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Hemorrhoid Coagulation

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82. Commissioning guide for rectal bleeding

or infra- red coagulation (laser) therapy, but neither is as effective as suction banding. At present surgery is reserved for bleeding or prolapsing haemorrhoids that have not responded to outpatient treatment (ASCRS Practice Parameters for the Management of Hemorrhoids). 16 Doppler-guided haemorrhoidal artery ligation and stapled haemorrhoidopexy are alternatives to formal haemorrhoidectomy. 17 These are associated with lower pain scores but neither procedure has long term outcomes data available yet (...) cause profuse rectal bleeding argon plasma coagulation (APC) endoscopic procedure used to control bleeding in the gastrointestinal tract asymptomatic having no symptoms audit evaluation of an investigation or treatment through systematic examination of data Bowel Cancer Screening Programme (BCSP) national screening programme for colorectal cancer based on FOB testing carcino-embryonic antigen (CEA) tumour marker associated with advanced colorectal cancer Clinical Commissioning Guide (CCG

2014 Association of Coloproctology of Great Britain and Ireland

83. Anal Squamous Neoplasms

recommendation based on low-quality evidence, 1C. Most patients present with a slow-growing mass located in the intraanal or perianal position. 20 Pain and bleeding are common, occurring in approximately half of patients, although up to 20% of patients may be asymptomatic. 21,22 Diagnosis of SCC may often be delayed, because the non- specific symptoms are initially attributed to other benign anorectal pathology such as hemorrhoids in 70% to 80% of patients. 20,23 With lymphatic spread primarily to the ingui (...) –144 Pretreatment Evaluation 1. A disease-specific history and physical examination should be performed for LGAIN/HGAIN, emphasiz- ing symptoms, risk factors, and location of disease. Grade of Recommendation: Strong recommendation based on low-quality evidence, 1C. LGAiN/HGAiN is often found incidentally during surgery for other unrelated problems such as hemorrhoids. However, high-risk populations include men who have sex with men (MSM), HiV-negative women with a history of anal recep- tive

2012 American Society of Colon and Rectal Surgeons

84. Appropriate use of GI endoscopy

structures. Common therapeutic endoscopic procedures include polypectomy, di- lation of strictures, stent placement, removal of foreign bod- ies, gastrostomy, treatment of GI bleeding with injection, banding, coagulation, sclerotherapy, and endoscopic therapy of intestinal metaplasia. Flexible sigmoidoscopy (FS) uses a ?exible instrument to examine the rectum, sigmoid, and a variable length of more proximal colon. Diagnostic and therapeutic inter- ventions include biopsy, hemostasis, hemorrhoidal band (...) of familial adenomatous polyposis. F. Stent placement. G. Removal of foreign bodies. H. Evaluation and treatment of anorectal disorders (eg, banding of hemorrhoids). I. Surveillance of the rectum after subtotal colectomy (eg, in familial adenomatous polyposis and ulcerative colitis). J. Evaluation for pouchitis. K. To obtain rectal and distal colon biopsy specimens in the evaluation of systemic diseases or infections (eg, cytomegalovirus, graft-versus-host disease, and amyloidosis). FS is generally

2012 American Society for Gastrointestinal Endoscopy

85. Safety and Effectiveness Evaluation of the ForConti Fecal Management System

neurological diagnosis Known life threatening disease such as cancer, immune deficiency state Significant cardiac arrhythmia Pregnant or Breastfeeding Inflammatory bowel disease Anti-coagulants and anti-platelets treatment, except Aspirin (low dose: 75-100 mg/day) Anorectal diseases: perianal abscess, active fistula, fissure, hemorrhoids grade 3 or 4, Pruritus ani or rectal bleeding Chronic pelvic pain Rectal surgery in past 6 months Contacts and Locations Go to Information from the National Library

2016 Clinical Trials

86. HDR Focal: Feasibility Study

lesions), on multiparametric MRI Prostate gland size <80cc Baseline IPSS <18 No TRUP within the past 6 months, nor large TURP defect Absence of radiological evidence of regional or distant metastases (optional evaluation, at physician discretion) No previous pelvic and/or prostate EBRT and/or brachytherapy No contraindications to general anesthesia, or spinal/epidural anesthesia Absence of bleeding diathesis and/or anti-coagulative therapy that cannot be temporarily ceased during brachytherapy (...) No contraindications to endorectal coil, surgically absent rectum, severe hemorrhoids or colorectal surgery Negative past medical history of Ulcerative Colitis, Crohn's Disease, Ataxia Telangiectasia, or SLE Absence of latex allergy No other medical conditions deemed by the PI to make patient ineligible for prostate HDR brachytherapy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using

2016 Clinical Trials

87. Motorized Spiral Colonoscopy Trial: A First Feasibility Trial

Colonoscopy Motorized Spiral Colonoscopy (MSC) with the novel motorized spiral endoscope represents a new technology which offers all of the advantageous options of spiral-assisted endoscopy with a faster and less invasive approach Procedure: Motorized Spiral Colonoscopy For any pathological finding during colonoscopy standard endoscopic techniques, e.g. forceps biopsy, injection, endoscopic mucosal resection, argon plasma coagulation Other Name: standard endoscopic interventions (not experimental (...) History of chronic inflammatory bowel disease Previously identified colorectal polyps/lesions with indication for endoscopic resection Any medical contraindication to standard colonoscopy Any prior abdominal surgery of the mid or lower gastrointestinal tract (except uncomplicated appendectomy) Known or suspected bowel obstruction or stenosis Known hemorrhoids 3rd degree Suspected perforation of the GI tract Inability to tolerate sedation for any reason Absence of a signed informed consent Contacts

2016 Clinical Trials

88. A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

, gastroesophageal reflux disease, gastrointestinal ulcer, hepatic disease,coagulation disorder,dyspepsia and being reliant on contact lenses for vision for the duration of study treatment and for 2 days after discontinuation of study treatment (eyeglasses are allowed). History of nausea, diarrhoea, recent surgery, use of tobacco or nicotine containing products, drug or alcohol use, periodontal disease, hemorrhoids with rectal bleeding and recent blood donation. Prior exposure to BMS-986141 or prothrombin (...) coagulation parameters. Subjects with body mass index of 18 to 32 kg/m2, inclusive. Women participants must have documented proof that they are not of childbearing potential. Men who are sexually active with WOCBP must agree to follow instructions for method(s) of contraception for the duration of treatment plus 5 half-lives of Rifampin (1 day) plus 90 days for a total of 91 days post-treatment completion. Exclusion Criteria: Acute or chronic medical illness, subjects with bleeding diathesis

2016 Clinical Trials

89. Validation of Sodergren Score for Haemorrhoids in Malaysia

provided by (Responsible Party): Galen Sha, University of Malaya Study Details Study Description Go to Brief Summary: To validate the ability of the Sodergren score in guiding the management of symptomatic haemorrhoids in a Malaysian population. Condition or disease Hemorrhoids Detailed Description: All participating, consented subjects will be scored with the Sodergren score prior to receiving a standardized ambulatory treatment regime. The questionnaire will be self-administered by the subjects (...) Estimated Enrollment : 500 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Validating the Ability of the Sodergren Score to Guide Management of Symptomatic Haemorrhoids in a Malaysian Population Study Start Date : January 2017 Estimated Primary Completion Date : June 2019 Estimated Study Completion Date : December 2019 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Symptomatic Hemorrhoid Consecutive

2016 Clinical Trials

90. Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery

Viladecans Study Details Study Description Go to Brief Summary: Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal surgery. Condition or disease Intervention/treatment Phase Fissure;Anal Fistula;Rectal Hemorrhoids Drug: anesthesics plus antiinflammatory, CLIFE1 Drug: local anesthesics, CLIFE2 Phase 4 Detailed Description: 120 patients (...) or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients undergoing benign anorectal surgery (out or inpatients), with the following diagnoses: anal fissure, fistula, hemorrhoids Use of subarachnoid anesthesia with lidocaine Exclusion Criteria

2016 Clinical Trials

91. Blood Flow Monitoring to Prevent Post-Polypectomy Induced Ulcer Bleeding

arm) with standard treatment using medical guidelines alone (controls) for prevention of delayed bleeding in high risk patients (on anti-coagulants or anti-platelet drugs or with large ulcers) after snare resection of benign colon polyps. Condition or disease Intervention/treatment Phase Delayed Post-Polypectomy Induced Ulcer Hemorrhage Device: Doppler Endoscopic Probe Not Applicable Detailed Description: Severe delayed post-polypectomy induced ulcer (PPIU) bleeding has become a much more common (...) problem with the increased numbers of colonoscopies being performed and with more patients taking anti-coagulants or anti-platelet drugs. Current medical guidelines may reduce bleeding during polypectomy, but are not effective for prevention of delayed bleeding. Empiric closure of PPIU's with clips is not effective because ulcers > 15 mm cannot be closed, does not treat the underlying artery in the ulcer base, and when the clips often fall off within 7 the underlying artery is exposed. As preliminary

2016 Clinical Trials

92. Comparison of a Hemorrhoidectomy With Ultrasonic Scalpel Versus a Conventional Hemorrhoidectomy (PubMed)

50 patients who had undergone a hemorrhoidectomy for grade III or IV internal hemorrhoids. The hemorrhoidal pedicle was coagulated with an ultrasonic device in the ultrasonic scalpel group (n = 25) and sutured with 3-0 vicryl material after excision in the conventional method group (n = 25).The patients' demographics, clinical characteristics, and lengths of hospital stay were similar in both groups. The mean ages of the conventional and the ultrasonic scalpel groups were, respectively, 20.8

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2016 Annals of coloproctology

93. Predictive Parameters of Symptomatic Hematochezia Following 5-Fraction Gantry-Based SABR in Prostate Cancer. (PubMed)

suppositories, 4% formalin, or 1 to 2 sessions of argon plasma coagulation (APC) was labeled grade 2. More than 2 sessions of APC, blood transfusion, or a course of hyperbaric oxygen was grade 3 and development of visceral fistula, grade 4. Various dosimetric and clinical factors were analyzed using univariate and multivariate analyses. Receiver operating characteristic (ROC) curve analysis and recursive partitioning analysis were used to determine clinically valid cut-off points and identify risk groups (...) of rectum receiving radiation dose of 38 Gy (V38) was a strong predictor of HH with an area under the curve of 0.65. In multivariate analysis, rectal V38 (≥2.0 cm(3); odds ratio [OR]: 4.7); use of anticoagulants in the follow-up period (OR: 6.5) and presence of hemorrhoids (OR: 2.7) were the strongest predictors. Recursive partitioning analysis showed rectal V38 < 2.0 cm(3), and use of anticoagulants or rectal V38 ≥ 2.0 cm(3) plus 1 other risk factor resulted in an HH risk of >30%.Rectal V38 and 2

2016 Biology and Physics

94. The role of endoscopy in patients with anorectal disorders

Society for Gastrointestinal Endoscopy (ASGE) 2 guideline and dis- cusses the role of endoscopy in patients with anorectal disorders, including chronic radiation proctopathy, anal ?ssures, internal hemorrhoids and fecal incontinence. Ad- ditional information about the role of endoscopy in the evaluation of patients with perianal disease in in?amma- tory bowel disease is described in another ASGE guideline. 3 CHRONIC RADIATION PROCTOPATHY Among patients receiving prostate irradiation, the rec- tum (...) ), topical formalin application, rectal instillation ther- apy (eg, hydrocortisone, sucralfate, 5-aminosalicylates, short-chain fatty acids, metronidazole), thermal therapy (eg, argon plasma coagulation, heater probe, 11 laser), and hyperbaric oxygen. 12 There are no large randomized, con- trolled studies of the management of chronic radiation Copyright©2010bytheAmericanSocietyforGastrointestinalEndoscopy 0016-5107/$36.00 doi:10.1016/j.gie.2010.04.022 www.giejournal.org Volume 72, No. 6 : 2010

2010 American Society for Gastrointestinal Endoscopy

95. The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure

of the study Subfissure injection of botulinum toxin in the 3 months prior to screening. Fissure resulting from inflammatory bowel disease, venereal disease, perianal psoriasis, immunodeficiency syndrome Atypical fissure (occurs off the midline) in which secondary causes were not excluded. Deemed by the investigator as anal fissure for which surgery is indicated Anal abscess; Grade 4 hemorrhoids Fixed anal stenosis Active or past history of cardiovascular or cerebrovascular disease including (...) to be clinically significant by the investigator at screening; Has used, in the last two weeks, drugs that may affect blood coagulation, such as Aspirin at a dose higher than 500 mg/day, Warfarin, Sintrom, Enoxaparin, Nadroparin, Heparin, Clopidogrel, Ticlopidine Rivaroxaban, Apixaban, Edoxaban Is treated with drugs that may affect the anal sphincter: Calcium channel blockers such as Nifedipine, Diltiazem or Verapamil Nitroglycerin or nitrates Has, upon physical examination, a rectal deformation or signs

2015 Clinical Trials

96. Bioequivalence Study of Rivaroxaban

be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal Subject with a history of relevant diseases of vital organs, of the central nervous system or other organs, eg instable coronary heart disease, heart failure, liver failure, kidney failure, hypotension, or history of stroke or myocardial infarction Subject with known coagulation disorders (eg von Willebrand's disease, hemophilia) Subject with known disorders with increased bleeding risk (...) (eg periodontosis, hemorrhoids, acute gastritis, peptic ulcer) Subject with known sensitivity to common causes of bleeding (eg nasal) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02537457 Locations Layout table for location information Japan

2015 Clinical Trials

97. Bioequivalence Study of Rivaroxaban in Japanese Healthy Adult Male Subjects

coagulation disorders (eg von Willebrand's disease, hemophilia) Subject with known disorders with increased bleeding risk (eg periodontosis, hemorrhoids, acute gastritis, peptic ulcer) Subject with known sensitivity to common causes of bleeding (eg nasal) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study

2015 Clinical Trials

98. Relative Bioavailability Study in Healthy Subjects Comparing 2 Dry Powder Oral Suspensions of Rivaroxaban Under Fasting and 20 mg of an Oral Suspension of Rivaroxaban Under Fed Conditions to 10 mg of an Immediate Release Tablet Under Fasting Conditions

& Development, LLC Information provided by (Responsible Party): Bayer Study Details Study Description Go to Brief Summary: Rivaroxaban is a substance developed for use in the treatment of blood coagulation disorders.Thrombosis (blood clots) can occur as a result of excessive coagulation activity in the blood vessels. Excessive coagulation activity can occur in children as well, and rivaroxaban is therefore being developed for the treatment of thromboembolic events in children and adolescents. As small (...) ) Sexes Eligible for Study: Male Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy male subjects Age: 18 to 55 years (inclusive) at the first screening examination White Body Mass Index (BMI): ≥18.0 and ≤29.9 kg/m2 at the screening visit. Exclusion Criteria Incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal Known coagulation disorders (e.g. von Willebrand's

2015 Clinical Trials

100. The Effect of Oxymetazoline Gel on Anal Pressure and Incontinence in Spinal Cord Injury Patients

, transient ischemic attacks/stroke, clinically significant arrhythmia, congestive heart failure, or cardiac valve abnormalities; Type 1 diabetes mellitus; Insulin treated type 2 diabetes mellitus; Renal insufficiency. Liver insufficiency. Malignant disease within 5 years of screening; History of rectal surgery. History of HIV, hepatitis B, hepatitis C. Has upon physical examination a rectal deformation or signs of rectal disease such as fissure, bleeding hemorrhoids, fistula, infection or space occupying (...) lesion. Has used, in the last 1 week, drugs that may affect blood coagulation, such as Aspirin (at a dose above 500 mg/day), Warfarin, Sintrom, Enoxaparin, Nadroparin, Heparin, Clopidogrel, Ticlopidine. Hypertension (blood pressure over 150/105 mm Hg in screening visit) Unable to understand the use instruction, as judged by the investigator. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research

2014 Clinical Trials

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