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Helicobacter pylori Noninvasive Testing

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21. Helicobacter pylori: The Past, Present, and Future in Management. (PubMed)

, suitable for application in the primary care setting. On completion of this article, one should be able to (1) state the indications for H pylori testing; (2) identify noninvasive and invasive tests to diagnose H pylori infection; and (3) describe the advantages and disadvantages of various treatment regimens.Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved. (...) Helicobacter pylori: The Past, Present, and Future in Management. Helicobacter pylori is a common bacterial pathogen responsible for substantial gastrointestinal morbidity worldwide. Helicobacter pylori infection can be clinically challenging, given the numerous diagnostic and therapeutic options available. In this article, we provide a systematic review of H pylori epidemiology and pathogenesis. In addition, we provide a simplified approach to the diagnosis and treatment of H pylori infection

2017 Mayo Clinic Proceedings

22. Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status (PubMed)

below the detection limit. CagA was particularly long lasting in both independent populations. An isolated CagA band often represents past eradication with a likelihood of 88.7%. In addition, a high recomLine score was significantly associated with high-grade gastritis, atrophy, intestinal metaplasia, and gastric cancer. Thus, the recomLine is a sensitive and specific noninvasive test for detecting serum responses against H. pylori in actively infected and eradicated individuals. Moreover, it allows (...) Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status Helicobacter pylori infection shows a worldwide prevalence of around 50%. However, only a minority of infected individuals develop clinical symptoms or diseases. The presence of H. pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric

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2017 Journal of immunology research

23. Use of the Noninvasive Entero-test in the Detection of Helicobacter pylori in Children in an Endemic Area in Colombia. (PubMed)

Use of the Noninvasive Entero-test in the Detection of Helicobacter pylori in Children in an Endemic Area in Colombia. Gastric infection with Helicobacter pylori (H pylori), a strong risk factor for gastric cancer, is highly prevalent in children residing in the Colombian Andes. We aimed to validate the use of the Entero-test to culture and genotype H pylori strains from asymptomatic Colombian children.Children (ages 10-15 years, n = 110, 80 of which were H pylori positive by the urea breath (...) as a noninvasive test to detect H pylori in asymptomatic children residing in high-risk areas for gastric cancer. Treatment of H pylori in children was associated with less virulent genotypes.

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2013 Journal of Pediatric Gastroenterology and Nutrition

24. Diagnosis of Helicobacter pylori infection by invasive and noninvasive tests (PubMed)

Diagnosis of Helicobacter pylori infection by invasive and noninvasive tests Although several invasive and noninvasive tests have been developed for the diagnosis of Helicobacter pylori infection, all of the tests have their limitations. We conducted a study to investigate and compare the suitability of rapid urease test (RUT), serology, histopathology and stool antigen tests with polymerase chain reaction (PCR) for detection of H. pylori, and correlate the diagnostic methods with PCR. Eighty (...) nine patients (61 adults, 28 children) referred to the Firoozgar Hospital and Children Medical Center Hospital for diagnostic upper gastrointestinal endoscopy entered to the study and noninvasive tests such as immunoassay for serological antibodies against H. pylori and detection of its antigen in feces were measured. The biopsies were utilized for histological examination, RUT and PCR. The H. pylori statuses were evaluated by the positivity of ureC PCR in biopsy specimens and 53 subjects had H

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2013 Brazilian Journal of Microbiology

25. Evidence-based Guidelines from ESPGHAN and NASPGHAN for Helicobacter Pylori Infection in Children

Noninvasive test for eradication HP eradicated? Observe Consider: •other antibiotic •bismuth •quadruple therapy •higher dosage Yes Yes No Yes No Yes No 1 2 3 6 8 9 11 10 12 12 13 Unknown 14 15 16 17 18 19 20 PPI-AMO-CLA PPI-AMO-MET # or PPI-AMO-CLA # or bismuth-AMO-MET or sequential therapy 4 7 56 Unknown CLA resistance or prior CLA therapy? FIGURE 1. Proposed algorithm of how to treat Helicobacter pylori infection in pediatric patients. AMO¼amoxicillin; CLA¼ clarithromycin; EGD¼esophagogastroduodenoscopy (...) . Noninvasive diagnostic tests for Helicobacter pylori infection in children. Can J Gastroenterol 2005;19:433–9. 65. Feydt-Schmidt A, Russmann H, Lehn N, et al. Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin- susceptible and clarithromycin-resistant Helicobacter pylori strains in gastric biopsies from children. Aliment Pharmacol Ther 2002; 16:2073–9. 66. Ni YH, Lin JT, Huang SF, et al. Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6

2011 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

26. Helicobacter pylori Noninvasive Testing

Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Aka: Helicobacter pylori Noninvasive Testing , H. pylori IgG , H. pylori Serology , H. pylori ELISA II. Indications evaluation III. Labs: First-Line Helicobacter Pylori tests : 97% : 100% Requires g for 6 hours, no PPI for 2 weeks before test, and expensive monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87

2015 FP Notebook

27. Investigation of Helicobacter pylori antigen in stool samples of patients with upper gastrointestinal complaints (PubMed)

Investigation of Helicobacter pylori antigen in stool samples of patients with upper gastrointestinal complaints Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal (...) , specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.Copyright © 2015 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

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2016 Brazilian Journal of Microbiology

28. Helicobacter pylori Stool Antigen

pylori Stool Antigen Helicobacter pylori Stool Antigen Aka: Helicobacter pylori Stool Antigen , H. pylori Stool Antigen , HpSA II. Indications evaluation Confirmation of cure after management III. Mechanism Measures antigen present in stool sample IV. Efficacy monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87% : 87-93% Variable reliability, but available for office based testing (...) Accurate for confirmation of cure at 7 days Antigen levels significantly suppressed with cure V. Protocol: Patient stops medications 2 weeks before test Stop s (but less affected than ) Stop all antibiotics Stop bismuth compounds (e.g. Pepto Bismol) VI. Advantages Excellent first line non-invasive test for diagnosis Noninvasive test of cure Inexpensive VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Helicobacter

2018 FP Notebook

29. Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children? (PubMed)

, both the (13)C-UBT and HpSA using enzyme-linked immunosorbent assay are reliable non-invasive tests to determine H. pylori status after eradication therapy, although children younger than 6 years are known to have high false positives. When invasive or noninvasive tests are applied to children to detect H. pylori infection, it should be noted that there are differences between children and adults in diagnosing H. pylori infection. (...) Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children? Helicobacter pylori infection is acquired mainly during childhood and causes various diseases such as gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and iron deficiency anemia. Although H. pylori infection in children differs from adults in many ways, this is often overlooked in clinical practice. Unlike adults, nodular gastritis may

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2016 Pediatric gastroenterology, hepatology & nutrition

30. Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children (PubMed)

Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children A number of noninvasive diagnostic tests are available to detect Helicobacter pylori infection. Data on serologic testing of children are lacking, however, and thus it remains unclear whether the serology cutoff points used for adults are appropriate for children.Serum and stool samples were obtained from 73 children who visited 5 hospitals in Japan between March 1993 (...) and December 2009. Analysis of stool samples was carried out using an H pylori stool antigen enzyme-linked immunosorbent assay (HpSA ELISA), and serum antibodies to H pylori were examined using an antibody determination kit (E-Plate Eiken H pylori antibody). The validity of the serologic test was evaluated based on its sensitivity, specificity, and receiver operating characteristics curve.Of the 73 children included in this study, 34 were HpSA-positive and 39 were negative. Among the 34 HpSA-positive

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2014 Journal of Epidemiology

31. Comparative Evaluation of RUT, PCR and ELISA Tests for Detection of Infection with Cytotoxigenic H. pylori (PubMed)

Comparative Evaluation of RUT, PCR and ELISA Tests for Detection of Infection with Cytotoxigenic H. pylori Helicobacter pylori is one of the most prevalent infectious agents in the world which causes a variety of gastrointestinal diseases including gastritis, peptic ulcer and gastric carcinoma. The objective of this study was to comparatively evaluate invasive (rapid urease test and polymerase chain reaction) and non-invasive (enzyme-linked immunosorbent assay) tests in diagnosis of infection (...) and cag A-IgG ELISA showed high prevalence of cag A-positive strain in the study population.Based on our findings, serum ELISA is a rapid noninvasive test for screening of H. pylori infection in the absence of endoscopy indication. In addition, considering the high prevalence of cytotoxigenic H. pylori strains, cag A is suggested as a promising target for PCR and non- invasive ELISA tests for detection of infection with toxigenic strains.

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2016 Advanced pharmaceutical bulletin

32. Helicobacter Pylori in Developing Countries

for diagnosing Hp—options for developing countries 11 Ten cascade notes for managing Hp 11 Gold standard treatment options 12 Treatment options in developing countries 13 Lower-cost options for limited-resource settings 14 List of tables Table 1 Helicobacter pylori infection globally 4 Table 2 Tests for Helicobacter pylori infection 5 Table 3 Comparison of diagnostic tests for Helicobacter pylori infection 6 Table 4 Indications for treatment of infection in Hp-positive patients 8 Table 5 Factors involved (...) ” is the first step in freeing patients with chronic dyspepsia and/or ulcer disease from an expensive lifetime of chronic medication use. Noninvasivetest-and-treat” strategies have to be balanced with clinical factors and an estimate of the possible cancer risk in each patient. This paper strikes a practical and useful balance. As you develop expertise in your own area, I am sure that you can even improve on the strategies listed here. Epidemiology—global aspects Globally, different strains of H. pylori

2010 World Gastroenterology Organisation

33. Quantitative detection and genotyping of Helicobacter pylori from stool using droplet digital PCR reveals variation in bacterial loads that correlates with cagA virulence gene carriage (PubMed)

Quantitative detection and genotyping of Helicobacter pylori from stool using droplet digital PCR reveals variation in bacterial loads that correlates with cagA virulence gene carriage Epidemiologic studies of the carcinogenic stomach bacterium Helicobacter pylori have been limited by the lack of noninvasive detection and genotyping methods. We developed a new stool-based method for detection, quantification, and partial genotyping of H. pylori using droplet digital PCR (ddPCR), which allows (...) for increased sensitivity and absolute quantification by PCR partitioning.Stool-based ddPCR assays for H. pylori 16S gene detection and cagA virulence gene typing were tested using a collection of 50 matched stool and serum samples from Costa Rican volunteers and 29 H. pylori stool antigen-tested stool samples collected at a US hospital.The stool-based H. pylori 16S ddPCR assay had a sensitivity of 84% and 100% and a specificity of 100% and 71% compared to serology and stool antigen tests, respectively

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2015 Helicobacter

34. MKSAP: 60-year-old woman with H. pylori gastritis

of the two noninvasive tests, either the urea breath test or fecal antigen test, is preferable. Key Point After eradication therapy for Helicobacter pylori infection, eradication should be confirmed using the urea breath test or fecal antigen test. This content is excerpted from with permission from the (ACP). Use is restricted in the same manner as that defined in the MKSAP 18 Digital license agreement. This material should never be used as a substitute for clinical judgment and does not represent (...) MKSAP: 60-year-old woman with H. pylori gastritis MKSAP: 60-year-old woman with H. pylori gastritis MKSAP: 60-year-old woman with H. pylori gastritis | | February 16, 2019 5 Shares Test your medicine knowledge with the , in partnership with the . A 60-year-old woman is evaluated 1 month after completing a 14-day course of Helicobacter pylori eradication therapy consisting of amoxicillin, clarithromycin, and omeprazole. Initial upper endoscopy before treatment showed patchy gastric erythema

2019 KevinMD blog

35. Helicobacter Pylori Infection (Treatment)

> Helicobacter Pylori Infection Treatment & Management Updated: Aug 08, 2018 Author: Luigi Santacroce, MD; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Helicobacter Pylori Infection Treatment Medical Care Only treat patients who have a positive test result for H pylori infection. The optimal timing of H pylori eradication in asymptomatic persons is during the period when the mucosal damage remains nonatrophic. [ ] Carefully educate patients regarding the importance (...) : update on testing and treatment. Postgrad Med . 2005 Jun. 117(6):17-22, 46. . Wang X, Wattiez R, Paggliacia C, et al. Membrane topology of VacA cytotoxin from H. pylori. FEBS Lett . 2000 Sep 15. 481(2):96-100. . Watts TL. Smoking, Helicobacter pylori, and periodontitis. BMJ . 2006 Jun 24. 332(7556):1513. . Wotherspoon AC. A critical review of the effect of Helicobacter pylori eradication on gastric MALT lymphoma. Curr Gastroenterol Rep . 2000 Dec. 2(6):494-8. . Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ

2014 eMedicine.com

36. Helicobacter Pylori Infection (Follow-up)

> Helicobacter Pylori Infection Treatment & Management Updated: Aug 08, 2018 Author: Luigi Santacroce, MD; Chief Editor: BS Anand, MD Share Email Print Feedback Close Sections Sections Helicobacter Pylori Infection Treatment Medical Care Only treat patients who have a positive test result for H pylori infection. The optimal timing of H pylori eradication in asymptomatic persons is during the period when the mucosal damage remains nonatrophic. [ ] Carefully educate patients regarding the importance (...) : update on testing and treatment. Postgrad Med . 2005 Jun. 117(6):17-22, 46. . Wang X, Wattiez R, Paggliacia C, et al. Membrane topology of VacA cytotoxin from H. pylori. FEBS Lett . 2000 Sep 15. 481(2):96-100. . Watts TL. Smoking, Helicobacter pylori, and periodontitis. BMJ . 2006 Jun 24. 332(7556):1513. . Wotherspoon AC. A critical review of the effect of Helicobacter pylori eradication on gastric MALT lymphoma. Curr Gastroenterol Rep . 2000 Dec. 2(6):494-8. . Chao CY, Wang CH, Che YJ, Kao CY, Wu JJ

2014 eMedicine.com

37. 13C-urea breath test for the diagnosis of Helicobacter pylori infection in children: a systematic review and meta-analysis. (PubMed)

13C-urea breath test for the diagnosis of Helicobacter pylori infection in children: a systematic review and meta-analysis. The (13) C-urea breath test ((13) C-UBT) is a safe, noninvasive and reliable method for diagnosing H. pylori infection in adults. However, the test has shown variable accuracy in the pediatric population, especially in young children. We aimed to carry out a systematic review and meta-analysis to evaluate the performance of the (13) C-UBT diagnostic test for H. pylori (...) , LR- 0.12, DOR 224.8). Therefore, the meta-analysis shows that the (13) C-UBT test is less accurate for the diagnosis of H. pylori infection in young children, but adjusting cutoff value, pretest meal, and urea dose, this accuracy can be improved.© 2011 Blackwell Publishing Ltd.

2011 Helicobacter

38. Utility of stool sample-based tests for the diagnosis of Helicobacter pylori infection in children. (PubMed)

Utility of stool sample-based tests for the diagnosis of Helicobacter pylori infection in children. Helicobacter pylori antigen or DNA in stool are meant to detect the bacteria; however, in children the colonization of the gastric mucosa by H pylori is usually weak and fecal excretion of antigen or DNA varies considerably, challenging the utility of these tests in this age group. The aim of the present study was to carry out a systematic review and meta-analysis to evaluate the performance (...) test showed sensitivity of 80.8%, specificity of 98%, LR+ of 17.1, and LR- of 0.18.Detection of H pylori antigen in stools with ELISA monoclonal antibodies is a noninvasive efficient test for diagnosis of infection in children. One-step tests showed low accuracy and more studies are needed to obtain a useful office-based screening test. The available molecular tests are still unreliable.

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2011 Journal of pediatric gastroenterology and nutrition

39. Helicobacter pylori Stool Antigen

pylori Stool Antigen Helicobacter pylori Stool Antigen Aka: Helicobacter pylori Stool Antigen , H. pylori Stool Antigen , HpSA II. Indications evaluation Confirmation of cure after management III. Mechanism Measures antigen present in stool sample IV. Efficacy monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87% : 87-93% Variable reliability, but available for office based testing (...) Accurate for confirmation of cure at 7 days Antigen levels significantly suppressed with cure V. Protocol: Patient stops medications 2 weeks before test Stop s (but less affected than ) Stop all antibiotics Stop bismuth compounds (e.g. Pepto Bismol) VI. Advantages Excellent first line non-invasive test for diagnosis Noninvasive test of cure Inexpensive VII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Helicobacter

2015 FP Notebook

40. Pharmacogenomics-based treatment of helicobacter pylori infection

on internal validity, the clinical relevance of the study is also limited for several reasons. The treatment approach used was relatively intensive, including genetic testing for CYP2C19, EGD with biopsy for all patients, and testing of H. pylori isolates for clarithromycin resistance. This treatment approach is much more intensive than generally used in the U.S., where the diagnosis of H. pylori is usually made by noninvasive methods and initial empiric treatment is instituted without isolating H. pylori (...) Pharmacogenomics-based treatment of helicobacter pylori infection Pharmacogenomics-based treatment of helicobacter pylori infection Pharmacogenomics-based treatment of helicobacter pylori infection BlueCross BlueShield Association Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation BlueCross BlueShield Association. Pharmacogenomics-based treatment of helicobacter

2008 Health Technology Assessment (HTA) Database.

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