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Herpes Simplex Keratitis

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181. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine.com

182. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine.com

183. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine.com

184. Herpes Zoster Ophthalmicus (Overview)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

185. Herpes Zoster (Overview)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

186. Herpes Zoster Ophthalmicus (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

187. Herpes Zoster (Follow-up)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

188. Herpes Zoster (Diagnosis)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine.com

189. Herpes Zoster Ophthalmicus (Treatment)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

190. Herpes Zoster (Treatment)

: clinicopathologic report of 12 cases and review of the literature. Medicine (Baltimore) . 1983 Mar. 62(2):81-97. . Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J Virol . 1999 Dec. 73(12):10514-8. . . Pavan-Langston D. Herpes zoster ophthalmicus. Neurology . 1995 Dec. 45(12 Suppl 8):S50-1. . Sweeney CJ, Gilden DH. Ramsay Hunt syndrome. J Neurol Neurosurg Psychiatry . 2001 Aug (...) necrosis and acute retinal necrosis in fellow eyes of a patient with acquired immunodeficiency syndrome. Am J Ophthalmol . 2001 Sep. 132(3):421-3. . Neves RA, Rodriguez A, Power WJ, Muccioli C, Lane L, Belfort R Jr, et al. Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. Cornea . 1996 Sep. 15(5):446-50. . Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. Herpes zoster following intra-articular corticosteroid injection. Acta

2014 eMedicine Emergency Medicine

191. Herpes Zoster (Diagnosis)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

192. Herpes Zoster Ophthalmicus (Diagnosis)

include hyperesthesia or, more rarely, hypoesthesia or anesthesia in the area of involvement Common features of herpes zoster ophthalmicus are as follows: Classic symptoms and lesions of herpes zoster Ophthalmic manifestations including conjunctivitis, scleritis, episcleritis, keratitis iridocyclitis, Argyll-Robertson pupil, glaucoma, retinitis, choroiditis, optic neuritis, optic atrophy, retrobulbar neuritis, exophthalmos, lid retraction, ptosis, and extraocular muscle palsies Other forms include (...) in the same host. Of more than 100 types of Herpesviridae viruses, eight are of particular interest in humans: herpes simplex viruses (HSVs)–1 and 2, VZV, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). [ ] Postmortem examination of trigeminal and/or facial ganglia detected these viruses in 30 (63.8%) of 47 subjects, with HHV-6 being the most prevalent, identified in 46.8% of them, followed by HSV-1 in 14.9%, VZV in 8.5%, EBV in 8.5%, HSV-2

2014 eMedicine Emergency Medicine

193. Herpes Simplex Virus (HSV) Infections

. Herpes simplex keratitis (HSV infection of the corneal epithelium) causes pain, tearing, photophobia, and corneal ulcers that often have a branching pattern. Herpetic whitlow Herpetic Whitlow DR P. MARAZZI/SCIENCE PHOTO LIBRARY , a swollen, painful, erythematous lesion of the distal phalanx, results from inoculation of HSV through the skin and is most common among health care practitioners. Neonatal herpes simplex develops in neonates, including those whose mothers have no suggestion of current (...) simplex keratitis involves topical antivirals, such as trifluridine , and should be supervised by an ophthalmologist. Neonatal herpes simplex Acyclovir 20 mg/kg IV q 8 h for 14 to 21 days should be used if renal function is normal. A dose of 20 mg/kg IV q 8 h for at least 21 days is indicated for CNS and disseminated HSV disease. CNS infection Encephalitis is treated with acyclovir 10 mg/kg IV q 8 h for 14 to 21 days if renal function is normal. Treatment for 14 to 21 days is preferred to prevent

2013 Merck Manual (19th Edition)

194. Acyclovir-resistant herpetic keratitis in a solid-organ transplant recipient on systemic immunosuppression (PubMed)

three times per day for herpetic keratitis with no resolution of the epithelial defect or symptoms. Corneal scrapes and swabs were taken for confirmation of the diagnosis and resistance testing. The results were positive for herpes simplex virus 1 and showed acyclovir resistance (inhibitor concentration 90 = 200 μg/mL) and foscarnet sensitivity (inhibitor concentration 90 = 200 μg/mL). The patient was treated with topical trifluridine 2-hourly for 3 weeks and weaned off the drops over the following (...) Acyclovir-resistant herpetic keratitis in a solid-organ transplant recipient on systemic immunosuppression To report a case of acyclovir-resistant herpetic keratitis in a solid-organ lung transplant recipient that was effectively treated with topical trifluridine.A case of a 35-year-old female with herpetic epithelial keratitis resistant to acyclovir is described. The patient presented following treatment for 4 weeks with topical acyclovir ointment five times per day and oral valacyclovir 1 g

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2013 Clinical ophthalmology (Auckland, N.Z.)

195. The prevention and management of herpes zoster

and its sequelae. Medicine 1982; 61: 310-316. Brisson M, Edmunds W, Law B, et al. Epidemiology of varicella zoster virus infection in Canada and the United Kingdom. Epidemiol Infect 2001; 127: 305-314. Dworkin RH, Johnson RW, Breuer J, et al. Recommendations for the management of herpes zoster. Clin Infect Dis 2007; 44 Suppl 1: S1-S26. Heininger U, Seward JF. Varicella. Lancet 2006; 368: 1365-1376. Dwyer DE, Cunningham AL. Herpes simplex and varicella-zoster virus infections. Med J Aust 2002; 177: 267 (...) The prevention and management of herpes zoster The prevention and management of herpes zoster | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect person_outline Login keyboard_arrow_down Individual Login Purchase options menu search Advertisement close The prevention

2008 MJA Clinical Guidelines

196. Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. (PubMed)

Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. To determine whether substance P (SP) in herpes simplex virus-1 (HSV-1) infected cornea regulates the severity of herpetic stromal keratitis (HSK) lesions in a mouse model.C57BL/6 mice were infected ocularly with HSV-1 (RE). The corneas with HSK lesions, on Day 15 postinfection, were grouped on the basis of the corneal opacity as mild (≤2) or severe (>2). The amount of SP was determined

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2011 Investigative Ophthalmology & Visual Science

197. Varicella-Zoster Virus Keratitis with Asymptomatic Conjunctival Viral Shedding in the Contralateral Eye (PubMed)

injections in the left eye. Bacterial cultures of the corneal scrapings and virus PCR analyses of tear fluid from both eyes were performed.No pathogen was found by bacterial cultures. PCR was negative for Acanthamoeba, herpes simplex virus and cytomegalovirus, but positive for VZV. VZV DNA was also detected in the unaffected eye. Based on the diagnosis of VZV keratitis, oral valacyclovir and acyclovir eye ointment were administered to the corneal infected eye. The infected eye was healed and VZV DNA (...) Varicella-Zoster Virus Keratitis with Asymptomatic Conjunctival Viral Shedding in the Contralateral Eye To report a case of varicella-zoster virus (VZV) keratitis with detection of VZV DNA in the tear fluid of not only the symptomatic eye but also the contralateral asymptomatic eye by polymerase chain reaction (PCR).This is a case report. A 63-year-old otherwise healthy woman presented with circular corneal ulcer and stromal opacity with infiltration accompanied by mild conjunctival and ciliary

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2012 Case reports in ophthalmology

198. Targeting Herpetic Keratitis by Gene Therapy (PubMed)

Targeting Herpetic Keratitis by Gene Therapy Ocular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness. Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution. This paper will focus on the current (...) situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies. Whereas the correction of inherited diseases was the initial goal of the field of gene therapy, here we discuss transgene expression, gene replacement, silencing, or clipping. Gene therapy of herpetic keratitis previously reported in the literature is screened emphasizing candidate gene therapy targets

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2012 Journal of ophthalmology

199. Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK (PubMed)

Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK Herpes simplex virus 1 (HSV-1) infection of the cornea leads to a potentially blinding disease, termed herpetic stromal keratitis (HSK) that is characterized by lesions of an immunoinflammatory nature. In spite of the fact that HSK typically presents as a recurrent disease due to reactivation of virus which latently infects the trigeminal ganglia, most murine studies of HSK have employed a primary and not recurrent

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2012 Clinical and Developmental Immunology

200. Viral Keratitis-Inhibitory Effect of 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate (PubMed)

Viral Keratitis-Inhibitory Effect of 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate Topical application of 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP) significantly inhibited the development of keratitis induced by types 1 and 2 herpes simplex virus and vaccinia virus in the eyes of rabbits. Parameters for evaluation of efficacy were infectivity (corneal opacity, lesion size, and type), Draize (erythema, conjunctival swelling, and discharge), and reduction in titer (...) of recoverable virus from the eye. When the relative efficacy of the related compounds 9-beta-d-arabinofuranosyladenine (ara-A), ara-A 5'-monophosphate (ara-AMP), and ara-Hx was determined against type 1 herpes simplex virus in a parallel experiment, the more water-soluble compounds (ara-HxMP, ara-AMP) were the most effective. The relative efficacy of ara-A was also determined against type 2 herpes and vaccinia virus-induced keratitis. Mortality in rabbits due to central nervous system involvement caused

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1975 Antimicrobial Agents and Chemotherapy

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