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Herpes Simplex Keratitis

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1. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis (HSK) submit The College submit You're here: Herpes Simplex Keratitis (HSK) Herpes Simplex Keratitis (HSK) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Herpes simplex virus (HSV) infection is extremely common, though usually latent up to 90 (...) is 5-15 per 100,000 per annum) can manifest as blepharoconjunctivitis, keratitis, iridocyclitis or acute retinal necrosis. The most common form is epithelial keratitis, accounting for 50% to 80% of ocular herpes Ocular HSV infection can be categorised into primary and recurrent disease Herpes simplex keratitis (HSK) is the leading cause of corneal blindness in developed countries. In UK, responsible for 1 in 10 corneal transplants Predisposing factors Poor general health, immunodeficiency, fatigue

2020 College of Optometrists

2. Herpes simplex - ocular: How should I assess a person with suspected ocular herpes simplex infection?

) may indicate significant epithelial involvement. Note: the absence of dendritic ulceration does not exclude a diagnosis of herpes simplex keratitis. Test visual acuity using a Snellen chart. Laboratory investigations are not necessary in primary care. Basis for recommendation Features of the initial assessment The recommendations on how to assess a person with suspected ocular herpes simplex are largely based on The College of Optometrists clinical management guidelines Herpes simplex keratitis (...) (HSK) [ ], a Cochrane systematic review Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis (Review) [ ], an American Academy of Ophthalmology treatment guideline Herpes simplex virus keratitis: a treatment guideline [ ], and expert opinion in review articles on herpes keratitis and herpes simplex infection [ ; ]. A history of previous episodes of herpes simplex keratitis significantly increases the risk of future recurrences [ ]. Use of contact

2019 NICE Clinical Knowledge Summaries

3. Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Full Text available with Trip Pro

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies (...) which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken.To assess the efficacy of oral antivirals such as acyclovir in any dosage when taken for six months or more, in preventing recurrence of herpetic keratitis in people having corneal graft surgery for herpetic keratitis.We searched CENTRAL (which contains the Cochrane Eyes and Vision

2016 Cochrane

4. What Is the Most Effective Treatment of Herpes Simplex Keratitis?

What Is the Most Effective Treatment of Herpes Simplex Keratitis? TAKE-HOME MESSAGE Treatmentofherpessimplexviruskeratitiscanbeaccomplishedwitheithertopical tri?uridineorganciclovir,whichhavesimilaref?cacy.Oralacyclovirisanacceptable treatment option in cases for which compliance with a topical ophthalmic regimen may be of concern. What Is the Most Effective Treatment of Herpes Simplex Keratitis? EBEM Commentators Joshua Bucher, MD Rutgers–Robert Wood Johnson Medical School New Brunswick, NJ (...) % con?dence interval [CI] 0.8 to 1.1). 1 Similarly, there was no difference in the primary outcome between interferon treatment and antivirals (RR 1.2; 95% CI 0.9 to 1.6). Commentary It is estimated that herpes simplex virus keratitis has an incidence of approximately12to31peopleper 100,000 annually. 2,3 Although it is a relatively uncommon diagno- sis in the emergency department setting, initiation of appropriate treatment is critical, given the potential to lead to serious visual impairment

2016 Annals of Emergency Medicine Systematic Review Snapshots

5. Epithelial keratitis mimicking herpes simplex keratitis in a patient after cataract surgery: A case report. Full Text available with Trip Pro

Epithelial keratitis mimicking herpes simplex keratitis in a patient after cataract surgery: A case report. Epithelial keratitis is a common complication after cataract surgery. Many factors have been attributed to this clinical phenomenon.An 82-year-old woman without previous herpes simplex keratitis (HSK) underwent an uncomplicated clear corneal phacoemulsification procedure in the right eye. In the late postoperative period, epithelial keratitis developed in this same eye.An initial (...) diagnosis of HSK was made clinically. The lesion was refractory to antiviral treatment and had progressed. After topical acyclovir cessation and vigorous lubrication, a diagnosis of toxic keratitis was finally made.The corneal epithelial defect and dendritic lesion presented initially. Responding to antiviral treatment, this corneal lesion aggravated and revealed large epithelial erosion. After topical acyclovir cessation and initiation of vigorous lubrication, the toxic keratitis was completely

2019 Medicine

6. Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis. Full Text available with Trip Pro

Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis. Herpes simplex virus type 1 (HSV-1) keratitis is a major cause of corneal blindness in the world, and an in-depth understanding of its pathogenesis may help improve existing diagnosis and treatment. The purpose of this study is to compare and analysis the total tear protein profile of HSV-1 epithelial keratitis patients, and to quantify the potential candidate biomarkers of HSV-1 epithelial (...) keratitis.We investigated the proteome in tear fluid from three HSV-1 epithelial keratitis patients and three healthy control subjects using nano-scale liquid chromatography-tandem mass spectrometry (nLC-MS/MS) analysis. Functional annotation of differentially expressed proteins was done with the Gene Ontology (GO) analysis. ELISA was done to quantify the potential candidate biomarkers in 26 clinical cases.Tear fluid from three HSV-1 epithelial keratitis patients and three healthy control subjects

2020 BMC Ophthalmology

7. DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis Full Text available with Trip Pro

DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis To investigate whether DNA vaccine encoding herpes simplex virus 1 (HSV-1) glycoprotein C (gC) and glycoprotein D (gD) will achieve better protective effect against herpes simplex keratitis (HSK) than DNA vaccine encoding gD alone.DNA vaccine expressing gD or gC combined gD (gD.gC) were constructed and carried by chitosan nanoparticle. The expression of fusion protein gD and gC were

2017 International journal of ophthalmology

8. Reactivation of herpes simplex viral keratitis following the botulinum toxin injection Full Text available with Trip Pro

Reactivation of herpes simplex viral keratitis following the botulinum toxin injection We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Contralateral eye was essentially normal. Following the botulinum toxin injection for the management of spastic entropion, subject (...) developed reactivation of herpetic necrotizing stromal keratitis. Diagnostic corneal scrapings were negative for herpes simplex virus-1 antigen by immunofluorescence assay and for DNA by molecular techniques. The case was successfully managed with topical steroids and antiviral medications.

2018 Indian journal of ophthalmology

9. Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence Full Text available with Trip Pro

Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 (...) to January 2015. Clinical features, ocular complications, and recurrences were recorded.In total, 149 eyes of the 133 patients (72 male and 61 female) were followed for an average of 24.6 ± 13.2 months. Sixteen (12.0%) patients had bilateral HSK. The most frequent HSK subtype was epithelial keratitis (49.7%), which was followed by stromal keratitis (23.5%). Epithelial keratitis was the most likely subtype to recur. Complications occurred in 122 (81.9%) eyes. The most common complication was corneal

2018 Korean journal of ophthalmology : KJO

10. Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty Full Text available with Trip Pro

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated.The incidence of new onset HSK after keratoplasty

2018 Journal of ophthalmology

11. Management of Herpes Simplex Virus Keratitis in the Pediatric Population. (Abstract)

Management of Herpes Simplex Virus Keratitis in the Pediatric Population. Herpes simplex virus (HSV) keratitis is a highly prevalent and visually disabling disease in both the pediatric and adult population. While many studies have investigated the treatment of HSV keratitis in adult patients, few have focused on managing this condition in children. Children are at particularly high risk for visual morbidity due to unique challenges in diagnosis and treatment, and the often more aggressive (...) disease course that results in corneal scarring, and subsequently amblyopia. This review presents the pathogenesis and most current recommendations for the medical and surgical management of HSV keratitis in the pediatric population.

2018 Pediatric Infectious Dsease Journal

12. Management of herpes simplex virus epithelial keratitis. (Abstract)

Management of herpes simplex virus epithelial keratitis. To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis.Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Resistance to ACV has become a concerning issue. The animal models of HSV vaccine are able to reduce HSV keratitis. New antivirals are under (...) development.Current cases of HSV epithelial keratitis are manageable with available medications, but new advancements are required to decrease disease burden in the future. HSV vaccine can be revolutionary.

2018 Current Opinion in Ophthalmology

13. A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis

A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical

2018 Clinical Trials

14. Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection Full Text available with Trip Pro

Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2.5 units of BTA injection in each lacrimal gland for functional epiphora. The patient had a history of herpes (...) simplex viral keratitis that was quiescent for more than 2 years. After 3 weeks, she developed reactivation of viral keratitis bilaterally, which was successfully managed with antivirals and topical steroids. Reactivation of quiescent herpes simplex keratitis is a possibility after lacrimal gland BTA and caution should be exercised in such cases.

2018 Indian journal of ophthalmology

15. Herpes simplex - ocular: What else could it be?

, watering, and a sensation of a foreign body in the eye. May have a stellate or dendritic appearance of the cornea on fluorescein staining. For more information, see the CKS topic on . For more detailed information on the differential diagnosis of acute red eye, see the CKS topic on . Basis for recommendation The information on the differential diagnosis of ocular herpes simplex infection is based on expert opinion in the College of Optometrists clinical management guidelines Herpes simplex keratitis (...) (HSK) [ ], an American Academy of Ophthalmology treatment guideline Herpes simplex virus keratitis: a treatment guideline [ ], and a Cochrane systematic review Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis (Review) [ ]. © .

2019 NICE Clinical Knowledge Summaries

16. Herpes simplex - ocular: Scenario: Management

; or there is suspected recurrent infection in a person with a clear history of previous episodes, and keratitis is confined to the epithelium. Advise the person on sources of information and support. Advise that herpes simplex virus is easily transmitted to other people. Avoid touching the lesions where possible, and wash hands with soap and water immediately if needed. Advise the person not to use contact lenses until 24 hours after all symptoms have resolved. Provide patient information leaflets (...) drug prophylaxis for people with recurrent epithelial or stromal keratitis. Surgical treatment such as penetrating keratoplasty (corneal transplantation) in some cases of stromal keratitis after the acute infection has resolved, where a sight-threatening scar remains. In the UK between 1987–1991, herpes simplex keratitis was responsible for 1 in 10 of all corneal transplants performed. Corneal opacification is treated by replacement of the scarred cornea with a full-thickness clear donor cornea

2019 NICE Clinical Knowledge Summaries

17. Herpes simplex - ocular

increasing after each subsequent episode. The diagnosis of suspected ocular herpes simplex infection in primary care is clinical. Symptoms and signs include: Eye pain, eye irritation or watering, and photophobia. Blurred vision. An acute red eye. Crops of vesicles, ulcers, or pustules along the lid margin or periocular skin. A hazy cornea or creamy opacity (suggests stromal keratitis). A fixed irregular pupil or limbal injection (suggests iritis or uveitis). Reduced corneal sensation. Reduced visual (...) Herpes simplex - ocular Herpes simplex - ocular | Topics A to Z | CKS | NICE Search CKS… Menu Herpes simplex - ocular Herpes simplex - ocular Last revised in November 2016 Herpes simplex virus (HSV) ocular infections can cause inflammation of the retina (retinitis), iris and associated uveal tract (iritis or uveitis) Diagnosis Management Background information Herpes simplex - ocular: Summary Herpes simplex virus (HSV) ocular infections can cause inflammation of the retina (retinitis), iris

2019 NICE Clinical Knowledge Summaries

18. Herpes simplex - ocular: When should I suspect ocular herpes simplex infection?

(in about 88% of cases), but may be bilateral, especially in children and people who are immunosuppressed or atopic. Suspect ocular herpes simplex infection if a person presents with: A past history of ocular herpes simplex infection. A recent history of blepharoconjunctivitis, which is not resolving as expected — herpes simplex keratitis tends to occur 1–2 weeks after conjunctivitis and lid disease. Typical symptoms of: Malaise and fever — more common in primary herpes simplex infection. Eye pain (...) a previous herpes episode) or a localized 'creamy' opacity (suggests ). A fixed irregular pupil or erythema around the whole cornea (limbal injection, suggests iritis or uveitis). Reduced corneal sensitivity — suggests keratitis. Reduced visual acuity. Basis for recommendation The recommendations on when to suspect ocular herpes simplex infection are based on expert opinion in an American Academy of Ophthalmology treatment guideline Herpes simplex virus keratitis: a treatment guideline [ ], and expert

2016 NICE Clinical Knowledge Summaries

19. Observation on the Herpes Simplex Keratitis

Observation on the Herpes Simplex Keratitis Observation on the Herpes Simplex Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Observation on the Herpes Simplex Keratitis (OHSV) The safety (...) by (Responsible Party): Yang Jiang, Peking Union Medical College Study Details Study Description Go to Brief Summary: As is reported, NSAIDs(pranoprofen ,bromfenac) eye drops can suppress herpes simplex virus(HSV-1) reactivation and reduce inflammatory reaction in vitro and in vivo. In Clinical, there is no risk of corneal tissue melting, glaucoma, cataract by topical application of NSAIDs. To explore more effective clinical treatment of viral keratitis patients to control the inflammatory damage, save

2017 Clinical Trials

20. Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis

Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03217474 Recruitment Status : Recruiting First Posted : July 14, 2017 Last Update Posted : February 22

2017 Clinical Trials

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