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173 results for

Helicobacter pylori Noninvasive Testing

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161. Breath test using a single 50-mg dose of 13C-urea to detect Helicobacter pylori infection in children. (PubMed)

Breath test using a single 50-mg dose of 13C-urea to detect Helicobacter pylori infection in children. The 13C-urea breath test is an accurate, noninvasive method for the diagnosis of in adults. A dose of 75 to 100 mg of urea is generally used, especially in adults, but the optimal dose in children is still unknown. Our aim was to determine whether urea breath test performed with a single 50-mg dose of 13C-urea was sufficient and accurate for diagnosing infection in children.Consecutive (...) children 4 to 14 years of age undergoing upper intestinal endoscopy to evaluate symptoms of recurrent abdominal pain were prospectively included. Exclusion criteria included use of antibiotics or proton pump inhibitors during the last month, gastric surgery, and previous eradication therapy. Reference criteria for diagnosis of infection were based on histology, culture, and serology. Urea breath test (TAU-KIT; Isomed, S.L., Madrid, Spain) was performed as follows: citric acid (Citral pylori) dissolved

2003 Journal of Pediatric Gastroenterology and Nutrition

162. Stool antigen test for diagnosis of Helicobacter pylori infection in children with symptomatic disease: a prospective study. (PubMed)

Stool antigen test for diagnosis of Helicobacter pylori infection in children with symptomatic disease: a prospective study. Noninvasive tests for the diagnosis of Helicobacter pylori (Hp) infection in children are limited by low accuracy rates and lack of validation. Existing studies indicate that the stool antigen test (HpSA) has an acceptable level of accuracy for the diagnosis of Hp infection in adults but not children. The aim of this study was to evaluate the accuracy of the HpSA test (...) for the detection of Hp infection in U.S. children.Children requiring upper endoscopic procedures were prospectively recruited from two pediatric gastroenterology clinics. Stool samples were collected from each participant before endoscopy. The presence of Hp infection was determined by positive histologic findings and positive rapid urease test (RUT). The presence of Hp organisms in stool was determined by an enzyme-linked immunosorbent assay using a commercially available polyclonal antibody kit (Meridian

2004 Journal of Pediatric Gastroenterology and Nutrition

163. Evaluation of 13C-urea breath test and fecal antigen immunoassay to detect Helicobacter pylori infection in Gambian infants. (PubMed)

Evaluation of 13C-urea breath test and fecal antigen immunoassay to detect Helicobacter pylori infection in Gambian infants. Helicobacter pylori colonization was measured by [13C]-urea breath test in 198 Gambian infants and by fecal enzyme-linked immunosorbent assay in 52 of the 198 at ages 2, 5, and 12 months. By 12 months there was good concordance between tests; 33 of 44 (75%) test results were positive by enzyme-linked immunosorbent assay, and 29 of 44 (66%) test results were positive (...) by urea breath test. H. pylori colonization is common among Gambian infants, and noninvasive tests can provide a reliable means of diagnosis.

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2007 Journal of Pediatric Gastroenterology and Nutrition

164. Sensitivity and specificity of various tests for the diagnosis of Helicobacter pylori in Egyptian children. (PubMed)

Sensitivity and specificity of various tests for the diagnosis of Helicobacter pylori in Egyptian children. Many noninvasive methods (using breath, blood, and stool samples) are available to diagnose Helicobacter pylori. However, because the noninvasive tests are proxy measures of the infection, they need validation before use. Factors that may affect test validity include patient age, gender, and geographic location. Because no data were available on the validation of noninvasive tests (...) . Stool and serum samples were tested for the presence of H. pylori by using commercially available enzyme-linked immunosorbent assay-based technology. The sensitivity, specificity, and positive and negative predictive values were calculated for each noninvasive test used in the study. Receiver operating curves also were charted to determine optimal cut points for the various tests when used in the current study cohort.One hundred eight children were enrolled in the study, with 52 children being under

2006 Pediatrics

165. Accuracy of the stool antigen test for the diagnosis of childhood Helicobacter pylori infection: a multicenter Japanese study. (PubMed)

Accuracy of the stool antigen test for the diagnosis of childhood Helicobacter pylori infection: a multicenter Japanese study. The (13)C-urea breath test (UBT) has been accepted as a reliable noninvasive test for detecting Helicobacter pylori infection. Recently, another noninvasive test, a new enzyme immunoassay for H. pylori antigens in stool, has been widely investigated for its clinical usefulness. The purpose of this multicenter study was to evaluate the diagnostic accuracy of the stool (...) . pylori and 188 were not infected. In these same children, HpSA results were positive in 77 children, negative in 183, and indeterminate in four. The overall sensitivity, specificity, and accuracy of the test were 96.0% (95% CI = 88.6-99.2%), 96.8% (95% CI = 94.2-99.3%), and 96.5% (95% CI = 94.3-98.8%), respectively. There were no significant differences in these results among age groups of < or =5, 6-10, and > or =11 yr. Receiver operating characteristic curve analysis demonstrated that the best

2003 American Journal of Gastroenterology

166. The stool antigen test for detection of Helicobacter pylori after eradication therapy. (PubMed)

The stool antigen test for detection of Helicobacter pylori after eradication therapy. Current noninvasive tests to confirm the eradication of Helicobacter pylori must be performed 4 weeks or more after eradication therapy is completed.To determine whether the stool antigen test, a relatively new noninvasive test for H. pylori, administered at various times after eradication therapy correctly identifies persons with persistent H. pylori infection.Prospective blinded study.Six clinical centers (...) in the United States and Europe.84 H. pylori --infected patients undergoing endoscopy for upper abdominal symptoms.At baseline and on day 35 after the completion of triple eradication therapy, all patients underwent endoscopy with histologic examination, rapid urease test and culture, urea breath test, and a stool antigen test. The stool antigen test was also performed on days 3, 7, 15, 21, 28, and 35 after completion of therapy.Compared with the gold-standard endoscopic tests on day 35 after antimicrobial

2002 Annals of Internal Medicine

167. The Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients. (PubMed)

The Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients. There is interest in noninvasive H pylori testing as a means of predicting diagnosis and determining management in dyspeptic patients.To assess the value of the 14C urea breath test as a predictor of peptic ulcer disease in patients presenting with dyspepsia.327 consecutive patients referred for investigation of dyspepsia had a 14C urea breath test performed before endoscopy. Patients were (...) not included if they had previously confirmed ulcer disease, previous gastric surgery, or were taking non-steroidal anti-inflammatory drugs.Of the 182 patients with a positive 14C urea breath test, duodenal and/or gastric ulcers were present in 45% and erosive duodenitis in a further 2%. Oesophagitis was present in 12% of the breath test positive patients with two thirds of the oesophagitis patients having co-existent ulcer disease. The prevalence of ulcer disease in the H pylori positive dyspeptic

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1997 Gut

168. 13C-urea breath test for the diagnosis of Helicobacter pylori infection. A further simplification for clinical practice. (PubMed)

13C-urea breath test for the diagnosis of Helicobacter pylori infection. A further simplification for clinical practice. The 13C-urea breath test is the most accurate noninvasive method for the diagnosis of Helicobacter pylori infection. The oral administration of citric acid solution as test drink 10 min before administration of 13C-urea appears to be the most valuable test procedure hitherto reported. To simplify the test for clinical routine, we evaluated in a prospective, randomized (...) , crossover study the accuracy of a new modification that consists in giving the 13C-urea dissolved in the test drink.Forty dyspeptic patients were studied. H. pylori status was assessed by histology, rapid urease test, and culture. A 13C-urea breath test was performed on 2 consecutive days by giving 200 ml 0.1N citric acid solution either 10 min previous to (protocol 1) or simultaneously with (protocol 2) the administration of 75 mg 13C-urea in randomized order. The 13CO2/12CO2 ratio was measured

1998 Scandinavian journal of gastroenterology Controlled trial quality: uncertain

169. [A systematic review of diagnosis of Helicobacter pylori infection by Helicobacter pylori stool antigen test]. (PubMed)

[A systematic review of diagnosis of Helicobacter pylori infection by Helicobacter pylori stool antigen test]. To evaluate the accuracy of Helicobacter pylori (Hp) stool antigen test for diagnosing Hp infection.Articles related to diagnosis of Hp infection by Hp stool antigen test, published before March 2004, were retrieved in the databanks such as CBMdisc, CMCC, CNKI, and VIP. Related journals were searched manually. Meta-analysis was performed by SROC curve recommended by Diagnostic (...) and Screening Group of the Cochrane Collaboration Web with the parameters such as sensitivity, specificity, accuracy, predictive values, and likelihood ratio.In total 19 studies including 3123 patients met the inclusion criteria. The sensitivity of Hp stool antigen for the diagnosis of Hp infection was 94% and its specificity was 93%.Helicobacter pylori stool antigen examination is a simple, noninvasive and highly accurate method in diagnosis of Hp infection.

2005 Zhonghua yi xue za zhi

170. High accuracy of noninvasive tests to diagnose Helicobacter pylori infection in very young children. (PubMed)

High accuracy of noninvasive tests to diagnose Helicobacter pylori infection in very young children. To validate the (13)C-urea-breath-test (UBT) and stool antigen test (HpSA) in children aged 5 years or younger, against invasive histologic study and rapid-urease-testing or culture.On all consecutive children aged 5 years or younger undergoing endoscopy in 1 single center during the last 7.5 years, UBT and HpSA were performed.Of a total of 184 children (median age 2.2 years, range 0.2-5.5), 30 (...) were Helicobacter pylori-positive (16.3%). Sensitivity and specificity of UBT were 93.3% (95%CI 77.9%-99.2%) and 95.5% (90.9-98.2), with a cutoff of 5 per thousand, but specificity increased to 98.1% (94.4%-99.6%) with a cutoff of 8 per thousand. Sensitivity and specificity of HpSA were 93.3% (77.9%-99.2%) and 98.7% (95.4%-99.8%).Accuracy of noninvasive tests in our single-center study were satisfactory: specificity of UBT improved with a cutoff at 8%, and sensitivity of HpSA was high when

2006 Journal of Pediatrics

171. Lack of accuracy of the noninvasive Helicobacter pylori stool antigen test in patients with gastroduodenal ulcer bleeding. (PubMed)

Lack of accuracy of the noninvasive Helicobacter pylori stool antigen test in patients with gastroduodenal ulcer bleeding. Oral presentation at Digestive Diseases Week, San Francisco, California, May 2002. The antigen-based stool assay has proven to be accurate in diagnosing Helicobacter pylori infection in dyspeptic patients. We evaluated the H. pylori antigen-based stool assay (HpSA) in patients with peptic ulcer bleeding (PUB).Thirty-six patients with PUB were endoscoped, and antral (...) and corpus biopsy specimens were taken for rapid urease test (RUT), histology, and culture. The first stool sample after admission was collected for the HpSA test. The gold standard was defined as either positive culture or positive RUT and histology. If only RUT or histology was positive, this was defined as indeterminate. To evaluate cross-reaction with blood constituents, citrated blood samples from 10 healthy volunteers (nine H. pylori serology negative and one H. pylori serology positive) were

2003 American Journal of Gastroenterology

172. Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients. (PubMed)

Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients. Helicobacter pylori infection is likely acquired in childhood. Helicobacter pylori is recognized as a cause of gastritis and peptic ulcer.To investigate some noninvasive tests, particularly H pylori fecal antigen, for the diagnosis of H pylori infection in comparison with the gold-standard invasive test, esophagogastroduodenoscopy with biopsy.We studied 250 patients (102 male; age range, 3-18 (...) years) who underwent esophagogastroduodenoscopy with biopsy (histologic examination and rapid urease test) for a suspicious upper gastrointestinal disease; in all of them, fecal H pylori antigen, serum H pylori immunoglobulin G, and cytotoxin-associated gene product A immunoglobulin G were measured. Sensitivity and specificity of noninvasive tests were compared with those of the gold-standard esophagogastroduodenoscopy with biopsy.Ninety-three patients (37%) had positive histopathologic (Giemsa

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2005 Archives of Pediatrics & Adolescent Medicine

173. Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. (PubMed)

Noninvasive detection of Helicobacter pylori infection in clinical practice: the 13C urea breath test. To validate the 13C urea breath test for the detection of Helicobacter pylori infection both before and after treatment.13C urea breath tests with 125-mg and 250-mg doses were carried out on each of 60 infected and 60 noninfected subjects. Results were compared with histological examination of gastric biopsies to establish detection limits. The best cut-off point was used in a clinical trial (...) % at 30 min, the accuracy was 94.8 (95% confidence interval = 92-97%) before antimicrobial therapy and 95.4% (95% confidence interval = 91-98%) after. An increase of 2.4% in the abundance of breath 13CO2 measured 30 min after a 125-mg dose of 13C urea reliably indicated the presence of active H.pylori infection either before or after antimicrobial therapy. The 13C urea breath test provides a simple and reliable and noninvasive method of assessing H.pylori status.

1996 The American journal of gastroenterology Controlled trial quality: uncertain

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