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Helicobacter pylori Noninvasive Testing

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41. Urea Breath Test

Test , Urease Breath Test II. Indications evaluation Initial diagnosis of Confirmation of cure after management (test 6 weeks after) III. Mechanism Measures urease activity Detected via nonradioactive isotope carbon 13 or carbon 14 IV. Efficacy: Accurate for Diagnosis for H. pylori : 97% : 100% V. Advantages In-office test with high accuracy Noninvasive test of cure VI. Disadvantages Stop s 2 weeks before test Patient must fast for 6 hours before test More expensive than stool antigen testing (...) Urea Breath Test Urea Breath Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urea Breath Test Urea Breath Test Aka: Urea Breath

2018 FP Notebook

42. Urea Breath Test

Test , Urease Breath Test II. Indications evaluation Initial diagnosis of Confirmation of cure after management (test 6 weeks after) III. Mechanism Measures urease activity Detected via nonradioactive isotope carbon 13 or carbon 14 IV. Efficacy: Accurate for Diagnosis for H. pylori : 97% : 100% V. Advantages In-office test with high accuracy Noninvasive test of cure VI. Disadvantages Stop s 2 weeks before test Patient must fast for 6 hours before test More expensive than stool antigen testing (...) Urea Breath Test Urea Breath Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urea Breath Test Urea Breath Test Aka: Urea Breath

2015 FP Notebook

43. 2020 Acute Coronary Syndromes (ACS) in Patients Presenting without Persistent ST-Segment Elevation (Management of) Guidelines Full Text available with Trip Pro

Israel Search for other works by this author on: , Julinda Mehilli Germany Search for other works by this author on: , Emanuele Meliga Italy Search for other works by this author on: , Béla Merkely Hungary Search for other works by this author on: , Christian Mueller Switzerland Search for other works by this author on: , Marco Roffi Switzerland Search for other works by this author on: , Frans H Rutten Netherlands Search for other works by this author on: , Dirk Sibbing Germany Search for other (...) Lewis, Julinda Mehilli, Emanuele Meliga, Béla Merkely, Christian Mueller, Marco Roffi, Frans H Rutten, Dirk Sibbing, George C M Siontis, ESC Scientific Document Group, 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC), European Heart Journal , , ehaa575

2020 European Society of Cardiology

44. Role of gastrointestinal endoscopy in the screening of digestive tract cancers in Europ

. World J Gastroenterol 2013; 19: 736–741 [32] Pimentel-Nunes P, Dinis-Ribeiro M, PonchonT et al. Endoscopic submucosal dissection: European Society of Gastrointestinal Endos- copy (ESGE) Guideline. Endoscopy 2015; 47: 829–854 [33] Ono H, Yao K, Fujishiro M et al. Guidelines for endoscopic submuco- sal dissection and endoscopic mucosal resection for earlygastric cancer. Dig Endosc 2016; 28: 3–15 [34] Dinis-Ribeiro M, Yamaki G, Miki Ket al. Meta-analysis on the validity of pepsinogen test (...) surveillance systems required. 1 For average-risk populations, ESGE recommends the implementation of organized population-based screening programs for colorectal cancer, based on fecal immuno- chemical testing (FIT), targeting individuals, irrespective of gender,agedbetween50and75years.Dependingonlocal factors,namelytheadherence of thetargetpopulationand availabilityofendoscopy services, primary screeningbyco- lonoscopyor sigmoidoscopy may also be recommendable. 2 In high-risk populations, endoscopic

2020 European Society of Gastrointestinal Endoscopy

45. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures

with clinically significant and persistent abnormal liver function tests (Grade A; upgraded by consensus rule). DOI:10.4158/GL-2019-0406 © 2019 AACE. 33 R27. (2013*). Routine screening for the presence of Helicobacter pylori before bariatric procedures may be considered in areas of high prevalence (Grade C; BEL 3). R28. (2013*). Prophylactic treatment for gouty attacks should be considered before bariatric procedures in patients with a history of gout (Grade C, BEL 3). R29. (2008*). There are insufficient (...) be advised that their fertility status might be improved after a bariatric procedure (Grade D). R20. (2019*). Case-by-case decisions to screen for monogenic and syndromic causes of obesity should be based on specific historical and physical findings. (Grade D). R21. (2019*). The need for an electrocardiogram and other noninvasive cardiac testing is determined on the basis of the individual risk factors and findings on history and DOI:10.4158/GL-2019-0406 © 2019 AACE. 31 physical examination, and should

2019 American Association of Clinical Endocrinologists

46. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada

In-Hospital Management of Diabetes Janine Malcolm MD, FRCPC, Ilana Halperin MD, FRCPC, David B. Miller MD, FRCPC, Sarah Moore RN(EC), BScN, MN, Kara A. Nerenberg MD, FRCPC, Vincent Woo MD, FRCPC, Catherine H. Yu MD, FRCPC S124 Weight Management in Diabetes Sean Wharton MD, FRCPC, PharmD, Sue D. Pedersen MD, FRCPC, David C.W. Lau MD, PhD, FRCPC, Arya M. Sharma MD, PhD, FRCPC S130 Diabetes and Mental Health David J. Robinson MD, FRCPC, FCPA, DFAPA, Michael Coons PhD, CPsych, CBSM, Heidi Haensel MD, FRCPC (...) . Prebtani MD, FRCPC, Vincent Woo MD, FRCPC S190 Management of Acute Coronary Syndromes Jean-Claude Tardif MD, FRCPC, FACC, FCAHS, Phillipe L. L'Allier MD, David H. Fitchett MD, FRCPCCONTENTS (continued): April 2018 Volume 42 Supplement 1 S196 Treatment of Diabetes in People With Heart Failure Kim A. Connelly MBBS, PhD, FCCS, Richard E. Gilbert MBBS, PhD, Peter Liu MD, FRCPC, FACC S201 Chronic Kidney Disease in Diabetes Philip McFarlane MD, PhD, FRCPC, David Cherney MD, PhD, FRCPC, Richard E. Gilbert

2018 Diabetes Canada

47. Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation Full Text available with Trip Pro

Thrombolysis In Myocardial Infarction TNK-tPA Tenecteplase tissue plasminogen activator TOTAL Trial of Routine Aspiration Thrombectomy with PCI versus PCI Alone in Patients with STEMI tPA tissue plasminogen activator UFH unfractionated heparin VALIANT VALsartan In Acute myocardial iNfarcTion VF ventricular fibrillation VT ventricular tachycardia 24/7 24 h a day, seven days a week 1. Preamble Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in selecting (...) (within 24 h) is recommended. In cases of recurrent episodes of ST-segment elevation or chest pain, immediate angiography is required. It is recommended to initiate ECG monitoring as soon as possible in all patients with suspected STEMI in order to detect life-threatening arrhythmias and allow prompt defibrillation if indicated. When a STEMI is suspected, a 12-lead ECG must be acquired and interpreted as soon as possible at the time of FMC to facilitate early STEMI diagnosis and triage. In patients

2017 European Society of Cardiology

48. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee

glands and the pancreas. Most laboratories measure total amylase levels, which contain both s-amylase (salivary) and p-amylase (pancreas) isoforms (45). Laboratory tests exist to fractionate p- and s-amylase, but this practice is less available. Amylase refer- ence values are different depending on the laboratory test used, but also vary with age and gender (46,47). Serum amylase levels can be altered by the etiology of pancreatitis as noted above. Amylase levels rise faster than lipase levels (...) proposed and studied in animal models or small clinical trials (reviewed in (45,50,51)). None has, however, gained prominence and many have yet to be validated for general clinical use. Several laboratory tests are helpful for monitoring the course of AP (52). In general, serum electrolytes, blood urea nitrogen (BUN) and creatinine and a complete blood cell count are important to monitor fluid/hydration status and renal function. A hepatic enzyme panel is indicated to seek biliary or gallstone etiology

2018 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

49. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology Full Text available with Trip Pro

device, RT, 2 h Suspected agent of bioterrorism Refer to CDC website for specimen collection and shipping: Serology 5 mL serum Clot tube, RT, 2 h Antigen test As described in the laboratory specimen collection manual Closed container, RT, 2 h NAAT 5 mL plasma EDTA tube, RT, 2 h Other specimen, ie, viral transport medium Closed container, RT, 2 h Specimen Type Specimen Required Collection Device, Temperature, and Ideal Transport Time Aerobic bacterial culture Tissue, fluid, aspirate, biopsy, etc (...) transport device, RT, 2 h Virus culture Tissue, fluid, aspirate, biopsy, etc Viral transport media, on ice, immediately Swab; flocked swabs are recommended Virus swab transport device, RT, 2 h Suspected agent of bioterrorism Refer to CDC website for specimen collection and shipping: Serology 5 mL serum Clot tube, RT, 2 h Antigen test As described in the laboratory specimen collection manual Closed container, RT, 2 h NAAT 5 mL plasma EDTA tube, RT, 2 h Other specimen, ie, viral transport medium Closed

2018 Infectious Diseases Society of America

50. The Association of Coloproctology of Great Britain and Ireland Consensus Guidelines in Surgery for Inflammatory Bowel Disease Full Text available with Trip Pro

pouch surgery, reoperation and readmission , . Overall, high‐volume centres are also more likely to offer a variety of restorative options in well‐selected patients . Evidence from qualitative research on patient experience in centralized stroke and cancer services suggest that the disadvantage of travelling further was outweighed by the opportunity to receive best care , . In cancer care, patients were willing to travel 75 min longer to reduce their risk of complications by 1% and over 5 h longer (...) and treatment with glucocorticoids. The management includes nutritional support, immunomodulators and surgery . Catch‐up growth is usually manifested in children within 6 months after surgery . Thus, surgery is an attractive option for treatment of children with localized disease after failure of noninvasive methods that enables relief from acute complications, maintaining remission and nutritional recovery . Statement 2.2 Surgery is indicated in children/adolescents with significant growth retardation due

2018 Association of Coloproctology of Great Britain and Ireland

51. Regular exploratory examination of the need for DMP revision - a feasibility study using the example of the DMP "CHD"

meist noch keine klinischen Symptome vorhanden. Im fortgeschrittenen Stadium entsteht mit Arbeitspapier GA14-06 Version 1.0 DMP Überprüfung 07.10.2014 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) - 5 - zunehmender Einengung der Gefäße ein Missverhältnis zwischen Sauerstoffbedarf und -angebot im Herzmuskel mit der Folge einer Myokardischämie. Diese äußert sich klinisch häufig als Angina Pectoris (AP), d. h. in Form plötzlich einsetzender, Sekunden bis Minuten anhaltender (...) -relevante Versorgungsaspekte (siehe Abschnitt 3.1.1.2) E3 DMP-relevante Informationen in medizinischen evidenzbasierten Leitlinien, Schadensmeldungen, Arzneimittel-Richtlinie, Nutzenbewertungen des IQWiG, SR und RCT (siehe Abschnitt 3.1.1.3) E4 Das Dokument bzw. die Information ist aktuell (Publikationszeitraum), d. h. nach der letzten Recherche für eine entsprechende systematische Leitliniensynopse zur DMP-Aktualisierung bzw. einer letzten Prüfung auf einen möglichen Überarbeitungsbedarf des DMP

2015 Institute for Quality and Efficiency in Healthcare (IQWiG)

52. National minimum retesting intervals in pathology: A final report detailing consensus recommendations for minimum retesting intervals for use in pathology

Clinical situation Recommendation Source B-CH1 HbA 1C monitoring in children and young people with type 1 diabetes 2 months NICE. Type 1 diabetes: Diagnosis and management of type 1 diabetes in children and young people. NICE, 2004. www.nice.org.uk/guidance/CG15 B-CH2 Coeliac serology in known paediatric patients on follow up Testing at 6 months in children Murch S, Jenkins H, Auth M, Bremner R, Butt a, France S et al. Joint ESPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac (...) administration and then as clinically indicated, usually no more than once daily (either trough, peak or both) Consensus of the haematology working group Coagulation factor inhibitor testing including the use of a Bethesda assay or equivalent, other inhibitor screens, ELISA or trough factor measurement H-CFI1 Surveillance in patients with severe haemophilia A or B After every 3rd factor exposure day (ED) or every 3 months (whichever is sooner) until 20 ED then every 3–6 months until 150 ED (then 1–2 times

2016 Royal College of Pathologists

53. Genetics of Colorectal Cancer (PDQ®): Health Professional Version

% or greater on MMRpro and MMRpredict are recommended for genetic evaluation referral and testing. Associated Genes and Syndromes Hereditary CRC has two well-described forms: (1) polyposis (including and (AFAP), which are caused by pathogenic variants in the gene; and , which is caused by pathogenic variants in the MUTYH gene); and (2) (often referred to as hereditary nonpolyposis colorectal cancer), which is caused by germline pathogenic variants in DNA MMR genes ( , , , and ) and . Other CRC syndromes (...) that all individuals with newly diagnosed CRC are evaluated for Lynch syndrome through molecular diagnostic tumor testing assessing MMR deficiency. A is supported, in which all CRC cases are evaluated regardless of age at diagnosis or fulfillment of existing clinical criteria for Lynch syndrome. A more cost-effective approach has been reported whereby all patients aged 70 years or younger with CRC and older patients who meet the revised Bethesda guidelines are tested for Lynch syndrome. Tumor

2018 PDQ - NCI's Comprehensive Cancer Database

54. Management of Patients With Acute Lower Gastrointestinal Bleeding

be indicative of an upper gastrointestinal (GI) bleeding source and thus warrants an upper endoscopy. In the majority of patients, colonoscopy should be the initial diagnostic procedure and should be performed within 24 h of patient presentation after adequate colon preparation. Endoscopic hemostasis therapy should be provided to patients with high-risk endoscopic stigmata of bleeding including active bleeding, non-bleeding visible vessel, or adherent clot. The endoscopic hemostasis modality used (...) glycol (PEG)-based solution or the equivalent should be administered over 3–4 h until the rectal ef? uent is clear of blood and stool. Unprepped colo- noscopy/sigmoidoscopy is not recommended (strong recommendation, low-quality evidence). 13. A nasogastric tube can be considered to facilitate colon preparation in high-risk patients with ongoing bleeding who are intolerant to oral intake and are at low risk of aspiration (conditional recommendation, low-quality evidence). Timing of colonoscopy 14

2016 American College of Gastroenterology

55. American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity

prospective or case-controlled trials; MRI = magnetic resonance imaging; MUFA = monoun- saturated fatty acid; NAFLD = nonalcoholic fatty liver disease; NASH = nonalcoholic steatohepatitis; NES = night eating syndrome; NHANES = National Health and Nutrition Examination Surveys; NHLBI = National Heart, Lung, and Blood Institute; NHS = Nurses’ Health Study; NICE = National Institute for Health and Care Excellence; OA = osteoarthritis; OGTT = oral glucose tolerance test; OR = odds ratio; OSA = obstructive

2016 American Association of Clinical Endocrinologists

56. Barrett's Esophagus

is very common, being described in up to 20% of asymptomatic subjects presenting for routine open access endoscopic examinations (18). Studies have suggested that IM of the cardia is not more common in BE patients compared with controls (19), and that the natural history of IM at the EGJ is associated with Helicobacter pylori infection and not associated with EAC (20). Based on this information, biopsy of a normal or slightly irregular EGJ is not recommended. The location of the EGJ has been defined (...) ) have been identified as potential BE risk factors. H. pylori infection, particularly infection with Cag A+ strains, is associated with a decreased risk of BE in some studies (54, 55). Risk factors associated with dysplasia and EAC in patients with BE. Advancing age and increasing BE segment length are known risk factors for the presence of dysplasia in patients with BE. In a multicenter study of 309 BE patients (5 with cancer, 11 with HGD, and 29 with LGD), the risk factors for prevalent dysplasia

2016 American Gastroenterological Association Institute

57. The role of endoscopy in dyspepsia

of alarm features. PATIENTS WITHOUT ALARM FEATURES Dyspeptic patients younger than 50 years of age and without alarm features are commonly evaluated by 1 of 3 methods: (1) noninvasive testing for Helicobacter pylori, with subsequent treatment if positive (the “test and treat” approach), (2) an empiric trial of acid suppression, or (3) initial endoscopy. Test and treat The rationale for testing and treating H pylori in patients with dyspepsia is that H pylori may be associated with true pathologic (...) population. Hence, testing and treating for H pylori may be relevant and cost-effective in regions with prevalence rates of H py- lori of 20% or higher. 18,19,29 Noninvasive testing options for H pylori include serology, urea breath testing, and stool antigen testing. Serologic testing has a sensitivity and speci?city ranging from 85% to 100% and 76% to 96%, respectively. 30,31 The speci?city of urea breath testing and stool antigen is higher than that of serologic testing. 32 In summary, an initial

2015 American Society for Gastrointestinal Endoscopy

58. Gastroesophageal Reflux Disease (GERD)

with typical GERD symptoms. • Urea breath testing (UBT; 13 C or 14 C) or H. pylori stool antigen testing are recommended as noninvasive tests for active H. pylori infection, as a basis for a “test-and-treat” strategy for H. pylori in regions in which the prevalence of H. pylori exceeds 20% [50]. H. pylori testing does not confirm or exclude a diagnosis of GERD, but in line with the Cascades approach, the diagnosis of upper gastrointestinal symptoms should be guided by local disease prevalence and economic (...) symptoms, no alarm features. For extraesophageal GERD A negative trial does not rule out GERD Urea breath test or H. pylori stool antigen test For uninvestigated dyspepsia, in populations in which the H. pylori prevalence is high (> 20%): “test- and-treat” strategy This approach is subject to local cost–benefit considerations It should be based on a noninvasive test of active infection [50] (UBT, monoclonal stool antigen test) Endoscopy For alarm symptoms, screening of high-risk patients, chest pain

2015 World Gastroenterology Organisation

59. The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis: STROBE compliant article. Full Text available with Trip Pro

The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis: STROBE compliant article. Neutrophil to lymphocyte ratio (NLR) is a simple, noninvasive, inexpensive inflammatory marker that can useful in the assessment of inflammatory activity, especially in pediatric ages. The aim of our study was to establish correlations between the presence of Helicobacter pylori (HP) proved histologically and NLR in children.A prospective, case-control study was performed on 137 (...) from rural area (P = .0089). Epigastric pain and loss of appetite were significantly associated with HP infection (P = .0350 /P = .0281). We noticed that the leukocyte and neutrophil counts were significantly higher in group 1 (P = .0076/P = .0306). We did not find any significant statistical differences between the 2 groups in terms of lymphocytes, erythrocyte sedimentation rate, and NLR or other assessed laboratory parameters. Regarding the IgA antibodies anti-HP and rapid urease test, they were

2019 Medicine

60. Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer 2

, and Gastrointestinal Endoscopy . The American Journal of GASTROENTEROLOGY VOLUME 104 | XXX 2014 www.amjgastro.com 2 Giardiello et al. METHODOLOGY Literature review A systematic computer-aided search of MEDLINE from 2005 to 2012 was performed focusing on LS, hereditary nonpolyposis colorectal cancer (HNPCC), and associated reports of genetic testing. Th e search identifi ed all literature under the medical sub- ject headings and text words, “ hereditary nonpolyposis colorectal ca ncer , ” “ HNPC C, ” “ L y nc h (...) of Lynch Syndrome clinical cr i ter ia — t h e r e vis e d B e t h es da guidelines ( 25,109 – 112 ). Evaluation of Genomic Application in Practice and Prevention, a project sponsored by the Offi ce of Public Health Genomics at the Center for Disease Control and Prevention, determined that suffi cient evidence exits to off er genetic testing for LS to all indi- viduals with newly diagnosed CRC ( 113 ). Th e rationale was to reduce morbidity and mortality of relatives of patients with LS. Evaluation

2014 American College of Gastroenterology

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