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Herpes Simplex Keratitis

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181. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine.com

182. Herpes Zoster Ophthalmicus (Treatment)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

183. Herpes Zoster (Treatment)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

184. Herpes Zoster Ophthalmicus (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

185. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

186. Herpes Zoster Ophthalmicus (Diagnosis)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

187. Herpes Zoster (Diagnosis)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

188. Herpes Zoster Ophthalmicus (Overview)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

189. Herpes Zoster (Overview)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

190. Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability and SNP Distribution. Full Text available with Trip Pro

Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability and SNP Distribution. Little is known about the role of sequence variation in the pathology of HSV-1 keratitis virus. The goal was to show that a multiplex, high-throughput genome-sequencing approach is feasible for simultaneously sequencing seven HSV-1 ocular strains.A genome sequencer was used to sequence the HSV-1 ocular isolates TFT401, 134, CJ311, CJ360, CJ394, CJ970, and OD4

2011 Investigative Ophthalmology & Visual Science

191. Sequence Variation in the Herpes Simplex Virus US1 Ocular Virulence Determinant. Full Text available with Trip Pro

Sequence Variation in the Herpes Simplex Virus US1 Ocular Virulence Determinant. The herpes simplex virus type 1 (HSV-1) U(S)1 gene encodes host-range and ocular virulence determinants. Mutations in U(S)1 affecting virulence are known in strain OD4, but the genomic variation across several strains is not known. The goal was to determine the degree of sequence variation in the gene from several ocular HSV isolates.The U(S)1 gene from six ocular HSV-1 isolates, as well as strains KOS and F, were (...) in the central core. Consensus-binding motifs for cyclin-dependent kinases and pocket proteins were also identified.These results suggest that significant sequence variation exists in the U(S)1 gene, that the α22 protein contains a conserved central core region with structurally variable regions at the amino- and carboxyl termini, that 10 amino acids are conserved in α-herpes U(S)1 homologs, and that additional host proteins may interact with the HSV-1 U(S)1 and U(S)1.5 proteins. This information

2011 Investigative Ophthalmology & Visual Science

192. Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes

Investigator, would prevent study completion. A history of HSV infection of the eye (herpes simplex interstitial keratitis or uveitis), or herpes-associated erythema multiforme. A history of immune suppression or autoimmune disorder. Continued use of suppressive anti-viral therapy for HSV-2; a one week washout of any anti-viral therapy (suppressive and episodic) is required prior to initiating the swabbing period. Concomitant use of systemic corticosteroids or immune-suppressive medications. The use (...) , 2015 Sponsor: Agenus Inc. Information provided by (Responsible Party): Agenus Inc. Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the effect the HerpV vaccine has on recurring episodes of genital herpes by evaluating viral shedding before, after treatment. Condition or disease Intervention/treatment Phase Herpes Simplex Type II Drug: HerpV and QS-21 Drug: Placebo Phase 2 Detailed Description: This study will evaluate the biological effectiveness

2012 Clinical Trials

193. Herpes simplex

virus type 1 from patients with genital herpes in Nova Scotia". Can J Infect Dis . 14 (2): 94–96. : . ^ John Leo (1982-08-02). . . from the original on 2010-02-02. ^ Chow AW, Roland A, Fiala M, et al. (March 1973). . Antimicrob. Agents Chemother . 3 (3): 412–17. : . . . Kaufman HE, Howard GM (August 1962). "Therapy of experimental herpes simplex keratitis". Investigative Ophthalmology . 1 : 561–4. . Ch'ien LT, Whitley RJ, Alford CA, Galasso GJ (June 1976). "Adenine arabinoside for therapy of herpes (...) Herpes simplex Herpes simplex - Wikipedia Herpes simplex From Wikipedia, the free encyclopedia Viral disease caused by the herpes simplex virus "Herpes" redirects here. For other uses, see . For the virus that causes herpes simplex, see . For all types of herpes viruses, see . Herpes simplex Other names Cold sores, fever blisters of the lower lip. Note the blisters in a group marked by an arrow. Symptoms Blisters that break open and form small , fever, swollen Duration 2–4 weeks Causes spread

2012 Wikipedia

194. Effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas. Full Text available with Trip Pro

virus and herpes simplex virus, respectively. In each monkey one eye served as a control for the full cycle of disease. In the other eye HIF treatment was initiated prophylactically 15 h before or simultaneously with the challenge virus infection or 6 to 20 h postinfectionally or therapeutically after onset of the disease, and the treatment was continued for 2 to 7 days. Prophylactic and simultaneous administration equally resulted in inhibition of both vaccinia and herpes keratitis. Postinfectional (...) Effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas. Pretreatment of human fibroblast cultures with human leukocyte interferon (HIF, 1,000 IU/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. Additional HIF treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. Equal results were obtained in simian cells with 3,000 IU of HIF

1975 Infection and immunity

195. Peripheral Ulcerative Keratitis

opacification. Infectious causes, such as bacteria, fungi, and herpes simplex virus, must be ruled out by culturing the ulcer and eyelid margins. Keratitis (Peripheral Ulcerative) DR M.A. ANSARY/SCIENCE PHOTO LIBRARY Among patients with autoimmune connective tissue disease and peripheral ulcerative keratitis, the 10-yr mortality rate is about 40% (usually due to MI) without treatment and about 8% with systemic cytotoxic therapy. Any patient with peripheral ulcerative keratitis should be promptly referred (...) Peripheral Ulcerative Keratitis Peripheral Ulcerative Keratitis - Eye Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / OTHER TOPICS IN THIS CHAPTER Test your knowledge Blurred Vision

2013 Merck Manual (19th Edition)

196. Herpes simplex virus keratitis: histopathology and corneal allograft outcomes Full Text available with Trip Pro

Herpes simplex virus keratitis: histopathology and corneal allograft outcomes Molecular biologic studies have elucidated the roles of specific and innate immune responses in the pathogenesis of HSV keratitis. Recent evidence suggests that interference with innate immune mechanisms may reduce the severity of HSV keratitis and its complications. The agents targeting innate immune responses are particularly amenable to translational therapy for patients at risk of complications of HSV keratitis

2010 Expert review of ophthalmology

197. Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Full Text available with Trip Pro

Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Herpes Simplex Virus (HSV) keratitis is a leading cause of corneal blindness. Definitive laboratory diagnosis is essential for timely management. Collection of corneal scrapings in patients with advanced epithelial keratitis and corneal thinning poses perforation risks; tear fluid is a feasible and convenient alternative (...) but has not been widely evaluated for HSV detection.Tear fluid alone (229) or along with corneal scrapings (153) from patients of suspected herpetic keratitis was tested for HSV-1 antigen by indirect immunofluorescence assay, virus isolation in Hep 2 cells and PCR to amplify the 111bp region of the thymidine kinase (tk) coding gene and the 144bp region from the DNA polymerase coding gene of HSV.HSV 1 antigen was detected in 31/229 (13.53%) tear specimen and 35/153 (22.87%) corneal scrapings

2010 British Journal of Ophthalmology

198. SELECTIVE CHANGES IN HUMAN CORNEAL SENSATION ASSOCIATED WITH HERPES SIMPLEX VIRUS KERATITIS. Full Text available with Trip Pro

SELECTIVE CHANGES IN HUMAN CORNEAL SENSATION ASSOCIATED WITH HERPES SIMPLEX VIRUS KERATITIS. To determine corneal sensitivity to selective mechanical, chemical, and thermal (heat and cold) stimulation in patients with a history of herpes simplex virus (HSV) keratitis.Corneal sensitivity to different modalities of stimulus was determined in both eyes of 16 patients with unilateral HSV keratitis diagnosed 1 to 12 months before the study. On slit lamp examination, 13 HSV-affected eyes showed (...) corneal scarring or opacities, and three had no signs of previous keratitis. Corneal sensitivity was determined with the Belmonte gas esthesiometer. Mechanical, chemical, heat, and cold stimuli were applied on the central cornea. Eyes from 10 healthy subjects served as controls.In all control and contralateral eyes, selective mechanical, chemical, heat, and cold stimulation evoked sensations of subjective intensity proportional to the magnitude of the applied stimulus. In one HSV patient, the affected

2010 Investigative Ophthalmology & Visual Science

199. [Clinical assessment of oral ganciclovir capsules on the treatment of herpes simplex keratitis]. (Abstract)

[Clinical assessment of oral ganciclovir capsules on the treatment of herpes simplex keratitis]. To evaluate the clinical values of oral ganciclovir on the treatment of herpes simplex keratitis (HSK).A randomized, controlled, single-blind and prospective study was carried out from May in 2008 to June in 2009 at Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University. 60 patients (60 eyes) with HSK, including stromal keratitis and corneal endotheliitis, were enrolled (...) to relieve the symptoms and signs and shorten the pathogenesis of herpes simplex stromal keratitis and corneal endotheliitis. And short-term oral ganciclovir has confirmed good safety.

2010 [Zhonghua yan ke za zhi] Chinese journal of ophthalmology Controlled trial quality: uncertain

200. Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. Full Text available with Trip Pro

Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. To determine whether substance P (SP) in herpes simplex virus-1 (HSV-1) infected cornea regulates the severity of herpetic stromal keratitis (HSK) lesions in a mouse model.C57BL/6 mice were infected ocularly with HSV-1 (RE). The corneas with HSK lesions, on Day 15 postinfection, were grouped on the basis of the corneal opacity as mild (≤2) or severe (>2). The amount of SP was determined

2011 Investigative Ophthalmology & Visual Science

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