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Hepatotoxic Medication

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181. Review article: therapeutic bile acids and the risks for hepatotoxicity. Full Text available with Trip Pro

Review article: therapeutic bile acids and the risks for hepatotoxicity. Bile acids play important roles in cholesterol metabolism and signal through farnesoid X receptor and G protein-coupled receptors. Given their importance in liver biology, bile acid therapy enables therapeutic applications beyond the treatment of cholestatic liver disease. However, predicting hepatotoxicity of bile acids in humans is obscured due to inconsistent extrapolations of animal data to humans.To review (...) the evidence that could explain discordant bile acids hepatotoxicity observed in humans and animals.Literature search was conducted in PubMed using keywords "bile acid," "transporter," "hepatotoxicity," "clinical study," "animal study," "species difference," "mechanism," "genetic disorder." Relevant articles were selected for review.Clinically significant hepatotoxicity was reported in response to certain bile acids, namely chenodeoxycholic acid, which was given a boxed warning for potential hepatotoxicity

2018 Alimentary Pharmacology & Therapeutics

182. Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin. (Abstract)

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin. Polygonum multiflorum Thund., a well-known and commonly-used TCM (Traditional Chinese Medicine) for treating hypertension, hyperlipidemia, premature graying of hair, and etc., has aroused wide concern for its reported potential liver toxicity. Due to its various active ingredients, the mechanisms underlying the hepatotoxicity of raw Polygonum multiflorum Thund (RPM) remain largely (...) unknown.1H NMR metabolomics was used to study the mechanism of RPM induced hepatotoxicity and disclosed the existence of hepatotoxicity and hepatoprotection conversion during RPM administration in mice.Three dosages of RPM were administered by gavage to mice for consecutive 28 days. The serum and liver samples were collected and then subjected for histopathology observation, biochemical measurement and 1H NMR metabolic profiling.RPM caused oxidative stress and mitochondria dysfunction in mice

2018 Journal of Ethnopharmacology

183. Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study. Full Text available with Trip Pro

Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study. Erlotinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Severe hepatotoxicity was observed in 4% to 31% of patients receiving erlotinib treatment prompting delay or termination of treatment. Only a few factors related to hepatotoxicity of erlotinib have been reported. No study has investigated the role of concomitant medications and erlotinib-induced hepatotoxicity (...) . The aim of this study was to investigate the association between erlotinib-induced hepatotoxicity and various factors including concomitant medications in patients with NSCLC and pancreatic cancer.From January 2014 to June 2017, a retrospective study was conducted in patients with NSCLC and pancreatic cancer, who were treated with erlotinib. Various data were reviewed, including sex, age, body weight, height, body surface area (BSA), underlying disease, Eastern Cooperative Oncology Group (ECOG

2018 BMC Cancer

184. Kombiglyze (metformin and saxagliptin)‐induced hepatotoxicity in a patient with non‐alcoholic fatty liver disease Full Text available with Trip Pro

Uclaf Causality Assessment Method is a scoring method to determine the probability of drug induced liver injury. RUCAM score for this case was 6 (probable adverse drug reaction). Hepatotoxicity from saxagliptin not been reported prior. Clinicians need to be more vigilant, particularly in patients with NASH. (...) Kombiglyze (metformin and saxagliptin)‐induced hepatotoxicity in a patient with non‐alcoholic fatty liver disease A 33-year-old man was referred with hyperosmotic symptoms of 4 weeks. Clinical examination showed palpable hepatomegaly and no stigmata of liver disease. Findings were random glucose 16.6 mmol/L, HbA1c 12.4%, triglyceride 6.2 mmol/L, normal LFTs and ultrasound liver: increased echogenicity. Management consisted of dietician referral and commencement of metformin 500 mg bd

2018 JGH Open: An Open Access Journal of Gastroenterology and Hepatology

185. Pharmacogenomics of Asparaginase Induced Hepatotoxicity

, 2025 Resource links provided by the National Library of Medicine related topics: available for: resources: Groups and Cohorts Go to Group/Cohort Intervention/treatment Biospecimen Collection Buccal swabs of prospective participants' saliva will be collected when participant achieves complete remission (during regular clinical visit) from their asparaginase treatment. Procedure: Biospecimen Collection Undergo collection of saliva Outcome Measures Go to Primary Outcome Measures : Hepatotoxicity (...) following treatment with asparaginase [ Time Frame: Up to 6 months ] Hepatotoxicity per Common Terminology Criteria for Adverse Events version 4.0 (CTCAE) and defined as > or = grade 3 of both aspartate aminotransferase (AST) and alanine aminotransferase (ALT), or > or = grade 3 bilirubin elevation. Biospecimen Retention: Samples With DNA Saliva Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk

2018 Clinical Trials

186. APAP Hepatotoxicity After Therapeutic Doses

APAP Hepatotoxicity After Therapeutic Doses APAP Hepatotoxicity After Therapeutic Doses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. APAP Hepatotoxicity After Therapeutic Doses The safety and scientific (...) factors such as malnutrition, fasting and low body weight as a result of glutathione depletion. However, no well conducted study has aimed to prospectively assess the impact of malnutrition/fasting on the toxicity to therapeutic doses of APAP. Considering the widespread use of APAP and the prevalence of malnutrition in hospitalized patients (up to 30%), it is of crucial importance to assess whether these patients are at higher risk of hepatotoxicity. It is indeed likely that cases of liver damage

2018 Clinical Trials

187. Hypolipidemic Effect of Psidium guajava Leaf Extract Against Hepatotoxicity in Rats Full Text available with Trip Pro

disease induction and silymarin drug was used as positive control to compare plant ethanolic extract. The lipid profiles were assessed in both plasma and liver tissue of diseased and control rats.Levels of total cholesterol, triglycerides, free fatty acids, phospholipids, and low-density lipoprotein cholesterol were increased and the level of high-density lipoprotein cholesterol (HDL-C) was decreased in CCl4-induced hepatotoxic rats. The treatment of P. guajava (100, 200, and 300 mg/kg, bw (...) Hypolipidemic Effect of Psidium guajava Leaf Extract Against Hepatotoxicity in Rats Plant-based natural extracts cure several diseases in human. However, the extract of Psidium guajava leaf is not yet evaluated on changes of lipid profile in hepatic disease affected rats.The present study was aimed to evaluate the mitigation effect of the ethanolic extract of P. guajava leaf and its isolated quercetin fraction on hepatotoxic rats.Carbon tetrachloride (CCl4) was injected to rats for hepatic

2018 Pharmacognosy magazine

188. Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide Full Text available with Trip Pro

Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on the autoimmune disorders and simultaneously ineluctable hepatotoxicity and nephrotoxicity. Combinational application of Panax notoginseng (PN) and Rehmannia glutinosa (RG) weakens the toxicity of TW (...) according the clinical application of traditional Chinese medicine. This article was aimed at the mechanism of decreasing toxicity of TW by the combinational application of PN and RG. Biochemical and pathohistological analysis were utilized to assess the toxicity on liver and kidney in rats administrated with TW, TW-PN, TW-RG and TW-PN-RG for 3 and 7 days. Meanwhile, the pharmacokinetics profiling of triptolide and wilforlide A was determined based on the plasma concentration analyzed by ultra-high

2018 International journal of molecular sciences

189. Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions Full Text available with Trip Pro

Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions The accurate prediction of hepatotoxicity demands validated human in vitro models that can close the gap between preclinical animal studies and clinical trials. In this study we investigated the response of primary human liver cells to toxic drug exposure in a perfused microscale 3D liver bioreactor. The cellularized bioreactors were treated with 5, 10, or 30 mM acetaminophen (APAP) used as a reference (...) , and apoptosis was differentially influenced by APAP exposure. Histological examinations revealed that primary human liver cells in untreated control bioreactors were reorganized in tissue-like cell aggregates. These aggregates were partly disintegrated upon APAP treatment, lacking expression of hepatocyte-specific proteins and transporters. In conclusion, our results validate the suitability of the microscale 3D liver bioreactor to detect hepatotoxic effects of drugs in vitro under perfusion conditions.

2018 Bioengineering

190. A Case of Levofloxacin-Induced Hepatotoxicity Full Text available with Trip Pro

A Case of Levofloxacin-Induced Hepatotoxicity BACKGROUND Levofloxacin covers a broad spectrum of pathogens and is readily prescribed by clinicians. Hepatotoxicity is a known but unusual complication of levofloxacin use. Here, we present a case of severe transaminitis caused by levofloxacin. CASE REPORT A young man in his thirties with a history of asthma, chronic alcoholism, methamphetamine intravenous drug abuse (IVDA), and non-compliant insulin-dependent diabetes mellitus (IDDM) presented (...) levofloxacin administration showed aminotransferase levels raised to approximately 50 times baseline within a few days. Levofloxacin was discontinued due to concern about drug-induced hepatotoxicity. After discontinuation, transaminase levels decreased immediately. Work-up for other causes of transaminitis revealed no other etiology. CONCLUSIONS Clinicians should remain mindful that levofloxacin can induce hepatotoxicity in rare cases. In patients presenting with acute liver injury who have recently taken

2018 The American journal of case reports

191. Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice Full Text available with Trip Pro

Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice Corynoline (CRL), an isoquinoline alkaloid, is the major constituent derived from Corydalis bungeana Herba, which is a well-known Chinese herbal medicine widely used in many prescriptions. The purpose of this study was to comprehensively investigate the metabolism and bioactivation of CRL, and identify the CYP450 isoforms involved in reactive ortho (...) and chemical inhibitor method, we found that CYP3A4, CYP2C19, CYP2C9, and CYP2D6 were mainly involved in the bioactivation of CRL. Furthermore, CRL had no obvious hepatotoxicity and did not induce acute liver injuries in the experimental dosage (125-500 mg/kg) used in this study. However, phenomena of abnormal behaviors and low body temperature appeared in mice after drug administration, and three of them were dead. Tissue distribution study of CRL in mice showed that the main target organ of CRL was liver

2018 Frontiers in pharmacology

192. Liver-specific metabolomics characterizes the hepatotoxicity of Dioscorea bulbifera rhizome in rats by integration of GC-MS and <sup>1</sup>H-NMR. (Abstract)

Liver-specific metabolomics characterizes the hepatotoxicity of Dioscorea bulbifera rhizome in rats by integration of GC-MS and 1H-NMR. Dioscorea bulbifera rhizome (DBR), one type of herbal medicine, is extensively used in both Indian and Chinese system of traditional medicine. It has been effective in treating various diseases, such as sore throat, struma, and tumors. However, more and more clinical investigations have suggested that DBR can cause liver injury.In the present study (...) , we aimed to characterize the corresponding molecular changes of liver dysfunction and reveal overall metabolic and physiological mechanisms of the subchronic toxic effect of DBR.A liver-specific metabolomics approach integrating GC-MS and 1H-NMR was developed to assess the hepatotoxicity in rats after DBR exposure for 12 weeks. Multivariate statistical analysis and pattern recognition were employed to examine different metabolic profiles of liver in DBR-challenged rats.A total of 61 metabolites

2018 Journal of Ethnopharmacology

193. Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan. Full Text available with Trip Pro

Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan. Two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI (nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for antiretroviral-naive HIV-positive patients in Taiwan. The three most commonly used nNRTIs are nevirapine (NVP (...) ), efavirenz (EFV) and rilpivirine (RPV). This study aimed to determine the incidences of hepatotoxicity and skin rashes within 4 weeks of initiation of cART containing 1 nNRTI plus 2 NRTIs.Between June, 2012 and November, 2015, all antiretroviral-naive HIV-positive adult patients initiating nNRTI-containing cART at 8 designated hospitals for HIV care were included in this retrospective observational study. According to the national HIV treatment guidelines, patients were assessed at baseline, 2 and 4

2017 PLoS ONE

194. A computational toxicogenomics approach identifies a list of highly hepatotoxic compounds from a large microarray database. Full Text available with Trip Pro

A computational toxicogenomics approach identifies a list of highly hepatotoxic compounds from a large microarray database. The liver and the kidney are the most common targets of chemical toxicity, due to their major metabolic and excretory functions. However, since the liver is directly involved in biotransformation, compounds in many currently and normally used drugs could affect it adversely. Most chemical compounds are already labeled according to FDA-approved labels using DILI-concern (...) scale. Drug Induced Liver Injury (DILI) scale refers to an adverse drug reaction. Many compounds do not exhibit hepatotoxicity at early stages of development, so it is important to detect anomalies at gene expression level that could predict adverse reactions in later stages. In this study, a large collection of microarray data is used to investigate gene expression changes associated with hepatotoxicity. Using TG-GATEs a large-scale toxicogenomics database, we present a computational strategy

2017 PLoS ONE

195. Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(Strong recom- mendation, low level of evidence). 11. The diagnosis of DILI in patients with CLD requires a high index of suspicion and exclusion of other more common causes of acute liver injury including a ? are-up of the underlying liver disease (Strong recommendation, low level of evidence). 12. The use of potentially hepatotoxic drugs in CLD patients should be based upon the risk vs. bene? t of the proposed therapy on a case-by-case basis (Strong recommendation, low level of evidence). 13 (...) of suspicion and exclusion of other more com- mon causes of acute liver injury, including a fl are-up of the underlying liver disease (Strong recommendation, low level of evidence). 2. Th e use of potentially hepatotoxic drugs in CLD patients should be based upon the risk versus benefi t of the proposed therapy on a case-by-case basis (Strong recommendation, low level of evidence). 3. Th ere are no data to recommend a specifi c liver biochem- istry monitoring plan when a potential hepatotoxic agent

2014 American College of Gastroenterology

196. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

therapy 3. Pharmaceutical equivalence and clinical interchangeability between lamivudine and emtricitabine 4. Use of efavirenz during pregnancy as part of first-line antiretroviral therapy: a public health perspective 5. Optimizing antiretroviral drugs for children: medium- and long-term priorities 6. Changing role of CD4 cell counts in HIV care and treatment 7. Scaling up viral load testing in resource-limited settings Supplementary sections to Chapter 9 – Guidance on operations and service delivery (...) of HIV/AIDS, WHO; Shirin Heidari, International AIDS Society; David Jamieson, PFSCM, United States of America; Janice Lee, Drugs for Neglected Diseases Initiative, Switzerland; Atieno Ojo, UNICEF.10 Community-based delivery of antiretroviral therapy We thank the meeting participants for their contribution: Marielle Bemelmans (Médecins Sans Frontières), Cephas Chikanda (Anova Health Institute), Tom Decroo (Institute for Tropical Medicine, Belgium), Bernard Michael Etukoit (The AIDS Support

2014 World Health Organisation HIV Guidelines

197. Vitamin Supplementation to Prevent Cancer and CVD: Preventive Medication

, MSPH, Co-Vice Chair (University of Missouri School of Medicine, Columbia, Missouri); Albert L. Siu. MD, MSPH, Co-Vice Chair (Mount Sinai School of Medicine, New York, and James J. Peters Veterans Affairs Medical Center, Bronx, New York); Linda Ciofu Baumann, PhD, RN (University of Wisconsin, Madison, Wisconsin); Susan J. Curry, PhD (University of Iowa College of Public Health, Iowa City, Iowa); Mark Ebell, MD, MS (University of Georgia Athens, Georgia); Francisco A.R. García, MD, MPH (Pima County (...) Vitamin Supplementation to Prevent Cancer and CVD: Preventive Medication Recommendation | United States Preventive Services Taskforce Toggle navigation Main navigation Main navigation Recommendation to see the latest documents available. Recommendation Summary Population Recommendation Use of β-carotene or Vitamin E for Prevention of Cardiovascular Disease or Cancer The USPSTF recommends against the use of ß-carotene or vitamin E supplements for the prevention of cardiovascular disease

2014 U.S. Preventive Services Task Force

198. Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity Full Text available with Trip Pro

it with classical animal-based toxicity assays. Our results suggested that the reported hepatotoxicity by one of the drugs, Fufangkushen injection, could be attributed at least in part to the interference of mitochondrial function in human HepG2 cells by some of its constituents. This method should be useful for both preclinical screen in a drug discovery program and postclinical evaluation of herbal medicine preparations. (...) Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity The safety of herbal medicine products has been a widespread concern due to their complex chemical nature and lack of proper evaluation methods. We have adapted a sensitive and reproducible multiparametric cell-based high-content analysis assay to evaluate the hepatic-safety of four Chinese medicine injections and validated

2015 Evidence-based Complementary and Alternative Medicine : eCAM

199. Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps Full Text available with Trip Pro

when HILI is first suspected as diagnosis. Although, herbal hepatotoxicity is of utmost clinical and regulatory importance, lack of a stringent causality assessment remains a major issue for patients with suspected HILI, while this problem is best overcome by the use of the hepatotoxicity specific CIOMS (Council for International Organizations of Medical Sciences) scale and the evaluation of unintentional reexposure test results. Sixty five different commonly used herbs, herbal drugs, and herbal (...) patients with intrinsic hepatotoxicity. It remains to be established whether these new technologies can identify idiosyncratic HILI cases. To enhance its globalization, herbal medicine should universally be marketed as herbal drugs under strict regulatory surveillance in analogy to regulatory approved chemical drugs, proving a positive risk/benefit profile by enforcing evidence based clinical trials and excellent herbal drug quality.

2015 Frontiers in pharmacology

200. Withdrawal of pain medicine flupirtine endorsed

-containing medicines continue to be exposed to serious risks which outweigh the benefits of these medicines. In order to protect public health, the endorsed the recommendation to withdraw the of flupirtine-containing medicines. Information for patients Flupirtine-containing medicines have been used to treat acute (short-term) pain for up to two weeks in adults who cannot use other painkillers (such as non-steroidal anti-inflammatory drugs (NSAIDs) and weak opioids). These medicines are being taken off (...) to be taken, including when the medicine will become unavailable. Since 2013, cases of serious liver injury, including 23 cases of acute liver failure, some of which were fatal or led to transplantation have been reported following flupirtine use. 2 The reactions are unpredictable and the exact mechanism by which flupirtine causes liver injury is not known. Six observational studies showed a lack of compliance with the measures that were introduced to minimise the risk of hepatotoxicity. More about

2018 European Medicines Agency - EPARs

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