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Herpes Simplex Keratitis

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1. Herpes Simplex Keratitis

Herpes Simplex Keratitis Herpes Simplex Keratitis (HSK) submit The College submit You're here: Herpes Simplex Keratitis (HSK) Herpes Simplex Keratitis (HSK) The CMGs are guidelines on the diagnosis and management of a range of common and rare, but important, eye conditions that present with varying frequency in primary and first contact care. Share options Please login to view the images or . Aetiology Herpes simplex virus (HSV) infection is extremely common, though usually latent up to 90 (...) is 5-15 per 100,000 per annum) can manifest as blepharoconjunctivitis, keratitis, iridocyclitis or acute retinal necrosis. The most common form is epithelial keratitis, accounting for 50% to 80% of ocular herpes Ocular HSV infection can be categorised into primary and recurrent disease Herpes simplex keratitis (HSK) is the leading cause of corneal blindness in developed countries. In UK, responsible for 1 in 10 corneal transplants Predisposing factors Poor general health, immunodeficiency, fatigue

2018 College of Optometrists

2. Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. (PubMed)

Oral antivirals for preventing recurrent herpes simplex keratitis in people with corneal grafts. Ocular herpes is a viral infection of the eye caused by the herpes simplex virus (HSV), a double-stranded DNA virus. Corneal scarring caused by herpes simplex keratitis (HSK) is the leading infectious cause of penetrating corneal graft in high-income countries. Acyclovir is an antiviral drug known to have a protective effect against recurrences in herpetic eye disease. While there are some studies (...) which have evaluated the effects of intervention with oral antiviral in preventing such recurrences in people with corneal grafts, a systematic review of all comparative clinical trials has not been previously undertaken.To assess the efficacy of oral antivirals such as acyclovir in any dosage when taken for six months or more, in preventing recurrence of herpetic keratitis in people having corneal graft surgery for herpetic keratitis.We searched CENTRAL (which contains the Cochrane Eyes and Vision

2016 Cochrane

3. What Is the Most Effective Treatment of Herpes Simplex Keratitis?

What Is the Most Effective Treatment of Herpes Simplex Keratitis? TAKE-HOME MESSAGE Treatmentofherpessimplexviruskeratitiscanbeaccomplishedwitheithertopical tri?uridineorganciclovir,whichhavesimilaref?cacy.Oralacyclovirisanacceptable treatment option in cases for which compliance with a topical ophthalmic regimen may be of concern. What Is the Most Effective Treatment of Herpes Simplex Keratitis? EBEM Commentators Joshua Bucher, MD Rutgers–Robert Wood Johnson Medical School New Brunswick, NJ (...) % con?dence interval [CI] 0.8 to 1.1). 1 Similarly, there was no difference in the primary outcome between interferon treatment and antivirals (RR 1.2; 95% CI 0.9 to 1.6). Commentary It is estimated that herpes simplex virus keratitis has an incidence of approximately12to31peopleper 100,000 annually. 2,3 Although it is a relatively uncommon diagno- sis in the emergency department setting, initiation of appropriate treatment is critical, given the potential to lead to serious visual impairment

2016 Annals of Emergency Medicine Systematic Review Snapshots

4. DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis (PubMed)

DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis To investigate whether DNA vaccine encoding herpes simplex virus 1 (HSV-1) glycoprotein C (gC) and glycoprotein D (gD) will achieve better protective effect against herpes simplex keratitis (HSK) than DNA vaccine encoding gD alone.DNA vaccine expressing gD or gC combined gD (gD.gC) were constructed and carried by chitosan nanoparticle. The expression of fusion protein gD and gC were

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2017 International journal of ophthalmology

5. Management of Herpes Simplex Virus Keratitis in the Pediatric Population. (PubMed)

Management of Herpes Simplex Virus Keratitis in the Pediatric Population. Herpes simplex virus (HSV) keratitis is a highly prevalent and visually disabling disease in both the pediatric and adult population. While many studies have investigated the treatment of HSV keratitis in adult patients, few have focused on managing this condition in children. Children are at particularly high risk for visual morbidity due to unique challenges in diagnosis and treatment, and the often more aggressive (...) disease course that results in corneal scarring, and subsequently amblyopia. This review presents the pathogenesis and most current recommendations for the medical and surgical management of HSV keratitis in the pediatric population.

2018 Pediatric Infectious Dsease Journal

6. Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection (PubMed)

Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2.5 units of BTA injection in each lacrimal gland for functional epiphora. The patient had a history of herpes (...) simplex viral keratitis that was quiescent for more than 2 years. After 3 weeks, she developed reactivation of viral keratitis bilaterally, which was successfully managed with antivirals and topical steroids. Reactivation of quiescent herpes simplex keratitis is a possibility after lacrimal gland BTA and caution should be exercised in such cases.

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2018 Indian journal of ophthalmology

7. Reactivation of herpes simplex viral keratitis following the botulinum toxin injection (PubMed)

Reactivation of herpes simplex viral keratitis following the botulinum toxin injection We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Contralateral eye was essentially normal. Following the botulinum toxin injection for the management of spastic entropion, subject (...) developed reactivation of herpetic necrotizing stromal keratitis. Diagnostic corneal scrapings were negative for herpes simplex virus-1 antigen by immunofluorescence assay and for DNA by molecular techniques. The case was successfully managed with topical steroids and antiviral medications.

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2018 Indian journal of ophthalmology

8. A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis

A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical

2018 Clinical Trials

9. Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty (PubMed)

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty.Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated.The incidence of new onset HSK after keratoplasty

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2018 Journal of ophthalmology

10. Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence (PubMed)

Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 (...) to January 2015. Clinical features, ocular complications, and recurrences were recorded.In total, 149 eyes of the 133 patients (72 male and 61 female) were followed for an average of 24.6 ± 13.2 months. Sixteen (12.0%) patients had bilateral HSK. The most frequent HSK subtype was epithelial keratitis (49.7%), which was followed by stromal keratitis (23.5%). Epithelial keratitis was the most likely subtype to recur. Complications occurred in 122 (81.9%) eyes. The most common complication was corneal

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2018 Korean journal of ophthalmology : KJO

11. Management of herpes simplex virus epithelial keratitis. (PubMed)

Management of herpes simplex virus epithelial keratitis. To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis.Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Resistance to ACV has become a concerning issue. The animal models of HSV vaccine are able to reduce HSV keratitis. New antivirals are under (...) development.Current cases of HSV epithelial keratitis are manageable with available medications, but new advancements are required to decrease disease burden in the future. HSV vaccine can be revolutionary.

2018 Current Opinion in Ophthalmology

12. Observation on the Herpes Simplex Keratitis

Observation on the Herpes Simplex Keratitis Observation on the Herpes Simplex Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Observation on the Herpes Simplex Keratitis (OHSV) The safety (...) by (Responsible Party): Yang Jiang, Peking Union Medical College Study Details Study Description Go to Brief Summary: As is reported, NSAIDs(pranoprofen ,bromfenac) eye drops can suppress herpes simplex virus(HSV-1) reactivation and reduce inflammatory reaction in vitro and in vivo. In Clinical, there is no risk of corneal tissue melting, glaucoma, cataract by topical application of NSAIDs. To explore more effective clinical treatment of viral keratitis patients to control the inflammatory damage, save

2017 Clinical Trials

13. Corneal Higher-order Aberrations and Visual Improvement Following Corneal Transplantation in Treating Herpes Simplex Keratitis. (PubMed)

Corneal Higher-order Aberrations and Visual Improvement Following Corneal Transplantation in Treating Herpes Simplex Keratitis. To examine corneal higher-order aberrations (HOAs) and visual improvement following corneal transplantation in treating corneal scar caused by herpes simplex keratitis (HSK).Retrospective consecutive case series.This study included a total of 52 eyes: 18 eyes of normal subjects, and 34 eyes of consecutive patients with corneal scar owing to HSK who underwent

2017 American Journal of Ophthalmology

14. Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. (PubMed)

Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis.Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015.13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes (...) with and without prior HSV keratitis with preoperative (9% vs 8%, p=1.00) or postoperative (57% vs 60%, p=1.00) corrected distance visual acuity (CDVA) ≥20/200 or in the percentage of contralateral eyes with preoperative CDVA ≥20/50 (55% vs 30%, p=0.18). While several postoperative complications occurred approximately twice as often in eyes with prior HSV keratitis, including persistent epithelial defect (63.6% vs 34.1%; p=0.10), corneal infiltrate (27.3% vs 12.3%; p=0.17) and sterile vitritis (18.2% vs 9.4

2017 British Journal of Ophthalmology

15. New Therapeutic Perceptions in a Patient with Complicated Herpes Simplex Virus 1 Keratitis: A Case Report and Review of the Literature (PubMed)

New Therapeutic Perceptions in a Patient with Complicated Herpes Simplex Virus 1 Keratitis: A Case Report and Review of the Literature BACKGROUND Keratitis caused by herpes simplex virus (HSV) can have detrimental effects on the cornea leading to loss of vision. Modern therapies can contribute to the prevention of anatomical and functional damage. CASE REPORT An 80-year-old male with complicated HSV-1 keratitis of the left eye (confirmed diagnosis after microbiological investigation) presented (...) vascular episode) and the cornea was sufficiently clear with no signs of epitheliopathy and almost complete subsidence of the neovascularization. CONCLUSIONS Transplantation of AM and stem cells in combination with anti-VEGF factors and topical administration of cyclosporine-A 1% and poly-carboxymethyl glucose sulfate (a regenerative factor of corneal matrix) contributed substantially in the management of herpetic keratitis complications.

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2017 The American journal of case reports

16. Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis

Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03217474 Recruitment Status : Recruiting First Posted : July 14, 2017 Last Update Posted : February 22

2017 Clinical Trials

17. Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis (PubMed)

Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokines are small proteins released by cells that play an important proinflammatory or anti

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2017 Journal of immunology research

18. Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation (PubMed)

Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant (...) diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes. Granulomatous inflammation, in microsporidial stromal keratitis, is never well described, and the authors in this article aim to describe the presence of granulomatous inflammation in microsporidial stromal keratitis, in patients with associated herpes simplex virus (HSV) keratitis.This was a retrospective and observational study conducted

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2017 Indian journal of ophthalmology

19. Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries (PubMed)

Practice patterns for herpes simplex keratitis: A survey of ophthalmologists in Gulf Coast countries Herpes simplex is a common cause of visual disability, and there are published evidence-based guidelines for therapy. This survey aims to determine the preferred practice patterns of ophthalmologists in Gulf Coast Countries regarding herpetic eye disease, as well as identify areas of controversy or barriers to acceptance of evidence-based protocols.Anonymous web-based survey of ophthalmologists (...) in Saudi Arabia, Bahrain, the United Arab Emirates, and Oman.There were 48 responses to the survey. For a first episode of epithelial dendritic keratitis, 28.2% reported "observation" rather than specific therapy. The majority of respondents utilize oral or topical antiviral for epithelial keratitis, with oral antiviral being the most popular (43.6%). The majority also included a corticosteroid with antiviral for stromal keratitis (83.9%) or iritis (70.3%). Over 90% prescribe a prophylactic antiviral

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2017 Saudi Journal of Ophthalmology

20. Herpes simplex keratitis: challenges in diagnosis and clinical management (PubMed)

Herpes simplex keratitis: challenges in diagnosis and clinical management Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea (...) , where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness. The diagnosis of these lesions as the result of a recurrent herpes simplex virus infection can at times be problematic. Currently, herpetic stromal keratitis is diagnosed by its clinical presentation on the slit-lamp examination, but the literature does not always support the accuracy of these clinical findings. Other diagnostic tests such as polymerase chain

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2017 Clinical ophthalmology (Auckland, N.Z.)

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