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Hepatotoxic Medication

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61. Halothane Hepatotoxicity (Treatment)

Halothane Hepatotoxicity (Treatment) Halothane Hepatotoxicity Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY2MjMyLXRyZWF0bWVudA== processing (...) > Halothane Hepatotoxicity Treatment & Management Updated: Oct 17, 2016 Author: Ruben Peralta, MD, FACS; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Halothane Hepatotoxicity Treatment Medical Care No specific therapy is available for either fulminant hepatic necrosis or mild hepatotoxicity due to halothane. Only supportive therapy and orthotopic liver transplantation are available for hepatic necrosis. Because halothane hepatitis

2014 eMedicine.com

62. Halothane Hepatotoxicity (Diagnosis)

necrosis from 1959-1962. [ ] This study found that, of 82 cases of fatal hepatic necrosis, 9 cases were deemed likely to be drug induced. Seven of the 9 patients had received halothane. Based on this study, the risk of fatal halothane hepatotoxicity was estimated to be 1 in 35,000. When the World Health Organization (WHO) drug monitoring database was reviewed for the medications that most commonly cause fatal hepatotoxicity; halothane was one of the 10 most common causes. Given this risk, halothane (...) unexplainable fatal hepatic necrosis after halothane administration in 1 per 35,000 cases. The incidence after administration of other halogenated agents is much lower, including 2 cases per 1 million patients after enflurane administration, a few reports after isoflurane administration, and a single confirmed case after desflurane administration. International Review of the WHO database of medications that cause fatal hepatotoxicity revealed that halothane is one of the top 10 most likely medications

2014 eMedicine.com

63. Drug-Induced Hepatotoxicity (Diagnosis)

. Excluding other causes of liver injury is essential. A positive dechallenge is a 50% fall in serum transaminase levels within 8 days of stopping the drug. A positive dechallenge is very helpful in cases of use of multiple medications. Previously documented reactions to a drug aid in diagnosis. Deliberate rechallenge in clinical situations is unethical and should not be attempted; however, inadvertent rechallenge in the past has provided valuable evidence that the drug was indeed hepatotoxic (...) with serious underlying medical illness. Fluconazole-associated hepatotoxicity is usually, but not always, reversible upon discontinuation of therapy. Isoniazid Severe and fatal hepatitis has been reported with INH therapy. The risk of developing hepatitis is age related, with an incidence of 8 cases per 1000 persons older than 65 years. In addition, the risk of hepatitis is increased with daily consumption of alcohol. Mild hepatic dysfunction evidenced by a transient elevation of serum transaminase levels

2014 eMedicine.com

64. Isoniazid Hepatotoxicity (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgwNTU0LXRyZWF0bWVudA== processing > Isoniazid Toxicity Treatment & Management Updated: Feb 07, 2019 Author: Joseph L D'Orazio, MD, FAAEM; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Isoniazid Toxicity Treatment Approach Considerations Medical care for isoniazid (INH) hepatotoxicity is essentially supportive. Discontinue INH and any other potentially toxic drug, and closely monitor the patient. Hospitalize persons who are more severely affected (eg, with significant elevation (...) undergoing INH prophylaxis may detect early cases of hepatotoxicity. Previous Next: Consultations Consider consultation with a medical toxicologist, if available, for bedside evaluation. US Poison Help Line 1-800-222-1222 (affiliated with the American Academy of Poison Control Centers) is available 24 hours, 7 days a week if a medical toxicologist is not available at your institution. Consider a psychiatric consultation in all cases of intentional overdose before the patient is discharged from

2014 eMedicine.com

65. Medical treatment of infantile spasms

Medical treatment of infantile spasms Evidence-based guideline update: Medical treatment of infantile spasms | Neurology Advertisement Search for this keyword Main menu User menu Search Search for this keyword The most widely read and highly cited peer-reviewed neurology journal Share June 12, 2012 ; 78 (24) Special Article Evidence-based guideline update: Medical treatment of infantile spasms Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice (...) Committee of the Child Neurology Society C.Y. Go , M.T. Mackay , S.K. Weiss , D. Stephens , T. Adams-Webber , S. Ashwal , O.C. Snead First published June 11, 2012, DOI: https://doi.org/10.1212/WNL.0b013e318259e2cf C.Y. Go M.T. Mackay S.K. Weiss D. Stephens T. Adams-Webber S. Ashwal O.C. Snead Evidence-based guideline update: Medical treatment of infantile spasms C.Y. Go , M.T. Mackay , S.K. Weiss , D. Stephens , T. Adams-Webber , S. Ashwal , O.C. Snead Neurology Jun 2012, 78 (24) 1974-1980; DOI: 10.1212

2012 American Academy of Neurology

66. Trastuzumab-Induced Hepatotoxicity: A Case Report (Full text)

Trastuzumab-Induced Hepatotoxicity: A Case Report Trastuzumab is a humanized monoclonal antibody approved for the treatment of breast cancer with HER2 amplification and/or overexpression. There are only 2 prior cases of trastuzumab-related hepatotoxicity reported in the literature.We report the case of a 60-year-old woman who was treated with trastuzumab for stage I invasive ductal carcinoma of the right breast. She successfully completed 6 months of therapy when an increase in liver (...) transaminases was noted on routine examination. A full work-up for causes of acute and chronic liver disease was negative. After review of the patient's medication list, trastuzumab was thought to be the most likely culprit for the liver injury, based on timing of administration and rise in liver enzymes.

2013 Breast Care

67. GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. (PubMed)

GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. The results of studies investigating the associations between GSTM1 and GSTT1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ADIH) risk exhibit much controversy. Therefore, a meta-analysis was performed in order to examine the associations between GST variants and ADIH risk. A total of 451 relevant studies were identified through the digital medical

2013 European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

68. Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs (Full text)

Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs We present the first description of amiodarone toxicity in the liver without phospholipidosis or steatosis. In doing so, we will review the various effects of amiodarone toxicity in various organs. The patient is a young adult who had cardiac reconstruction as a child for transposition of the great vessels. A needle biopsy was taken due to elevated liver (...) 409 mg/dL (60-350). Liver ultrasound was unremarkable. The clinical differential was broad and included hepatic congestion along with autoimmune hepatitis. Sections showed only ballooned hepatocytes with Mallory-Denk bodies and perisinusoidal fibrosis. Arrival to the diagnosis was possible only after careful review of the patient's medications. After discontinuation of amiodarone, the patient's liver enzymes returned to normal levels.

2013 Case Reports in Pathology

69. Herbal hepatotoxicity: a tabular compilation of reported cases. (PubMed)

method such as the scale of CIOMS (Council for International Organizations of Medical Sciences).This compilation presents details of herbal hepatotoxicity, assisting thereby clinical assessment of involved physicians in the future.© 2012 John Wiley & Sons A/S. (...) Herbal hepatotoxicity: a tabular compilation of reported cases. Herbal hepatotoxicity is a field that has rapidly grown over the last few years along with increased use of herbal products worldwide.To summarize the various facets of this disease, we undertook a literature search for herbs, herbal drugs and herbal supplements with reported cases of herbal hepatotoxicity.A selective literature search was performed to identify published case reports, spontaneous case reports, case series

2012 Liver International

70. Amoxicillin-Clavulanic Acid Hepatotoxicity In Children. (Full text)

-collection protocol was complied with, taking note of patient demographics, characteristics of the treatment assumed to provoke the reaction, concomitant medication, course and outcome of the episode, and laboratory variables during the reaction. The latter were determined every 6 months from the outset to the eventual resolution of the case.A total of 11 cases of AC hepatotoxicity were detected, affecting 9 boys and 2 girls, ages 1 to 11 years. Causality criteria were assessed using the Council (...) for International Organizations of Medical Sciences scale.We conclude that the introduction of hepatotoxicity record systems in paediatric care, together with the continuing study and development of existing systems, would contribute to improving our epidemiological knowledge about the harmful effects of drugs on the liver.

2012 Journal of Pediatric Gastroenterology and Nutrition

71. Tetracycline Hepatotoxicity (Full text)

Tetracycline Hepatotoxicity 14211749 1996 12 01 2018 12 01 0007-1447 2 5424 1964 Dec 19 British medical journal Br Med J TETRACYCLINE HEPATOTOXICITY. 1545-6 eng Journal Article England Br Med J 0372673 0007-1447 0 Anti-Bacterial Agents 0 Protein Synthesis Inhibitors F8VB5M810T Tetracycline OM Anti-Bacterial Agents Gastrointestinal Diseases Protein Synthesis Inhibitors Tetracycline Toxicology TOXICOLOGIC REPORT 1964 12 19 1964 12 19 0 1 1964 12 19 0 0 ppublish 14211749 PMC1817573 AMA Arch Intern

1964 British medical journal

72. Tetracycline Hepatotoxicity (Full text)

Tetracycline Hepatotoxicity 14260641 1996 12 01 2018 12 01 0007-1447 1 5440 1965 Apr 10 British medical journal Br Med J TETRACYCLINE HEPATOTOXICITY. 995 BREWER T T eng Journal Article England Br Med J 0372673 0007-1447 F8VB5M810T Tetracycline OM Chemical and Drug Induced Liver Injury Drug Therapy Fatty Liver Female Hepatitis Hepatitis A Pregnancy Pregnancy Complications Pregnancy Complications, Infectious Tetracycline Toxicology DRUG THERAPY FATTY LIVER HEPATITIS, TOXIC PREGNANCY PREGNANCY

1965 British medical journal

73. Possible hepatotoxic effect of methadone. (Full text)

Possible hepatotoxic effect of methadone. 5794138 1969 08 30 2016 11 22 0008-4409 101 2 1969 Jul 26 Canadian Medical Association journal Can Med Assoc J Possible hepatotoxic effect of methadone. 113 Lapierre J J eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 UC6VBE7V1Z Methadone AIM IM Chemical and Drug Induced Liver Injury etiology Hematopoiesis drug effects Humans Infectious Mononucleosis chemically induced Male Methadone adverse effects 1969 7 26 1969 7 26 0 1 1969 7 26 0 0

1969 Canadian Medical Association Journal

74. Allergy to iprindole (Prondol) with hepatotoxicity. (Full text)

Allergy to iprindole (Prondol) with hepatotoxicity. 5443418 1970 06 24 2016 11 22 0007-1447 2 5703 1970 Apr 25 British medical journal Br Med J Allergy to iprindole (Prondol) with hepatotoxicity. 238-9 Price J C JC Collings-Wells J A JA eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Adult Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury etiology Drug Hypersensitivity Female Humans Indoles adverse effects Male Middle

1970 British medical journal

75. Possible hepatotoxic effect of methadone. (Full text)

Possible hepatotoxic effect of methadone. 5763242 1969 03 06 2013 11 21 0008-4409 100 5 1969 Feb 01 Canadian Medical Association journal Can Med Assoc J Possible hepatotoxic effect of methadone. 265-6 Walter A J AJ eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 UC6VBE7V1Z Methadone AIM IM Humans Liver drug effects Liver Function Tests Methadone adverse effects Substance-Related Disorders 1969 2 1 1969 2 1 0 1 1969 2 1 0 0 ppublish 5763242 PMC1945565

1969 Canadian Medical Association Journal

76. Allergy to iprindole (Prondol) with hepatotoxicity. (Full text)

Allergy to iprindole (Prondol) with hepatotoxicity. 5416820 1970 04 16 2016 11 22 0007-1447 1 5692 1970 Feb 07 British medical journal Br Med J Allergy to iprindole (Prondol) with hepatotoxicity. 367 Young P J PJ eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Adult Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury etiology Depression drug therapy Drug Hypersensitivity etiology Female Humans Indoles adverse effects Liver

1970 British medical journal

77. Allergy to iprindole (prondol) with hepatotoxicity. (Full text)

Allergy to iprindole (prondol) with hepatotoxicity. 5472818 1970 12 09 2016 11 22 0007-1447 4 5731 1970 Nov 07 British medical journal Br Med J Allergy to iprindole (prondol) with hepatotoxicity. 368-9 Harrison D F DF Stanley I M IM eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Adult Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury diagnosis Depression drug therapy Female Humans Indoles adverse effects Middle Aged

1970 British medical journal

78. Allergy to iprindole (Prondole) with hepatotoxicity. (Full text)

Allergy to iprindole (Prondole) with hepatotoxicity. 5481235 1971 01 12 2016 11 22 0007-1447 4 5733 1970 Nov 21 British medical journal Br Med J Allergy to iprindole (Prondole) with hepatotoxicity. 495 Richards D J DJ eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury epidemiology Humans Indoles adverse effects 1970 11 21 1970 11 21 0 1 1970 11 21 0 0 ppublish 5481235

1970 British medical journal

79. Allergy to iprindole (Prondole) with hepatotoxicity. (Full text)

Allergy to iprindole (Prondole) with hepatotoxicity. 5481233 1971 01 12 2016 11 22 0007-1447 4 5733 1970 Nov 21 British medical journal Br Med J Allergy to iprindole (Prondole) with hepatotoxicity. 494 Clein L J LJ eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury etiology Depression drug therapy Humans Indoles adverse effects Male 1970 11 21 1970 11 21 0 1 1970 11 21 0 0

1970 British medical journal

80. Allergy to iprindole (Prondole) with hepatotoxicity. (Full text)

Allergy to iprindole (Prondole) with hepatotoxicity. 5481234 1971 01 12 2016 11 22 0007-1447 4 5733 1970 Nov 21 British medical journal Br Med J Allergy to iprindole (Prondole) with hepatotoxicity. 494-5 Cashman M D MD eng Journal Article England Br Med J 0372673 0007-1447 0 Antidepressive Agents 0 Indoles AIM IM Antidepressive Agents adverse effects Chemical and Drug Induced Liver Injury etiology Humans Indoles adverse effects 1970 11 21 1970 11 21 0 1 1970 11 21 0 0 ppublish 5481234

1970 British medical journal

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