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Herpes Simplex Keratitis

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61. Keratitis, Herpes Simplex (Overview)

Keratitis, Herpes Simplex (Overview) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes (...) Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

62. Keratitis, Herpes Simplex (Treatment)

Keratitis, Herpes Simplex (Treatment) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

63. Keratitis, Herpes Simplex (Follow-up)

Keratitis, Herpes Simplex (Follow-up) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

64. Keratitis, Herpes Simplex (Diagnosis)

Keratitis, Herpes Simplex (Diagnosis) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing (...) > Herpes Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

65. Herpes zoster ophthalmicus

% of patients and is: chronic and severe in about 7% Complications can occur months or years after the acute phase Differential diagnosis Ocular lesions: herpes simplex keratitis Cutaneous lesions: cellulitis, contact dermatitis, atopic eczema, impetigo Management by Optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation always relates to the statement(s) immediately above Non (...) Herpes zoster ophthalmicus Herpes Zoster Ophthalmicus (HZO) submit The College submit You're here: Herpes Zoster Ophthalmicus (HZO) Herpes Zoster Ophthalmicus (HZO) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Varicella zoster virus (VZV), also known as human herpesvirus-3 (HHV- 3) previous

2020 College of Optometrists

66. Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. Full Text available with Trip Pro

Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. Herpes keratitis (HK) remains the leading cause of cornea-derived blindness in the developed world, despite the availability of effective antiviral drugs. Treatment toxicity and the emergence of drug resistance highlight the need for additional therapeutic approaches. This study examined ataxia telangiectasia mutated (ATM), an apical kinase in the host DNA damage response (...) , as a potential new target for the treatment of HK.Small molecule inhibitor of ATM (KU-55933) was used to treat herpes simplex virus type 1 (HSV-1) infection in three experimental models: (1) in vitro--cultured human corneal epithelial cells, hTCEpi, (2) ex vivo--organotypically explanted human and rabbit corneas, and (3) in vivo--corneal infection in young C57BL/6J mice. Infection productivity was assayed by plaque assay, real-time PCR, Western blot, and disease scoring.Robust ATM activation was detected

2013 Investigative Ophthalmology & Visual Science

67. Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. Full Text available with Trip Pro

Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. To analyse high-order aberrations (HOA), modulation transfer function (MTF) and Strehl ratio in patients with a history of herpes simplex keratitis (HSK) and apparently normal vision.Fifteen patients with a history of recurrent unilateral HSK and normal Snellen visual acuity (0 logMAR) were enrolled. Eyes with HSK (HSK group) were statistically compared with normal fellow eyes (Control group (...) ). HOA, MTF and Strehl ratio were measured using the OPD-SCAN II (Nidek Co, Gamagori, Japan) aberrometer. Measures were performed at least 3 months after the last episode of herpes. Statistical significance was indicated by p<0.05.Despite apparently normal vision in both eyes (as assessed by routine visual acuity charts), significantly higher total HOA, trefoil and tetrafoil were present in the HSK group compared with the Control group. The MTF and strehl ratio were lower in the HSK group compared

2013 British Journal of Ophthalmology

68. Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient. Full Text available with Trip Pro

Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient. We investigated thymidine kinase (tk) mutants isolated during multiple episodes of recurrent bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient. From one eye, we found a single guanine insertion, previously shown to greatly reduce TK expression, and from the other, a previously unidentified substitution, which genetic (...) experiments confirmed confers drug resistance. The substitution, although distant from substrate binding sites, reduced thymidine phosphorylation 10-20-fold, and acyclovir phosphorylation >100-fold. This phenotype should permit reactivation from latency to cause recurrent disease. The results may have implications for the prevalence and prevention of acyclovir resistance in patients with herpes simplex keratitis.

2013 Journal of Infectious Diseases

69. Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Full Text available with Trip Pro

Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Parallel comparison with 0.15% ganciclovir (GCV) ophthalmic gel to evaluate the effectiveness and safety of 0.15% GCV in situ ophthalmic gel for the treatment of herpes simplex keratitis (HSK).This was a multicenter, randomized, investigator-masked, parallel group study. HSK patients were randomly divided

2013 Drug design, development and therapy Controlled trial quality: uncertain

70. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Herpes Simplex Keratitis Herpes (...) Simplex Keratitis Aka: Herpes Simplex Keratitis , Herpes Keratitis , Herpetic Keratitis , Herpes Simplex Conjunctivitis , HSV Conjunctivitis , Herpetic Dendrite , Dendritic Keratitis , Dendritic Ulcer From Related Chapters II. Epidemiology Outbreaks in winter and early summer III. Symptoms Previous history of Herpes Keratitis Coexisting (herpetic rash) on lip or upper face Recent Absent history of Severe Photophobia Gritty sensation in eye IV. Signs Unilateral inflammation of and Dendritic Ulcers

2015 FP Notebook

71. Role of TH17 Responses in Increasing Herpetic Keratitis in the Eyes of Mice Infected with HSV-1. Full Text available with Trip Pro

Role of TH17 Responses in Increasing Herpetic Keratitis in the Eyes of Mice Infected with HSV-1. TH17 cells play an important role in host defense and autoimmunity yet very little is known about the role of IL17 in herpes simplex virus (HSV)-1 infectivity. To better understand the relationship between IL17 and HSV-1 infection, we assessed the relative impact of IL17A-deficiency and deficiency of its receptors on HSV-1 responses in vivo.We generated IL17RA-/- and IL17RA-/-RC-/- mice in-house

2020 Investigative Ophthalmology & Visual Science

72. Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) Full Text available with Trip Pro

Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) Using CJLAT, a chimeric herpes simplex virus (HSV-1) that produces a high incidence of herpes stromal keratitis (HSK) in latently infected rabbits, and in vivo confocal microscopy (CM), we characterized the cellular events that precede the development of HSK.Thirty days after infection, in vivo CM was performed daily for 10 days and then weekly for up to 80 days after infection.We

2016 Cornea

73. Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis Full Text available with Trip Pro

Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis To design, optimize and validate a rapid, internally controlled real-time polymerase chain reaction (RT-PCR) test for herpes simplex virus (HSV) in the diagnosis of necrotizing herpes stromal keratitis.Tears alone or together with corneal epithelium scrapings from 30 patients (30 eyes) suspected of necrotizing herpes stromal keratitis were tested for HSV DNA by RT-PCR. The samples were collected during (...) for the diagnosis of necrotizing herpes stromal keratitis.

2016 International journal of ophthalmology

74. A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. Full Text available with Trip Pro

A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. We verified a multiplex dot hybridization (MDH) assay for the rapid detection and differentiation of Acanthamoeba keratitis (AK) and herpes simplex keratitis (HSK).Molecular detection of Acanthamoeba and herpes simplex virus in corneal scrapes was performed with the MDH assay and standard diagnostic methods. The experimental group included corneal scrapes (n = 33) from patients (...) with culture- or pathology-confirmed AK (n = 15) and real-time PCR-confirmed HSK (n = 16). The control group included 50 samples from cases of bacterial keratitis (n = 15), fungal keratitis (n = 15), and initially presumed AK (n = 5) or HSK (n = 17) which finally were excluded by culture for Acanthamoeba or by real-time PCR for herpes simplex virus, respectively. Discrepant results between methods were resolved by DNA sequencing of the PCR amplicons.After discrepant analysis, the sensitivity

2016 Investigative Ophthalmology & Visual Science

75. A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Full Text available with Trip Pro

A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Herpes simplex virus type 1 (HSV-1) is a neurotrophic virus that can cause herpes stromal keratitis (HSK), a severe corneal inflammation that can lead to corneal scarring and blindness. This study identified neurologic changes that occur in HSV-1-infected corneas and related them to HSV-1-induced immunopathology.Corneas of BALB/c and C57BL/6 mice were infected with HSV-1 strains that induce HSK. Changes in sensory nerves

2016 Investigative Ophthalmology & Visual Science

76. Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. (Abstract)

Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. The novel immunochromatographic assay (ICGA) kit was recently developed to diagnose herpes simplex virus (HSV) infection. This multicentre study aimed to evaluate the value of the ICGA kit for the diagnosis of herpetic epithelial keratitis by comparing it with immunofluorescence assay (IFA) and real-time PCR.Corneal scrapings were collected from 117 patients (...) , including 77 with herpetic keratitis as their final clinical diagnosis as well as 40 others at 21 facilities. These samples were tested by the ICGA kit, IFA and real-time PCR.The positive concordance between final clinical diagnosis and ICGA was 46.7% (35/75 cases) and the negative concordance was 100% (39/39). The positive and negative concordance between real-time PCR and ICGA were 57.4% (35/61 cases) and 100% (53/53), respectively. The positive and negative concordance between IFA and ICGA were 61.1

2012 British Journal of Ophthalmology

77. Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. Full Text available with Trip Pro

Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. Herpes simplex virus (HSV) is associated with a variety of ocular diseases, including epithelial and stromal keratitis. HSV can cause stromal opacification and is believed to be the leading cause of infectious blindness in the developed world. An improved understanding of the global burden of HSV keratitis, including the incidence of severe vision loss, could have a significant effect on prevention and treatment and place (...) it in perspective among causes of corneal ulceration. We found that the global incidence of HSV keratitis is roughly 1.5 million, including 40,000 new cases of severe monocular visual impairment or blindness each year. We also discuss relevant epidemiologic issues regarding HSV epithelial and stromal disease.Copyright © 2012 Elsevier Inc. All rights reserved.

2012 Survey of Ophthalmology

78. Herpes Zoster - Diagnosis

(Table 2). However, polymerase chain reaction (PCR) studies demonstrated that the differential diagnosis with zosteriform herpes simplex virus (HSV) infections is erroneous in up to 4–20%. 26–29 Therefore, laboratory testing is suggested in the event of diagnostic uncertainty, particularly in case of HZ of the face and genital areas, as these areas are the natural sites for recurrent labial and genital herpes respectively (Table 2). Atypical mucocutaneous forms are clinically dif?cult to diag- nose (...) ClinVirol 2003; 26:277–289; discussion 91-3. 25 Zerngast WW, Paauw DS, O’Connor KM. Varicellazoster with extended prodrome: acase series.Am J Med 2013;126: 359–361. 26 Kalman CM, Laskin OL. Herpes zoster and zosteriform herpes simplex virus infections in immunocompetent adults. Am JMed 1986;81: 775– 778. 27 Rubben A,Baron JM, Grussendorf-Conen EI.Routinedetection of her- pessimplex virus and varicella zoster virus by polymerase chain reaction reveals that initial herpeszoster is frequently misdiagnosed

2017 European Dermatology Forum

79. Herpes Zoster - Treatment

,Nikkels AF.Chronic mucocutaneous herpes simplex virusandvaricella zoster virus infections. JAm Acad Dermatol 2012; 66: e217–e227. 45 Breton G, Fillet AM, Katlama C,BricaireF,CaumesE. Acyclovir-resistant herpeszosterinhuman immunode?ciency virus-infected patients: results offoscarnet therapy. ClinInfect Dis1998; 27: 1525–1527. 46 Schliefer K,Gumbel HO,Rockstroh JK,SpenglerU.Managementofpro- gressive outerretinal necrosis withcidofovir ina human immunode?- ciency virus-infected patient. Clin Infect Dis (...) Herpes Zoster - Treatment GUIDELINES Europeanconsensus-based(S2k)Guidelineonthe ManagementofHerpesZoster –guidedbytheEuropean DermatologyForum(EDF)incooperationwiththeEuropean AcademyofDermatologyandVenereology(EADV),Part2: Treatment R.N.Werner, 1, *A.F.Nikkels, 2 B.Marinovi c, 3 M.Sch€ afer, 4 M.Czarnecka-Operacz, 5 A.M.Agius, 6 Z.Bata-Cs€ org} o, 7 J.Breuer, 8 G.Girolomoni, 9 G.E.Gross, 10 S.Langan, 11 R.Lapid-Gortzak, 12 T.H.Lesser, 13 U.Pleyer, 14 J.Sellner, 15 G.M.Verjans, 16 P.Wutzler, 17

2017 European Dermatology Forum

80. Cryotherapy of herpes simplex keratitis. (Abstract)

Cryotherapy of herpes simplex keratitis. Twenty-one cases of epithelial herpetic keratitis were treated with cryotherapy and 14 cases were treated with Iodoxouridine (IDU). Cryotherapy was found statistically superior to IDU. The average healing time was 2.4 days for cryotherapy and 6.2 days for IDU. The advantages of cryotherapy are emphasized.

1978 Annals of ophthalmology Controlled trial quality: uncertain

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