How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,140 results for

Hepatotoxic Medication

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis

A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

62. Trastuzumab-Induced Hepatotoxicity: A Case Report (PubMed)

Trastuzumab-Induced Hepatotoxicity: A Case Report Trastuzumab is a humanized monoclonal antibody approved for the treatment of breast cancer with HER2 amplification and/or overexpression. There are only 2 prior cases of trastuzumab-related hepatotoxicity reported in the literature.We report the case of a 60-year-old woman who was treated with trastuzumab for stage I invasive ductal carcinoma of the right breast. She successfully completed 6 months of therapy when an increase in liver (...) transaminases was noted on routine examination. A full work-up for causes of acute and chronic liver disease was negative. After review of the patient's medication list, trastuzumab was thought to be the most likely culprit for the liver injury, based on timing of administration and rise in liver enzymes.

Full Text available with Trip Pro

2013 Breast Care

63. Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs (PubMed)

Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs We present the first description of amiodarone toxicity in the liver without phospholipidosis or steatosis. In doing so, we will review the various effects of amiodarone toxicity in various organs. The patient is a young adult who had cardiac reconstruction as a child for transposition of the great vessels. A needle biopsy was taken due to elevated liver (...) 409 mg/dL (60-350). Liver ultrasound was unremarkable. The clinical differential was broad and included hepatic congestion along with autoimmune hepatitis. Sections showed only ballooned hepatocytes with Mallory-Denk bodies and perisinusoidal fibrosis. Arrival to the diagnosis was possible only after careful review of the patient's medications. After discontinuation of amiodarone, the patient's liver enzymes returned to normal levels.

Full Text available with Trip Pro

2013 Case Reports in Pathology

64. GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. (PubMed)

GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. The results of studies investigating the associations between GSTM1 and GSTT1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ADIH) risk exhibit much controversy. Therefore, a meta-analysis was performed in order to examine the associations between GST variants and ADIH risk. A total of 451 relevant studies were identified through the digital medical

2013 European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

65. Medical treatment of infantile spasms

Medical treatment of infantile spasms Evidence-based guideline update: Medical treatment of infantile spasms | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share June 12, 2012 ; 78 (24) Special Article Evidence-based guideline update: Medical treatment of infantile spasms Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice (...) Committee of the Child Neurology Society C.Y. Go , M.T. Mackay , S.K. Weiss , D. Stephens , T. Adams-Webber , S. Ashwal , O.C. Snead First published June 11, 2012, DOI: https://doi.org/10.1212/WNL.0b013e318259e2cf C.Y. Go M.T. Mackay S.K. Weiss D. Stephens T. Adams-Webber S. Ashwal O.C. Snead Evidence-based guideline update: Medical treatment of infantile spasms C.Y. Go , M.T. Mackay , S.K. Weiss , D. Stephens , T. Adams-Webber , S. Ashwal , O.C. Snead Neurology Jun 2012, 78 (24) 1974-1980; DOI: 10.1212

2012 American Academy of Neurology

66. Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

medication treatment, will be offered naltrexone (50 mg per day), which is an FDA-Approved medication for alcohol use disorder. According to the package insert for NTX, the medication has been associated with liver toxicity at very high doses (up to 300 mg/day); however, a number of clinical trials and published studies suggest there are few serious adverse effects, including minimal hepatotoxicity, associated with daily dose of 50 mg of naltrexone. Its most common side effects in opioid-free individuals (...) Participants, who choose medication treatment, will be offered naltrexone (50 mg per day), which is an FDA-Approved medication for alcohol use disorder. According to the package insert for NTX, the medication has been associated with liver toxicity at very high doses (up to 300 mg/day); however, a number of clinical trials and published studies suggest there are few serious adverse effects, including minimal hepatotoxicity, associated with daily dose of 50 mg of naltrexone. Its most common side effects

2016 Clinical Trials

67. The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges (PubMed)

The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges In 2013, physicians at the Honolulu Queen's Medical Center (QMC) noticed that seven liver disease patients reported the use of OxyELITE Pro (OEP), a widely consumed dietary supplement (DS). Assuming a temporal association between OEP use and disease, they argued that OEP was the cause of this mysterious cluster. Subsequent reexamination, however, has revealed that this QMC cohort is heterogeneous (...) and not a cluster with a single agent causing a single disease. It is heterogeneous because patients used multiple DS's and drugs and because patients appeared to have suffered from multiple liver diseases: liver cirrhosis, liver failure by acetaminophen, hepatotoxicity by non-steroidal antiinflammatory drugs (NSAIDs), resolving acute viral hepatitis by hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella zoster virus (VZV), and suspected hepatitis E virus (HEV). Failing to exclude

Full Text available with Trip Pro

2016 International journal of molecular sciences

68. Herbal hepatotoxicity: a tabular compilation of reported cases. (PubMed)

method such as the scale of CIOMS (Council for International Organizations of Medical Sciences).This compilation presents details of herbal hepatotoxicity, assisting thereby clinical assessment of involved physicians in the future.© 2012 John Wiley & Sons A/S. (...) Herbal hepatotoxicity: a tabular compilation of reported cases. Herbal hepatotoxicity is a field that has rapidly grown over the last few years along with increased use of herbal products worldwide.To summarize the various facets of this disease, we undertook a literature search for herbs, herbal drugs and herbal supplements with reported cases of herbal hepatotoxicity.A selective literature search was performed to identify published case reports, spontaneous case reports, case series

2012 Liver International

69. Agomelatine (Valdoxan/ Thymanax): risk of dose-related hepatotoxicity and liver failure

Agomelatine (Valdoxan/ Thymanax): risk of dose-related hepatotoxicity and liver failure Agomelatine (Valdoxan/ Thymanax): risk of dose-related hepatotoxicity and liver failure - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Agomelatine (Valdoxan/ Thymanax): risk of dose-related hepatotoxicity and liver failure Liver function tests should be carried out at treatment initiation, during treatment, and also when the dose is increased. Published 11 December 2014 From: Therapeutic (...) area: Article date: October 2012 Agomelatine is an antidepressant indicated for the treatment of major depressive episodes in adults. Agomelatine is a melatonin MT1 and MT2 receptor agonist, and antagonist at the serotonin 5-HT2C receptor, thereby increasing levels of dopamine and noradrenaline in areas of the brain involved in mood control. Following several reports of liver injury, including hepatic failure, all available data on elevated transaminases and hepatotoxicity with agomelatine use have

2012 MHRA Drug Safety Update

70. Amoxicillin-Clavulanic Acid Hepatotoxicity In Children. (PubMed)

-collection protocol was complied with, taking note of patient demographics, characteristics of the treatment assumed to provoke the reaction, concomitant medication, course and outcome of the episode, and laboratory variables during the reaction. The latter were determined every 6 months from the outset to the eventual resolution of the case.A total of 11 cases of AC hepatotoxicity were detected, affecting 9 boys and 2 girls, ages 1 to 11 years. Causality criteria were assessed using the Council (...) for International Organizations of Medical Sciences scale.We conclude that the introduction of hepatotoxicity record systems in paediatric care, together with the continuing study and development of existing systems, would contribute to improving our epidemiological knowledge about the harmful effects of drugs on the liver.

Full Text available with Trip Pro

2012 Journal of Pediatric Gastroenterology and Nutrition

71. Polypharmacy, multiple natural health products and hepatotoxicity (PubMed)

Polypharmacy, multiple natural health products and hepatotoxicity 21727224 2011 12 07 2018 11 13 1488-2329 183 14 2011 Oct 04 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Polypharmacy, multiple natural health products and hepatotoxicity. E1085-9 10.1503/cmaj.091948 Cvijovic Kosta K Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont. Boon Heather H Jaeger Walter W Vohra Sunita S SONAR group eng Journal Article 2011 07 04 Canada

Full Text available with Trip Pro

2011 CMAJ : Canadian Medical Association Journal

72. Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity

adding more. Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01456845 Recruitment Status : Completed First Posted : October 21, 2011 Last Update Posted : August 31, 2012 Sponsor: All India Institute of Medical Sciences (...) , New Delhi Information provided by (Responsible Party): S.K.SHARMA, All India Institute of Medical Sciences, New Delhi Study Details Study Description Go to Brief Summary: The purpose of the study is to estimate plasma drug levels ( free and total drug levels ) of rifampicin and other antituberculosis drugs and compare these drug levels in patients who develop drug induced hepatotoxicity versus those who do not .The study hypothesis is that the ATT drug induced hepatotoxicity is related to free

2011 Clinical Trials

73. Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs

Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs (PESOHHERZ) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01436929 Recruitment Status : Unknown Verified December 2012 by Seoul National University Hospital. Recruitment status

2011 Clinical Trials

74. Hepatotoxicity of dextropropoxyphene. (PubMed)

Hepatotoxicity of dextropropoxyphene. 871865 1977 09 02 2018 11 13 0007-1447 2 6082 1977 Jul 30 British medical journal Br Med J Hepatotoxicity of dextropropoxyphene. 296-7 Lee T H TH Rees P J PJ eng Case Reports Journal Article England Br Med J 0372673 0007-1447 S2F83W92TK Dextropropoxyphene AIM IM Aged Chemical and Drug Induced Liver Injury Dextropropoxyphene adverse effects Female Humans Jaundice chemically induced Male Middle Aged 1977 7 30 1977 7 30 0 1 1977 7 30 0 0 ppublish 871865

Full Text available with Trip Pro

1977 British medical journal

75. Disulfiram hepatotoxicity. (PubMed)

Disulfiram hepatotoxicity. 871808 1977 09 02 2018 11 13 0007-1447 2 6079 1977 Jul 09 British medical journal Br Med J Disulfiram hepatotoxicity. 94-6 Ranek L L Buch Andreasen P P eng Case Reports Journal Article England Br Med J 0372673 0007-1447 TR3MLJ1UAI Disulfiram AIM IM Adult Aged Alcoholism drug therapy Chemical and Drug Induced Liver Injury etiology Disulfiram adverse effects therapeutic use Female Humans Liver drug effects Male Middle Aged 1977 7 9 1977 7 9 0 1 1977 7 9 0 0 ppublish

Full Text available with Trip Pro

1977 British medical journal

76. Salicylate hepatotoxicity in systemic lupus erythematosus: a common occurrence? (PubMed)

Salicylate hepatotoxicity in systemic lupus erythematosus: a common occurrence? 728711 1979 03 28 2018 11 13 0007-1447 2 6151 1978 Dec 02 British medical journal Br Med J Salicylate hepatotoxicity in systemic lupus erythematosus: a common occurrence? 1532-3 Travers R L RL Hughes G R GR eng Journal Article England Br Med J 0372673 0007-1447 R16CO5Y76E Aspirin AIM IM Aspirin adverse effects Chemical and Drug Induced Liver Injury Humans Liver Function Tests Lupus Erythematosus, Systemic drug

Full Text available with Trip Pro

1978 British medical journal

77. Hepatotoxic effects of repeated anaesthetics. (PubMed)

Hepatotoxic effects of repeated anaesthetics. 421060 1979 05 23 2016 11 23 0007-1447 1 6158 1979 Jan 27 British medical journal Br Med J Hepatotoxic effects of repeated anaesthetics. 265 Dundee J W JW Black G W GW Neill D W DW eng Comparative Study Letter England Br Med J 0372673 0007-1447 0 Methyl Ethers 91I69L5AY5 Enflurane UQT9G45D1P Halothane AIM IM Chemical and Drug Induced Liver Injury Enflurane adverse effects Halothane adverse effects Humans Methyl Ethers adverse effects 1979 1 27 1979

Full Text available with Trip Pro

1979 British medical journal

78. Hepatotoxicity of erythromycin derivatives. (PubMed)

Hepatotoxicity of erythromycin derivatives. 445081 1979 09 01 2018 11 13 0007-1447 1 6174 1979 May 19 British medical journal Br Med J Hepatotoxicity of erythromycin derivatives. 1357 Pessayre D D Benhamou J P JP eng Letter England Br Med J 0372673 0007-1447 63937KV33D Erythromycin XRJ2P631HP Erythromycin Estolate AIM IM Chemical and Drug Induced Liver Injury Erythromycin adverse effects analogs & derivatives Erythromycin Estolate adverse effects 1979 5 19 1979 5 19 0 1 1979 5 19 0 0 ppublish

Full Text available with Trip Pro

1979 British medical journal

79. Halothane Hepatotoxicity (PubMed)

Halothane Hepatotoxicity 14052979 1996 12 01 2018 12 01 0008-4409 89 1963 Nov 02 Canadian Medical Association journal Can Med Assoc J HALOTHANE HEPATOTOXICITY. 944-6 KERBEL N C NC HILLIARD I M IM eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 EC 2.6.1.1 Aspartate Aminotransferases UQT9G45D1P Halothane OM Anesthesia Anesthesia, Inhalation Anesthesia, Obstetrical Aspartate Aminotransferases Blood Chemical Analysis Chemical and Drug Induced Liver Injury Halothane Hepatitis Kidney

Full Text available with Trip Pro

1963 Canadian Medical Association Journal

80. Allergy to iprindole (Prondol) with hepatotoxicity. (PubMed)

Allergy to iprindole (Prondol) with hepatotoxicity. 5416820 1970 04 16 2016 11 22 0007-1447 1 5692 1970 Feb 07 British medical journal Br Med J Allergy to iprindole (Prondol) with hepatotoxicity. 367 Young P J PJ eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Adult Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury etiology Depression drug therapy Drug Hypersensitivity etiology Female Humans Indoles adverse effects Liver

Full Text available with Trip Pro

1970 British medical journal

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>