How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

173 results for

Helicobacter pylori Noninvasive Testing

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. Stool antigen assay to screen H. pylori infection and to assess the success of 3-Day and 7-Day eradication therapy in the patients with partial gastrectomy. (PubMed)

Stool antigen assay to screen H. pylori infection and to assess the success of 3-Day and 7-Day eradication therapy in the patients with partial gastrectomy. Even after partial gastrectomy, Helicobacter pylori may persist in the residual stomach but be less abundant in the bacterial load. H. pylori stool antigen is a reliable noninvasive tool to detect H. pylori infection in patients without gastrectomy. We thus test whether [1] the course of H. pylori eradication therapy could be diminished [2 (...) ]; stool antigen can effectively detect H. pylori infection for the patients with gastrectomy.One hundred and eight patients who had undergone partial gastrectomy were enrolled to receive panendoscopy and provided stool samples for H. pylori stool antigen within 3 days after endoscopy. The H. pylori-infected patients were then randomized to receive either a 3- or 7-day triple therapy for H. pylori eradication. Six weeks later, to evaluate the success of H. pylori eradication, patients received a follow

2002 Helicobacter Controlled trial quality: uncertain

142. Helicobacter and disease: still more questions than answers (PubMed)

be confidently diagnosed by noninvasive serologic tests and the urea breath test. Triple therapy is almost always curative, and the infection almost never recurs in Canadian adults, but eradicating the bacteria in the absence of peptic ulcer only rarely leads to resolution of dyspepsia. New studies suggest that treating Helicobacter may increase the risk of peptic esophagitis and adenocarcinoma of the esophagus and cardia. (...) Helicobacter and disease: still more questions than answers Since the causative role of Helicobacter pylori in peptic ulcer and gastritis was established, a number of advances have been made. Helicobacter virulence factors have been identified, the changes it causes in gastric acid secretion has been elucidated, and the entire genome of H. pylori has been mapped. Multiple lines of evidence indicate a strong link between the bacterium and noncardia gastric cancer. The infection can

Full Text available with Trip Pro

2000 Canadian Journal of Surgery

143. Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis (PubMed)

Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis OBJECTIVE: To perform a systematic review and a meta-analysis of accuracy of monoclonal stool antigen test (SAT) for the diagnosis of Helicobacter pylori infection. METHODS: SELECTION OF STUDIES: assessing the accuracy of monoclonal SAT for the diagnosis of H. pylori infection. SEARCH STRATEGY: electronic and manual bibliographical searches. DATA EXTRACTION: independently (...) a single outlier study was excluded. Subanalysis depending on the reference method, the study population, or the study quality showed similar results. CONCLUSION: Monoclonal SAT is an accurate noninvasive method both for the initial diagnosis of H. pylori infection and for the confirmation of its eradication after treatment. The monoclonal technique has higher sensitivity than the polyclonal one, especially in the post-treatment setting.

2006 EvidenceUpdates

144. Can you give me the basic details of a stool antigen test for H. pylori. info re sensitivity, specificity, cost etc would be useful especially in contrast with the urea breath test.

details of a stool antigen test for H. pylori. info re sensitivity, specificity, cost etc would be useful especially in contrast with the urea breath test. A 2005 review published in the Journal of Clinical Pathology [1]. This answers the question “Which non-invasive helicobacter test should I use?” reporting: “The most accurate test (95% specificity and sensitivity) is the urea breath test, which detects current infection. This is available on prescription (FP10 BNF section 1.3.1). It requires (...) Journal of Gastroenterology has published a systematic review of accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection [2], this gives results covering a variety of tests and scenarios and can be read by following the URL below. It concludes: “Monoclonal SAT is an accurate noninvasive method both for the initial diagnosis of H. pylori infection and for the confirmation of its eradication after treatment. The monoclonal technique has higher sensitivity than the polyclonal

2007 TRIP Answers

145. Posttreatment 13C-urea breath test is predictive of antimicrobial resistance to H. pylori after failed therapy. (PubMed)

Posttreatment 13C-urea breath test is predictive of antimicrobial resistance to H. pylori after failed therapy. We tested whether a 13C-urea breath test can predict antimicrobial resistance of Helicobacter pylori (H. pylori).Seventy patients who had failed triple eradication therapy and 108 untreated H. pylori-infected patients were given a 13C-urea breath test, endoscopy for culture of H. pylori, and assessment of clarithromycin resistance. The patients who had failed triple therapy (...) and predicts efficacy of the rescue regimen. The value of the noninvasive test is promising for primary care physicians who need to select a rescue regimen without invasive H. pylori culture.

Full Text available with Trip Pro

2005 Journal of General Internal Medicine

146. Use of a Novel Enzyme Immunoassay Based on Detection of Circulating Antigen in Serum for Diagnosis of Helicobacter pylori Infection (PubMed)

Use of a Novel Enzyme Immunoassay Based on Detection of Circulating Antigen in Serum for Diagnosis of Helicobacter pylori Infection Recently, noninvasive diagnostic tests for Helicobacter pylori infection have gained in significance. We have developed a sensitive and specific noninvasive immunoassay based on the detection of an H. pylori circulating antigen (HpCA) in sera from H. pylori-infected individuals. Monospecific antibody and Western blot analyses were used to demonstrate the presence (...) , specificity, and efficiency (>90%), and ELISA results show no significant difference (P > 0.05) from results of H. pylori culture of gastric biopsy specimens. The test's positive and negative predictive values were also high (95 and 86%, respectively). In conclusion, a sensitive and specific immunoassay was developed for the detection of HpCA in human serum. This test can be applied for noninvasive laboratory and field diagnoses of H. pylori infection.

Full Text available with Trip Pro

2004 Clinical and Diagnostic Laboratory Immunology

147. Helicobacter pylori antigens in stool specimens of gastritis children before and after treatment. (PubMed)

Helicobacter pylori antigens in stool specimens of gastritis children before and after treatment. Various testing methods are successfully applied to the diagnosis of Helicobacter pylori infection, but noninvasive techniques are still needed for therapeutic monitoring, especially in children. In the search for new noninvasive techniques for the diagnosis of H. pylori infection, the authors evaluated an enzyme immunoassay for the detection of H. pylori antigen in stool (HpSA).The authors studied (...) 62 H. pylori-positive children with chronic gastritis and 45 control subjects. H. pylori infection was diagnosed using cultures and histology of gastric biopsy specimens and a stool antigen test before treatment (clarithromycin, amoxicillin, omeprazole for 7 days) and 4 weeks to 6 weeks after treatment.Before therapy, antigen in stool was detected in 55 of 62 H. pylori-positive patients, which indicates that the sensitivity of the HpSA test was 88.7%. Of the 45 control subjects (with negative

2003 Journal of Pediatric Gastroenterology and Nutrition

148. Comparison of Different Criteria for Interpretation of Immunoglobulin G Immunoblotting Results for Diagnosis of Helicobacter pylori Infection (PubMed)

Comparison of Different Criteria for Interpretation of Immunoglobulin G Immunoblotting Results for Diagnosis of Helicobacter pylori Infection Gastric infection with Helicobacter pylori is one of the most common chronic infections in humans, causing substantial morbidity and mortality. The diagnosis of H. pylori infection usually involves upper endoscopy with biopsy since the only noninvasive method of comparable accuracy, the [(13)C]urea breath test, requires technical equipment (...) that is not available in most gastroenterological units. Serological methods for detection of H. pylori infection have reached sufficient accuracy to be used as screening tests before endoscopy or for seroepidemiological surveys. In the present study we evaluated different interpretation criteria for use with immunoglobulin G immunoblotting for the diagnosis of H. pylori infection. We applied five different sets of interpretation criteria, four of which had been published previously, to the Western blot results

Full Text available with Trip Pro

2004 Clinical and Diagnostic Laboratory Immunology

149. What is new related to Helicobacter pylori infection in children and teenagers? (PubMed)

disorders, including refractory iron-deficiency (sideropenic) anemia and chronic autoimmune thrombocytopenic purpura. Virulence factors of H pylori and host genetic factors are both considered important determinants of disease outcome. Multiple tests, including novel noninvasive approaches, are available for establishing the presence of H pylori infection, but there is still little consensus about which study should be performed and in what clinical setting. Eradicating H pylori uses combination therapy (...) What is new related to Helicobacter pylori infection in children and teenagers? Helicobacter pylori infection is a common bacterial infection for humans, and the organism is the most prevalent gastric microbial pathogen. However, the major route of transmission remains poorly understood. The outcome of chronic H pylori infection varies from asymptomatic gastritis to peptic ulceration and gastric malignancies. Recently, H pylori has been associated with the development of extradigestive

Full Text available with Trip Pro

2005 Archives of Pediatrics & Adolescent Medicine

150. Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. (PubMed)

Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. Little is known about the influence of environmental factors on the epidemiology of idiopathic thrombocytopenic purpura (ITP). The role of Helicobacter pylori infection in relation to the development and/or persistence of ITP in infected patients remains controversial. Therapy used for eradicating H. pylori has led to a rise in platelet counts in a significant number (...) of adult patients. but few paediatric studies have been undertaken to evaluate such treatment. The aim of this prospective study was to determine the prevalence of H. pylori and to evaluate whether H. pylori eradication can induce chronic ITP regression in children.To investigate new, noninvasive techniques for diagnosis of H. pylori infection, an enzyme immunoassay for H. pylori antigens in faeces (HpSA) was evaluated. Patient eligibility criteria included isolated thrombocytopenia (< or = 50 x 10(9

2003 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

151. 13C urea breath test for (Helicobacter pylori): evaluation of 10-minute breath collection. (PubMed)

13C urea breath test for (Helicobacter pylori): evaluation of 10-minute breath collection. AIM: To determine whether a shortened (13)C urea breath test ((13)C UBT) (breath collection time of 10 min) is as reliable as the standard assay (30 min). METHODS: Two hundred ninety-seven patients (mean +/- SD: 53+/-16 years, 57% female) completed a (13)C UBT. Breath samples were obtained at baseline and at 5 min intervals up to 30 min. Sixty-seven patients also underwent endoscopic biopsy. Cluster (...) is an accurate, noninvasive test, even when the breath sample interval is reduced to 10 min. The present study confirms the validity of a cut-off point of 3.0 delta/1000 for the 10 min and 30 min (13)C UBT.

Full Text available with Trip Pro

2007 EvidenceUpdates

152. 13C urea breath test for (Helicobacter pylori): determination of the optimal cut-off point in a Canadian community population. (PubMed)

13C urea breath test for (Helicobacter pylori): determination of the optimal cut-off point in a Canadian community population. AIM: To determine the test characteristics and the optimal cut-off point for the (13)C urea breath test ((13)C UBT) in a Canadian community laboratory setting. METHODS: Of 2232 patients (mean age +/- SD: 51+/-21 years, 56% female) who completed a (13)C UBT, 1209 were tested to evaluate the primary diagnosis of (Helicobacter pylori) infection and 1023 were tested (...) /1000 for the diagnosis group (n=1209) and 2.88 delta/1000 for the post-treatment group (n=1023). When replacing the calculated cut-off points by a practical cut-off point of 3.0 delta/1000, the risk of false-positive and false-negative results was lower than 2.3%. The (13)C UBT showed 100% sensitivity and 98.5% specificity compared with histology and microbiology (n=176) for the diagnosis of active (H pylori) infection. CONCLUSIONS: The (13)C UBT is an accurate, noninvasive test for the diagnosis

Full Text available with Trip Pro

2007 EvidenceUpdates

153. Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection

Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection Hahn M, Fennerty M B, Corless C L, Magaret N, Lieberman D A, Faigel D O Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of invasive and noninvasive tests for the diagnosis of Helicobacter pylori (H. pylori) infection in patients with a negative rapid urease test (RUT). The diagnostic tests considered were histology (based on 1 fundic and 2 antral biopsies), 13-C Urea Breath Test (UBT), FlexSure HP whole blood test, FlexSure HP

2000 NHS Economic Evaluation Database.

154. Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis. (PubMed)

Use of serum-specific immunoglobulins A and G for detection of Helicobacter pylori infection in patients with chronic gastritis by immunoblot analysis. Multiple invasive and noninvasive tests for detecting Helicobacter pylori infection are available. The current "gold standard" for the diagnosis of H. pylori infection requires histology and the rapid urease test. Our aim was to test the performance of immunoglobulin A (IgA) and IgG immunoblot assays in comparison with that of the gold standard (...) immunoblot assay were 98 and 71%, respectively, with positive and negative predictive values of 87 and 96%, respectively. Therefore, the IgG immunoblot assay proved to be a sensitive and useful, noninvasive test for the diagnosis of H. pylori infection.

Full Text available with Trip Pro

1997 Journal of clinical microbiology

155. Production and Application of New Monoclonal Antibodies Specific for a Fecal Helicobacter pylori Antigen (PubMed)

Production and Application of New Monoclonal Antibodies Specific for a Fecal Helicobacter pylori Antigen The aim of the present study was to establish monoclonal antibodies that could be used to produce a diagnostic test composed of one kind of monoclonal antibody recognizing a fecal Helicobacter pylori antigen. The need to develop such a test arose from disadvantages of the diagnostic test that uses a polyclonal antibody or plural kinds of monoclonal antibodies, such as the lower specificity (...) of the cellular antigen and the fecal antigen were the same, 260 kDa. The antigen was labile in response to sodium dodecyl sulfate and heat treatments. A single-step direct sandwich EIA using a single monoclonal antibody, 21G2, was developed. The EIA could detect the antigen in 41 H. pylori clinical isolates and in fecal samples from seven H. pylori-positive subjects. Several kinds of Helicobacter species (Helicobacter felis, Helicobacter hepaticus, Helicobacter mustelae, and Helicobacter cinaedi) except H

Full Text available with Trip Pro

2002 Clinical and Diagnostic Laboratory Immunology

156. Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review. (PubMed)

Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review. Recently a new, noninvasive diagnostic test based on the detection of Helicobacter pylori stool antigen (SA) has been developed. The aim of this study was to systematically review the experience on H. pylori SA test for the diagnosis of H. pylori infection. Bibliographic searches were performed in the PubMed database and abstracts from several congresses. A total of 43 studies fulfilled the inclusion (...) criteria and evaluated H. pylori SA test accuracy for the diagnosis of H. pylori infection in nontreated patients. Overall, 4769 patients were included. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) (weighted mean) were, respectively: 92.4% (95% CI = 91-93%), 91.9% (91-92%), 92.1% (91-93%), and 90.5% (90-91%). Therefore the SA test can definitively be considered an accurate noninvasive method for the diagnosis of H. pylori infection in untreated

2001 The American journal of gastroenterology

157. Comparison of salivary and serum enzyme immunoassays for the diagnosis of Helicobacter pylori infection (PubMed)

Comparison of salivary and serum enzyme immunoassays for the diagnosis of Helicobacter pylori infection Infection with Helicobacter pylori has been established as an important risk factor for the development of peptic ulcer disease, gastritis and gastric cancer. The diagnosis of H pylori infection can be established by invasive or noninvasive techniques. Two noninvasive enzyme immunoassays (EIAs) for antibody detection - HeliSal and Pylori Stat - were compared with histology. Both assays detect (...) %, 64% and 96%, respectively. Although the salivary EIA is an appealing noninvasive test, it was not a sensitive and specific assay. The serum EIA also lacked specificity, but was highly sensitive with a good negative predictive value. Although a negative serum EIA rules out H pylori infection, a positive result must be interpreted in the clinical context and confirmed with a more specific measure.

Full Text available with Trip Pro

1998 The Canadian Journal of Infectious Diseases

158. Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori (PubMed)

Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori Eradication of Helicobacter pylori infection cures gastritis and prevents recurrence of peptic ulcers. Endoscopy is usually used to evaluate the effectiveness of eradication therapy. We designed a new noninvasive assay system for the early evaluation of eradication of H. pylori infection in which a crude H. pylori outer membrane protein preparation (HPOmp (...) serological test with HPOmp might be a clinically useful tool for assessment of eradication of H. pylori.

Full Text available with Trip Pro

1998 Clinical and Diagnostic Laboratory Immunology

159. Utility of serology in determining Helicobacter pylori eradication after therapy. (PubMed)

Utility of serology in determining Helicobacter pylori eradication after therapy. To determine the usefulness of four serological tests in confirming cure of H pylori infection before the previously reported six-month post-treatment delay.As part of a prospective, blinded, controlled trial, in which patients with duodenal ulcers were randomized to receive different combinations of antibiotics, serum samples were obtained in 89 patients before treatment, as well as on several occasions after (...) and therapy was prolonged. Six months after therapy, the IgG test from Bio-Rad achieved 100% sensitivity and 80% specificity, and that from Pyloriset achieved 88% sensitivity and 100% specificity. At three months, however, test performance was quite good, with 90% sensitivity and 80% specificity when using a Pyloriset IgA titre drop of 20% or greater to predict successful eradication.Serology is a simple, easily available, noninvasive method that exhibits good positive predictive value in the confirmation

1998 Canadian journal of gastroenterology = Journal canadien de gastroenterologie Controlled trial quality: uncertain

160. Evaluation of a Monoclonal Antibody-Based Test for Detection of Helicobacter pylori-Specific Antigen in Stool Samples from Mice (PubMed)

Evaluation of a Monoclonal Antibody-Based Test for Detection of Helicobacter pylori-Specific Antigen in Stool Samples from Mice A test using monoclonal antibodies for detection of antigen in stool samples was compared with culture and histology for noninfected (n = 25), Helicobacter pylori-infected (n = 25), and Helicobacter felis-infected (n = 6) mice. Sensitivity and specificity were 96%. The monoclonal antibody-based test is therefore a noninvasive technique that is able to diagnose H (...) . pylori infection in mice.

Full Text available with Trip Pro

2004 Clinical and Diagnostic Laboratory Immunology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>