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Herpes Simplex Keratitis

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801. Herpes simplex virus bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma: an unusual presentation (Full text)

Herpes simplex virus bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma: an unusual presentation To report an unusual case of herpetic bullous keratitis misdiagnosed as a case of pseudophakic bullous keratopathy with secondary glaucoma.A retrospective analysis of the case record of a 60-year-old man who had earlier undergone bilateral cataract surgery, was done. He presented with a complaint of decrease in vision in the right eye of 20 days (...) duration. On examination, cornea showed epithelial bullae all over the surface with stromal and epithelial edema. Intraocular pressure was 30 mm of Hg in RE. He was treated with anti-glaucoma medications. Two dendritic lesions were seen in the cornea during a subsequent visit four days later. Virological investigations confirmed a diagnosis of Herpes simplex keratitis. He was treated with topical acyclovir.This case highlights the fact that herpes simplex keratitis can present initially as a more

2001 BMC ophthalmology

802. Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis (Full text)

Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis 11914228 2002 05 22 2018 11 13 0007-1161 86 4 2002 Apr The British journal of ophthalmology Br J Ophthalmol Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. 478-9 Siverio C D CD Jr Whitcher J P JP eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Adult Corneal Ulcer virology Haemophilus Infections (...) complications Haemophilus influenzae Humans Keratitis, Dendritic complications Keratoconjunctivitis, Infectious virology Male 2002 3 27 10 0 2002 5 25 10 1 2002 3 27 10 0 ppublish 11914228 PMC1771094 Am J Ophthalmol. 1980 Jul;90(1):38-47 7395957 Arch Ophthalmol. 1982 Jan;100(1):77-80 6173033 Br J Ophthalmol. 1982 Jun;66(6):357-60 7082605 CLAO J. 1996 Jul;22(3):213-4 8828940 Br J Ophthalmol. 1985 Dec;69(12):920-6 3936534 Am J Ophthalmol. 1991 Jan 15;111(1):92-9 1985498 Am J Ophthalmol. 1991 Apr 15;111(4):466

2002 The British journal of ophthalmology

803. Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers (Full text)

Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers Herpes simplex keratitis (HSK) is an inflammatory response to viral infection and self antigens in the cornea and is a major cause of blindness. Using two strains of mice which are susceptible (129/SVEV) and resistant (C57BL/6) to herpes simplex virus (HSV) strain KOS, (129/SVEV x C57BL/6)F(2) mice were generated and examined for their disease susceptibility in terms of clinical

2002 Journal of virology

804. Herpes simplex keratitis in renal transplant recipients. (Full text)

Herpes simplex keratitis in renal transplant recipients. Herpes simplex epithelial keratitis developed in four renal transplant recipients while they were receiving high-dose systemic corticosteroid and immunosuppressive therapy. In all cases the presentation was atypical, and in two cases the course was protracted, leading to some visual loss from corneal scarring and opacification. With the immunocompromised patient it is important to seek early ophthalmologic consultation when even minor

1981 Canadian Medical Association Journal

805. Oral antiviral drugs in experimental herpes simplex keratitis. (Full text)

Oral antiviral drugs in experimental herpes simplex keratitis. Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears.

1983 Antimicrobial Agents and Chemotherapy

806. Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. (Full text)

Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. 6288065 1982 12 03 2018 11 13 0007-1161 66 10 1982 Oct The British journal of ophthalmology Br J Ophthalmol Isolation of herpes simplex virus from the cornea in chronic stromal keratitis. 643-7 Shimeld C C Tullo A B AB Easty D L DL Thomsitt J J eng Case Reports Journal Article Research Support, Non-U.S. Gov't England Br J Ophthalmol 0421041 0007-1161 IM Adult Cornea microbiology ultrastructure Female Humans (...) Keratitis microbiology pathology Male Microscopy, Electron Middle Aged Simplexvirus isolation & purification ultrastructure 1982 10 1 1982 10 1 0 1 1982 10 1 0 0 ppublish 6288065 PMC1039889 Trans Ophthalmol Soc U K. 1977 Jul;97(2):305-13 345532 Arch Ophthalmol. 1972 Oct;88(4):412-7 4342439 Lancet. 1976 Dec 18;2(7999):1364-5 63844 Med Microbiol Immunol. 1981;169(2):91-6 6261108 Surv Ophthalmol. 1976 Sep-Oct;21(2):121-35 988644 Am J Ophthalmol. 1964 Apr;57:551-64 14141470 Arch Ophthalmol. 1968 Jun;79(6

1982 The British journal of ophthalmology

807. Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine. (Full text)

Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine. Systemic vaccination of rabbits with an inactivated type 1 virus subunit vaccine induced humoral and cell-mediated immune responses. Following ocular infection with type 1 herpes virus corneal ulceration and virus excretion were reduced in the vaccinated rabbits.

1981 The British journal of ophthalmology

808. Herpes simplex keratitis in renal transplant patients. (Full text)

Herpes simplex keratitis in renal transplant patients. Five out of 430 patients (1.16%) undergoing kidney transplantation developed an atypical clinical picture of herpetic dendritic keratitis within four weeks after surgery. It was manifested by multiple dendrites, located mainly in the corneal periphery or the limbus, developing in relatively uninflamed eyes. The response to acyclovir therapy was prolonged and took at least three weeks. Additionally, subepithelial infiltrates with ultimate

1991 The British journal of ophthalmology

809. Herpes simplex keratitis in renal transplant patients. (Full text)

Herpes simplex keratitis in renal transplant patients. 1751473 1992 01 28 2018 11 13 0007-1161 75 11 1991 Nov The British journal of ophthalmology Br J Ophthalmol Herpes simplex keratitis in renal transplant patients. 704 Robin J B JB eng Comment Letter England Br J Ophthalmol 0421041 0007-1161 IM X Br J Ophthalmol. 1991 Feb;75(2):94-6 1995052 Acquired Immunodeficiency Syndrome complications Cornea pathology Humans Keratitis, Herpetic complications Kidney Transplantation Postoperative

1991 The British journal of ophthalmology

810. Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. (Full text)

Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. 7908153 1994 04 26 2018 11 13 0065-9533 91 1993 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Murine herpes simplex virus keratitis is accentuated by CD4+, V beta 8.2+ Th2 T cells. 325-48; discussion 349-50 Foster C S CS Hilles Immunology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston. Rodriguez Garcia A A Pedroza-Seres M M Berra (...) A A Heiligenhaus A A Soukiasian S S Jayaraman S S eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Lymphokines 0 Receptors, Antigen, T-Cell, alpha-beta 0 Viral Envelope Proteins 0 glycoprotein D, Human herpesvirus 1 IM Animals CD4-Positive T-Lymphocytes immunology Cell Line Clone Cells Corneal Stroma microbiology Disease Models, Animal Female Herpesvirus 1, Human immunology Immunoenzyme Techniques Immunophenotyping Immunotherapy, Adoptive Incidence Keratitis, Herpetic immunology

1993 Transactions of the American Ophthalmological Society

811. A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis. (PubMed)

A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis. 7043864 1982 07 22 2018 11 13 0065-9533 79 1981 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis. 168-79 Yeakley W R WR Laibson P R PR Michelson M A MA Arentsen J J JJ eng Clinical Trial Comparative Study Journal Article Randomized (...) Controlled Trial United States Trans Am Ophthalmol Soc 7506106 0065-9533 0 Ointments 5Z93L87A1R Guanine 66341-16-0 acyclovir monophosphate FA2DM6879K Vidarabine X4HES1O11F Acyclovir IM Acyclovir analogs & derivatives Adolescent Adult Aged Child Clinical Trials as Topic Double-Blind Method Female Guanine analogs & derivatives therapeutic use Humans Keratitis, Dendritic diagnosis drug therapy Male Middle Aged Ointments Vidarabine therapeutic use 1981 1 1 1981 1 1 0 1 1981 1 1 0 0 ppublish 7043864

1982 Transactions of the American Ophthalmological Society Controlled trial quality: uncertain

812. A double-blind study of the effect of 5-iodo-2'-deoxyuridine on experimental herpes simplex keratitis. (PubMed)

A double-blind study of the effect of 5-iodo-2'-deoxyuridine on experimental herpes simplex keratitis. 14023210 1998 11 01 2018 12 01 0002-9394 55 1963 Feb American journal of ophthalmology Am. J. Ophthalmol. A double-blind study of the effect of 5-iodo-2'-deoxyuridine on experimental herpes simplex keratitis. 225-9 CORWIN M E ME OKUMOTO M M THYGESON P P JAWETZ E E eng Journal Article United States Am J Ophthalmol 0370500 0002-9394 14259-58-6 5'-deoxy-5'-iodouridine LGP81V5245 Idoxuridine OM (...) Double-Blind Method Humans Idoxuridine Keratitis Keratitis, Dendritic Keratitis, Herpetic IDOXURIDINE KERATITIS, DENDRITIC 1963 2 1 1963 2 1 0 1 1963 2 1 0 0 ppublish 14023210 0002-9394(63)92672-2

1998 American Journal of Ophthalmology Controlled trial quality: uncertain

813. A DOUBLE-BLIND STUDY OF IDU IN HUMAN HERPES SIMPLEX KERATITIS. (PubMed)

A DOUBLE-BLIND STUDY OF IDU IN HUMAN HERPES SIMPLEX KERATITIS. 14048801 1996 12 01 2018 12 01 0003-9950 70 1963 Sep Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. A DOUBLE-BLIND STUDY OF IDU IN HUMAN HERPES SIMPLEX KERATITIS. 381-4 BURNS R P RP eng Journal Article United States Arch Ophthalmol 7706534 0003-9950 0 Fluoresceins 0 Placebos LGP81V5245 Idoxuridine OM Double-Blind Method Erythema Fluoresceins Humans Idoxuridine Iritis Keratitis Keratitis, Dendritic Keratitis (...) , Herpetic Light Pain Placebos Tears Toxicology ERYTHEMA FLUORESCEINS IDOXURIDINE IRITIS KERATITIS, DENDRITIC LIGHT PAIN PLACEBOS TEARS TOXICOLOGIC REPORT 1963 9 1 1963 9 1 0 1 1963 9 1 0 0 ppublish 14048801

1996 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

814. Prevention of herpes simplex keratitis and iritis. (PubMed)

Prevention of herpes simplex keratitis and iritis. 9488290 1998 03 09 2015 04 17 0003-9950 116 2 1998 Feb Archives of ophthalmology (Chicago, Ill. : 1960) Arch. Ophthalmol. Prevention of herpes simplex keratitis and iritis. 259 Bachman D M DM eng Clinical Trial Comment Letter Randomized Controlled Trial United States Arch Ophthalmol 7706534 0003-9950 0 Antiviral Agents X4HES1O11F Acyclovir AIM IM Arch Ophthalmol. 1997 Jun;115(6):703-12 9194719 Acyclovir administration & dosage Administration (...) , Oral Antiviral Agents administration & dosage Clinical Trials as Topic Humans Iritis prevention & control Keratitis, Herpetic prevention & control Recurrence 1998 3 6 1998 3 6 0 1 1998 3 6 0 0 ppublish 9488290

1998 Archives of ophthalmology (Chicago, Ill. : 1960) Controlled trial quality: uncertain

815. Secretory IgA specific for herpes simplex virus in lacrimal fluid from patients with herpes keratitis--a possible diagnostic parameter. (Full text)

Secretory IgA specific for herpes simplex virus in lacrimal fluid from patients with herpes keratitis--a possible diagnostic parameter. In the present study a solid-phase radioimmune assay was used for the demonstration of herpes simplex virus-specific IgG and secretory IgA antibodies in the lacrimal fluid from patients with active recurrent herpes keratitis. The method was quantitative and made it possible to test specifically for the production of secretory IgA antibodies produced during (...) an active herpes simplex virus infection. The production of secretory IgA was followed in 2 patients with fresh recurrent lesions. The HSV-specific secretory IgA could be demonstrated during the first 10 days of infection, where the maximal concentration was reached 3-5 days after the first symptoms occurred. The secretory antibodies were locally produced, and it is shown for the first time that herpes virus-specific secretory antibodies were of diagnostic value.

1982 The British journal of ophthalmology

816. Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. (PubMed)

Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. To investigate the effect of oral acyclovir therapy for recurrences of herpes simplex virus (HSV) epithelial keratitis and stromal keratitis and to determine if certain patients derive differential benefit.This randomized, double-masked clinical trial enrolled 703 immunocompetent patients with prior HSV eye disease within the preceding year (...) epithelial keratitis (rate ratio, 0.62; 95% confidence interval, 0.39-0.97) and stromal keratitis (rate ratio, 0. 57; 95% confidence interval, 0.36-0.89). Although a relative benefit of treatment on preventing any type of recurrence was present in most subgroups, the magnitude of absolute benefit was greatest among patients with the highest number of prior episodes of ocular HSV disease. The benefit in preventing stromal keratitis was seen solely among patients with a history of stromal keratitis.Long

2000 Archives of ophthalmology Controlled trial quality: predicted high

817. A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. (PubMed)

A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. To evaluate the efficacy of oral acyclovir in preventing stromal keratitis or iritis in patients with epithelial keratitis caused by herpes simplex virus (HSV).Patients with HSV epithelial keratitis of 1-week or less duration were treated with topical trifluridine and were randomly (...) assigned to receive a 3-week course of oral acyclovir, 400 mg 5 times a day (hereafter referred to as the acyclovir group), or placebo (hereafter referred to as the placebo group). The development of HSV stromal keratitis or iritis was assessed during 12 months of follow-up.Stromal keratitis or iritis developed in 17 (11%) of the 153 patients in the acyclovir group and in 14 (10%) of the 134 patients in the placebo group. Compared with the placebo group, the adjusted rate ratio for the development

1997 Archives of ophthalmology Controlled trial quality: predicted high

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