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Helicobacter pylori Noninvasive Testing

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21. Audit of Helicobacter pylori Testing in Microbiology Laboratories in England: To Inform Compliance with NICE Guidance and the Feasibility of Routine Antimicrobial Resistance Surveillance Full Text available with Trip Pro

Audit of Helicobacter pylori Testing in Microbiology Laboratories in England: To Inform Compliance with NICE Guidance and the Feasibility of Routine Antimicrobial Resistance Surveillance Introduction. The National Institute for Health and Clinical Excellence (NICE) guidance recommends that dyspeptic patients are tested for Helicobacter pylori using a urea breath test, stool antigen test, or serology. Antibiotic resistance in H. pylori is globally increasing, but treatment in England is rarely (...) as their noninvasive test; 3/4 of these encouraged urea breath tests in their acute trusts. Only 22/94 (23%) of the laboratories performed H. pylori cultures from gastric biopsies on site; 9/22 performed AST, but the vast majority processed less than one specimen/week. Conclusions. Only five laboratories in England do not comply with NICE guidance; these will need the guidance reinforced. National surveillance needs to be implemented; culture-based AST would need to be centralised. Moving forward, detection

2016 International journal of microbiology

22. Dyspepsia: When and How to Test for Helicobacter pylori Infection Full Text available with Trip Pro

the physician in discerning between functional dyspepsia and organic causes. For patients without alarm symptoms, noninvasive testing for H. pylori, with either carbon-13-labeled urea breath testing or stool antigen testing, is recommended as a first-line strategy. In this review, we provide recommendations to guide primary care physicians for appropriate use of diagnostic tests and for H. pylori management in dyspeptic patients. (...) Dyspepsia: When and How to Test for Helicobacter pylori Infection Dyspepsia is defined as symptoms related to the upper gastrointestinal tract. Approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to ROME III

2016 Gastroenterology research and practice

23. Evidence-based Guidelines from ESPGHAN and NASPGHAN for Helicobacter Pylori Infection in Children

. Noninvasive diagnostic tests for Helicobacter pylori infection in children. Can J Gastroenterol 2005;19:433–9. 65. Feydt-Schmidt A, Russmann H, Lehn N, et al. Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin- susceptible and clarithromycin-resistant Helicobacter pylori strains in gastric biopsies from children. Aliment Pharmacol Ther 2002; 16:2073–9. 66. Ni YH, Lin JT, Huang SF, et al. Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6 (...) infection. Conclusions: These clinical practice guidelines represent updated, best- available evidence and are meant for children and adolescents living in Europe and North America, but they may not apply to those living on other continents, particularly in developing countries with a high H pylori infection rate and limited health care resources. Key Words: antibiotic resistance, children and adolescents, diagnostic tests, Helicobacter pylori, treatment (JPGN 2011;53: 230–243) SYNOPSIS T he current

2011 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

24. Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children? Full Text available with Trip Pro

, both the (13)C-UBT and HpSA using enzyme-linked immunosorbent assay are reliable non-invasive tests to determine H. pylori status after eradication therapy, although children younger than 6 years are known to have high false positives. When invasive or noninvasive tests are applied to children to detect H. pylori infection, it should be noted that there are differences between children and adults in diagnosing H. pylori infection. (...) Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children? Helicobacter pylori infection is acquired mainly during childhood and causes various diseases such as gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and iron deficiency anemia. Although H. pylori infection in children differs from adults in many ways, this is often overlooked in clinical practice. Unlike adults, nodular gastritis may

2016 Pediatric gastroenterology, hepatology & nutrition

25. Investigation of Helicobacter pylori antigen in stool samples of patients with upper gastrointestinal complaints Full Text available with Trip Pro

Investigation of Helicobacter pylori antigen in stool samples of patients with upper gastrointestinal complaints Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal (...) , specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.Copyright © 2015 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

2016 Brazilian Journal of Microbiology

26. MKSAP: 60-year-old woman with H. pylori gastritis

MKSAP: 60-year-old woman with H. pylori gastritis MKSAP: 60-year-old woman with H. pylori gastritis MKSAP: 60-year-old woman with H. pylori gastritis | | February 16, 2019 5 Shares Test your medicine knowledge with the , in partnership with the . A 60-year-old woman is evaluated 1 month after completing a 14-day course of Helicobacter pylori eradication therapy consisting of amoxicillin, clarithromycin, and omeprazole. Initial upper endoscopy before treatment showed patchy gastric erythema (...) to confirm eradication should be pursued in all cases of identified and treated Helicobacter pylori infection because of the established risks for peptic ulcer disease and gastric malignancy in patients with chronic H. pylori infection. To maximize the accuracy of testing to confirm eradication, testing should be performed a minimum of 4 weeks after completion of H. pylori eradication therapy and after proton pump inhibitor therapy has been discontinued for 1 to 2 weeks and H 2 -blockers for 1 to 2 days

2019 KevinMD blog

27. Quantitative detection and genotyping of Helicobacter pylori from stool using droplet digital PCR reveals variation in bacterial loads that correlates with cagA virulence gene carriage Full Text available with Trip Pro

Quantitative detection and genotyping of Helicobacter pylori from stool using droplet digital PCR reveals variation in bacterial loads that correlates with cagA virulence gene carriage Epidemiologic studies of the carcinogenic stomach bacterium Helicobacter pylori have been limited by the lack of noninvasive detection and genotyping methods. We developed a new stool-based method for detection, quantification, and partial genotyping of H. pylori using droplet digital PCR (ddPCR), which allows (...) for increased sensitivity and absolute quantification by PCR partitioning.Stool-based ddPCR assays for H. pylori 16S gene detection and cagA virulence gene typing were tested using a collection of 50 matched stool and serum samples from Costa Rican volunteers and 29 H. pylori stool antigen-tested stool samples collected at a US hospital.The stool-based H. pylori 16S ddPCR assay had a sensitivity of 84% and 100% and a specificity of 100% and 71% compared to serology and stool antigen tests, respectively

2015 Helicobacter

28. Diagnosis of Helicobacter pylori infection by invasive and noninvasive tests Full Text available with Trip Pro

Diagnosis of Helicobacter pylori infection by invasive and noninvasive tests Although several invasive and noninvasive tests have been developed for the diagnosis of Helicobacter pylori infection, all of the tests have their limitations. We conducted a study to investigate and compare the suitability of rapid urease test (RUT), serology, histopathology and stool antigen tests with polymerase chain reaction (PCR) for detection of H. pylori, and correlate the diagnostic methods with PCR. Eighty (...) nine patients (61 adults, 28 children) referred to the Firoozgar Hospital and Children Medical Center Hospital for diagnostic upper gastrointestinal endoscopy entered to the study and noninvasive tests such as immunoassay for serological antibodies against H. pylori and detection of its antigen in feces were measured. The biopsies were utilized for histological examination, RUT and PCR. The H. pylori statuses were evaluated by the positivity of ureC PCR in biopsy specimens and 53 subjects had H

2013 Brazilian Journal of Microbiology

29. Use of the Noninvasive Entero-test in the Detection of Helicobacter pylori in Children in an Endemic Area in Colombia. Full Text available with Trip Pro

Use of the Noninvasive Entero-test in the Detection of Helicobacter pylori in Children in an Endemic Area in Colombia. Gastric infection with Helicobacter pylori (H pylori), a strong risk factor for gastric cancer, is highly prevalent in children residing in the Colombian Andes. We aimed to validate the use of the Entero-test to culture and genotype H pylori strains from asymptomatic Colombian children.Children (ages 10-15 years, n = 110, 80 of which were H pylori positive by the urea breath (...) as a noninvasive test to detect H pylori in asymptomatic children residing in high-risk areas for gastric cancer. Treatment of H pylori in children was associated with less virulent genotypes.

2013 Journal of Pediatric Gastroenterology and Nutrition

30. Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children Full Text available with Trip Pro

Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children A number of noninvasive diagnostic tests are available to detect Helicobacter pylori infection. Data on serologic testing of children are lacking, however, and thus it remains unclear whether the serology cutoff points used for adults are appropriate for children.Serum and stool samples were obtained from 73 children who visited 5 hospitals in Japan between March 1993 (...) and December 2009. Analysis of stool samples was carried out using an H pylori stool antigen enzyme-linked immunosorbent assay (HpSA ELISA), and serum antibodies to H pylori were examined using an antibody determination kit (E-Plate Eiken H pylori antibody). The validity of the serologic test was evaluated based on its sensitivity, specificity, and receiver operating characteristics curve.Of the 73 children included in this study, 34 were HpSA-positive and 39 were negative. Among the 34 HpSA-positive

2014 Journal of Epidemiology

31. Helicobacter pylori Noninvasive Testing

Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Aka: Helicobacter pylori Noninvasive Testing , H. pylori IgG , H. pylori Serology , H. pylori ELISA II. Indications evaluation III. Labs: First-Line Helicobacter Pylori tests : 97% : 100% Requires g for 6 hours, no PPI for 2 weeks before test, and expensive monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87 (...) Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4

2015 FP Notebook

32. Comparative Evaluation of RUT, PCR and ELISA Tests for Detection of Infection with Cytotoxigenic H. pylori Full Text available with Trip Pro

Comparative Evaluation of RUT, PCR and ELISA Tests for Detection of Infection with Cytotoxigenic H. pylori Helicobacter pylori is one of the most prevalent infectious agents in the world which causes a variety of gastrointestinal diseases including gastritis, peptic ulcer and gastric carcinoma. The objective of this study was to comparatively evaluate invasive (rapid urease test and polymerase chain reaction) and non-invasive (enzyme-linked immunosorbent assay) tests in diagnosis of infection (...) and cag A-IgG ELISA showed high prevalence of cag A-positive strain in the study population.Based on our findings, serum ELISA is a rapid noninvasive test for screening of H. pylori infection in the absence of endoscopy indication. In addition, considering the high prevalence of cytotoxigenic H. pylori strains, cag A is suggested as a promising target for PCR and non- invasive ELISA tests for detection of infection with toxigenic strains.

2016 Advanced pharmaceutical bulletin

33. Helicobacter Pylori in Developing Countries

” is the first step in freeing patients with chronic dyspepsia and/or ulcer disease from an expensive lifetime of chronic medication use. Noninvasivetest-and-treat” strategies have to be balanced with clinical factors and an estimate of the possible cancer risk in each patient. This paper strikes a practical and useful balance. As you develop expertise in your own area, I am sure that you can even improve on the strategies listed here. Epidemiology—global aspects Globally, different strains of H. pylori (...) % Netherlands 2–4 1.2% WGO Global Guideline H. pylori 5 © World Gastroenterology Organization, 2010 Country Age groups Prevalence Serbia 7–18 36.4% Sweden 25–50 11% Switzerland 18–85 26.6% Switzerland 18–85 11.9% Middle East Egypt 3 50% Egypt Adults 90% Country Age groups Prevalence Libya 1–9 50% Libya 10–19 84% Libya Adults 94% Saudi Arabia 5–9 40% Saudi Arabia Adults 80% Turkey 6–17 64% Turkey Adults 80% 2 Diagnosis of Helicobacter pylori infection Diagnostic tests for Hp infection include endoscopic

2010 World Gastroenterology Organisation

34. Helicobacter Pylori Infection (Treatment)

> Helicobacter Pylori Infection Treatment & Management Updated: Aug 08, 2018 Author: Luigi Santacroce, MD; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Helicobacter Pylori Infection Treatment Medical Care Only treat patients who have a positive test result for H pylori infection. The optimal timing of H pylori eradication in asymptomatic persons is during the period when the mucosal damage remains nonatrophic. [ ] Carefully educate patients regarding the importance (...) : update on testing and treatment. Postgrad Med . 2005 Jun. 117(6):17-22, 46. . Wang X, Wattiez R, Paggliacia C, et al. Membrane topology of VacA cytotoxin from H. pylori. FEBS Lett . 2000 Sep 15. 481(2):96-100. . Watts TL. Smoking, Helicobacter pylori, and periodontitis. BMJ . 2006 Jun 24. 332(7556):1513. . Wotherspoon AC. A critical review of the effect of Helicobacter pylori eradication on gastric MALT lymphoma. Curr Gastroenterol Rep . 2000 Dec. 2(6):494-8. . Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ

2014 eMedicine.com

35. Helicobacter Pylori Infection (Follow-up)

> Helicobacter Pylori Infection Treatment & Management Updated: Aug 08, 2018 Author: Luigi Santacroce, MD; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Helicobacter Pylori Infection Treatment Medical Care Only treat patients who have a positive test result for H pylori infection. The optimal timing of H pylori eradication in asymptomatic persons is during the period when the mucosal damage remains nonatrophic. [ ] Carefully educate patients regarding the importance (...) : update on testing and treatment. Postgrad Med . 2005 Jun. 117(6):17-22, 46. . Wang X, Wattiez R, Paggliacia C, et al. Membrane topology of VacA cytotoxin from H. pylori. FEBS Lett . 2000 Sep 15. 481(2):96-100. . Watts TL. Smoking, Helicobacter pylori, and periodontitis. BMJ . 2006 Jun 24. 332(7556):1513. . Wotherspoon AC. A critical review of the effect of Helicobacter pylori eradication on gastric MALT lymphoma. Curr Gastroenterol Rep . 2000 Dec. 2(6):494-8. . Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ

2014 eMedicine.com

36. Point-of-care testing for Heliobacter pylori infection

pylori infection-comparison between infrared spectrometer and mass spectrometry analysis. Alimentary pharmacology & therapeutics. 2000;14(10):1359-63. 43. Chen TS, Chang FY, Chen PC, Huang TW, Ou JT, Tsai MH, et al. Simplified 13C-urea breath test with a new infrared spectrometer for diagnosis of Helicobacter pylori infection. Journal of gastroenterology and hepatology. 2003;18(11):1237-43. 44. Peng N-J, Lai K-H, Lo G-H, Hsu P-I. Comparison of noninvasive diagnostic tests for Helicobacter pylori (...) data meta-analysis. Gastroenterology. 2005;128(7):1838-44. 6. McNulty CAM, Freeman E, Bowen J, Delaney BC. Variation in the use of H. pylori tests in UK general practice--a qualitative study. Alimentary pharmacology & therapeutics. 2005;21(12):1425- 33. 7. Atkinson NS, Braden B. Helicobacter Pylori Infection: Diagnostic Strategies in Primary Diagnosis and After Therapy. Digestive diseases and sciences. 2016;61(1):19-24. 8. Burucoa C, Delchier JC, Courillon-Mallet A, de Korwin JD, Megraud F, Zerbib

2017 Publication 4878904

37. Helicobacter pylori Stool Antigen

pylori Stool Antigen Helicobacter pylori Stool Antigen Aka: Helicobacter pylori Stool Antigen , H. pylori Stool Antigen , HpSA II. Indications evaluation Confirmation of cure after management III. Mechanism Measures antigen present in stool sample IV. Efficacy monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87% : 87-93% Variable reliability, but available for office based testing (...) Accurate for confirmation of cure at 7 days Antigen levels significantly suppressed with cure V. Protocol: Patient stops medications 2 weeks before test Stop s (but less affected than ) Stop all antibiotics Stop bismuth compounds (e.g. Pepto Bismol) VI. Advantages Excellent first line non-invasive test for diagnosis Noninvasive test of cure Inexpensive VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Helicobacter

2015 FP Notebook

38. Helicobacter pylori Infection

for antibodies to H. pylori have a sensitivity and specificity of > 85% and previously were considered the noninvasive tests of choice for initial documentation of H. pylori infection. However, as the prevalence of infection has declined, the percentage of false-positive results with serologic assays has increased significantly, making these tests too unreliable in most countries and regions. As a result, urea breath testing and stool antigen testing are preferred for initial diagnosis. Qualitative assays (...) ; an office-based stool test is under development. Invasive tests Endoscopy is used to obtain mucosal biopsy samples for a rapid urease test (RUT) or histologic staining. Bacterial culture is of limited use because of the fastidious nature of the organism. Endoscopy is not recommended solely for diagnosis of H. pylori ; noninvasive tests are preferred unless endoscopy is indicated for other reasons. The RUT, in which presence of bacterial urease in the biopsy sample causes a color change on a special

2013 Merck Manual (19th Edition)

39. Helicobacter pylori Full Text available with Trip Pro

Helicobacter pylori Helicobacter pylori - Wikipedia Helicobacter pylori From Wikipedia, the free encyclopedia Species of bacteria Helicobacter pylori Other names Campylobacter pylori staining of H. pylori from a Pronunciation , Symptoms None, abdominal pain, nausea , Causes Helicobacter pylori spread by , , Medication , , , Frequency >50% Helicobacter pylori , previously known as Campylobacter pylori , is a , usually found in the . It was identified in 1982 by Australian scientists and , who (...) with a number of disorders of the . Testing for H. pylori is not routinely recommended. Testing is recommended if or low-grade gastric is present, after resection of early , for first-degree relatives with gastric cancer, and in certain cases of . Several methods of testing exist, including invasive and noninvasive testing methods. Noninvasive tests for H. pylori infection may be suitable and include tests, stool s, or the (in which the patient drinks —or -labelled , which the bacterium metabolizes

2012 Wikipedia

40. Timeline of peptic ulcer disease and Helicobacter pylori

a "test-and-treat" strategy for H. pylori in young patients without atypical symptoms. This strategy advocates the use of noninvasive testing to evaluate for H. pylori and simply treating if found, even in the absence of ulcer disease documented on . 2005 Warren and Marshall are awarded the for their work on H. pylori and PUD. References [ ] ^ Kidd, Mark; Irvin M. Modlin (1998). . Digestion . 59 (1): 1–15. : . . ^ Unge, Peter (2002). " Helicobacter pylori treatment in the past and in the 21st century (...) Timeline of peptic ulcer disease and Helicobacter pylori Timeline of peptic ulcer disease and Helicobacter pylori - Wikipedia Timeline of peptic ulcer disease and Helicobacter pylori From Wikipedia, the free encyclopedia Electron micrograph of H. pylori Gastric ulcer This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori . In 2005, and were awarded the for their discovery that (PUD) was primarily caused by , a with affinity

2012 Wikipedia

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