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Herpes Simplex Keratitis

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41. PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. Full Text available with Trip Pro

PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice.Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils (...) neovascularization.PEDF and its derived peptides reduce the severity of herpetic simplex keratitis in mice, representing the potential therapeutic approach to control HSK lesions.

2018 Investigative Ophthalmology & Visual Science

42. Clinical management of herpes simplex virus infections: past, present, and future Full Text available with Trip Pro

Clinical management of herpes simplex virus infections: past, present, and future Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis

2018 F1000Research

43. Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes. Full Text available with Trip Pro

Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes. The effect of storage time and temperature on the recovery of pathogen DNA from polytetrafluorethylene (PTFE) was investigated. PTFE impression membranes were inoculated with Pseudomonas aeruginosa, Herpes Simplex Virus-1 (HSV-1) or Acanthamoeba and stored at -70 °C, -20 °C, +4 °C or +35 °C. PCR was performed on days 0, 1, 2, 3, 7 and months (...) the investigation of microbial keratitis where access to microbiological testing is not readily available.

2018 Journal of Medical Microbiology

44. In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis. Full Text available with Trip Pro

In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis. To report bilateral corneal endothelial cell density (ECD), as well as its correlation with subbasal nerve changes, in patients with unilateral herpes simplex keratitis (HSK).Thirty-six eyes of 36 patients with corneal scarring caused by HSK, as well as their respective contralateral clinically unaffected eyes, were prospectively studied and compared with 26 eyes of 26 healthy

2015 Investigative Ophthalmology & Visual Science

45. Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population Full Text available with Trip Pro

Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population Acquired immune deficiency syndrome (AIDS) is associated with a wide spectrum of systemic and ocular infectious diseases. Little information is known about Herpes Simplex Virus type 1 (HSV-1) keratoconjunctivitis in association with AIDS. Because HSV-1 is becoming, day by day, a common eye disease (nearly 100% patients of over 60 years old harbor HSV in their trigeminal ganglia at autopsy (...) ), this article discussing a worldwide public health problem.The purpose of this paper is to compare the incidence and clinical aspects of HSV-1 Keratitis in HIV/ AIDS patients compared with the general population who develops HSV- 1 Keratitis.The study is retrospective and comparative. Each patient was examined thoroughly at the biomicroscope ocular slit after corneal staining with fluorescein or rose bengal. Visual acuity, intraocular pressure and corneal sensitivity were also examined.From 170 patients

2015 Journal of medicine and life

46. Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis. Full Text available with Trip Pro

Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis. Herpes simplex keratitis (HSK) caused by herpes simplex virus 1 (HSV-1), which has high recurrent rate and incidence of severe vision loss, is the leading cause of infectious blindness in the world. The aim was to explore the clinical efficacy of oral ganciclovir (GCV) in the prevention of recurrent HSK.A multicenter, prospective, randomized, single-blind, and controlled clinical trial (...) was conducted from April 2010 to June 2013. One hundred seventy-three patients (173 eyes involved) who were diagnosed as recurrent HSK definitely, including stromal keratitis and corneal endotheliitis, were divided into three groups randomly: negative control (placebo) group was topically administered with 0.15% GCV ophthalmic gel, 4 times per day and 0.1% fluorometholone eye drops, 3 times per day until resolution of HSK; positive control acyclovir (ACV) group was topically adopted the same ophthalmic gel

2015 Chinese medical journal Controlled trial quality: uncertain

47. Keratitis (CL-associated infiltrative)

be similar, therefore monitor closely especially over the first 24 hours and if diagnosis remains in doubt, refer to ophthalmologist as an emergency Marginal keratitis Corneal scar Herpes simplex keratitis Adenovirus keratoconjunctivitis Management by optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation always relates to the statement(s) immediately above Non (...) Keratitis (CL-associated infiltrative) Keratitis, CL-associated infiltrative submit The College submit You're here: Keratitis, CL-associated infiltrative Keratitis, CL-associated infiltrative The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Aetiology Contact lens-associated infiltrative events, including: contact lens-associated peripheral

2018 College of Optometrists

48. Keratitis (marginal)

of the peripheral cornea: microbial keratitis contact lens-associated corneal infiltrate rosacea keratitis Mooren’s ulcer peripheral keratitis associated with rheumatoid arthritis or other systemic collagen vascular disease corneal phlyctenulosis Terrien’s marginal degeneration marginal herpes simplex keratitis Management by optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation (...) Keratitis (marginal) Keratitis (marginal) submit The College submit You're here: Keratitis (marginal) Keratitis (marginal) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Aetiology Toxic or hypersensitivity response to bacterial (e.g. Staphylococcal ) exotoxins Predisposing factors Bacterial (e.g. Staphylococcal ) blepharitis Current or recent

2018 College of Optometrists

49. Microbial keratitis (amoebic)

or subepithelial infiltrates pseudodendrites radial keratoneuritis (infiltrates along corneal nerves) recurrent breakdown of the corneal epithelium Later signs deep inflammation of the cornea consisting of a central or paracentral ring-shaped or disciform infiltrate or abscess stromal thinning extension of inflammation into sclera anterior chamber cells and flare hypopyon Differential diagnosis Signs may masquerade as herpes simplex with temporary improvement on anti-herpetic treatment, further delaying (...) Microbial keratitis (amoebic) Microbial keratitis (Acanthamoeba sp.) submit The College submit You're here: Microbial keratitis (Acanthamoeba sp.) Microbial keratitis (Acanthamoeba sp.) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Acanthamoebae are ubiquitous free-living protozoans, present

2018 College of Optometrists

50. Herpes zoster ophthalmicus

% of patients and is: chronic and severe in about 7% Complications can occur months or years after the acute phase Differential diagnosis Ocular lesions: herpes simplex keratitis Cutaneous lesions: cellulitis, contact dermatitis, atopic eczema, impetigo Management by Optometrist Practitioners should recognise their limitations and where necessary seek further advice or refer the patient elsewhere GRADE* Level of evidence and strength of recommendation always relates to the statement(s) immediately above Non (...) Herpes zoster ophthalmicus Herpes Zoster Ophthalmicus (HZO) submit The College submit You're here: Herpes Zoster Ophthalmicus (HZO) Herpes Zoster Ophthalmicus (HZO) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Varicella zoster virus (VZV), also known as human herpesvirus-3 (HHV- 3) previous

2020 College of Optometrists

51. Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model. (Abstract)

Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model. To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis.Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined. The effectiveness of ASP2151 was compared with that of acyclovir and valacyclovir (...) acyclovir ointment. Topical instillation of ASP2151 improved the herpetic dendritic keratitis score significantly and reduced the titre of HSV DNA in the tears in a dose-responsive way.ASP2151 had significantly better anti-HSV activity against herpes simplex keratitis than valacyclovir and acyclovir after systemic or topical use. These findings indicate that ASP2151 should be considered as an alternative treatment for herpes simplex keratitis.

2013 British Journal of Ophthalmology

52. The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis

The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02045082 Recruitment Status : Terminated First Posted : January 24, 2014 Last

2014 Clinical Trials

53. Deep anterior lamellar keratoplasty using precut anterior lamellar cap for herpes simplex keratitis: a long-term follow-up study. (Abstract)

Deep anterior lamellar keratoplasty using precut anterior lamellar cap for herpes simplex keratitis: a long-term follow-up study. To evaluate the feasibility, safety and efficacy of deep anterior lamellar keratoplasty (DALK) using precut anterior lamellar cap (ALC) for patients with herpes simplex keratitis.In this single-centre retrospective study, 48 consecutive patients with herpes simplex keratitis and having undergone DALK using either big bubble technique or manual lamellar dissection

2014 British Journal of Ophthalmology

54. Cenegermin (Oxervate) - neurotrophic keratitis

cranial nerve, from the trigeminal nucleus to the corneal nerve endings, resulting in the development of NK. The most common causes of impaired corneal sensation are herpetic keratitis (herpes simplex and herpes zoster viral infection), intracranial space-occupying lesions, and/or neurosurgical procedures that damage the trigeminal ophthalmic branch. Other ocular causes of impairment of corneal sensitivity include chemical burns, physical injuries, corneal dystrophy, chronic use of topical medications (...) Cenegermin (Oxervate) - neurotrophic keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 18 May 2017 EMA/351805/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report OXERVATE International non

2017 European Medicines Agency - EPARs

55. Keratitis, Herpes Simplex (Overview)

Keratitis, Herpes Simplex (Overview) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes (...) Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

56. Keratitis, Herpes Simplex (Treatment)

Keratitis, Herpes Simplex (Treatment) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

57. Keratitis, Herpes Simplex (Diagnosis)

Keratitis, Herpes Simplex (Diagnosis) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing (...) > Herpes Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

58. Keratitis, Herpes Simplex (Follow-up)

Keratitis, Herpes Simplex (Follow-up) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

59. Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. Full Text available with Trip Pro

Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. To analyse high-order aberrations (HOA), modulation transfer function (MTF) and Strehl ratio in patients with a history of herpes simplex keratitis (HSK) and apparently normal vision.Fifteen patients with a history of recurrent unilateral HSK and normal Snellen visual acuity (0 logMAR) were enrolled. Eyes with HSK (HSK group) were statistically compared with normal fellow eyes (Control group (...) ). HOA, MTF and Strehl ratio were measured using the OPD-SCAN II (Nidek Co, Gamagori, Japan) aberrometer. Measures were performed at least 3 months after the last episode of herpes. Statistical significance was indicated by p<0.05.Despite apparently normal vision in both eyes (as assessed by routine visual acuity charts), significantly higher total HOA, trefoil and tetrafoil were present in the HSK group compared with the Control group. The MTF and strehl ratio were lower in the HSK group compared

2013 British Journal of Ophthalmology

60. Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Full Text available with Trip Pro

Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Parallel comparison with 0.15% ganciclovir (GCV) ophthalmic gel to evaluate the effectiveness and safety of 0.15% GCV in situ ophthalmic gel for the treatment of herpes simplex keratitis (HSK).This was a multicenter, randomized, investigator-masked, parallel group study. HSK patients were randomly divided

2013 Drug design, development and therapy Controlled trial quality: uncertain

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