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Herpes Simplex Keratitis

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61. Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. (Abstract)

Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis. The novel immunochromatographic assay (ICGA) kit was recently developed to diagnose herpes simplex virus (HSV) infection. This multicentre study aimed to evaluate the value of the ICGA kit for the diagnosis of herpetic epithelial keratitis by comparing it with immunofluorescence assay (IFA) and real-time PCR.Corneal scrapings were collected from 117 patients (...) , including 77 with herpetic keratitis as their final clinical diagnosis as well as 40 others at 21 facilities. These samples were tested by the ICGA kit, IFA and real-time PCR.The positive concordance between final clinical diagnosis and ICGA was 46.7% (35/75 cases) and the negative concordance was 100% (39/39). The positive and negative concordance between real-time PCR and ICGA were 57.4% (35/61 cases) and 100% (53/53), respectively. The positive and negative concordance between IFA and ICGA were 61.1

2012 British Journal of Ophthalmology

62. A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. Full Text available with Trip Pro

A Multiplex Dot Hybridization Assay For Detection and Differentiation of Acanthamoeba and Herpes Keratitis. We verified a multiplex dot hybridization (MDH) assay for the rapid detection and differentiation of Acanthamoeba keratitis (AK) and herpes simplex keratitis (HSK).Molecular detection of Acanthamoeba and herpes simplex virus in corneal scrapes was performed with the MDH assay and standard diagnostic methods. The experimental group included corneal scrapes (n = 33) from patients (...) with culture- or pathology-confirmed AK (n = 15) and real-time PCR-confirmed HSK (n = 16). The control group included 50 samples from cases of bacterial keratitis (n = 15), fungal keratitis (n = 15), and initially presumed AK (n = 5) or HSK (n = 17) which finally were excluded by culture for Acanthamoeba or by real-time PCR for herpes simplex virus, respectively. Discrepant results between methods were resolved by DNA sequencing of the PCR amplicons.After discrepant analysis, the sensitivity

2016 Investigative Ophthalmology & Visual Science

63. A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Full Text available with Trip Pro

A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. Herpes simplex virus type 1 (HSV-1) is a neurotrophic virus that can cause herpes stromal keratitis (HSK), a severe corneal inflammation that can lead to corneal scarring and blindness. This study identified neurologic changes that occur in HSV-1-infected corneas and related them to HSV-1-induced immunopathology.Corneas of BALB/c and C57BL/6 mice were infected with HSV-1 strains that induce HSK. Changes in sensory nerves

2016 Investigative Ophthalmology & Visual Science

64. Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis Full Text available with Trip Pro

Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis To design, optimize and validate a rapid, internally controlled real-time polymerase chain reaction (RT-PCR) test for herpes simplex virus (HSV) in the diagnosis of necrotizing herpes stromal keratitis.Tears alone or together with corneal epithelium scrapings from 30 patients (30 eyes) suspected of necrotizing herpes stromal keratitis were tested for HSV DNA by RT-PCR. The samples were collected during (...) for the diagnosis of necrotizing herpes stromal keratitis.

2016 International journal of ophthalmology

65. Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) Full Text available with Trip Pro

Confocal microscopic analysis of a rabbit eye model of high incidence recurrent herpes stromal keratitis (HSK) Using CJLAT, a chimeric herpes simplex virus (HSV-1) that produces a high incidence of herpes stromal keratitis (HSK) in latently infected rabbits, and in vivo confocal microscopy (CM), we characterized the cellular events that precede the development of HSK.Thirty days after infection, in vivo CM was performed daily for 10 days and then weekly for up to 80 days after infection.We

2016 Cornea

66. Herpes Zoster - Treatment

,Nikkels AF.Chronic mucocutaneous herpes simplex virusandvaricella zoster virus infections. JAm Acad Dermatol 2012; 66: e217–e227. 45 Breton G, Fillet AM, Katlama C,BricaireF,CaumesE. Acyclovir-resistant herpeszosterinhuman immunode?ciency virus-infected patients: results offoscarnet therapy. ClinInfect Dis1998; 27: 1525–1527. 46 Schliefer K,Gumbel HO,Rockstroh JK,SpenglerU.Managementofpro- gressive outerretinal necrosis withcidofovir ina human immunode?- ciency virus-infected patient. Clin Infect Dis (...) Herpes Zoster - Treatment GUIDELINES Europeanconsensus-based(S2k)Guidelineonthe ManagementofHerpesZoster –guidedbytheEuropean DermatologyForum(EDF)incooperationwiththeEuropean AcademyofDermatologyandVenereology(EADV),Part2: Treatment R.N.Werner, 1, *A.F.Nikkels, 2 B.Marinovi c, 3 M.Sch€ afer, 4 M.Czarnecka-Operacz, 5 A.M.Agius, 6 Z.Bata-Cs€ org} o, 7 J.Breuer, 8 G.Girolomoni, 9 G.E.Gross, 10 S.Langan, 11 R.Lapid-Gortzak, 12 T.H.Lesser, 13 U.Pleyer, 14 J.Sellner, 15 G.M.Verjans, 16 P.Wutzler, 17

2017 European Dermatology Forum

67. Herpes Zoster - Diagnosis

(Table 2). However, polymerase chain reaction (PCR) studies demonstrated that the differential diagnosis with zosteriform herpes simplex virus (HSV) infections is erroneous in up to 4–20%. 26–29 Therefore, laboratory testing is suggested in the event of diagnostic uncertainty, particularly in case of HZ of the face and genital areas, as these areas are the natural sites for recurrent labial and genital herpes respectively (Table 2). Atypical mucocutaneous forms are clinically dif?cult to diag- nose (...) ClinVirol 2003; 26:277–289; discussion 91-3. 25 Zerngast WW, Paauw DS, O’Connor KM. Varicellazoster with extended prodrome: acase series.Am J Med 2013;126: 359–361. 26 Kalman CM, Laskin OL. Herpes zoster and zosteriform herpes simplex virus infections in immunocompetent adults. Am JMed 1986;81: 775– 778. 27 Rubben A,Baron JM, Grussendorf-Conen EI.Routinedetection of her- pessimplex virus and varicella zoster virus by polymerase chain reaction reveals that initial herpeszoster is frequently misdiagnosed

2017 European Dermatology Forum

68. NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX Full Text available with Trip Pro

NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX 18169905 2008 01 11 2008 11 20 0007-1161 27 2 1943 Feb The British journal of ophthalmology Br J Ophthalmol NOTES ON FORMS OF KERATITIS PRESUMABLY DUE TO THE VIRUS OF HERPES SIMPLEX. 80-7 Hamilton J B JB A.A.M.C. Abroad. eng Journal Article England Br J Ophthalmol 0421041 0007-1161 1943 2 1 0 0 1943 2 1 0 1 1943 2 1 0 0 ppublish 18169905 PMC510308

1943 The British journal of ophthalmology

69. Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis Full Text available with Trip Pro

Phosphonoacetic Acid in the Treatment of Experimental Herpes Simplex Keratitis In a rabbit model of herpes simplex corneal ulceration, 5% phosphonoacetic acid solution or ophthalmic ointment suppressed clinical disease and virus replication. The effect of 5% phosphonoacetic acid ointment was equivalent to that of 0.5% idoxuridine ointment in the treatment of this established herpetic eye infection.

1975 Antimicrobial Agents and Chemotherapy

70. Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis Full Text available with Trip Pro

Effect of 9-β-d-Arabinofuranosyladenine 5′-Monophosphate and 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate on Experimental Herpes Simplex Keratitis Treatment of established experimental keratitis caused by herpes simplex virus with 9-beta-d-arabinofuranosyladenine 5'-monophosphate (Ara-AMP) or 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP (...) showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.

1976 Antimicrobial Agents and Chemotherapy

71. Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. Full Text available with Trip Pro

Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model. The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte

1977 Infection and immunity

72. Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. Full Text available with Trip Pro

Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis. In the rabbit 5% phosphonoacetic acid ointment suppressed herpetic keratitis as well as 0-5% idoxuridine ointment. After 5 days of treatment quantitative virus titres showed that phosphonoacetic acid was superior to idoxuridine in the inhibition of herpes virus replication. Phosphonoacetic acid was found to be nontoxic to the eye in both clinical and histopathological studies. Recent reports suggest (...) that the mechanism of action of phosphonoacetic acid appears to be the blocking of the virus DNA polymerase, which is essential for the synthesis of herpes virus DNA.

1977 The British journal of ophthalmology

73. Histopathology of human superficial herpes simplex keratitis. Full Text available with Trip Pro

Histopathology of human superficial herpes simplex keratitis. In vivo corneal replicas were made in 20 cases of patients with superficial dendritic ulcers of the cornea. Histopathological study of the replicas and superficial epithelial cells showed that the dendrites are composed of rounded epithelial cells and variable sized syncytia containing bizarre shaped nuclei. Pseudopodia-like processes containing DNA and some RNA extend from the syncytia into the surrounding epithelial cells, which

1978 The British journal of ophthalmology

74. Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid Full Text available with Trip Pro

Inhibition of Herpes Simplex Virus Strains Isolated from Herpetic Keratitis by Polyinosinic Acid-Polycytidylic Acid Fifty strains of herpes simplex virus, isolated from patients with herpetic keratitis, were examined in vitro for susceptibility to polyinosinic acid-polycytidylic acid [poly(I:C)] in the presence of a constant concentration of diethylaminoethyl-dextran. The minimal inhibitory concentration of poly(I:C) for 44 of these strains ranged from 0.0001 to 0.1 mug/ml; for the remaining

1977 Antimicrobial Agents and Chemotherapy

75. Treatment of experimental herpes simplex keratitis with acycloguanosine. Full Text available with Trip Pro

Treatment of experimental herpes simplex keratitis with acycloguanosine. Acycloguanosine, a recently developed compound with high inhibitory activity against viruses belonging to the herpes group, has been evaluated in experimental herpes simplex keratitis in rabbits in comparison with trifluorothymidine and preparations of idoxuridine and vidarabine at present in clinical use. All compunds were used in the form of ophthalmic ointments which were applied 5 times a day at intervals of 2 hours

1979 The British journal of ophthalmology

76. Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. Full Text available with Trip Pro

Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 4351680 1973 08 31 2018 11 13 0007-1161 57 5 1973 May The British journal of ophthalmology Br J Ophthalmol Photodynamic inactivation in the treatment of experimental herpes simplex keratitis. 336-8 Thomas J V JV Dunlap W A WA Rich A M AM eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 Aniline Compounds 0 Coloring Agents IM Aniline Compounds Animals Coloring Agents Keratitis, Dendritic therapy

1973 The British journal of ophthalmology

77. Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis Full Text available with Trip Pro

Ophthalmology—Epitomes of Progress: Herpes Simplex Keratitis 18748204 2010 06 30 2010 06 30 0093-0415 128 5 1978 May The Western journal of medicine West. J. Med. Ophthalmology-epitomes of progress: herpes simplex keratitis. 428-9 O'Connor G R GR eng Journal Article United States West J Med 0410504 0093-0415 1978 5 1 0 0 1978 5 1 0 1 1978 5 1 0 0 ppublish 18748204 PMC1238157

1978 Western Journal of Medicine

78. Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. Full Text available with Trip Pro

Scanning electron microscope study of herpes simplex virus experimental disciform keratitis. Scanning electron microscopy of the endothelium of experimental disciform keratitis revealed corneal endothelial changes which distinguished disciform oedema from the more progressive stages of disciform keratitis. The endothelium of corneas with disciform oedema were wholly intact and characterised by subtle morphological alterations. In contrast, the more progressive stages of disciform keratitis were

1978 The British journal of ophthalmology

79. Experimental stromal herpes simplex keratitis in rabbits. Full Text available with Trip Pro

Experimental stromal herpes simplex keratitis in rabbits. 4295148 1968 03 30 2018 11 13 0065-9533 65 1967 Transactions of the American Ophthalmological Society Trans Am Ophthalmol Soc Experimental stromal herpes simplex keratitis in rabbits. 189-210 Irvine A R AR Kimura S J SJ eng Journal Article United States Trans Am Ophthalmol Soc 7506106 0065-9533 IM Animals Anterior Chamber pathology Antibody Formation Blood Cell Count Cornea pathology Hypersensitivity Iritis immunology Keratitis

1967 Transactions of the American Ophthalmological Society

80. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. Full Text available with Trip Pro

Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 5662199 1968 09 05 2018 11 13 0035-9157 61 6 1968 Jun Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Changes in the permeability of the corneal endothelium in herpes simplex stromal keratitis. 541-2 Starr P A PA eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Fluoresceins IM Aqueous Humor metabolism Biological Transport Cell Membrane Permeability Cornea Fluoresceins Humans (...) Keratitis, Dendritic pathology 1968 6 1 1968 6 1 0 1 1968 6 1 0 0 ppublish 5662199 PMC1902596 Exp Eye Res. 1963 Jan;2:33-8 13934003

1968 Proceedings of the Royal Society of Medicine

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