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Hemorrhoid Coagulation

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101. Appropriate use of GI endoscopy

structures. Common therapeutic endoscopic procedures include polypectomy, di- lation of strictures, stent placement, removal of foreign bod- ies, gastrostomy, treatment of GI bleeding with injection, banding, coagulation, sclerotherapy, and endoscopic therapy of intestinal metaplasia. Flexible sigmoidoscopy (FS) uses a ?exible instrument to examine the rectum, sigmoid, and a variable length of more proximal colon. Diagnostic and therapeutic inter- ventions include biopsy, hemostasis, hemorrhoidal band (...) of familial adenomatous polyposis. F. Stent placement. G. Removal of foreign bodies. H. Evaluation and treatment of anorectal disorders (eg, banding of hemorrhoids). I. Surveillance of the rectum after subtotal colectomy (eg, in familial adenomatous polyposis and ulcerative colitis). J. Evaluation for pouchitis. K. To obtain rectal and distal colon biopsy specimens in the evaluation of systemic diseases or infections (eg, cytomegalovirus, graft-versus-host disease, and amyloidosis). FS is generally

2012 American Society for Gastrointestinal Endoscopy

104. A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand

Wand. The generator and wand are cleared by the FDA for human use and the wand is specifically cleared for treatment of anal neoplasia. The present FDA indication for use statement is: "The Barrx™ catheters are indicated for use in the coagulation of bleeding and non-bleeding sites in the gastrointestinal tract including, but not limited to, the esophagus. Indications include esophageal ulcers, Mallory-Weiss tears, arteriovenous malformations, angiomata, Barrett's esophagus, Dieulafoy lesions (...) the trial History of ablation or resection therapy within the ETZ within 3 months prior to the 0 month RFA visit (other than cauterization or excision of condylomata) History of topical therapy (e.g. Imiquimod, 5-FU, Trichloroacetic acid) within the ETZ within 3 months prior to the 0 month RFA visit Hemorrhoids > grade III Fecal incontinence Concurrent disease requiring systemic immunosuppression therapy Concurrent malignancy requiring systemic therapy Life expectancy < 2 years Contacts and Locations Go

2017 Clinical Trials

105. Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study

coagulation (APC) or topical formalin. We proposed this prospective cohort study, to assess the efficacy and safety of colostomy in treating refractory hemorrhagic CRP with moderate to severe anemia, to provide higher-quality evidence of colostomy in these patients. Condition or disease Intervention/treatment Phase Chronic Radiation Proctitis Rectal Bleeding Colostomy Stoma Anemia Procedure: Transverse colostomy Not Applicable Detailed Description: Chronic radiation proctitis (CRP) is a common (...) complication after radiotherapy of pelvic malignancies, accounting for 5%-20% of cases. Rectal bleeding is the most common symptom, which accounts for > 80% of CRP patients. Mild to moderate bleeding can be controlled by medical agents like sucralfate, endoscopic argon plasma coagulation (APC) or topical formalin. Severe and refractory bleeding is still problematic and refractory to these above medical treatments. Our previous retrospective study found that colostomy obtained a higher rate of bleeding

2017 Clinical Trials

106. A Pharmacokinetic Study Comparing MB02 And US And EU Avastin® In Healthy Male Volunteers

, at Screening. In good health, determined by no clinically significant findings from medical history, physical examination, 12-lead ECG, vital sign measurements, and clinical laboratory evaluations (congenital nonhaemolytic hyperbilirubinemia [eg, Gilbert's syndrome] is acceptable) at Screening or Check-in as assessed by the Investigator (or designee). Relevant clinical laboratory evaluations of haematology, coagulation, urinalysis and clinical chemistry within normal range at Screening and Check (...) bleeding, haemorrhoids and/or haemoptysis. History of GI perforation, ulcers, gastro oesophageal reflux, inflammatory bowel disease, diverticular disease, or any fistulae. Alcohol consumption of >24 units per week. One unit of alcohol equals ½ pint (285 mL) of beer or lager, 1 glass (125 mL) of wine, or 1/6 gill (25 mL) of spirits. Positive hepatitis panel, positive human immunodeficiency test. Subjects whose results are compatible with prior immunisation and not infection may be included

2017 Clinical Trials

107. A Study to Evaluate the Safety and Effectiveness of the Left Atrial Appendage Closure Therapy Using BSJ003W

intervention for control (excluding dental/nasal/skin/hemorrhoid), Bleeding requiring intravenous vasoactive agents Type 3c: Intracranial hemorrhage (does not include microbleeds or hemorrhagic transformation, does include intraspinal), Subcategories confirmed by autopsy or imaging or lumbar puncture Intraocular bleed compromising vision Type 5: fatal bleeding Type 5a: Probable fatal bleeding; no autopsy or imaging confirmation but clinically suspicious Type 5b: Definite fatal bleeding; overt bleeding (...) has documented paroxysmal, persistent or permanent non-valvular atrial fibrillation The subject has a calculated CHA2DS2-VASc score of 2 or greater and is recommended for long-term oral anti-coagulation therapy The subject is deemed by their physicians to be suitable for anticoagulant therapy and have an appropriate rationale to seek a non-pharmacologic alternative to warfarin The subject is eligible to come off warfarin therapy if the LAA (left atrial appendage) is sealed (i.e. the subject has

2017 Clinical Trials

108. A Study Comparing the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution With PREPOPIK® for Colon Cleansing in Preparation for Colonoscopy

level of consciousness or inability to swallow without aspiration Any prior colorectal surgery, excluding appendectomy, hemorrhoid surgery, or prior endoscopic procedures Upper gastrointestinal surgery (gastrectomy, gastric banding, gastric by-pass) Uncontrolled angina and/or myocardial infarction (MI) within last three months, congestive heart failure (CHF), uncontrolled hypertension, or ascites Severely reduced renal function (<30 mL/min/1.73 m2) Pregnant or lactating women Any clinically relevant (...) abnormal findings in medical history, physical examination, vital signs, ECG, clinical chemistry, hematology, coagulation, or urinalysis at Screening Visit 1 Rhabdomyolysis Chronic nausea and vomiting Hypermagnesemia Undergoing treatment with Lithium Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its

2017 Clinical Trials

109. Prognostic Value of Copeptin for Infarct Size and Prognosis in Patients With ST-elevation Myocardial Infarction

dental/nasal/skin/hemorrhoid) Bleeding requiring intravenous vasoactive agents;Type 3c Intracranial hemorrhage (does not include microbleeds or hemorrhagic transformation, does include intraspinal) Subcategories confirmed by autopsy or imaging or lumbar puncture Intraocular bleed compromising vision Type 5: fatal bleeding Type 5a Probable fatal bleeding; no autopsy or imaging confirmation but clinically suspicious Type 5b Definite fatal bleeding; overt bleeding or autopsy or imaging confirmation (...) Infarction ST Elevation Myocardial Infarction Diabetes Insipidus Ischemia Pathologic Processes Necrosis Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases Kidney Diseases Urologic Diseases Pituitary Diseases Endocrine System Diseases Arginine Vasopressin Hemostatics Coagulants Vasoconstrictor Agents Antidiuretic Agents Natriuretic Agents Physiological Effects of Drugs

2017 Clinical Trials

110. Traditional Chinese Medicine (TCM) Colon Dialysis Treats Non-dialysis End-Stage Kidney Disease

therapy; 3. no gastrointestinal diseases (including ulcerative colitis, irritable bowel syndrome, inflammation, cancer, infection, bleeding, etc.) in the past 1 year; 4.not associated with rectal-related disorders (hemorrhoids, anal fistula, rectal cancer, cancer, infection, bleeding, etc.); 5.Sign informed consent. Exclusion Criteria: 1. having used antibiotics, hormones, immunosuppressive, probiotics and laxatives in past three months; 2. pregnant or lactating patients; 3.cannot cooperate (...) or tolerate colonic dialysis treatment; 4.combined with active stage of malignant tumors, cardiovascular, respiratory system, decompensated liver cirrhosis or blood system diseases (including coagulation disorders, hematopoietic dysfunction, etc.) and other serious primary disease; 5. recent merger of patients with infectious diseases; 6.having known to be allergic to some drugs in the study. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you

2017 Clinical Trials

111. Comparing Early Versus Elective Colonoscopy

Frame: 0-4 day ] SRH based on colonoscopic visualization of lesions, such as diverticulosis, tumor, ulcer, hemorrhoid, angioectasia, and polyps exhibiting active bleeding, a visible vessel, or an adherent clot. Secondary Outcome Measures : Success rate of endoscopic treatment [ Time Frame: 0-4 day ] Success rate will be defined as the number achieving hemostasis per total number of attempts at endoscopic hemostasis during colonoscopy examination. Need for additional endoscopic examinations [ Time (...) or blood transfusion. Patients who have undergone total colectomy. Patients with suspected disseminated intravascular coagulation. Patients with end-stage malignant disease. Patients with severe cardiac failure. Patients with active thrombosis. Patients with severe respiratory failure. Pregnant patients. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information

2017 Clinical Trials

112. Efficacy and Safety of Rivaroxaban in Acute Non-neoplastic Portal Vein Thrombosis in HCV

due to portal pyemia complicated infected thrombosed internal piles (n=1), appendicular abscess (n=1), ulcerative colitis (n=2). Control group It included 30 patients who had acute non-neoplastic PVT with the same inclusion criteria and were given symptomatic therapy for ascites, abdominal pain and followed synchronously with the study group. Laboratory investigations They included investigation preliminary to splenectomy as liver function tests, coagulation profile, renal function tests, complete

2017 Clinical Trials

113. Management and outcome of gastrointestinal bleeding in patients taking oral anticoagulants or antiplatelet drugs. (Abstract)

by comparing cases of gastrointestinal bleeding associated with NOAC, VKA, or antiplatelet therapy.All major gastrointestinal bleeding events documented in the prospective Dresden NOAC registry were identified, and bleeding location, lesion type, endoscopic treatment, use of blood and coagulation factor transfusion, length of stay, and in-hospital mortality were compared with historical data from a large cohort of consecutive gastrointestinal bleeding patients.In the 143 NOAC therapy cases, upper (...) , hemorrhoid bleeding was the predominant lesion type for lower gastrointestinal tract bleeding with NOAC therapy, with a rate of 33.3%, compared with 10.6% with VKA therapy and 8.7% with antiplatelet therapy. NOAC-associated gastrointestinal bleeding resulted in comparatively low resource consumption, shorter hospitalization, and low in-hospital mortality (1.6%) compared with gastrointestinal bleeding historically seen with use of VKAs (in-hospital mortality 5.6%) or antiplatelet agents (in-hospital

2017 Journal of gastroenterology

114. Commissioning guide for rectal bleeding

or infra- red coagulation (laser) therapy, but neither is as effective as suction banding. At present surgery is reserved for bleeding or prolapsing haemorrhoids that have not responded to outpatient treatment (ASCRS Practice Parameters for the Management of Hemorrhoids). 16 Doppler-guided haemorrhoidal artery ligation and stapled haemorrhoidopexy are alternatives to formal haemorrhoidectomy. 17 These are associated with lower pain scores but neither procedure has long term outcomes data available yet (...) (FOB) stool test to check whether there is blood hidden in faeces flexible sigmoidoscopy telescope examination of the lower bowel full blood count (FBC) a blood test for anaemia glyceryltrinitrate (GTN) medication to relax the anal sphincter and improve blood supply to allow fissure healing haemorrhoidal artery ligation operation (HALO) doppler guided haemorrhoidal operation designed to identify and tie off blood vessels haemorrhoids piles high value care pathway clear and consistent commissioning

2014 Association of Coloproctology of Great Britain and Ireland

115. Thoughts On Prolonged Bleeding Whilst Taking Baby Aspirin

of categorizing bleeding events, the BARC bleeding types. By far, the most common bleeding on aspirin is the kind I had: Type 1 BARC. Type 1: bleeding that is not actionable and does not cause the patient to seek unscheduled performance of studies, hospitalization, or treatment by a healthcare professional. Examples include, but are not limited to, bruising, hematoma, nosebleeds, or hemorrhoidal bleeding for which the patient does not seek medical attention. Type 1 bleeding may include episodes that lead (...) a rapid reversal drug for the blood thinning effect of warfarin (Kcentra for example), such drugs do not exist for aspirin or Eliquis type drugs (as far as I know). I do not have atrial fibrillation so “on label” the newer Eliquis drugs are not prescribed for people like me. However, these newer drugs could be prescribed “off label” to non a-fib patients. The newer drugs like Eliquis claim that the blood thinning effect is so precise that coagulation type measurements are not required. However, I have

2018 The Skeptical Cardiologist

116. Bruising

, dabigatran, and rivaroxaban. [ ; ; ; ; ] Diagnosis Diagnosis of bruising causes How should I assess a person with bruising? How should I assess a person with bruising? Ask about symptoms which suggest an underlying platelet or coagulation disorder: Nosebleeds or gingival bleeding (mucocutaneous bleeding). Excessive or prolonged bleeding from haemorrhoids, other rectal bleeding, haematuria, or menorrhagia. Previous excessive bruising, or excessive or prolonged bleeding, that: Occurs soon after trauma (...) by, an underlying bleeding disorder or medical condition, including: Vascular disorders (for example senile or simple purpura). Platelet disorders (for example idiopathic thrombocytopenic purpura, leukaemia, or liver disease). Coagulation disorders (for example haemophilia, vitamin K deficiency, or von Willebrand disease). Drugs (such as corticosteroids, warfarin, and alcohol). The presence of a bleeding disorder or underlying medical condition does not rule out non-accidental injury as a cause of abnormal

2016 NICE Clinical Knowledge Summaries

118. Predictive Parameters of Symptomatic Hematochezia Following 5-Fraction Gantry-Based SABR in Prostate Cancer. (Abstract)

suppositories, 4% formalin, or 1 to 2 sessions of argon plasma coagulation (APC) was labeled grade 2. More than 2 sessions of APC, blood transfusion, or a course of hyperbaric oxygen was grade 3 and development of visceral fistula, grade 4. Various dosimetric and clinical factors were analyzed using univariate and multivariate analyses. Receiver operating characteristic (ROC) curve analysis and recursive partitioning analysis were used to determine clinically valid cut-off points and identify risk groups (...) of rectum receiving radiation dose of 38 Gy (V38) was a strong predictor of HH with an area under the curve of 0.65. In multivariate analysis, rectal V38 (≥2.0 cm(3); odds ratio [OR]: 4.7); use of anticoagulants in the follow-up period (OR: 6.5) and presence of hemorrhoids (OR: 2.7) were the strongest predictors. Recursive partitioning analysis showed rectal V38 < 2.0 cm(3), and use of anticoagulants or rectal V38 ≥ 2.0 cm(3) plus 1 other risk factor resulted in an HH risk of >30%.Rectal V38 and 2

2016 Biology and Physics Controlled trial quality: uncertain

119. Comparison of a Hemorrhoidectomy With Ultrasonic Scalpel Versus a Conventional Hemorrhoidectomy Full Text available with Trip Pro

50 patients who had undergone a hemorrhoidectomy for grade III or IV internal hemorrhoids. The hemorrhoidal pedicle was coagulated with an ultrasonic device in the ultrasonic scalpel group (n = 25) and sutured with 3-0 vicryl material after excision in the conventional method group (n = 25).The patients' demographics, clinical characteristics, and lengths of hospital stay were similar in both groups. The mean ages of the conventional and the ultrasonic scalpel groups were, respectively, 20.8

2016 Annals of coloproctology Controlled trial quality: uncertain

120. A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

, gastroesophageal reflux disease, gastrointestinal ulcer, hepatic disease,coagulation disorder,dyspepsia and being reliant on contact lenses for vision for the duration of study treatment and for 2 days after discontinuation of study treatment (eyeglasses are allowed). History of nausea, diarrhoea, recent surgery, use of tobacco or nicotine containing products, drug or alcohol use, periodontal disease, hemorrhoids with rectal bleeding and recent blood donation. Prior exposure to BMS-986141 or prothrombin (...) coagulation parameters. Subjects with body mass index of 18 to 32 kg/m2, inclusive. Women participants must have documented proof that they are not of childbearing potential. Men who are sexually active with WOCBP must agree to follow instructions for method(s) of contraception for the duration of treatment plus 5 half-lives of Rifampin (1 day) plus 90 days for a total of 91 days post-treatment completion. Exclusion Criteria: Acute or chronic medical illness, subjects with bleeding diathesis

2016 Clinical Trials

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