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Herpes Simplex Keratitis

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21. Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis

Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03217474 Recruitment Status : Recruiting First Posted : July 14, 2017 Last Update Posted : February 22

2017 Clinical Trials

22. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Herpes Simplex Keratitis Herpes (...) Simplex Keratitis Aka: Herpes Simplex Keratitis , Herpes Keratitis , Herpetic Keratitis , Herpes Simplex Conjunctivitis , HSV Conjunctivitis , Herpetic Dendrite , Dendritic Keratitis , Dendritic Ulcer From Related Chapters II. Epidemiology Outbreaks in winter and early summer III. Symptoms Previous history of Herpes Keratitis Coexisting (herpetic rash) on lip or upper face Recent Absent history of Severe Photophobia Gritty sensation in eye IV. Signs Unilateral inflammation of and Dendritic Ulcers

2018 FP Notebook

23. PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. Full Text available with Trip Pro

PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice. The purpose of this study was to explore the effects of pigment epithelium derived factor (PEDF) and PEDF-derived peptides Mer44 and Mer34 on the severity of herpetic simplex keratitis (HSK) in mice.Adult C57BL/6 mice were infected ocularly with the herpes simplex virus type 1 (HSV-1, McKrae strain) and injected subconjunctivally with PEDF, Mer44, or Mer34. Corneal nerve degeneration, neovascularization, sensitivity, neutrophils (...) neovascularization.PEDF and its derived peptides reduce the severity of herpetic simplex keratitis in mice, representing the potential therapeutic approach to control HSK lesions.

2018 Investigative Ophthalmology & Visual Science

24. Use of a corneal impression membrane and PCR for the detection of herpes simplex virus type-1. (Abstract)

Use of a corneal impression membrane and PCR for the detection of herpes simplex virus type-1. Purpose. To investigate the use of a corneal impression membrane (CIM) for the detection of herpes simplex virus type 1 (HSV-1) in suspected herpes simplex keratitis (HSK).Methodology. In the laboratory study, swabs and CIMs made from polytetrafluoroethylene were spiked with different concentrations of HSV-1. DNA was extracted and real-time PCR undertaken using two sets of primers. In the clinical (...) . Overall, 73 patients (66.4 %) had probable, 20 patients (18.2 %) presumed and 17 patients (15.5 %) possible HSV-1 keratitis. The HSV-1 detection rate was significantly higher using a CIM (40/110, 36.4 %) than a swab (28/110, 25.5 %) (P=0.004). In the probable HSV keratitis group, the detection rate using a CIM was 43.8 % compared to 27.4 % for a swab (P=0.004). The cycle threshold values obtained for the conjunctival swabs were higher than those obtained for the CIMs (P<0.001).Conclusions

2019 Journal of Medical Microbiology

25. Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan. (Abstract)

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan. Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.We enrolled patients with SLE recorded between 1997 and 2012

2019 Annals of the Rheumatic Diseases

26. Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. Full Text available with Trip Pro

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection.The patient developed a sudden

2019 Medicine

27. Ocular manifestations of herpes simplex virus. (Abstract)

Ocular manifestations of herpes simplex virus. To review ocular manifestations and complications of herpes simplex virus (HSV) and discuss recent advancements in diagnostic and treatment strategy.In-vivo confocal microscopy has expanded our understanding of corneal nerve degeneration, corneal dendritic cell activity, and changes in biomechanical properties in HSV keratitis. Although currently available only as a research tool, metagenomic deep sequencing has the potential to improve diagnostic (...) accuracy beyond the well established PCR technology, especially in atypical cases. Development of an HSV vaccine has shown some encouraging results in a murine model. New treatment options for neurotrophic cornea offer promise, specifically cenegermin nerve growth factor.Ocular herpes simplex infection and its complications continue to cause significant visual burden and decreased quality of life. Familiarity with its clinical features, wider adoption of viral PCR diagnostic technology, and recognition

2019 Current opinion in ophthalmology

28. Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis. Full Text available with Trip Pro

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis. To evaluate bilateral tear function and corneal sensitivity in patients with unilateral quiescent herpes simplex keratitis (HSK) and determine the correlation between corneal sensitivity and tear secretion in both eyes.Thirty-five patients diagnosed with unilateral quiescent HSK and 35 heathy controls were included in this study. Bilateral tear osmolarity, Schirmer's test, the tear break-up time

2016 Acta ophthalmologica

29. Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis. Full Text available with Trip Pro

Persistent Impairment of Quality of Life in Patients with Herpes Simplex Keratitis. To evaluate the quality of life (QoL) in patients with quiescent herpes simplex keratitis compared with control patients without ocular herpes.Prospective, case-control study.Thirty-three patients with a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were

2016 Ophthalmology

30. Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. Full Text available with Trip Pro

Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. To analyze the characteristics and long-term outcomes of patients that underwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus (HSV) keratitis.Retrospective, interventional, consecutive case series.Observational report of outcomes and findings for 9 patients with history of HSV keratitis that underwent PPK and were followed in a single institution. Difference between the median (...) with PPK for HSV keratitis in children provide improvement in BCVA when not compromised by amblyopia.Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

2016 American Journal of Ophthalmology

31. A novel rare sugar inhibitor of murine herpes simplex keratitis Full Text available with Trip Pro

A novel rare sugar inhibitor of murine herpes simplex keratitis To determine the therapeutic efficacy of a novel rare sugar, l-psicose, for the treatment of HSV-1 induced herpetic stromal keratitis (HSK) in a mouse eye model.One rare sugar l-psicose was assayed for HSV-1 inhibition of in vitro virus adsorption. The IC50 and IC90 values of l-psicose were determined using plaque reduction assay (PRA) in CV-1 cell. Female Balb/c mice were corneally infected with HSV-1, strain KOS-GFP; A topical

2016 Journal of Pharmacological Sciences

32. Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis Full Text available with Trip Pro

Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis To evaluate the efficacy of systemic and topical antiviral therapy in the treatment of active herpes simplex virus (HSV) necrotizing stromal keratitis (NSK).Prospective interventional case series.Patients with a diagnosis of HSV NSK based on history and clinical findings were enrolled in the study. A standard protocol was used for microbiologic investigations. Ten weeks regime of systemic (...) of antiviral treatment reduced significantly (P = 0.007). All patients showed a complete resolution of keratitis at the end of study.Topical and systemic acyclovir for treatment of NSK facilitates healing of ulceration. Topical steroids after initial antiviral therapy are safe and decreases inflammation and improve visual recovery. Early initiation of therapy has better outcomes as compared to late presentations.

2016 Indian journal of ophthalmology

33. Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis Full Text available with Trip Pro

Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis 26712448 2016 04 22 2018 11 13 2542-5641 129 1 2016 Jan 05 Chinese medical journal Chin. Med. J. Corrigendum: Clinical Efficacy of Oral Ganciclovir for Prophylaxis and Treatment of Recurrent Herpes Simplex Keratitis. 115 10.4103/0366-6999.172610 eng Published Erratum China Chin Med J (Engl) 7513795 0366-6999 Chin Med J (Engl). 2015 Jan 5;128(1):46-50 25563312 2015 12 30 6 0

2016 Chinese medical journal

34. Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes. Full Text available with Trip Pro

Effect of storage time and temperature on the detection of Pseudomonas aeruginosa, Acanthamoeba and Herpes Simplex Virus from corneal impression membranes. The effect of storage time and temperature on the recovery of pathogen DNA from polytetrafluorethylene (PTFE) was investigated. PTFE impression membranes were inoculated with Pseudomonas aeruginosa, Herpes Simplex Virus-1 (HSV-1) or Acanthamoeba and stored at -70 °C, -20 °C, +4 °C or +35 °C. PCR was performed on days 0, 1, 2, 3, 7 and months (...) the investigation of microbial keratitis where access to microbiological testing is not readily available.

2018 Journal of Medical Microbiology

35. Clinical management of herpes simplex virus infections: past, present, and future Full Text available with Trip Pro

Clinical management of herpes simplex virus infections: past, present, and future Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis

2018 F1000Research

36. In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis. Full Text available with Trip Pro

In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis. To report bilateral corneal endothelial cell density (ECD), as well as its correlation with subbasal nerve changes, in patients with unilateral herpes simplex keratitis (HSK).Thirty-six eyes of 36 patients with corneal scarring caused by HSK, as well as their respective contralateral clinically unaffected eyes, were prospectively studied and compared with 26 eyes of 26 healthy

2015 Investigative Ophthalmology & Visual Science

37. Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis. Full Text available with Trip Pro

Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis. Herpes simplex keratitis (HSK) caused by herpes simplex virus 1 (HSV-1), which has high recurrent rate and incidence of severe vision loss, is the leading cause of infectious blindness in the world. The aim was to explore the clinical efficacy of oral ganciclovir (GCV) in the prevention of recurrent HSK.A multicenter, prospective, randomized, single-blind, and controlled clinical trial (...) was conducted from April 2010 to June 2013. One hundred seventy-three patients (173 eyes involved) who were diagnosed as recurrent HSK definitely, including stromal keratitis and corneal endotheliitis, were divided into three groups randomly: negative control (placebo) group was topically administered with 0.15% GCV ophthalmic gel, 4 times per day and 0.1% fluorometholone eye drops, 3 times per day until resolution of HSK; positive control acyclovir (ACV) group was topically adopted the same ophthalmic gel

2015 Chinese medical journal Controlled trial quality: uncertain

38. Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population Full Text available with Trip Pro

Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population Acquired immune deficiency syndrome (AIDS) is associated with a wide spectrum of systemic and ocular infectious diseases. Little information is known about Herpes Simplex Virus type 1 (HSV-1) keratoconjunctivitis in association with AIDS. Because HSV-1 is becoming, day by day, a common eye disease (nearly 100% patients of over 60 years old harbor HSV in their trigeminal ganglia at autopsy (...) ), this article discussing a worldwide public health problem.The purpose of this paper is to compare the incidence and clinical aspects of HSV-1 Keratitis in HIV/ AIDS patients compared with the general population who develops HSV- 1 Keratitis.The study is retrospective and comparative. Each patient was examined thoroughly at the biomicroscope ocular slit after corneal staining with fluorescein or rose bengal. Visual acuity, intraocular pressure and corneal sensitivity were also examined.From 170 patients

2015 Journal of medicine and life

39. Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function Full Text available with Trip Pro

Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function Ocular infection with herpes simplex virus 1 (HSV-1) sets off an inflammatory reaction in the cornea which leads to both virus clearance and chronic lesions that are orchestrated by CD4 T cells. Approaches that enhance the function of regulatory T cells (Treg) and dampen effector T cells can be effective to limit stromal keratitis (SK) lesion severity. In this report, we explore

2017 Journal of virology

40. Dendritic cells in the cornea during Herpes simplex viral infection and inflammation. (Abstract)

Dendritic cells in the cornea during Herpes simplex viral infection and inflammation. Herpes simplex keratitis is commonly caused by Herpes simplex virus type 1, which primarily infects eyelids, corneas, or conjunctiva. Herpes simplex virus type 1-through sophisticated interactions with dendritic cells (DCs), a type of antigen-presenting cell)-initiates proinflammatory responses in the cornea. Corneas were once thought to be an immune-privileged region; however, with the recent discovery of DCs (...) that reside in the cornea, this long-held conjecture has been overturned. Therefore, evaluating the clinical, preclinical, and cell-based studies that investigate the roles of DCs in corneas infected with Herpes simplex virus is critical. With in vivo confocal microscopy, animal models, and cell culture experiments, we may further the understanding of the sophisticated interactions of Herpes simplex virus with DCs in the cornea and the molecular mechanism associated with it. It has been shown

2017 Survey of Ophthalmology

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