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Hepatotoxic Medication

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21. Ciprofloxacin Exposure Leading to Fatal Hepatotoxicity: An Unusual Correlation (PubMed)

Ciprofloxacin Exposure Leading to Fatal Hepatotoxicity: An Unusual Correlation BACKGROUND Ciprofloxacin is a commonly used fluoroquinolone antibiotic. It is occasionally associated with benign elevations in liver enzymes. Few reports in the literature correlate ciprofloxacin with significant liver injury. We present a fatal case of ciprofloxacin-induced liver failure. CASE REPORT  A 74-year-old female was successfully treated with ciprofloxacin for a urinary tract infection (UTI (...) unremarkable. Liver biopsy showed cholestatic hepatitis of unclear etiology. The patient was discharged again following a mild decline in liver enzymes. Soon after, the patient was admitted to our institution with similar complaints. Serum transaminases remained elevated, with an increase in alkaline phosphatase and bilirubin. The Council for International Organizations of Medical Sciences/the Roussel Uclaf Causality Assessment Method (CIOMS/RUCAM) scale was found to be 8, outlining a high or definite

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2016 The American journal of case reports

22. Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily? (PubMed)

Unexpected paracetamol (acetaminophen) hepatotoxicity at standard dosage in two older patients: time to rethink 1 g four times daily? We present two cases of acute hepatotoxicity associated with elevated paracetamol (acetaminophen) levels in older patients. Both patients were receiving a standard European dose of oral paracetamol (2 × 500 mg QDS) with no risk factors for slowed metabolism (weight <50 kg, interacting medications, hepatic enzyme inducers, history of liver disease). Significantly (...) , both patients had recently had a dose escalation from 'as needed' dosing to 4 g daily, and the medication was being administered by nursing staff. Our experience shows that even when prescribed appropriately at the usual therapeutic dosage, paracetamol can be hepatotoxic.© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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2016 Age and ageing

23. Hepatotoxicity Associated with the Use of Anti-TNF-α Agents (PubMed)

Hepatotoxicity Associated with the Use of Anti-TNF-α Agents Medications to inhibit the actions of tumour necrosis factor alpha have revolutionized the treatment of several pro-inflammatory autoimmune conditions. Despite their many benefits, several serious side effects exist and adverse reactions do occur from these medications. While many of the medications' potential adverse effects were anticipated and recognized in clinical trials prior to drug approval, several more rare adverse reactions (...) were recorded in the literature as the popularity, availability and distribution of these medications grew. Of these potential adverse reactions, liver injury, although uncommon, has been observed in some patients. As case reports accrued over time and ultimately case series developed, the link became better established between this family of medicines and various patterns of liver injury. Interestingly, it appears that the majority of cases exhibit an autoimmune hepatitis profile both

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2016 Drug Safety

24. Gastrointestinal Nodules and Bleeding with Long-Term Lanthanum Use; DRESS and Hepatotoxicity Due to Rivaroxaban; Thrombocytopenia Induced by Pentoxifylline; Amlodipine-Induced Schamberg's Disease; Varenicline-Induced Acute Liver Injury (PubMed)

Gastrointestinal Nodules and Bleeding with Long-Term Lanthanum Use; DRESS and Hepatotoxicity Due to Rivaroxaban; Thrombocytopenia Induced by Pentoxifylline; Amlodipine-Induced Schamberg's Disease; Varenicline-Induced Acute Liver Injury The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported (...) an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in co-operation with the FDA's MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch partner.

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2016 Hospital pharmacy

25. Prevalence of Hepatotoxicity From Antituberculosis Therapy: A Five-Year Experience From South India (PubMed)

Prevalence of Hepatotoxicity From Antituberculosis Therapy: A Five-Year Experience From South India Antituberculosis (ATT) drug-induced liver injury (DILI) is a common and serious adverse effect of tuberculosis (TB) treatment. This retrospective study was carried out to study the prevalence of DILI among patients who had received anti-TB medications and to study some of the known risk factors responsible for causing DILI.This longitudinal descriptive study was performed to evaluate cases

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2016 Journal of primary care & community health

26. ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme: Acute Liver Injury Due to Febuxostat: Intravenous Acetaminophen-Induced Acute Hepatotoxicity: Acute Transient Myopia Induced by Zanamivir: Lidocaine-Induced Hoigne Syndrome (PubMed)

ISMP Adverse Drug Reactions: Sildenafil-Induced Erythema Multiforme: Acute Liver Injury Due to Febuxostat: Intravenous Acetaminophen-Induced Acute Hepatotoxicity: Acute Transient Myopia Induced by Zanamivir: Lidocaine-Induced Hoigne Syndrome The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have (...) reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in cooperation with the FDA's MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch

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2016 Hospital pharmacy

27. Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity (PubMed)

Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity Purpose: Triptans are the drug category mostly prescribed for abortive treatment of migraine. Most recent cases of liver toxicity induced by triptans have been described, but the mechanisms of liver toxicity of these medications have not been clear. Methods: In the present study, we obtained LC50 using dose-response curve and investigated cell viability, free radical generation, lipid peroxide

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2016 Advanced pharmaceutical bulletin

28. Research Advances on Hepatotoxicity of Herbal Medicines in China (PubMed)

Research Advances on Hepatotoxicity of Herbal Medicines in China In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed (...) the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact

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2016 BioMed research international

29. Sex-related Difference in Protective Role of Aerobic Exercise against Cisplatin-induced Hepatotoxicity (PubMed)

Sex-related Difference in Protective Role of Aerobic Exercise against Cisplatin-induced Hepatotoxicity 27413515 2016 07 14 2018 11 13 2008-7802 7 2016 International journal of preventive medicine Int J Prev Med Sex-related Difference in Protective Role of Aerobic Exercise against Cisplatin-induced Hepatotoxicity. 84 10.4103/2008-7802.184312 Zeynali Farzaneh F Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Noroozi Jalaledin J Water and Electrolytes (...) Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Pezeshki Zahra Z Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Nematbakhsh Mehdi M Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Institute of Basic and Applied Sciences Research, Isfahan, Iran. eng Journal Article 2016 06 20 Iran Int J Prev Med

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2016 International journal of preventive medicine

30. Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature (PubMed)

Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature Clindamycin is a bacteriostatic lincosamide antibiotic with a broad spectrum. Side effects include nausea, vomiting, diarrhea, and metallic taste; however, hepatotoxicity is rare. The incidence is unknown. It is characterized by increases in aspartate and alanine transaminases. There may be no symptoms and the treatment is to stop (...) the administration of clindamycin. We have described a 62-year-old African American female medicated with acetaminophen and clindamycin who had initially presented to the dental clinic for the evaluation of gum pain following tooth extraction. She had significantly increased levels of liver transaminases, which trended downwards on quitting the medication.

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2016 Case Reports in Hepatology

31. CRACKCast E164 – Plants, Mushrooms, and Herbal Medications

CRACKCast E164 – Plants, Mushrooms, and Herbal Medications CRACKCast E164 – Plants, Mushrooms, and Herbal Medications - CanadiEM CRACKCast E164 – Plants, Mushrooms, and Herbal Medications In by Chris Lipp March 26, 2018 This episode of CRACKCast covers Rosen’s 9th Edition Chapter 158, Plants, Mushrooms, and Herbal Medications. Most of these ingestions occur in children, and much more commonly in the developing world. However, many of these species and herbals are available in North America (...) ingestion will prove to involve a non–life-threatening substance GI symptoms that onset in more than 6 to 8 hours suggest a potentially life-threatening ingestion, such as the cyclopeptide and gyromitrin groups Use local poison control centers, mycologists, and botanists to help identify serious plants and mushrooms that have been ingested. We recommend digital photography with expert consultation Herbal medications are unregulated and may have inherent toxicity, herb-drug interactions, or contaminants

2018 CandiEM

32. American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity

American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity ENDOCRINE PRACTICE Vol 22 (Suppl 3) July 2016 1 AACE/ACE Guidelines AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY W. Timothy Garvey, MD, FACE 1 ; Jeffrey I. Mechanick, MD, FACP , FACE, FACN, ECNU 2 (...) ; Elise M. Brett, MD, FACE, CNSC, ECNU 3 ; Alan J. Garber, MD, PhD, FACE 4 ; Daniel L. Hurley, MD, FACE 5 ; Ania M. Jastreboff, MD, PhD 6 ; Karl Nadolsky, DO 7 ; Rachel Pessah-Pollack, MD 8 ; Raymond Plodkowski, MD 9 ; and Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines* American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice are systematically devel- oped statements to assist health care professionals in medical decision-making for specific clinical

2016 American Association of Clinical Endocrinologists

33. Hepatotoxic Medication

Hepatotoxic Medication Hepatotoxic Medication Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hepatotoxic Medication Hepatotoxic (...) Medication Aka: Hepatotoxic Medication , Hepatotoxic Supplement , Hepatotoxin From Related Chapters II. Causes: Medications associated with Cirrhosis Alpha- (no longer available in United States) III. Causes: Most common drug causes of Acute Hepatitis -Clavulanic Acid ( , most common cause) (AST often rises above 5000, most common cause of in U.S.) Anti- medications Trimethoprim-sulfamethoxazole (mimics ) (mimics ) IV. Causes: Hepatotoxic Medications (including mild transaminase elevations) s s Avoid

2015 FP Notebook

34. Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies. (PubMed)

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies. Phase I (PhI): assess the safety of Polyphenon E in people with multiple sclerosis (MS) and determine the futility of Polyphenon E as a neuroprotective agent. Correlate plasma levels of EGCG with neuroprotective effects. Phase II (PhII): Further assess safety and confirm the neuroprotective effects of Polyphenon E.PhI: single (...) criteria (both studies): 1) complete bone marrow ablation or alentuzumab use at any time; 2) mitoxantrone, cyclophosphamide, natalizumab or fingolimod use in the prior nine months; 3) liver problems or significant medical problems.PhI: Polyphenon E, a green tea extract containing 50% of the antioxidant Epigallocatechin-gallate (EGCG), two capsules twice daily (200mg of EGCG per capsule; total daily dose 800mg) for six months. PhII: Polyphenon E or matching placebo capsules, same dose for one year. Only

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2015 Journal of the neurological sciences

35. Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response (PubMed)

Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response 26567032 2017 12 07 2018 12 02 1937-6995 12 2 2016 06 Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response. 218 10.1007/s13181-015-0514-8 Levine Michael M Section of Medical (...) Toxicology, Department of Emergency Medicine, University of Southern California, Los Angeles, CA, USA. Michael.Levine@bannerhealth.com. Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA. Michael.Levine@bannerhealth.com. O'Connor Ayrn D AD Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA. Padilla-Jones Angela A Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA. Gerkin Richard R Department

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2015 Journal of Medical Toxicology

36. In Response to: “Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.” (PubMed)

In Response to: “Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.” 26574022 2017 12 07 2018 12 02 1937-6995 12 2 2016 06 Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.". 217 10.1007/s13181-015-0513-9 Fernandez Denise D 0000

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2015 Journal of Medical Toxicology

37. Critical review of resveratrol in xenobiotic-induced hepatotoxicity (PubMed)

Critical review of resveratrol in xenobiotic-induced hepatotoxicity Use of natural products is increasingly popular. In fact, many patients with liver diseases self-medicate with herbal supplements. Resveratrol (RSV), in particular, is a common natural product that can reduce injury in experimental models of liver disease. Xenobiotic hepatotoxicity is a particularly important area-of-need for therapeutics. Drug-induced liver injury, for example, is the most common cause of acute liver failure (...) (ALF) and ALF-induced deaths in many countries. Importantly, RSV protects against hepatotoxicity in animal models in vivo caused by several drugs and chemicals and may be an effective intervention. Although many mechanisms have been proposed to explain the protection, not all are consistent with other data. Furthermore, RSV suffers from other issues, including limited bioavailability due to extensive hepatic metabolism. The purpose of this article is to summarize recent findings on the protective

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2015 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

38. Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps (PubMed)

when HILI is first suspected as diagnosis. Although, herbal hepatotoxicity is of utmost clinical and regulatory importance, lack of a stringent causality assessment remains a major issue for patients with suspected HILI, while this problem is best overcome by the use of the hepatotoxicity specific CIOMS (Council for International Organizations of Medical Sciences) scale and the evaluation of unintentional reexposure test results. Sixty five different commonly used herbs, herbal drugs, and herbal (...) Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps Plants are natural producers of chemical substances, providing potential treatment of human ailments since ancient times. Some herbal chemicals in medicinal plants of traditional and modern medicine carry the risk of herb induced liver injury (HILI) with a severe or potentially lethal clinical course, and the requirement of a liver transplant. Discontinuation of herbal use is mandatory in time

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2015 Frontiers in pharmacology

39. Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia

asked on each visit about signs of hepatotoxicity , their laboratory data were revised , any side effects resulted from use Omega-3 fatty acids: (increased bleeding tendency, fishy smell , nausea , diarrhea , or if there is any relapses occurred , and to be sure that the patients were compliant to prescribed medication. Investigations: Blood samples were collected from every patient at day 0 of maintenance and after six months for estimation of Malondialdehyde (MDA), Total antioxidant capacity (TAC (...) Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2015 Clinical Trials

40. Statin therapy and hepatotoxicity: Appraisal of the safety profile of atorvastatin in hyperlipidemic patients. (PubMed)

Statin therapy and hepatotoxicity: Appraisal of the safety profile of atorvastatin in hyperlipidemic patients. Statins are one of the most frequently prescribed medications to reduce the risk of cardiovascular events. Statins appear to be safe however, there are contradictory data regarding their adverse effects, which might be due to genetic variation in their metabolism. Hence, this prospective study was aimed to evaluate the effects of atorvastatin on liver transaminase changes in a clinical

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2014 Advanced biomedical research

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