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Hematuria in Sickle Cell Anemia

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1. Hematuria in Sickle Cell Anemia

Hematuria in Sickle Cell Anemia Hematuria in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hematuria in Sickle (...) Cell Anemia Hematuria in Sickle Cell Anemia Aka: Hematuria in Sickle Cell Anemia From Related Chapters II. Epidemiology Occurs in 20% Most common complication of III. Pathophysiology Results from necrosis of tip of renal papilla IV. Signs Gross, Painless V. Diagnosis Rule out other causes of VI. Management Does not require hospitalization Aminocaproic Acid (EACA) VII. Course Often continues for weeks Spontaneous resolution Images: Related links to external sites (from Bing) These images

2018 FP Notebook

2. Nutcracker Syndrome and Sickle Cell Trait: A Perfect Storm for Hematuria. (PubMed)

Nutcracker Syndrome and Sickle Cell Trait: A Perfect Storm for Hematuria. We describe the case of a 27-year-old woman with a history of sickle cell trait (SCT) who presented with several months of hematuria and was found to have nutcracker syndrome (NCS). While SCT is a common cause of hematuria resulting from renal papillary necrosis, our patient had concomitant abdominal pain and anemia, prompting further evaluation and the subsequent diagnosis of NCS. Interestingly, the anoxia in the left (...) renal vein from NCS predisposes patients with SCT to sickling. Our case highlights key clinical features of both NCS and SCT and the relationship between the two disease processes.

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2017 Journal of General Internal Medicine

3. CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders

] List 4 intrinsic and 4 extrinsic causes of hemolytic anemia Refer to box 112.8 for intrinsic and extrinsic causes of hemolytic anemia Intrinsic Causes of Hemolytic Anemia Enzyme defect (pyruvate kinase deficiency, G6PD deficiency) Membrane defect (spherocytosis, elliptostomatocytosis, paroxysmal nocturnal hemoglobinuria) Hemoglobin defect (Thalassemias, hemoglobin M, unstable hemoglobin, sickle cell) Extrinsic Causes of Hemolytic Anemia Immunologic (allo or autoantibodies) Mechanical (...) will have specific RBC morphologies suggesting etiology (bite cells, sickle cells, spherocytes, spur cells, Howell-Jolly bodies, etc.) Intravascular – peripheral smear will predominantly show schistocytes (RBC fragments) [17] Which types of hemolytic anemia tend to be intravascular? Which are extravascular? Extravascular – enzyme/membrane/hemoglobin defects, autoimmune hemolysis, toxins, hypersplenism Intravascular – MAHA (DIC, TTP, HUS), transfusion reactions, sepsis, heat injury, paroxysmal nocturnal

2017 CandiEM

4. Hematuria in Sickle Cell Anemia

Hematuria in Sickle Cell Anemia Hematuria in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hematuria in Sickle (...) Cell Anemia Hematuria in Sickle Cell Anemia Aka: Hematuria in Sickle Cell Anemia From Related Chapters II. Epidemiology Occurs in 20% Most common complication of III. Pathophysiology Results from necrosis of tip of renal papilla IV. Signs Gross, Painless V. Diagnosis Rule out other causes of VI. Management Does not require hospitalization Aminocaproic Acid (EACA) VII. Course Often continues for weeks Spontaneous resolution Images: Related links to external sites (from Bing) These images

2015 FP Notebook

5. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

6. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

7. Sickle Cell Anemia (Overview)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine.com

8. Sickle Cell Anemia (Diagnosis)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine Pediatrics

9. Sickle Cell Anemia (Overview)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine Pediatrics

10. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

11. Anemia, Sickle Cell (Overview)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine Emergency Medicine

12. Anemia, Sickle Cell (Follow-up)

Anemia, Sickle Cell (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

13. Sickle Cell Anemia (Diagnosis)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine.com

14. Anemia, Sickle Cell (Treatment)

Anemia, Sickle Cell (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

15. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

16. Anemia, Sickle Cell (Diagnosis)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine Emergency Medicine

17. Hematuria in a Case of Sickle Cell Disease (PubMed)

Hematuria in a Case of Sickle Cell Disease 13642027 2000 07 01 2018 12 01 0027-9684 51 2 1959 Mar Journal of the National Medical Association J Natl Med Assoc Studies of sickle cell disease. II. Hematuria in a case of sickle cell disease. 97-101 HENDERSON A B AB GRAY H O HO eng Journal Article United States J Natl Med Assoc 7503090 0027-9684 OM Anemia Anemia, Sickle Cell Hematuria complications Humans 5936:15919:33:244 ANEMIA, SICKLE CELL HEMATURIA/complications 1959 3 1 1959 3 1 0 1 1959 3 1 0

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1959 Journal of the National Medical Association

18. Pulmonary hypertension in chronic hemolytic anemias: Pathophysiology and treatment. (PubMed)

Pulmonary hypertension in chronic hemolytic anemias: Pathophysiology and treatment. Pulmonary hypertension has emerged as a major cause of morbidity and mortality in patients with hemoglobinopathies and chronic hemolytic anemias. These hematological diseases include - but are not limited to - sickle cell disease (SCD), thalassemia, paroxysmal nocturnal hematuria, and hereditary spherocytosis. Although most studies have been based on the use of echocardiography as a screening tool for pulmonary (...) hypertension as opposed to the gold standard of right heart catheterization for definitive diagnosis, the association between chronic hemolytic anemia and pulmonary hypertension is evident. Studies have shown that patients with SCD and a tricuspid regurgitant velocity (TRV) ≥ 2.5 m/sec are at increased risk of pulmonary hypertension and are at increased mortality risk. Additional markers of risk of pulmonary hypertension and increased mortality include a pro-BNP >160 pg/mL combined with a 6-min walk

2018 Respiratory medicine

19. Pediatrics, Sickle Cell Disease (Follow-up)

Pediatrics, Sickle Cell Disease (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA== processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have

2014 eMedicine Emergency Medicine

20. Pediatrics, Sickle Cell Disease (Diagnosis)

persistence of fetal Hb (S/HPHP) - Very mild or asymptomatic phenotype HbS/HbE syndrome - Very rare with a phenotype usually similar to HbS/b+ thalassemia Rare combinations of HbS with other abnormal hemoglobins such as HbD Los Angeles, G-Philadelphia, HbO Arab, and others Sickle cell trait or the carrier state is the heterozygous form characterized by the presence of around 40% HbS, absence of anemia, inability to concentrate urine (isosthenuria), and hematuria. Under conditions leading to hypoxia (...) In the United States, approximately 100,000 people have SCD SCD occurs in about 1 of every 16,300 Hispanic-American births Approximately 1 in 13 black or African Americans has sickle cell trait In the United States, SCD accounts for less than 1% of all new cases of end-stage renal disease (ESRD). [ ] The following factors are known to portend a greater likelihood of progression to overt renal failure: hypertension, nephrotic-range proteinuria, hematuria, severe anemia, and a Central African Republic

2014 eMedicine Emergency Medicine

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