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Herpes Simplex Keratitis

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21. Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. (Abstract)

Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis.Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015.13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes (...) with and without prior HSV keratitis with preoperative (9% vs 8%, p=1.00) or postoperative (57% vs 60%, p=1.00) corrected distance visual acuity (CDVA) ≥20/200 or in the percentage of contralateral eyes with preoperative CDVA ≥20/50 (55% vs 30%, p=0.18). While several postoperative complications occurred approximately twice as often in eyes with prior HSV keratitis, including persistent epithelial defect (63.6% vs 34.1%; p=0.10), corneal infiltrate (27.3% vs 12.3%; p=0.17) and sterile vitritis (18.2% vs 9.4

2017 British Journal of Ophthalmology

22. Corneal Higher-order Aberrations and Visual Improvement Following Corneal Transplantation in Treating Herpes Simplex Keratitis. (Abstract)

Corneal Higher-order Aberrations and Visual Improvement Following Corneal Transplantation in Treating Herpes Simplex Keratitis. To examine corneal higher-order aberrations (HOAs) and visual improvement following corneal transplantation in treating corneal scar caused by herpes simplex keratitis (HSK).Retrospective consecutive case series.This study included a total of 52 eyes: 18 eyes of normal subjects, and 34 eyes of consecutive patients with corneal scar owing to HSK who underwent

2017 American Journal of Ophthalmology

23. Herpes simplex keratitis: challenges in diagnosis and clinical management Full Text available with Trip Pro

Herpes simplex keratitis: challenges in diagnosis and clinical management Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea (...) , where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness. The diagnosis of these lesions as the result of a recurrent herpes simplex virus infection can at times be problematic. Currently, herpetic stromal keratitis is diagnosed by its clinical presentation on the slit-lamp examination, but the literature does not always support the accuracy of these clinical findings. Other diagnostic tests such as polymerase chain

2017 Clinical ophthalmology (Auckland, N.Z.)

24. Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis Full Text available with Trip Pro

Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokines are small proteins released by cells that play an important proinflammatory or anti

2017 Journal of immunology research

25. Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation Full Text available with Trip Pro

Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant (...) diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes. Granulomatous inflammation, in microsporidial stromal keratitis, is never well described, and the authors in this article aim to describe the presence of granulomatous inflammation in microsporidial stromal keratitis, in patients with associated herpes simplex virus (HSV) keratitis.This was a retrospective and observational study conducted

2017 Indian journal of ophthalmology

26. Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries Full Text available with Trip Pro

Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries Herpes simplex is a common cause of visual disability, and there are published evidence-based guidelines for therapy. This survey aims to determine the preferred practice patterns of ophthalmologists in Gulf Coast Countries regarding herpetic eye disease, as well as identify areas of controversy or barriers to acceptance of evidence-based protocols.Anonymous web-based survey of ophthalmologists (...) in Saudi Arabia, Bahrain, the United Arab Emirates, and Oman.There were 48 responses to the survey. For a first episode of epithelial dendritic keratitis, 28.2% reported "observation" rather than specific therapy. The majority of respondents utilize oral or topical antiviral for epithelial keratitis, with oral antiviral being the most popular (43.6%). The majority also included a corticosteroid with antiviral for stromal keratitis (83.9%) or iritis (70.3%). Over 90% prescribe a prophylactic antiviral

2017 Saudi Journal of Ophthalmology

27. In vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with herpes simplex keratitis, HLA-B27 anterior uveitis and acute attack of primary angle closure Full Text available with Trip Pro

In vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with herpes simplex keratitis, HLA-B27 anterior uveitis and acute attack of primary angle closure To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43

2017 Scientific reports

28. New Therapeutic Perceptions in a Patient with Complicated Herpes Simplex Virus 1 Keratitis: A Case Report and Review of the Literature Full Text available with Trip Pro

New Therapeutic Perceptions in a Patient with Complicated Herpes Simplex Virus 1 Keratitis: A Case Report and Review of the Literature BACKGROUND Keratitis caused by herpes simplex virus (HSV) can have detrimental effects on the cornea leading to loss of vision. Modern therapies can contribute to the prevention of anatomical and functional damage. CASE REPORT An 80-year-old male with complicated HSV-1 keratitis of the left eye (confirmed diagnosis after microbiological investigation) presented (...) vascular episode) and the cornea was sufficiently clear with no signs of epitheliopathy and almost complete subsidence of the neovascularization. CONCLUSIONS Transplantation of AM and stem cells in combination with anti-VEGF factors and topical administration of cyclosporine-A 1% and poly-carboxymethyl glucose sulfate (a regenerative factor of corneal matrix) contributed substantially in the management of herpetic keratitis complications.

2017 The American journal of case reports

29. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Herpes Simplex Keratitis Herpes (...) Simplex Keratitis Aka: Herpes Simplex Keratitis , Herpes Keratitis , Herpetic Keratitis , Herpes Simplex Conjunctivitis , HSV Conjunctivitis , Herpetic Dendrite , Dendritic Keratitis , Dendritic Ulcer From Related Chapters II. Epidemiology Outbreaks in winter and early summer III. Symptoms Previous history of Herpes Keratitis Coexisting (herpetic rash) on lip or upper face Recent Absent history of Severe Photophobia Gritty sensation in eye IV. Signs Unilateral inflammation of and Dendritic Ulcers

2018 FP Notebook

30. Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review. (Abstract)

Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review. Herpes simplex virus (HSV) infection during pregnancy can cause severe neonatal infections. It is also a rare cause of congenital infections. We aimed to describe fetal and neonatal abnormalities of congenital HSV infection in order to define the features that are accessible to prenatal diagnosis during ultrasound screening and/or during a work-up for congenital malformations.We analysed all (...) cases of congenital HSV infection (CHI) described before and/or after birth and identified in Pubed and classified the findings as accessible or not to prenatal diagnosis.Thirty-six cases of congenital herpes infection were reported, of which 15 were described prenatally and 21 postnatally. The most frequently reported malformations accessible to prenatal diagnosis were cerebral anomalies. The most common abnormalities described after birth were skin lesions and keratitis, which are not considered

2020 Prenatal diagnosis

31. PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. Full Text available with Trip Pro

PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice.Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils (...) neovascularization.PEDF and its derived peptides reduce the severity of herpetic simplex keratitis in mice, representing the potential therapeutic approach to control HSK lesions.

2018 Investigative Ophthalmology & Visual Science

32. Use of a corneal impression membrane and PCR for the detection of herpes simplex virus type-1. Full Text available with Trip Pro

Use of a corneal impression membrane and PCR for the detection of herpes simplex virus type-1. Purpose. To investigate the use of a corneal impression membrane (CIM) for the detection of herpes simplex virus type 1 (HSV-1) in suspected herpes simplex keratitis (HSK).Methodology. In the laboratory study, swabs and CIMs made from polytetrafluoroethylene were spiked with different concentrations of HSV-1. DNA was extracted and real-time PCR undertaken using two sets of primers. In the clinical (...) . Overall, 73 patients (66.4 %) had probable, 20 patients (18.2 %) presumed and 17 patients (15.5 %) possible HSV-1 keratitis. The HSV-1 detection rate was significantly higher using a CIM (40/110, 36.4 %) than a swab (28/110, 25.5 %) (P=0.004). In the probable HSV keratitis group, the detection rate using a CIM was 43.8 % compared to 27.4 % for a swab (P=0.004). The cycle threshold values obtained for the conjunctival swabs were higher than those obtained for the CIMs (P<0.001).Conclusions

2019 Journal of Medical Microbiology

33. Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. Full Text available with Trip Pro

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection.The patient developed a sudden

2019 Medicine

34. Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan. (Abstract)

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan. Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.We enrolled patients with SLE recorded between 1997 and 2012

2019 Annals of the Rheumatic Diseases

35. Ocular manifestations of herpes simplex virus. (Abstract)

Ocular manifestations of herpes simplex virus. To review ocular manifestations and complications of herpes simplex virus (HSV) and discuss recent advancements in diagnostic and treatment strategy.In-vivo confocal microscopy has expanded our understanding of corneal nerve degeneration, corneal dendritic cell activity, and changes in biomechanical properties in HSV keratitis. Although currently available only as a research tool, metagenomic deep sequencing has the potential to improve diagnostic (...) accuracy beyond the well established PCR technology, especially in atypical cases. Development of an HSV vaccine has shown some encouraging results in a murine model. New treatment options for neurotrophic cornea offer promise, specifically cenegermin nerve growth factor.Ocular herpes simplex infection and its complications continue to cause significant visual burden and decreased quality of life. Familiarity with its clinical features, wider adoption of viral PCR diagnostic technology, and recognition

2019 Current opinion in ophthalmology

36. Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis Full Text available with Trip Pro

Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis 26712448 2016 04 22 2018 11 13 2542-5641 129 1 2016 Jan 05 Chinese medical journal Chin. Med. J. Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis. 115 10.4103/0366-6999.172610 eng Published Erratum China Chin Med J (Engl) 7513795 0366-6999 Chin Med J (Engl). 2015 Jan 5;128(1):46-50 25563312 2015 12 30 6 0

2016 Chinese medical journal

37. A novel rare sugar inhibitor of murine herpes simplex keratitis Full Text available with Trip Pro

A novel rare sugar inhibitor of murine herpes simplex keratitis To determine the therapeutic efficacy of a novel rare sugar, l-psicose, for the treatment of HSV-1 induced herpetic stromal keratitis (HSK) in a mouse eye model.One rare sugar l-psicose was assayed for HSV-1 inhibition of in vitro virus adsorption. The IC50 and IC90 values of l-psicose were determined using plaque reduction assay (PRA) in CV-1 cell. Female Balb/c mice were corneally infected with HSV-1, strain KOS-GFP; A topical

2016 Journal of Pharmacological Sciences

38. Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis Full Text available with Trip Pro

Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis To evaluate the efficacy of systemic and topical antiviral therapy in the treatment of active herpes simplex virus (HSV) necrotizing stromal keratitis (NSK).Prospective interventional case series.Patients with a diagnosis of HSV NSK based on history and clinical findings were enrolled in the study. A standard protocol was used for microbiologic investigations. Ten weeks regime of systemic (...) of antiviral treatment reduced significantly (P = 0.007). All patients showed a complete resolution of keratitis at the end of study.Topical and systemic acyclovir for treatment of NSK facilitates healing of ulceration. Topical steroids after initial antiviral therapy are safe and decreases inflammation and improve visual recovery. Early initiation of therapy has better outcomes as compared to late presentations.

2016 Indian journal of ophthalmology

39. Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis. Full Text available with Trip Pro

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis. To evaluate bilateral tear function and corneal sensitivity in patients with unilateral quiescent herpes simplex keratitis (HSK) and determine the correlation between corneal sensitivity and tear secretion in both eyes.Thirty-five patients diagnosed with unilateral quiescent HSK and 35 heathy controls were included in this study. Bilateral tear osmolarity, Schirmer's test, the tear break-up time

2016 Acta ophthalmologica

40. Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis. Full Text available with Trip Pro

Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis. To evaluate the quality of life (QoL) in patients with quiescent herpes simplex keratitis compared with control patients without ocular herpes.Prospective, case-control study.Thirty-three patients with a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were

2016 Ophthalmology

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