How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

817 results for

Herpes Simplex Keratitis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Herpes simplex - ocular

Herpes simplex - ocular Herpes simplex - ocular - NICE CKS Share Herpes simplex - ocular: Summary Herpes simplex virus (HSV) ocular infections can cause inflammation of the retina (retinitis), iris and associated uveal tract (iritis or uveitis), cornea (keratitis), conjunctiva (conjunctivitis), eyelids (blepharitis), and surrounding skin (periocular dermatitis). Infection is usually caused by HSV type 1 (HSV-1), and rarely by HSV-2. The majority of primary HSV ocular infection is asymptomatic (...) within 2 weeks, and epithelial keratitis tends to resolve in 1–2 weeks. About 25% of people with epithelial keratitis will develop stromal keratitis or iritis. Recurrent ocular HSV is common, with the risk increasing after each subsequent episode. The diagnosis of suspected ocular herpes simplex infection in primary care is clinical. Symptoms and signs include: Eye pain, eye irritation or watering, and photophobia. Blurred vision. An acute red eye. Crops of vesicles, ulcers, or pustules along the lid

2016 NICE Clinical Knowledge Summaries

62. Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. (Full text)

Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. Herpes simplex virus (HSV) is associated with a variety of ocular diseases, including epithelial and stromal keratitis. HSV can cause stromal opacification and is believed to be the leading cause of infectious blindness in the developed world. An improved understanding of the global burden of HSV keratitis, including the incidence of severe vision loss, could have a significant effect on prevention and treatment and place (...) it in perspective among causes of corneal ulceration. We found that the global incidence of HSV keratitis is roughly 1.5 million, including 40,000 new cases of severe monocular visual impairment or blindness each year. We also discuss relevant epidemiologic issues regarding HSV epithelial and stromal disease.Copyright © 2012 Elsevier Inc. All rights reserved.

2012 Survey of Ophthalmology

63. Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. (PubMed)

Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. The novel immunochromatographic assay (ICGA) kit was recently developed to diagnose herpes simplex virus (HSV) infection. This multicentre study aimed to evaluate the value of the ICGA kit for the diagnosis of herpetic epithelial keratitis by comparing it with immunofluorescence assay (IFA) and real-time PCR.Corneal scrapings were collected from 117 patients (...) , including 77 with herpetic keratitis as their final clinical diagnosis as well as 40 others at 21 facilities. These samples were tested by the ICGA kit, IFA and real-time PCR.The positive concordance between final clinical diagnosis and ICGA was 46.7% (35/75 cases) and the negative concordance was 100% (39/39). The positive and negative concordance between real-time PCR and ICGA were 57.4% (35/61 cases) and 100% (53/53), respectively. The positive and negative concordance between IFA and ICGA were 61.1

2012 British Journal of Ophthalmology

64. Herpes zoster ophthalmicus

% of patients and is: chronic and severe in about 7% Complications can occur months or years after the acute phase Differential diagnosis Ocular lesions: herpes simplex keratitis Cutaneous lesions: cellulitis, contact dermatitis, atopic eczema, impetigo Management by Optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation always relates to the statement(s) immediately above Non (...) Herpes zoster ophthalmicus Herpes Zoster Ophthalmicus (HZO) submit The College submit You're here: Herpes Zoster Ophthalmicus (HZO) Herpes Zoster Ophthalmicus (HZO) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Varicella zoster virus (VZV), also known as human herpesvirus-3 (HHV- 3) previous

2018 College of Optometrists

65. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Herpes Simplex Keratitis Herpes (...) Simplex Keratitis Aka: Herpes Simplex Keratitis , Herpes Keratitis , Herpetic Keratitis , Herpes Simplex Conjunctivitis , HSV Conjunctivitis , Herpetic Dendrite , Dendritic Keratitis , Dendritic Ulcer From Related Chapters II. Epidemiology Outbreaks in winter and early summer III. Symptoms Previous history of Herpes Keratitis Coexisting (herpetic rash) on lip or upper face Recent Absent history of Severe Photophobia Gritty sensation in eye IV. Signs Unilateral inflammation of and Dendritic Ulcers

2015 FP Notebook

66. Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. (Full text)

(7.9%, 2.5%, respectively, P = 0.012) in the epithelial defect group was higher than in the non-defects group. Multivariate logistic regression revealed that male sex (P = 0.001), age ≥ 60 years (P = 0.024), graft diameter >9mm (P = 0.001), bacterial (P = 0.039) and herpes simplex keratitis (P = 0.008), rheumatism (P = 0.031) and cancer treated with chemo- or radiotherapy (P = 0.032) were independent risk factors for epithelial defects. Graft clarity after epithelial defects were significantly (...) Epithelial defects after penetrating keratoplasty in infectious keratitis: An analysis of characteristics and risk factors. To investigate the clinical characteristics, treatment, risk factors of occurrence and graft transparency of corneal epithelial defects after penetrating keratoplasty in patients with infectious keratitis. 594 patients (594 eyes) with infectious keratitis treated by penetrating keratoplasty at Shandong Eye Institute were reviewed retrospectively between January 2008

2018 PLoS ONE

67. Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) (Full text)

Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) Using CJLAT, a chimeric herpes simplex virus (HSV-1) that produces a high incidence of herpes stromal keratitis (HSK) in latently infected rabbits, and in vivo confocal microscopy (CM), we characterized the cellular events that precede the development of HSK.Thirty days after infection, in vivo CM was performed daily for 10 days and then weekly for up to 80 days after infection.We

2016 Cornea

68. Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis (Full text)

Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis To design, optimize and validate a rapid, internally controlled real-time polymerase chain reaction (RT-PCR) test for herpes simplex virus (HSV) in the diagnosis of necrotizing herpes stromal keratitis.Tears alone or together with corneal epithelium scrapings from 30 patients (30 eyes) suspected of necrotizing herpes stromal keratitis were tested for HSV DNA by RT-PCR. The samples were collected during (...) for the diagnosis of necrotizing herpes stromal keratitis.

2016 International journal of ophthalmology

69. A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. (Full text)

A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. We verified a multiplex dot hybridization (MDH) assay for the rapid detection and differentiation of Acanthamoeba keratitis (AK) and herpes simplex keratitis (HSK).Molecular detection of Acanthamoeba and herpes simplex virus in corneal scrapes was performed with the MDH assay and standard diagnostic methods. The experimental group included corneal scrapes (n = 33) from patients (...) with culture- or pathology-confirmed AK (n = 15) and real-time PCR-confirmed HSK (n = 16). The control group included 50 samples from cases of bacterial keratitis (n = 15), fungal keratitis (n = 15), and initially presumed AK (n = 5) or HSK (n = 17) which finally were excluded by culture for Acanthamoeba or by real-time PCR for herpes simplex virus, respectively. Discrepant results between methods were resolved by DNA sequencing of the PCR amplicons.After discrepant analysis, the sensitivity

2016 Investigative Ophthalmology & Visual Science

70. A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. (Full text)

A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Herpes simplex virus type 1 (HSV-1) is a neurotrophic virus that can cause herpes stromal keratitis (HSK), a severe corneal inflammation that can lead to corneal scarring and blindness. This study identified neurologic changes that occur in HSV-1-infected corneas and related them to HSV-1-induced immunopathology.Corneas of BALB/c and C57BL/6 mice were infected with HSV-1 strains that induce HSK. Changes in sensory nerves

2016 Investigative Ophthalmology & Visual Science

71. Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. (PubMed)

Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty with Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis. To compare long-term outcomes of full-bed deep lamellar keratoplasty (DLK) with penetrating keratoplasty (PK) for treating corneal leucoma caused by herpes simplex keratitis (HSK).Retrospective, comparative, interventional case series.setting: Institutional. patients: Inclusion criteria were patients with corneal scarring induced exclusively (...) which recurrent epithelial keratitis amounted to 13 episodes in the PK group, remarkably more frequent than the 1 episode in the full-bed DLK group. Twenty-six eyes (41.3%) encountered rejection episodes in the PK group, but no rejection episode was found in the full-bed DLK group (P < .001). In 14 eyes in the PK group, graft failure developed because of graft rejection, recurrence of HSK, or both, whereas only in 1 eye in the full-bed DLK group did graft failure develop because of recurrence of HSK

2011 American Journal of Ophthalmology

72. Herpes Zoster - Treatment

,Nikkels AF.Chronic mucocutaneous herpes simplex virusandvaricella zoster virus infections. JAm Acad Dermatol 2012; 66: e217–e227. 45 Breton G, Fillet AM, Katlama C,BricaireF,CaumesE. Acyclovir-resistant herpeszosterinhuman immunode?ciency virus-infected patients: results offoscarnet therapy. ClinInfect Dis1998; 27: 1525–1527. 46 Schliefer K,Gumbel HO,Rockstroh JK,SpenglerU.Managementofpro- gressive outerretinal necrosis withcidofovir ina human immunode?- ciency virus-infected patient. Clin Infect Dis (...) Herpes Zoster - Treatment GUIDELINES Europeanconsensus-based(S2k)Guidelineonthe ManagementofHerpesZoster –guidedbytheEuropean DermatologyForum(EDF)incooperationwiththeEuropean AcademyofDermatologyandVenereology(EADV),Part2: Treatment R.N.Werner, 1, *A.F.Nikkels, 2 B.Marinovi c, 3 M.Sch€ afer, 4 M.Czarnecka-Operacz, 5 A.M.Agius, 6 Z.Bata-Cs€ org} o, 7 J.Breuer, 8 G.Girolomoni, 9 G.E.Gross, 10 S.Langan, 11 R.Lapid-Gortzak, 12 T.H.Lesser, 13 U.Pleyer, 14 J.Sellner, 15 G.M.Verjans, 16 P.Wutzler, 17

2017 European Dermatology Forum

73. Herpes Zoster - Diagnosis

(Table 2). However, polymerase chain reaction (PCR) studies demonstrated that the differential diagnosis with zosteriform herpes simplex virus (HSV) infections is erroneous in up to 4–20%. 26–29 Therefore, laboratory testing is suggested in the event of diagnostic uncertainty, particularly in case of HZ of the face and genital areas, as these areas are the natural sites for recurrent labial and genital herpes respectively (Table 2). Atypical mucocutaneous forms are clinically dif?cult to diag- nose (...) ClinVirol 2003; 26:277–289; discussion 91-3. 25 Zerngast WW, Paauw DS, O’Connor KM. Varicellazoster with extended prodrome: acase series.Am J Med 2013;126: 359–361. 26 Kalman CM, Laskin OL. Herpes zoster and zosteriform herpes simplex virus infections in immunocompetent adults. Am JMed 1986;81: 775– 778. 27 Rubben A,Baron JM, Grussendorf-Conen EI.Routinedetection of her- pessimplex virus and varicella zoster virus by polymerase chain reaction reveals that initial herpeszoster is frequently misdiagnosed

2017 European Dermatology Forum

74. Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis (Full text)

Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

1975 Antimicrobial Agents and Chemotherapy

75. Experimental stromal herpes simplex keratitis in rabbits. (Full text)

Experimental stromal herpes simplex keratitis in rabbits. 4295148 1968 03 30 2018 11 13 0065-9533 65 1967 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Experimental stromal herpes simplex keratitis in rabbits. 189-210 Irvine A R AR Kimura S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 IM Animals Anterior Chamber pathology Antibody Formation Blood Cell Count Cornea pathology Hypersensitivity Iritis immunology Keratitis

1967 Transactions of the American Ophthalmological Society

76. Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis (Full text)

Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis Treatment of established experimental keratitis caused by herpes simplex virus with 9-beta-d-arabinofuranosyladenine 5'-monophosphate (Ara-AMP) or 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP (...) showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.

1976 Antimicrobial Agents and Chemotherapy

77. Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid (Full text)

Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid Fifty strains of herpes simplex virus, isolated from patients with herpetic keratitis, were examined in vitro for susceptibility to polyinosinic acid-polycytidylic acid [poly(I:C)] in the presence of a constant concentration of diethylaminoethyl-dextran. The minimal inhibitory concentration of poly(I:C) for 44 of these strains ranged from 0.0001 to 0.1 mug/ml; for the remaining

1977 Antimicrobial Agents and Chemotherapy

78. Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. (Full text)

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest (...) that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.

1977 The British journal of ophthalmology

79. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. (Full text)

Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte

1977 Infection and immunity

80. Histopathology of human superficial herpes simplex keratitis. (Full text)

Histopathology of human superficial herpes simplex keratitis. In vivo corneal replicas were made in 20 cases of patients with superficial dendritic ulcers of the cornea. Histopathological study of the replicas and superficial epithelial cells showed that the dendrites are composed of rounded epithelial cells and variable sized syncytia containing bizarre shaped nuclei. Pseudopodia-like processes containing DNA and some RNA extend from the syncytia into the surrounding epithelial cells, which

1978 The British journal of ophthalmology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>