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Hemolytic Anemia

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6. Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation (PubMed)

Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation New-onset autoimmune hemolytic anemia (AIHA) occurs in 2% to 6% of pediatric patients post-hematopoietic stem cell transplantation (HSCT) and is a significant complication. Incomplete immune recovery following HSCT may predispose to immune dysregulation including autoimmune cytopenias. We describe an innovative therapy for AIHA refractory to proteasome inhibition. In potentially life

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2018 Blood advances

7. Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab (PubMed)

Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab 30480056 2018 12 07 2341-4545 25 6 2018 Nov GE Portuguese journal of gastroenterology GE Port J Gastroenterol Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab. 340-341 10.1159/000486803 Martins Diana D Gastroenterology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal. Ministro Paula P Gastroenterology Department, Centro Hospitalar (...) Tondela-Viseu, Viseu, Portugal. Silva Américo A Gastroenterology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal. eng Journal Article 2018 02 14 Switzerland GE Port J Gastroenterol 101685861 2387-1954 Hemolytic anemia Pouchitis Ulcerative colitis Vedolizumab 2017 12 09 2018 01 07 2018 11 28 6 0 2018 11 28 6 0 2018 11 28 6 1 ppublish 30480056 10.1159/000486803 pjg-0025-0340 PMC6243957 N Engl J Med. 2013 Aug 22;369(8):699-710 23964932 Dig Liver Dis. 2017 Apr;49(4):397-404 28063954 Aliment

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2018 GE Portuguese journal of gastroenterology

8. Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. (PubMed)

Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. The physiology of the immune system involves morphologic and functional changes occurring along ageing, with a decrease in immune response and an increase in autoimmune phenomena, even in the absence of overt disese. Autoimmune cytopenias, namely autoimmune hemolytic anemia (AIHA), chronic idiopathic neutropenia (CIN) and aplastic anemia (AA), show different epidemiologic predilection, but are increasingly

2018 European journal of internal medicine

9. Post-Babesiosis Warm Autoimmune Hemolytic Anemia. (PubMed)

Post-Babesiosis Warm Autoimmune Hemolytic Anemia. Background Babesiosis, a tickborne zoonotic disease caused by intraerythrocytic protozoa of the genus babesia, is characterized by nonimmune hemolytic anemia that resolves with antimicrobial treatment and clearance of parasitemia. The development of warm-antibody autoimmune hemolytic anemia (also known as warm autoimmune hemolytic anemia [WAHA]) in patients with babesiosis has not previously been well described. Methods After the observation

2017 NEJM

10. Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. (PubMed)

Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia (AIHA) is a rare, but often severe, complication of ICPis. We identified 14 patients from nine institutions across the United States who developed

2019 American journal of hematology

11. Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure. (PubMed)

Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure. Etoricoxib is a selective inhibitor of cyclooxygenase 2 used mainly to treat osteoarticular pain. Here, we report the case of a patient who developed acute kidney failure and immune hemolytic anemia after the use of etoricoxib.An 83-year-old female patient developed immune hemolytic anemia and acute kidney failure after treatment with etoricoxib for articular pain. Given the acute kidney failure, she (...) required five hemodialysis sessions. She was discharged after 17 days. The case of immune hemolytic anemia and kidney failure was fully resolved.The direct antiglobulin test was not only positive for IgG but also for C3b and C3d, showing a very intense reactivity (++++). The eluate's reactivity was weaker (++) and showed no defined specificity. The investigation of unexpected antibodies in the serum of the patient showed a reactivity pattern similar to the eluate's: weak reactivity without specificity

2019 Transfusion

12. Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker. (PubMed)

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker. Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin (...) any intervention following two weeks of the acute infection.Cold type autoimmune hemolytic anemia is a rare manifestation of infectious mononucleosis and serum ferritin is used very rarely as an important biomarker. Management of cold type anemia is mainly supportive and elevated serum ferritin indicates severe viral disease.

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2019 BMC Infectious Diseases

13. A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication (PubMed)

A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients

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2017 Oxford Medical Case Reports

14. The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes (PubMed)

The effect of vitamin C on mice hemolytic anemia induced by phenylhydrazine: an animal model study using histological changes in testis, pre-implantation embryo development, and biochemical changes The aim of the present study was to assess the effects of vitamin C (Vit C) on hemolytic anemia induced by phenylhydrazine (PHZ).Twenty-four healthy male mice were divided into four groups, randomly: Control group (0.1 ml/day, normal slaine, IP), PHZ group that received only PHZ 8 mg/100 g/48 hr, IP

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2018 Iranian journal of basic medical sciences

15. Successful treatment of acute-on-chronic liver failure and hemolytic anemia with hepato-protective drugs in combination with intravenous ozone without steroids: A case report (PubMed)

Successful treatment of acute-on-chronic liver failure and hemolytic anemia with hepato-protective drugs in combination with intravenous ozone without steroids: A case report Both acute-on-chronic liver failure (ACLF) and autoimmune hemolytic anemia (AIHA) are common causes of jaundice. A co-occurrence of ACLF and AIHA is rare in clinical practice. This report describes a male elderly patient who developed persistently increased levels of total bilirubin and ascites after endoscopic retrograde

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2018 Intractable & rare diseases research

16. Efficacy of D- red blood cell transfusion and rituximab therapy in autoimmune hemolytic anemia with anti-D and panreactive autoantibodies arising after hematopoietic stem cell transplant. (PubMed)

Efficacy of D- red blood cell transfusion and rituximab therapy in autoimmune hemolytic anemia with anti-D and panreactive autoantibodies arising after hematopoietic stem cell transplant. Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies to red blood cells (RBCs), which can be panreactive and/or specific to Rh/other blood group antigens. We report a severe case of AIHA after bone marrow transplantation (BMT) due to autoanti-D triggered by reactivation of Epstein-Barr virus (EBV

2018 Transfusion

17. Pulmonary hypertension in chronic hemolytic anemias: Pathophysiology and treatment. (PubMed)

Pulmonary hypertension in chronic hemolytic anemias: Pathophysiology and treatment. Pulmonary hypertension has emerged as a major cause of morbidity and mortality in patients with hemoglobinopathies and chronic hemolytic anemias. These hematological diseases include - but are not limited to - sickle cell disease (SCD), thalassemia, paroxysmal nocturnal hematuria, and hereditary spherocytosis. Although most studies have been based on the use of echocardiography as a screening tool for pulmonary (...) hypertension as opposed to the gold standard of right heart catheterization for definitive diagnosis, the association between chronic hemolytic anemia and pulmonary hypertension is evident. Studies have shown that patients with SCD and a tricuspid regurgitant velocity (TRV) ≥ 2.5 m/sec are at increased risk of pulmonary hypertension and are at increased mortality risk. Additional markers of risk of pulmonary hypertension and increased mortality include a pro-BNP >160 pg/mL combined with a 6-min walk

2018 Respiratory medicine

18. Immunotherapy-Associated Hemolytic Anemia with Pure Red-Cell Aplasia. (PubMed)

Immunotherapy-Associated Hemolytic Anemia with Pure Red-Cell Aplasia. 26981948 2016 03 22 2017 11 16 1533-4406 374 11 2016 Mar 17 The New England journal of medicine N. Engl. J. Med. Immunotherapy-Associated Hemolytic Anemia with Pure Red-Cell Aplasia. 1096-7 10.1056/NEJMc1509362 Nair Ranjit R Lehigh Valley Health Network, Allentown, PA ranjit_r.nair@lvhn.org. Gheith Shereen S Lehigh Valley Health Network, Allentown, PA ranjit_r.nair@lvhn.org. Nair Suresh G SG Lehigh Valley Health Network (...) , Allentown, PA ranjit_r.nair@lvhn.org. eng Case Reports Letter United States N Engl J Med 0255562 0028-4793 0 Antibodies, Monoclonal 0 Antibodies, Monoclonal, Humanized 0 B7-H1 Antigen 0 CTLA-4 Antigen 0 Glucocorticoids 0 Ipilimumab DPT0O3T46P pembrolizumab AIM IM Anemia, Hemolytic etiology Antibodies, Monoclonal adverse effects Antibodies, Monoclonal, Humanized adverse effects B7-H1 Antigen antagonists & inhibitors CTLA-4 Antigen antagonists & inhibitors Female Glucocorticoids therapeutic use Humans

2016 NEJM

19. Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Españo (PubMed)

Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Españo Autoimmune hemolytic anemia (AIHA) is a complication of allogeneic hematopoietic stem cell transplantation (HSCT) associated with poor outcome. However, an optimal therapeutic approach is lacking. Between 2000 and 2015, 4099 allogeneic HSCT

2018 Transfusion medicine reviews

20. A Case Report of Congenital Non-spherocytic Hemolytic Anemia in a Patient from India (PubMed)

A Case Report of Congenital Non-spherocytic Hemolytic Anemia in a Patient from India Congenital non-spherocytic hemolytic anemia (CNSHA) is a rare autosomal recessive condition that presents as a congenital hemolytic anemia. The absence of vital enzymes required for glycolysis such as homozygous glucose phosphate isomerase (GPI) and red blood cell (RBC) nucleotide metabolism predisposes the RBCs to hemolysis. No spherocytosis is seen on peripheral smear as well as no signs of immune-mediated

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2018 Cureus

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