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Hemorrhoid Coagulation

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181. The Effects of Lovaza® in Acute Myocardial Infarction

significant dementia or sedation from medication) Ingested 325 mg of chewed aspirin as part of the acute coronary syndrome treatment protocol. Exclusion Criteria: No informed consent Daily aspirin use prior to index hospitalization Known prior myocardial infarction Known pregnancy Known allergy to fish, fish oil, or aspirin Known active internal or non-superficial bleeding, known bleeding disorder, coagulation defect, or thrombocytopenia Thrombolysis in the past 12 hours Treatment with a IIbIIIa inhibitor (...) during index hospitalization Cardiogenic shock or symptomatic hypotension or sitting SBP < 95 mmHg Severe uncontrolled hypertension (≥180/110) or hypertensive retinopathy A history of major surgery, trauma, retinal hemorrhage, significant gastrointestinal (not hemorrhoidal) or genitourinary bleeding in the past 6 weeks A history of cerebrovascular attack within two years, or cerebrovascular attack with a significant residual neurological deficit A known arteriovenous malformation or aneurysm Severe

2010 Clinical Trials

182. Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis

documented generalized bleeding disorder concurrent thrombocytopenia (<100 x 10E9/L) documented severe hepatic or renal dysfunction, that interferes with normal coagulation uncontrolled severe hypertension (diastolic > 120 mm Hg) known recent (< 3 months) gastrointestinal tract hemorrhage (not including he¬morrhage from rectal hemorrhoids) Any known associated condition (such as terminal cancer) with a poor short term (1 year) prognosis independent of CVT Clinical and radiological signs of impending (...) or thrombosis of the deep cerebral venous system) and the responsible physician is uncertain if ET or standard anti-coagulant treatment is better. Intervention: Patients will be randomized to receive either ET or standard therapy (therapeutic doses of heparin). ET consists of local application of alteplase or urokinase within the thrombosed sinuses, and/or mechanical thrombectomy. Glasgow coma score, NIH stroke scale and relevant laboratory parameters will be assessed at baseline. Endpoints: The primary

2010 Clinical Trials

183. Treatment of Hemorrhagic Radiation Proctitis Using the Halo System

of radiation treatments that can lead to bleeding). In medical procedures, the RF energy used with this device, has been historically used in shrinking or removing soft-tissue, for surgical cutting, and for stopping bleeding. The device is cleared by the Food and Drug Administration (FDA) for use in coagulation (to assit with stoping bleeding and clotting of blood) of tissue within the digestive tract. The device has been used in areas outside the esophagus (inner lining of the throat), including (...) the performance of an endoscope-mounted radiofrequency (RF) energy device, which utilizes RF energy for the coagulation of gastrointestinal tissue in the setting of bleeding of radiation proctitis. The study device, the HALO90 Ablation catheter, has an FDA 510(k) clearance for human use. The study design is a single-site, prospective clinical trial to gather performance data regarding a 510(k)-cleared, endoscopically-guided radiofrequency energy ablation device for the coagulation of hemorrhagic radiation

2010 Clinical Trials

184. Recto Anal Repair or Milligan Morgans Operation of Grade 3 and 4 Symptomatic Haemorrhoidal Disease

Study Start Date : November 2009 Actual Primary Completion Date : September 2013 Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Milligan Morgan Procedure: Surgery for advanced haemorrhoidal disease Milligan Morgan vs Recto Anal Repair Other Names: Transanal doppler-guided hemorrhoidal artery ligation. Transanal hemorrhoidal dearterialization (THD). Active Comparator: Recto Anal Repair Procedure: Surgery for advanced haemorrhoidal disease Milligan Morgan vs Recto Anal (...) Repair Other Names: Transanal doppler-guided hemorrhoidal artery ligation. Transanal hemorrhoidal dearterialization (THD). Outcome Measures Go to Primary Outcome Measures : Evaluation of pain [ Time Frame: up to 21 days ] Secondary Outcome Measures : Evaluation of sick leave [ Time Frame: up to 21 days ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends

2009 Clinical Trials

185. Study of Safety and Tolerability of PCI-27483 in Patients With Pancreatic Cancer Patients Receiving Treatment With Gemcitabine

participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Phase II Study of Coagulation Factor VIIa Inhibitor PCI-27483 in Pancreatic Cancer Patients Receiving Treatment With Gemcitabine Study Start Date : November 2009 Actual Primary Completion Date : August 2012 Resource links provided by the National Library of Medicine related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment (...) ductal adenocarcinoma of the pancreas diagnosed ≤ 3 months prior to enrollment or metastatic ductal adenocarcinoma diagnosed ≤ 2 months. Measurable disease by spiral CT scan (SCT) in accordance with RECIST criteria. Patients after non-curative surgery are eligible if at least 4 weeks after surgery and recovered from significant surgical morbidity. Estimated life expectancy of at least 4 months. ECOG performance status 0 to 1. Normal baseline coagulation function as defined by: PT 10-16 seconds

2009 Clinical Trials

186. Study to Examine the Effect of Coated Phenylephrine Suppositories on Anal Pressure in Healthy Subjects

for acute illness. Has used, in the last four weeks, drugs that may affect blood coagulation, such as Aspirin, Warfarin, Sintrom, Enoxaparin, Nadroparin, Heparin, Clopidogrel, Ticlopidine. Has upon physical examination a rectal deformation or signs of rectal disease such as fissure, bleeding hemorrhoids, fistula., infection or space occupying lesion. Receipt of any investigational treatment (drug or device) within 90 days prior to screening. Contacts and Locations Go to Information from the National

2009 Clinical Trials

187. An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects

, hepatitis C In need of chronic use of medication, with the exception of birth control medications Currently uses medication for acute illness (other than medications for use of treatment/pain relief of anal fissure) Has used, in the last four weeks, drugs that may affect blood coagulation, such as Aspirin at a dose higher than 500 mg/day , Warfarin, Sintrom, Enoxaparin, Nadroparin, Heparin, Clopidogrel, Ticlopidine Is using drug that may affect rectal tone Calcium Channel Blocker such as: Nifedipine (...) hemorrhoids, fistula., infection or space occupying lesion Is an immediate family member of personnel directly affiliated with the study at the investigative site, or is personally directly affiliated with the study at the investigative site; or is employed by RDD Pharma Ltd Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer

2009 Clinical Trials

188. High-Dose-Rate Brachytherapy

consent indicating their understanding of the investigational nature and risks of the study before any protocol related studies are performed. Exclusion Criteria: Radiological evidence of regional or distant metastases Contraindications to MRI (Patient weighing >136kg (scanner weight limit), Patients with pacemakers, cerebral aneurysm clips, shrapnel injury, or implantable electronic devices not compatible with MRI) Bleeding diathesis and anti-coagulative therapy that cannot be temporarily ceased (...) during brachytherapy Previous prostate brachytherapy Active hormonal therapy (Arm 1) ->50% of contiguous sextants involved with tumor (Arm 1) Previous pelvic radiotherapy (Arm 2) Contraindications to endorectal coil, surgically absent rectum, severe hemorrhoids or colorectal surgery. Latex Allergy Contraindications to conscious sedation, local anesthesia, or spinal/epidural anesthesia. IPSS >18 Large TURP defect TURP within the past 6 months Prostate gland size >80cc History of Ulcerative Colitis

2009 Clinical Trials

189. Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects

in this study as heart rate < 50 bpm based on vital signs and ECG performed within 21 days of Study Day 1) History or evidence of abnormal bleeding or coagulation disorder (e.g., history of prolonged bleeding during dental procedures, pregnancy delivery, previous surgery or injury) and/or having a first degree relative under 50 years of age with a history of abnormal bleeding or coagulation disorder per patient's report History of unexplained syncope Presence of external hemorrhoids with signs of rectal

2009 Clinical Trials

190. Pycnogenol

-aging" products. It is also applied to the skin to treat foot ulcers in people with diabetes, hemorrhoids, and mouth ulcers caused by chemotherapy. There is limited scientific research to support most of these uses. How effective is it? Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate (...) suggests that standardized maritime pine bark extract, used alone or in combination with L-arginine, might improve sexual function in men with ED. It seems to take up to 3 months of treatment for significant improvement. Heart failure . Early research suggests that taking a specific combination product containing standardized maritime pine bark and coenzyme Q10 for 12 weeks improves some symptoms of heart failure. Hemorrhoids . Early research shows that taking a standardized extract of maritime pine

2009 National Centre for Complementary and Alternative Medicine

191. Dose-Seeking Trial of PCK3145 in Asymptomatic, Castrate Metastatic Prostate Cancer Patients.

than 6 months. Hematologic: WBC ≥ 3000K/μl. Absolute neutrophil count ≥ 1500 K/μl Platelet count ≥ 100,000 K/μl. Hepatic: Total Bilirubin - within normal institutional limits AST < 1.5 x ULN, ALT < 1.5 x ULN. Renal: Creatinine < 2.0 or creatinine clearance > 55 mL/min Coagulation: Prothrombin time - Less than or equal to the ULN (upper limit of normal) unless patient is taking anticoagulants Patients must have recovered from the acute toxicities of any prior therapy, and not received chemotherapy (...) such as PC Plus, saw palmetto or Zyflamend. No rectal bleeding except that seen following radiation proctitis or known history of hemorrhoids. Non-prostate primary carcinoma except for non-melanoma skin cancer within previous 5 years. No uncontrolled cardiac arrhythmias. Patient taking steroids for cord compression or pain control are excluded. Patient on steroids for chronic conditions such as arthritis or asthma or on chronic hydrocortisone post ketoconazole will be permitted. Contacts and Locations Go

2008 Clinical Trials

192. MRI-Guided Biopsy of Recurrent Prostate Cancer After Radiotherapy

years ECOG performance status 0 or 1 with >10 year life expectancy Fit for local anaesthesia Informed consent: Exclusion Criteria: Contraindications to MRI Severe claustrophobia Bleeding diathesis and anti-coagulative therapy that cannot be temporarily ceased precluding brachytherapy Previous brachytherapy Active hormonal therapy Radiologic evidence of LN or distant metastases Other urinary or medical conditions deemed by the PI or associates to make the patient ineligible for MRI-guided prostate (...) biopsy. Contraindications to endorectal coil, surgically absent rectum, severe hemorrhoids or previous colorectal surgery Contraindications to conscious sedation Contraindication to IV Gadolinium administration latex allergy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov

2008 Clinical Trials

193. Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe

treatment for bleeding internal hemorrhoids. Condition or disease Intervention/treatment Phase Hemorrhoids Procedure: Rubber band ligation Procedure: Bipolar coagulation Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 45 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Randomized Study Of Endoscopic Band Ligation Versus (...) Bipolar Probe Electrocoagulation Of Bleeding Internal Hemorrhoids Study Start Date : December 1997 Actual Primary Completion Date : May 2000 Actual Study Completion Date : May 2001 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: 1 Rubber band ligation Procedure: Rubber band ligation placing rubber bands around the internal hemorrhoids Active Comparator: 2 Bipolar coagulation Procedure: Bipolar

2008 Clinical Trials

194. Leech bites: massive bleeding, coagulation profile disorders, and severe anemia. (PubMed)

Leech bites: massive bleeding, coagulation profile disorders, and severe anemia. Leeches have been in use for centuries, especially in plastic and reconstructive surgery wound and flap healing, in venous insufficiencies, and in the treatment of many disorders such as hemorrhoids and varicosity. With this study, we aimed to discuss coagulation disorder due to uncontrolled leech bites, consequent excessive skin hemorrhage, and anemia requiring blood transfusion. A 65-year-old male patient (...) suspension. Bleeding stopped by decreasing after the transfusion of fresh frozen plasma. Although the complications due to leech injuries are rare, they may be an important cause of morbidity and mortality when an injury or prolonged bleeding in an internal region occurs. Prolonged skin hemorrhages rarely cause anemia, and deaths are caused by intractable hemorrhages. However, a coagulation disorder and consequent intractable hemorrhage have not been reported previously in the literature. In conclusion

2008 American Journal of Emergency Medicine

195. Effective management of posthemorrhoidectomy secondary hemorrhage using rectal irrigation

lumens, rectal irrigation was performed until the washout became clear. Examination under anaesthesia was conducted in the operating room, and suture ligation with or without coagulation was performed if there was an active bleeder. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients on whom elective closed haemorrhoidectomy for symptomatic haemorrhoidal disease was performed, and who then developed PHSH. Only (...) . Outcome of delayed haemorrhage following surgical haemorrhoidectomy. Diseases of the Colon and Rectum 1993;36:743-6. Eu KW, Seow-Choen F, Goh HS. Comparison of emergency and elective hemorrhoidectomy. British Journal of Surgery 1994;81:308-10. Indexing Status Subject indexing assigned by NLM MeSH Adult; Case-Control Studies; Female; Hemorrhoids /surgery; Hospital Costs; Humans; Length of Stay /economics; Male; Operating Rooms; Patient Satisfaction; Postoperative Hemorrhage /therapy; Prospective

2002 NHS Economic Evaluation Database.

196. Urinalysis

," such as epithelial cells, , and crystals. Cells and other substances that may be seen are listed below. Normally, a few RBCs are present in urine sediment (0-5 RBCs per high power field, HPF). A positive chemical test for hemoglobin and an increase in the number of RBCs seen under the microscope indicates that there is blood in the urine. However, this test cannot be used to identify where the blood is coming from. For instance, contamination of urine with blood from hemorrhoids or vaginal bleeding cannot (...) for a yeast infection. Trichomonas vaginalis is a that may be found in the urine of women, or rarely, men. As with yeast, T. vaginalis infects the vaginal canal and their presence in urine is due to contamination during sample collection. If these are found during a urinalysis, then may be performed to look for a vaginal infection. Casts are cylindrical particles sometimes found in urine that are formed from coagulated protein released by kidney cells. They are formed in the long, thin, hollow tubes

2004 Lab Tests Online USA

197. Safety and Efficacy Study of Metaglidasen in Type 2 Diabetes in Patients Suboptimally Controlled on Insulin

have liver function tests ≤ 2X the upper limits of normal for AST, ALT, and bilirubin, and ≤ 2.5X the upper limits of normal for ALP and GGT Patients must have serum creatinine ≤ 1.8 mg/dl for males and ≤ 1.5 mg/dl for females and BUN ≤ 40 mg/dl Fecal occult blood test must be negative All other clinical laboratory parameters must be within normal limits or considered not clinically significant for participation in this study, including: hematology, coagulation, other serum chemistry, and other (...) with subsequent treatment and no recurrence) Prior history of GI bleeding within last 5 years (except for hemorrhoids or perianal disease) Known infection with the human immunodeficiency virus (HIV) or history of viral hepatitis type B or C History of congestive heart failure within last 5 years (NYHA Class III-IV) History of significant pulmonary disease, myocardial infarction, cerebrovascular accident, or nephrotic syndrome within last 1 year Elevated creatine phosphokinase (> 2X the upper limits of normal

2006 Clinical Trials

198. Randomized, clinical trial of Ligasure vs conventional diathermy in hemorrhoidectomy. (PubMed)

into two groups by preoperative assignment of sealed envelopes. Patients with coexisting perianal disease, previous perianal surgery, or thrombosed hemorrhoids were excluded. All patients were anesthetized and operated on by a single team. In one group, monopolar diathermy in the coagulation mode was used to dissect hemorrhoidal tissue from the internal sphincter. In the second group, tissue was coagulated by Ligasure and then divided with scissors. Operating time was documented by theater staff (...) Randomized, clinical trial of Ligasure vs conventional diathermy in hemorrhoidectomy. Hemorrhoidectomy is frequently associated with significant postoperative pain, and new techniques to reduce this pain are constantly under evaluation. The present study was conducted to determine the usefulness of the Ligasure system and compare it with conventional diathermy for hemorrhoidectomy.Thirty-four consecutive patients with Grade 3 or 4 hemorrhoids requiring surgery were recruited and randomized

2003 Diseases of the colon and rectum

199. Venous lake of the lip treated with a sclerosing agent: report of two cases. (PubMed)

Venous lake of the lip treated with a sclerosing agent: report of two cases. A venous lake is a venous ectasia that appears mostly on the lower lip and other sun-exposed areas of an older person. Treatment of lip venous lake includes surgical excision, laser therapy, infrared coagulation, and cryotherapy. Although the use of sclerotherapy on varicose veins, leg telangiectasia, hemorrhoids, and hemangiomas is well established, the use of sclerotherapy for lip venous lake has not been reported.We

2003 Dermatologic Surgery

200. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study. (PubMed)

combination nor placebo affected blood coagulation tests. We conclude that intramuscular administration of the fixed combination of troxerutin 150 mg and carbazochrome 1.5 mg is effective, well tolerated and superior to placebo in improving hemorrhoidal and post-surgical symptoms during the five days following surgery. (...) uncomplicated hemorrhoids. The purpose of this randomized, double-blind, placebo-controlled study was to investigate the efficacy and tolerability of the active combination in the treatment of post-hemorrhoidectomy patients. 30 patients were randomized to receive one of two treatments: troxerutin 150 mg and carbazochrome 1.5 mg, or placebo, i.m. 3 ml ampoules twice a day for five consecutive days after the surgical procedure, starting from the day of surgery. Efficacy parameters were assessed as follows

2001 Current medical research and opinion

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