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Hepatotoxic Medication

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101. Hydroxycut® (herbal weight loss supplement) Induced Hepatotoxicity: A Case Report and Review of Literature (PubMed)

Hydroxycut® (herbal weight loss supplement) Induced Hepatotoxicity: A Case Report and Review of Literature Use of supplement and alternative drugs continues to thrive and is becoming an increasing cause of concern since many of these substances may have unexpected or unexplained medical consequences. We present below the first reported case of hepatotoxicity from Hydroxycut(®) in Hawaii.Hawaii Medical Journal Copyright 2010.

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2010 Hawaii Medical Journal

102. [Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review]. (PubMed)

, Cochrane Database, databases of medical publishers and search engines. Total amount of patients in all trials was 1121. 583 patients took diclofenac and 538 ones took placebo. Meta-analysis was performed in StatsDirect software. We estimated 95% confidence interval, Q and 12 criteria, Mantel-Haenszel and DerSimonian-Laird statistics and relative risk of adverse reactions. Relative risk of hepatitis in diclofenac group did not differ from placebo. Hereby the fact of diclofenac hepatotoxicity needs more (...) [Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review]. Diclofenac sodium is one of the most prescribed NSAIDs in the world which is frequently used in therapy of musculosceletal diseases. Therefore it is important to justify clinical and literary data about diclofenac hepatotoxicity. We searched for diclofenac versus placebo investigations performed in patients with osteoarthrosis. A method of the search included international databases such as EMBASE

2010 Ėksperimental'nai͡a i klinicheskai͡a gastroėnterologii͡a = Experimental & clinical gastroenterology

103. Dissimilar Hepatotoxicity Profiles of Propylthiouracil and Methimazole in Children. (PubMed)

Dissimilar Hepatotoxicity Profiles of Propylthiouracil and Methimazole in Children. The antithyroid drugs propylthiouracil and methimazole were introduced for clinical use about 60 yr ago and are estimated to be used in more than 6000 children and adolescents per year in the United States. Over the years that these medications have been used, reports of adverse events involving hepatotoxicity have appeared. To date, there has not been a systematic and comparative evaluation of the adverse (...) events associated with antithyroid drug use.Our objective was to assess safety and hepatotoxicity profiles of propylthiouracil and methimazole by age in the U.S. Food and Drug Administration's Adverse Event Reporting System (AERS).We used the multi-item gamma-Poisson shrinker (MGPS) data mining algorithm to analyze more than 40 yr of safety data in AERS. MGPS uses a Bayesian model to calculate adjusted observed to expected ratios [empiric Bayes geometric mean (EBGM) values] for every drug-adverse

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2010 Journal of Clinical Endocrinology and Metabolism

104. Hepatotoxicity Due to Hydroxycut: A Case Series. (PubMed)

Hepatotoxicity Due to Hydroxycut: A Case Series. Muscletech Hydroxycut (Iovate Health Sciences Research, Oakville, Ontario, Canada) was a popular weight-loss supplement that was recalled by the manufacturer in May 2009 on the basis of reports of hepatotoxicity associated with this supplement. We sought to characterize the clinical presentation of Hydroxycut-associated liver injury and to adjudicate these cases for causal association with Hydroxycut.We assessed the causality and grading (...) of severity of liver injury using methodology developed by the Drug-Induced Liver Injury Network (DILIN) study.Eight patients who developed liver injury after taking Hydroxycut treated at different medical centers were identified. All were hospitalized, and three of eight patients required liver transplantation. Nine other cases with adequate clinical information were obtained from the FDA MedWatch database, including one fatal case of acute liver failure. Usual symptoms were jaundice, fatigue, nausea

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2010 American Journal of Gastroenterology

105. Public health guidance on screening and vaccination for infectious diseases in newly arrived migrants within the EU/EEA

(CRC) provides specifically for children’s access to health services and obliges states to ‘ensure appropriate prenatal and postnatal healthcare for mothers’ (49). The reference to adequate access to healthcare for mothers is motivated by the strong impact that maternal morbidity and mortality may have on children’s health. The CRC requires that Member States ensure the provision of necessary medical assistance and healthcare with an emphasis on provision of primary healthcare (50). Article 12 [2 (...) ] of the UN Convention on the Elimination of all Forms of Discrimination against Women provides similar healthcare rights to pregnant women (51). At the EU level, the Charter of Fundamental Rights of the European Union (the Charter) includes the right to healthcare under Article 35, which states that ‘everyone has the right of access to preventive healthcare and the right to benefit from medical treatment under the conditions established by national laws and practices’ (52). The Charter’s application

2019 European Centre for Disease Prevention and Control - Public Health Guidance

106. Programmatic management of latent tuberculosis infection in the European Union

opinions; the evidence collection, appraisal and synthesis; the expert consultation and the first draft of this guidance were produced by Marije Vonk Noordegraaf-Schouten, Femke van Kessel and Anouk Oordt, members of a consortium of Pallas Health Research and Consultancy (Rotterdam) and Erasmus University Medical Center (framework contracts no ECDC/2013/005 and ECDC/2014/032). Invaluable input was received from ad hoc scientific panel chairs Gerard de Vries (the Netherlands) and Dominik Zenner (United (...) ). People with drug use disorders Persons who use narcotic drugs and psychotropic substances without medical supervision, for non- medical purposes [11]. This definition includes people who inject drugs. Other terms such as drug users, injecting drug users or problematic drug users are used only if the cited reference has used these terms. Programmatic management of LTBI Management of latent tuberculosis infection requires input from different components or units responsible for tuberculosis prevention

2019 European Centre for Disease Prevention and Control - Public Health Guidance

107. A Case Management Tool for TB Prevention, Care and Control in the UK

assessment (Form: 3) 41 – DOT chart/log (Form: 4) 43 2. Sample DOT contract 44 3. Sample social/network questionnaire 46 4. Standard case management – flow chart 47 5. Tips for giving medication to children 48 6. Home isolation policy 49 7. Sample cohort review action log 52 8. Cohort review incident reporting form 53 9. Outreach and safe practice 54 10. Methadone and anti-tuberculous treatment containing rifamycins 55 11. Managing treatment interruptions 58 12. Drug therapy – adverse effects requiring (...) (ECM) commences from suspicion of disease and may include directly observed treatment (DOT), monitoring drug levels, hepatotoxicity, and/or a package of supportive care tailored to a patient’s needs which should be available in both high and low incidence areas. The service should include all socially and/or clinically complex patients, including those who are vulnerable (older people), those in denial of diagnosis, and those where there is interruption to TB treatment. ECM must be available to TB

2019 Royal College of Nursing

108. Canadian Rheumatology Association recommendations for the assessment and monitoring of systemic lupus erythematosus

. S.O. Keeling, 8-129 Clinical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2G3, Canada. E-mail: Stephanie.keeling@ualberta.ca Full Release Article. For details see Reprints and Permissions at jrheum.org Accepted for publication July 13, 2018. of Rheumatology The Journal on March 26, 2019 - Published by www.jrheum.org Downloaded from for the assessment and monitoring of SLE. The International Committee of Medical Journal Editors conflict of interest form was completed and reviewed (...) -risk medications, or who have hypogonadism or premature menopause. This recommen- dation does not apply to the pediatric SLE population, where osteoporosis is defined by fractures and not BMD (www.iscd.org/official-positions/2013-iscd-official- positions-pediatric). Justification: Current guidelines in Canada recommend assessing risk of osteoporosis in individuals over age 50 every 1 to 3 years 38 . There is no evidence comparing outcomes related to osteoporosis in patients with SLE who had or did

2018 CPG Infobase

109. Paracetamol overdose

. The definition of hepatotoxicity after paracetamol overdose is a serum AST concentration at least 1000 IU/L. Paracetamol is known as acetaminophen in some countries. History and exam attempted self-harm repeated non-prescription analgesic use for pain relief asymptomatic presentation nausea, vomiting, or abdominal pain right upper quadrant pain and tenderness jaundice confusion, decreased consciousness level, and/or asterixis history of self-harm history of frequent or repeated use of medications for pain (...) Paracetamol overdose Paracetamol overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Paracetamol overdose Last reviewed: February 2019 Last updated: September 2018 Summary Overdose may occur after an acute single ingestion of a large amount of paracetamol or paracetamol-containing medication, or repeated ingestion of an amount exceeding recommended dosage. Patients are often asymptomatic or have only mild

2018 BMJ Best Practice

110. Paracetamol overdose

. The definition of hepatotoxicity after paracetamol overdose is a serum AST concentration at least 1000 IU/L. Paracetamol is known as acetaminophen in some countries. History and exam attempted self-harm repeated non-prescription analgesic use for pain relief asymptomatic presentation nausea, vomiting, or abdominal pain right upper quadrant pain and tenderness jaundice confusion, decreased consciousness level, and/or asterixis history of self-harm history of frequent or repeated use of medications for pain (...) Paracetamol overdose Paracetamol overdose - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Paracetamol overdose Last reviewed: February 2019 Last updated: September 2018 Summary Overdose may occur after an acute single ingestion of a large amount of paracetamol or paracetamol-containing medication, or repeated ingestion of an amount exceeding recommended dosage. Patients are often asymptomatic or have only mild

2018 BMJ Best Practice

111. Acute liver failure

://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381946/ http://www.ncbi.nlm.nih.gov/pubmed/18318440?tool=bestpractice.com History and exam presence of risk factors hepatotoxic medication jaundice signs of hepatic encephalopathy absence of hx of chronic liver disease abdominal pain nausea vomiting malaise signs of cerebral oedema abdominal or right upper quadrant tenderness hepatomegaly absence of splenomegaly absence of spider angiomata absence of palmar erythema absence of ascites depression or suicidal ideation exposure (...) to hepatotoxins illicit drug abuse and high-risk behaviours chronic alcohol abuse poor nutritional status female sex age >40 years pregnancy chronic hepatitis B chronic pain and narcotic use complementary and alternative medicine hepatotoxicity paracetamol and antidepressant therapy chronic hepatitis C HIV and hepatitis C co-infection Diagnostic investigations liver function tests prothrombin time/INR basic metabolic panel FBC blood type and screen arterial blood gas arterial blood lactate paracetamol level

2018 BMJ Best Practice

112. Statins for the primary prevention of cardiovascular events

the risks, benefits, alternatives, and uncertainties; • has weighed his or her values regarding the potential benefits and harms associated with the service; • has engaged in decision making at a level at which he or she desires and feels comfortable. Whether or not the overall benefit-harm balance justifies the use of a medication for an individual patient cannot be determined by a guidelines committee, a health care system, or even the attending physician. Instead, it is the individual patient who has (...) HISTORICAL AND CURRENT STATIN USE IN BELGIUM 3.1 Introduction Statins (also known as HMG-CoA reductase inhibitors) are a class of lipid- lowering medications. Statins proved to reduce the relative risk for cardiovascular disease (CVD), CVD events and mortality similarly in all individuals, but the absolute risk reduction is much greater in those who are at high risk of CVD events. Statins are used both in the primary and secondary prevention of CVD. Clinical practice guidelines generally recommend

2019 Belgian Health Care Knowledge Centre

113. Tuberculosis

Adherence, treatment completion and follow-up 56 1.8 Service organisation 62 T erms used in this guideline 77 Context 87 More information 88 Recommendations for research 89 1 Universal compared with risk-based approach to using rapid diagnostic tests 89 2 Diagnosis in children 89 3 Treating isoniazid-resistant TB 90 4 Impact of infection control measures on quality of life 90 5 Treatment interruptions caused by adverse events (specifically hepatotoxicity) 90 Update information 92 Recommendations from (...) the potential interaction of TB medication with other drugs, for example, oral contraceptives and opioids (especially methadone) and HIV treatment TB/HIV co-infection how to address the myths about TB infection and treatment (for example, to counter the belief that TB is hereditary) how to address the stigma associated with TB the risk of migrants from high-incidence countries developing active TB – even if they have already screened negative for it contact tracing. [2012, amended 2016] [2012, amended 2016

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

114. Kaiser Permanente National Cholesterol and Cardiovascular Risk Clinician Guide

intensity of statin therapy: • Reinforce medication adherence; • Reinforce adherence to intensive lifestyle changes; and • Exclude secondary causes of hyperlipidemia. } Consider using the following indicators of anticipated therapeutic response to the recommended intensity of statin therapy. Focus is on the intensity of the statin therapy. As an aid to monitoring: • High-intensity statin therapy generally results in an average LDL–C reduction of = 50% from the untreated baseline. • Moderate-intensity (...) . } For adults taking any dose of statins, consider using caution in those aged >75 years and in those taking concomitant medications that alter drug metabolism, multiple drugs, or drugs for conditions that require complex medication regimens (e.g., those who have undergone solid organ transplantation or are receiving treatment for HIV). A review of the manufacturer’s prescribing information may be useful before initiating any cholesterol-lowering drug. } As on-treatment LDL-C falls to very low levels

2018 Kaiser Permanente National Guideline Program

115. Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV

(Stellenbosch University, South Africa), Tendani Gaolathe (Ministry of Health, Botswana), Eric Goemaere (MSF, South Africa), Andreas Jahn (ITECH, Malawi), Nagalingeswaran Kumarasamy (YRGCARE Medical Centre, India), Thuy Le (Duke University, USA), Valeriane Leroy (Institut National de la Santé et de la Recherché Médicale, ANRS, France), Othoman Mellouk (ITPC, Morrocco), Irene Mukui (Ministry of Health, Kenya), Angela Mushavi (Ministry of Health and Child Care, Zimbabwe), Landon Myer (University of Cape Town (...) , South Africa), Thanyawee Puthanakit (Chulalong University, Bangkok, Thailand), Pablo Rojo (Complutense University of Madrid, Spain), Gayle Sherman (University of the Witwatersrand, South Africa), Wendy Stevens (NHLS and University of the Witwatersrand, South Africa), François Venter (University of the Witwatersrand, South Africa), and Annemarie Wensing (University Medical Centre of Utrecht, Netherlands). Declarations of interest for members of the Guideline Development Group Three members

2019 World Health Organisation HIV Guidelines

116. Levofloxacin

of levofloxacin was unfavourable as first-line treatment for these indications. The risks contributing to this assessment included serious hepatotoxicity, cardiac arrhythmia 2012 12. Choice between Levofloxacin and Moxifloxacin and Multidrug-Resistant Tuberculosis Treatment Outcomes. RATIONALE: We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-TB) did not affect sputum culture conversion at 3 (...) or not with a macrolide) or III: levofloxacin . It was accomplished Rx. thorax to 7-10 days, to the month and, other reviews if was necessary. 29 cases were in standard therapy (I or II) and 20 cases 2002 14. An open-label, three-arm pilot study of the safety and efficacy of topical Microcyn Rx wound care versus oral levofloxacin versus combined therapy for mild diabetic foot infections. 22106196 2011 11 22 2012 04 03 2013 11 21 1930-8264 101 6 2011 Nov-Dec Journal of the American Podiatric Medical Association J Am

2018 Trip Latest and Greatest

117. Gemfibrozil

of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression. 331-339 10.15171/apb.2018.038 Purpose: Gemfibrozil (GEM) apart from agonist activity at peroxisome proliferator-activated receptor-alpha (PPAR (...) . Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Dehbashi Fereshteh F Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. eng Journal Article 2018 (...) a moderate increase in the area under the curve (AUC) of atorvastatin, but the effect of fenofibrate on atorvastatin pharmacokinetics has not been described 2011 13. The effect of gemfibrozil , niacin and cholestyramine combination therapy on metabolic syndrome in the Armed Forces Regression Study. 21358314 2011 04 26 2011 06 23 2015 11 19 1538-2990 341 5 2011 May The American journal of the medical sciences Am. J. Med. Sci. The effect of gemfibrozil , niacin and cholestyramine combination therapy

2018 Trip Latest and Greatest

118. Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life

Giaquinto, 12 D Gibb, 13 L Galli, 14 M Hainaut, 15 M Koros, 16 L Marques, 17 E Nastouli, 18 T Niehues, 19 A Noguera-Julian, 20 P Rojo, 21 C Rudin, 22 HJ Scherpbier, 23 G Tudor-Williams 24 and SB Welch 25 (PENTA Steering Committee) 1 Department of Paediatric Infectious Diseases and Immunology, Great Ormond Street Hospital NHS Trust, London, UK, 2 Medical Research Council Clinical Trials Unit, London, UK, 3 Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK, 4 (...) Institute of Child Health, University College London, London, UK, 5 Radboud University Medical Center, Nijmegan, The Netherlands, 6 University Department of Immunology and Infectious Disease, Bambino Gesù Children’s Hospital, Rome, Italy, 7 Our Lady’s Children’s Hospital Crumlin & University College Dublin, Dublin, Ireland, 8 Meyer University Hospital, Florence University, Florence, Italy, 9 HIV i-Base, London, UK, 10 Emilio Ribas Institute of Infectious Diseases, Sao Paulo, Brazil, 11 Paediatric

2018 The Children's HIV Association

119. International evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS)

International evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018Publication approval The guideline recommendations on pages 16 to 34 of this document were approved by the Chief Executive Officer of the National Health and Medical Research Council (NHMRC) on 2 July 2018 under section 14A of the National Health and Medical Research Council Act 1992 (...) of all clinicians that are members of the partner and collaborating societies. The information provided in this document does not constitute business, medical or other professional advice, and is subject to change.International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2018 1 Acknowledgments We gratefully acknowledge the contribution of our engaged, funding, partner and collaborating organisations: 1 The Australian National Health and Medical Research

2018 European Society of Human Reproduction and Embryology

120. Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

transplants. The risk of statin-induced serious muscle injury, including rhabdomyolysis, is <0.1%, and the risk of serious hepatotoxicity is ≈0.001%. The risk of statin-induced newly diagnosed diabetes mellitus is ≈0.2% per year of treatment, depending on the underlying risk of diabetes mellitus in the population studied. In patients with cerebrovascular disease, statins possibly increase the risk of hemorrhagic stroke; however, they clearly produce a greater reduction in the risk of atherothrombotic (...) with the use of a medication is an adverse event . Thus, an adverse event is not necessarily caused by the medication. When caused by the medication, these undesirable experiences are called adverse effects or adverse drug reactions . Adverse events in a clinical trial are a combination of events that are purely subjective, have subjective and objective components, or are solely objective, such as an increase in blood pressure or an increased risk of newly diagnosed diabetes mellitus

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2019 American Gastroenterological Association Institute

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