients with prior HSV eye disease within the preceding year (...) epithelial keratitis (rate ratio, 0.62; 95% confidence interval, 0.39-0.97) and stromal keratitis (rate ratio, 0. 57; 95% confidence interval, 0.36-0.89). Although a relative benefit of treatment on preventing any type of recurrence was present in most subgroups, the magnitude of absolute benefit was greatest among patients with the highest number of prior episodes of ocular HSV disease. The benefit in preventing stromal keratitis was seen solely among patients with a history of stromal keratitis.Long

2000 Archives of ophthalmology Controlled trial quality: predicted high

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