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Herpes Simplex Keratitis

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41. Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence Full Text available with Trip Pro

Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) genes. The vTK-associated ACVr HSV-1 shows reduced virulence, but the association between the level of resistance and the virulence of the vTK-associated ACVr (...) concentrations (IC50), demonstrating that the higher the ACV-sensitvity, the the higher the virulence among the ACVr clones. One of the ACVr HSV-1 clones with a relatively low IC50 value maintained similar virulence to that of the parent TAS. The infection in mice with ACVr HSV-1 due to a single amino acid substitution in vTK induced local diseases, keratitis and dermatitis, while vTK-deficient clone did not.A statistically significant correlation between the virulence and susceptibility to ACV among ACVr

2017 Virology journal

42. The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection Full Text available with Trip Pro

The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly

2017 DNA and cell biology

43. Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology Full Text available with Trip Pro

Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology Stromal keratitis (SK) is a chronic immunopathological lesion of the eye, caused by HSV-1 infection, and a common cause of vision impairment in humans. The inflammatory lesions in the cornea are primarily caused by neutrophils with the active participation of CD4+ T cells. Therefore, the targeting of these immune cell types and their products represents a potentially valuable form

2017 Journal of leukocyte biology

44. Analysis of Herpes Simplex Virus Reactivation in Explant Reveals a Method-Dependent Difference in Measured Timing of Reactivation Full Text available with Trip Pro

Analysis of Herpes Simplex Virus Reactivation in Explant Reveals a Method-Dependent Difference in Measured Timing of Reactivation Herpes simplex virus (HSV) infection is widespread in the human population. Following orofacial infection, HSV establishes latency in innervating sensory neurons, primarily located in the trigeminal ganglia. A central feature of HSV pathogenesis is the ability to periodically reactivate in those neurons and be transported back to the body surface. Both transmission (...) and disease, such as keratitis, encephalitis, and neurodegeneration, have been linked to reactivation. Despite invaluable insights obtained from model systems, interactions between viral and host functions that regulate reactivation are still incompletely understood. Various assays are used for measuring reactivation in animal models, but there have been limited comparisons between methods and the accuracy of detecting the timing of reactivation and the corresponding amount of infectious virus produced

2017 Journal of virology

45. Exposure Stress Induces Reversible Corneal Graft Opacity in Recipients With Herpes Simplex Virus-1 Infections. Full Text available with Trip Pro

Exposure Stress Induces Reversible Corneal Graft Opacity in Recipients With Herpes Simplex Virus-1 Infections. Most of the inflammation in murine herpes simplex virus type 1 (HSV-1)-induced stromal keratitis (HSK) is due to exposure stress resulting from loss of corneal nerves and blink reflex. Corneal grafts often fail when placed on corneal beds with a history of HSK. We asked if corneal exposure contributes to the severe pathology of corneal grafts on HSV-1-infected corneal beds.Herpes (...) simplex virus type 1-infected corneas were tested for blink reflex. Opacity and vascularization were monitored in allogeneic and syngeneic corneal grafts that were transplanted to corneal beds with no blink reflex or to those that retained blink reflex in at least one quadrant following infection.Retention of any level of blink reflex significantly reduced inflammation in HSV-1-infected corneas. Corneal allografts placed on HSV-1-infected beds lacking corneal blink reflex developed opacity faster

2017 Investigative Ophthalmology & Visual Science

46. Cenegermin (Oxervate) - neurotrophic keratitis

cranial nerve, from the trigeminal nucleus to the corneal nerve endings, resulting in the development of NK. The most common causes of impaired corneal sensation are herpetic keratitis (herpes simplex and herpes zoster viral infection), intracranial space-occupying lesions, and/or neurosurgical procedures that damage the trigeminal ophthalmic branch. Other ocular causes of impairment of corneal sensitivity include chemical burns, physical injuries, corneal dystrophy, chronic use of topical medications (...) Cenegermin (Oxervate) - neurotrophic keratitis 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 18 May 2017 EMA/351805/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report OXERVATE International non

2017 European Medicines Agency - EPARs

47. Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model. (Abstract)

Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model. To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis.Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined. The effectiveness of ASP2151 was compared with that of acyclovir and valacyclovir (...) acyclovir ointment. Topical instillation of ASP2151 improved the herpetic dendritic keratitis score significantly and reduced the titre of HSV DNA in the tears in a dose-responsive way.ASP2151 had significantly better anti-HSV activity against herpes simplex keratitis than valacyclovir and acyclovir after systemic or topical use. These findings indicate that ASP2151 should be considered as an alternative treatment for herpes simplex keratitis.

2013 British Journal of Ophthalmology

48. The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis

The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02045082 Recruitment Status : Terminated First Posted : January 24, 2014 Last

2014 Clinical Trials

49. Deep anterior lamellar keratoplasty using precut anterior lamellar cap for herpes simplex keratitis: a long-term follow-up study. (Abstract)

Deep anterior lamellar keratoplasty using precut anterior lamellar cap for herpes simplex keratitis: a long-term follow-up study. To evaluate the feasibility, safety and efficacy of deep anterior lamellar keratoplasty (DALK) using precut anterior lamellar cap (ALC) for patients with herpes simplex keratitis.In this single-centre retrospective study, 48 consecutive patients with herpes simplex keratitis and having undergone DALK using either big bubble technique or manual lamellar dissection

2014 British Journal of Ophthalmology

50. Herpes simplex - ocular

Herpes simplex - ocular Herpes simplex - ocular - NICE CKS Share Herpes simplex - ocular: Summary Herpes simplex virus (HSV) ocular infections can cause inflammation of the retina (retinitis), iris and associated uveal tract (iritis or uveitis), cornea (keratitis), conjunctiva (conjunctivitis), eyelids (blepharitis), and surrounding skin (periocular dermatitis). Infection is usually caused by HSV type 1 (HSV-1), and rarely by HSV-2. The majority of primary HSV ocular infection is asymptomatic (...) within 2 weeks, and epithelial keratitis tends to resolve in 1–2 weeks. About 25% of people with epithelial keratitis will develop stromal keratitis or iritis. Recurrent ocular HSV is common, with the risk increasing after each subsequent episode. The diagnosis of suspected ocular herpes simplex infection in primary care is clinical. Symptoms and signs include: Eye pain, eye irritation or watering, and photophobia. Blurred vision. An acute red eye. Crops of vesicles, ulcers, or pustules along the lid

2016 NICE Clinical Knowledge Summaries

51. Keratitis, Herpes Simplex (Diagnosis)

Keratitis, Herpes Simplex (Diagnosis) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing (...) > Herpes Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

52. Keratitis, Herpes Simplex (Overview)

Keratitis, Herpes Simplex (Overview) Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC1vdmVydmlldw== processing > Herpes (...) Simplex Virus (HSV) Keratitis Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Overview Practice Essentials Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. The prognosis in HSV keratitis, however, is generally favorable

2014 eMedicine.com

53. Keratitis, Herpes Simplex (Treatment)

Keratitis, Herpes Simplex (Treatment) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

54. Keratitis, Herpes Simplex (Follow-up)

Keratitis, Herpes Simplex (Follow-up) Herpes Simplex Virus (HSV) Keratitis Treatment & Management: Approach Considerations, Infectious Epithelial Keratitis, Stromal Keratitis Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTE5NDI2OC10cmVhdG1lbnQ= processing > Herpes Simplex Virus (HSV) Keratitis Treatment & Management Updated: Jan 18, 2019 Author: Jim C Wang (王崇安), MD; Chief Editor: Andrew A Dahl, MD, FACS Share Email Print Feedback Close Sections Sections Herpes Simplex Virus (HSV) Keratitis Treatment Approach Considerations Since most cases of herpes simplex virus (HSV) epithelial keratitis resolve spontaneously within 3 weeks, the rationale for treatment is to minimize stromal damage and scarring. Gentle epithelial debridement may

2014 eMedicine.com

55. Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. Full Text available with Trip Pro

Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis. Herpes keratitis (HK) remains the leading cause of cornea-derived blindness in the developed world, despite the availability of effective antiviral drugs. Treatment toxicity and the emergence of drug resistance highlight the need for additional therapeutic approaches. This study examined ataxia telangiectasia mutated (ATM), an apical kinase in the host DNA damage response (...) , as a potential new target for the treatment of HK.Small molecule inhibitor of ATM (KU-55933) was used to treat herpes simplex virus type 1 (HSV-1) infection in three experimental models: (1) in vitro--cultured human corneal epithelial cells, hTCEpi, (2) ex vivo--organotypically explanted human and rabbit corneas, and (3) in vivo--corneal infection in young C57BL/6J mice. Infection productivity was assayed by plaque assay, real-time PCR, Western blot, and disease scoring.Robust ATM activation was detected

2013 Investigative Ophthalmology & Visual Science

56. Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. Full Text available with Trip Pro

Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. To analyse high-order aberrations (HOA), modulation transfer function (MTF) and Strehl ratio in patients with a history of herpes simplex keratitis (HSK) and apparently normal vision.Fifteen patients with a history of recurrent unilateral HSK and normal Snellen visual acuity (0 logMAR) were enrolled. Eyes with HSK (HSK group) were statistically compared with normal fellow eyes (Control group (...) ). HOA, MTF and Strehl ratio were measured using the OPD-SCAN II (Nidek Co, Gamagori, Japan) aberrometer. Measures were performed at least 3 months after the last episode of herpes. Statistical significance was indicated by p<0.05.Despite apparently normal vision in both eyes (as assessed by routine visual acuity charts), significantly higher total HOA, trefoil and tetrafoil were present in the HSK group compared with the Control group. The MTF and strehl ratio were lower in the HSK group compared

2013 British Journal of Ophthalmology

57. Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient. Full Text available with Trip Pro

Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient. We investigated thymidine kinase (tk) mutants isolated during multiple episodes of recurrent bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient. From one eye, we found a single guanine insertion, previously shown to greatly reduce TK expression, and from the other, a previously unidentified substitution, which genetic (...) experiments confirmed confers drug resistance. The substitution, although distant from substrate binding sites, reduced thymidine phosphorylation 10-20-fold, and acyclovir phosphorylation >100-fold. This phenotype should permit reactivation from latency to cause recurrent disease. The results may have implications for the prevalence and prevention of acyclovir resistance in patients with herpes simplex keratitis.

2013 Journal of Infectious Diseases

58. Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Full Text available with Trip Pro

Effectiveness and safety of 0.15% ganciclovir in situ ophthalmic gel for herpes simplex keratitis - a multicenter, randomized, investigator-masked, parallel group study in Chinese patients. Parallel comparison with 0.15% ganciclovir (GCV) ophthalmic gel to evaluate the effectiveness and safety of 0.15% GCV in situ ophthalmic gel for the treatment of herpes simplex keratitis (HSK).This was a multicenter, randomized, investigator-masked, parallel group study. HSK patients were randomly divided

2013 Drug design, development and therapy Controlled trial quality: uncertain

59. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Herpes Simplex Keratitis Herpes (...) Simplex Keratitis Aka: Herpes Simplex Keratitis , Herpes Keratitis , Herpetic Keratitis , Herpes Simplex Conjunctivitis , HSV Conjunctivitis , Herpetic Dendrite , Dendritic Keratitis , Dendritic Ulcer From Related Chapters II. Epidemiology Outbreaks in winter and early summer III. Symptoms Previous history of Herpes Keratitis Coexisting (herpetic rash) on lip or upper face Recent Absent history of Severe Photophobia Gritty sensation in eye IV. Signs Unilateral inflammation of and Dendritic Ulcers

2015 FP Notebook

60. Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. Full Text available with Trip Pro

Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update. Herpes simplex virus (HSV) is associated with a variety of ocular diseases, including epithelial and stromal keratitis. HSV can cause stromal opacification and is believed to be the leading cause of infectious blindness in the developed world. An improved understanding of the global burden of HSV keratitis, including the incidence of severe vision loss, could have a significant effect on prevention and treatment and place (...) it in perspective among causes of corneal ulceration. We found that the global incidence of HSV keratitis is roughly 1.5 million, including 40,000 new cases of severe monocular visual impairment or blindness each year. We also discuss relevant epidemiologic issues regarding HSV epithelial and stromal disease.Copyright © 2012 Elsevier Inc. All rights reserved.

2012 Survey of Ophthalmology

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