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Helicobacter pylori Noninvasive Testing

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1. Helicobacter pylori Noninvasive Testing

Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Helicobacter pylori Noninvasive Testing Helicobacter pylori Noninvasive Testing Aka: Helicobacter pylori Noninvasive Testing , H. pylori IgG , H. pylori Serology , H. pylori ELISA II. Indications evaluation III. Labs: First-Line Helicobacter Pylori tests : 97% : 100% Requires g for 6 hours, no PPI for 2 weeks before test, and expensive monoclonal antigen tests (enzyme immunoassay) : 92% : 94% Most accurate, but more expensive than immunochromatography monoclonal antigen tests (Immunochromatography) : 69-87

2018 FP Notebook

2. Impact of patient adherence on the cost-effectiveness of noninvasive tests for the initial diagnosis of Helicobacter pylori infection in the United States (PubMed)

Impact of patient adherence on the cost-effectiveness of noninvasive tests for the initial diagnosis of Helicobacter pylori infection in the United States Previous US-based economic models of noninvasive tests for diagnosis of Helicobacter pylori infection did not consider patient adherence or downstream costs of continuing infection. This analysis evaluated the long-term cost-effectiveness of the urea breath test (UBT), fecal antigen test (FAT), and serology for diagnosis of H. pylori (...) costs and higher QALYs; the UBT was cost-effective vs serology (incremental cost/QALY gained $74).Based on a comprehensive modeled analysis that included consideration of patient test adherence and long-term consequences resulting from continuing H. pylori infection, the UBT provided the greatest economic value among noninvasive tests for diagnosis of H. pylori infection, because of high patient adherence and excellent test performance.

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2016 Patient preference and adherence

3. Cost-effectiveness analysis of universal noninvasive testing for post-treatment confirmation of Helicobacter pylori eradication and the impact of patient adherence (PubMed)

Cost-effectiveness analysis of universal noninvasive testing for post-treatment confirmation of Helicobacter pylori eradication and the impact of patient adherence The treatment failure rate for Helicobacter pylori eradication therapy is ~20% due to poor patient compliance and increased antibiotic resistance. This analysis assessed the cost-effectiveness of universal post-treatment testing to confirm eradication of H. pylori infection in adults.Decision-analytic models evaluated the cost (...) , excess lifetime costs and reduced quality-adjusted life-years (QALYs) due to continuing H. pylori infection were considered in the model.Expected total costs per patient were higher for post-treatment testing (UBT: US$325.76; mFAT: US$242.12) vs no testing (US$182.41) in Model 1 and for UBT (US$336.75) vs mFAT (US$326.24) in Model 2. Expected QALYs gained per patient were 0.71 and 0.72 for UBT and mFAT, respectively, vs no testing (Model 1), and the same was 0.37 for UBT vs mFAT (Model 2

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2016 Patient preference and adherence

4. Stool Antigen Tests for Helicobacter pylori Infection

Stool Antigen Tests for Helicobacter pylori Infection TITLE: Stool Antigen Tests for Helicobacter pylori Infection: A Review of Clinical and Cost-Effectiveness and Guidelines DATE: 08 January 2015 CONTEXT AND POLICY ISSUES Helicobacter pylori (H. pylori) is Gram negative bacillus that colonizes the mucus layer of the human stomach and the upper part of small intestine (duodenum). 1,2 It is the principal cause of peptic ulcer disease and the main risk of gastric cancer. 2 Most infected (...) the full-text publications for the final article selection, according to selection criteria presented in Table 1. Table 1: Selection Criteria Population Adult patients with suspected Helicobacter pylori infection Intervention Stool antigen tests (other names may be fecal testing for H. pylori, fecal testing, fecal calprotectin assay) Comparator Endoscopy/biopsy procedure Carbon-13 urea breath test Outcomes • Clinical effectiveness and diagnostic accuracy (accuracy, clinical benefit, patient harms

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

5. Diagnosis of Helicobacter pylori Using Invasive and Noninvasive Approaches (PubMed)

Diagnosis of Helicobacter pylori Using Invasive and Noninvasive Approaches Helicobacter pylori (H. pylori) as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of H. pylori in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests (...) in diagnosis of the H. pylori infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the H. pylori in clinical

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2018 Journal of pathogens

6. Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy? (PubMed)

Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy? The main problem of Helicobacter pylori (H. pylori) infection management is linked to antibiotic resistances. This phenomenon has grown in the last decade, inducing a dramatic decline in conventional regimen effectiveness. The causes of resistance are point mutations in bacterial DNA, which interfere with antibiotic mechanism of action, especially clarithromycin and levofloxacin. Therefore (...) of a potential availability of noninvasive investigations able to detect H. pylori resistances to antibiotics. These kinds of analysis are currently at a very early phase of development and caution should be paid about their clinical application. Only further studies aimed to evaluate their sensitivity and specificity will afford novel data for solid considerations. Nevertheless, noninvasive molecular tests may improve patient compliance, time/cost of infection management and therapeutic outcome. Moreover

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2017 World Journal of Gastroenterology

7. Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents

for 14 days or bismuth- based quadruple therapy is recommended. Success of therapy should be monitored after 4 to 8 weeks by reliable noninvasive tests. Conclusions: The primary goal of clinical investigation is to identify the cause of upper gastrointestinal symptoms rather than H pylori infection. Therefore, we recommend against a test and treat strategy. Decreasing eradication rates with previously recommended treatments call for changes to ?rst-line therapies and broader availability of culture (...) or molecular-based testing to tailor treatment to the individual child. Key Words: adolescents, antibiotic susceptibility, 13 C-urea breath test, children, eradication, Helicobacter pylori, triple therapy (JPGN 2017;64: 991–1003) H elicobacter pylori infection is acquired in childhood and remains an important cause of peptic ulcer disease (PUD) and gastric cancer (1). In comparison with adults, children and adolescents, however, infrequently develop these complications of infection. FurthermoreHpylori

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

8. Non-Invasive Testing for Patients with Suspected Helicobacter pylori: Clinical Evidence and Guidelines

, Terzi Y. Comparison of the diagnostic values of the 3 different stool antigen tests for the noninvasive diagnosis of Helicobacter pylori infection. J Investig Med. 2010 Dec;58(8):982-6. PubMed: PM20729762 16. Mahmood S, Hamid A. Comparison between invasive and noninvasive tests in diagnosis of Helicobacter pylori infection. Pak J Biol Sci. 2010 May 15;13(10):509-12. Non-Invasive Testing for Patients with Suspected H. pylori 7 PubMed: PM21848076 17. Palka M, Tomasik T, Windak A, Margas G, Mach T (...) of Helicobacter pylori infection in children. World J Gastroenterol [Internet]. 2009 Jan 28 [cited 2012 Sep 10];15(4):484-8. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653372 PubMed: PM19152455 25. Peng NJ, Lai KH, Lo GH, Hsu PI. Comparison of noninvasive diagnostic tests for Helicobacter pylori infection. Med Princ Pract. 2009;18(1):57-61. PubMed: PM19060493 Non-Invasive Testing for Patients with Suspected H. pylori 8 26. Shimoyama T, Oyama T, Matsuzaka M, Danjo K, Nakaji S, Fukuda S

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

9. Evaluation of Invasive and Noninvasive Methods for the Diagnosis of Helicobacter Pylori Infection (PubMed)

Evaluation of Invasive and Noninvasive Methods for the Diagnosis of Helicobacter Pylori Infection Objective: The present study was conducted to evaluate invasive and noninvasive diagnostic methods for detection of Helicobacter pylori (H. pylori) in patients admitted with dyspeptic complaints and to compare sensitivities and specificities. Method: Sets of four gastric biopsy specimens were obtained from a total of 126 patients included in the study. The presence of H. pylori was determined (...) by invasive tests including culture, rapid urease test, polymerase chain reaction (PCR) and histopathology. Among noninvasive tests, urea breath test, serological tests and enzyme-linked immunosorbent assay (ELISA) were performed. Results: H. pylori was isolated in 79 (62.7%) gastric biopsy cultures, whereas positivity was concluded for 105 (83.3%) patients by rapid urease test, for 106 (84.1%) by PCR, for 110 (87.3%) by histopathology, for 119 (94.4%) by urea breath test, and for 107 (84.9%) by ELISA

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2016 Asian Pacific journal of cancer prevention : APJCP

10. Point-of-care testing for Heliobacter pylori infection

pylori infection-comparison between infrared spectrometer and mass spectrometry analysis. Alimentary pharmacology & therapeutics. 2000;14(10):1359-63. 43. Chen TS, Chang FY, Chen PC, Huang TW, Ou JT, Tsai MH, et al. Simplified 13C-urea breath test with a new infrared spectrometer for diagnosis of Helicobacter pylori infection. Journal of gastroenterology and hepatology. 2003;18(11):1237-43. 44. Peng N-J, Lai K-H, Lo G-H, Hsu P-I. Comparison of noninvasive diagnostic tests for Helicobacter pylori (...) Point-of-care testing for Heliobacter pylori infection NIHR Diagnostic Evidence Cooperative Oxford www.oxford.dec.nihr.ac.uk Diagnostic Evidence Co-operative Oxford Clinical Question: In adults attending primary care with upper gastrointestinal symptoms, what is the accuracy and utility of point-of-care testing to detect Helicobacter pylori infection? Background Helicobacter pylori (HP) is a spiral-shaped gram-negative bacterium with unipolar sheathed flagellae often tipped with a distinctive

2017 NIHR DEC Oxford

11. Characteristics of Helicobacter pylori-seropositive subjects according to the stool antigen test findings: a prospective study (PubMed)

Characteristics of Helicobacter pylori-seropositive subjects according to the stool antigen test findings: a prospective study In countries with a higher risk of gastric atrophic gastritis, noninvasive tests are helpful for a more reliable diagnosis of Helicobacter pylori infection. The aim of this study was to evaluate the characteristics of seropositive subjects according to their stool H. pylori antigen test, serum pepsinogen (PG) assay, and endoscopic findings.Consecutive subjects who (...) visited Konkuk University Medical Center for upper gastrointestinal endoscopy for a regular check-up were included in a prospective setting if the serum anti-H. pylori immunoglobulin G assay was positive. A H. pylori antigen stool test was measured using a stool H. pylori antigen enzyme-linked immunosorbent assay kit on the same day as a serum PG assay and endoscopy.Of 318 seropositive subjects, 256 (80.5%) showed positive stool test findings. Subjects with a negative stool test result showed lower

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2017 The Korean journal of internal medicine

12. Performances of a Fast Test for the Detection of Helicobacter Pylori Antigens in Child Stool

Catholic University Collaborator: Hôpital Cochin Information provided by (Responsible Party): Lille Catholic University Study Details Study Description Go to Brief Summary: The diagnostic tests used to detect Helicobacter pylori (H. pylori) infection are either direct and invasive, as in culture, histology and the rapid urease test (RUT) or noninvasive, such as serology, the 13C-Urea breathe test or the stool antigen test. However, there is no single reference method to detect the H. pylori infection (...) Performances of a Fast Test for the Detection of Helicobacter Pylori Antigens in Child Stool Performances of a Fast Test for the Detection of Helicobacter Pylori Antigens in Child Stool - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

13. The Evaluation of Diagnostic and Predictive Values of Helicobacter pylori Stool Antigen Test in Iranian Patients with Dyspepsia (PubMed)

The Evaluation of Diagnostic and Predictive Values of Helicobacter pylori Stool Antigen Test in Iranian Patients with Dyspepsia Iran, as a developing country, is experiencing high burdens of Helicobacter pylori (Hp)-associated non-communicable diseases. Hp stool antigen test (HpSA) is widely used as an inexpensive and feasible noninvasive method to diagnose Hp infection, instead of invasive approaches. The current study aimed at evaluating the diagnostic and predictive values of HpSA test (...) to age (r=0.213, P-value=0.034). Considering 0.385 as a cutoff point, the HpSA test had 80.4% sensitivity and 85.7% specificity.Based on cost-effectiveness of HpSA test, the current study findings corroborated the use of HpSA test to detect and follow-up patients with Hp infection, as an alternative method to detect Hp rather than invasive procedures.

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2017 Iranian Journal of Pathology

14. Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children (PubMed)

Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children H. pylori infection is a global public health problem associated with some gastrointestinal diseases in children, especially in developing countries, since prevalence of H. pylori is low in the developed world. Both noninvasive (stool antigen test, urea breath test, and blood test) and invasive (histology, rapid urease test, and microbiological culture) tests have been utilized to detect H. pylori infection (...) aims to determine the gaps in the knowledge of the epidemiology, risk factors, and diagnostic tests of H. pylori infection among children. How to cite this article: Ozbey G, Hanafiah A. Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children. Euroasian J Hepato-Gastroenterol 2017;7(1):34-39.

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2017 Euroasian journal of hepato-gastroenterology

15. Helicobacter pylori resistance to current therapies. (PubMed)

antimicrobial susceptibility testing by both invasive and noninvasive means is crucial to accurately evaluate resistance rates for the optimization of both regional and personalized H. pylori treatment strategies. (...) Helicobacter pylori resistance to current therapies. Helicobacter pylori eradication rates have fallen in recent years, mainly because of the emergence of antibiotic-resistant infections. Indeed the WHO has recently designated clarithromycin-resistant H. pylori infection a high priority for antibiotic resistance research and development. This review aims to discuss the most up-to-date information on the methods to detect H. pylori antibiotic resistance, the recent data on resistance rates

2019 Current opinion in gastroenterology

16. Dyspepsia: When and How to Test for Helicobacter pylori Infection (PubMed)

Dyspepsia: When and How to Test for Helicobacter pylori Infection Dyspepsia is defined as symptoms related to the upper gastrointestinal tract. Approximately 25% of western populations complain of dyspeptic symptoms each year. 70% of them do not have an organic cause and symptoms are related to the so-called functional dyspepsia, characterized by epigastric pain, early satiety, and/or fullness during or after a meal occurring at least weekly and for at least 6 months according to ROME III (...) the physician in discerning between functional dyspepsia and organic causes. For patients without alarm symptoms, noninvasive testing for H. pylori, with either carbon-13-labeled urea breath testing or stool antigen testing, is recommended as a first-line strategy. In this review, we provide recommendations to guide primary care physicians for appropriate use of diagnostic tests and for H. pylori management in dyspeptic patients.

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2016 Gastroenterology research and practice

17. Audit of Helicobacter pylori Testing in Microbiology Laboratories in England: To Inform Compliance with NICE Guidance and the Feasibility of Routine Antimicrobial Resistance Surveillance (PubMed)

Audit of Helicobacter pylori Testing in Microbiology Laboratories in England: To Inform Compliance with NICE Guidance and the Feasibility of Routine Antimicrobial Resistance Surveillance Introduction. The National Institute for Health and Clinical Excellence (NICE) guidance recommends that dyspeptic patients are tested for Helicobacter pylori using a urea breath test, stool antigen test, or serology. Antibiotic resistance in H. pylori is globally increasing, but treatment in England is rarely (...) as their noninvasive test; 3/4 of these encouraged urea breath tests in their acute trusts. Only 22/94 (23%) of the laboratories performed H. pylori cultures from gastric biopsies on site; 9/22 performed AST, but the vast majority processed less than one specimen/week. Conclusions. Only five laboratories in England do not comply with NICE guidance; these will need the guidance reinforced. National surveillance needs to be implemented; culture-based AST would need to be centralised. Moving forward, detection

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2016 International journal of microbiology

18. Helicobacter Pylori Infection. (PubMed)

elements in the differential diagnosis have been ruled out. H. pylori can be detected with noninvasive methods (13C-urea breathing test, stool antigen detection) and with invasive methods (histology, culture, rapid urease test). An important consideration for treatment is that primary clarithromycin resistance is common in many groups of patients; in Germany, its prevalence is now 10.9%. Primary treatment can be with either standard triple therapy (clarithromycin and amoxicillin or metronidazole (...) Helicobacter Pylori Infection. Infection with Helicobacter pylori (H. pylori) is a major pathogenic factor for gastroduodenal ulcer disease and gastric carcinoma, as well as for other types of gastric and extragastric disease. As a result of changing epidemiologic conditions (e.g., immigration), changing resistance patterns with therapeutic implications, and new knowledge relating to the indications for pathogen eradication, the medical management of H. pylori is a dynamic process in need

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2018 Deutsches Arzteblatt international

19. Usefulness of detection of clarithromycin-resistant Helicobacter pylori from fecal specimens for young adults treated with eradication therapy. (PubMed)

Usefulness of detection of clarithromycin-resistant Helicobacter pylori from fecal specimens for young adults treated with eradication therapy. To prevent Helicobacter pylori infection in the younger generation, it is necessary to investigate the prevalence of antibiotic-resistant H. pylori.The aim of this study was to evaluate the method of PCR-based sequencing to detect clarithromycin (CAM) resistance-associated mutations using fecal samples as a noninvasive method.DNA extracted from fecal (...) specimens and isolates from gastric biopsy specimens were collected from patients with H. pylori infection. Antibiotic resistance to CAM was analyzed by molecular and culture methods. The detection rates of CAM resistance-associated mutations (A2142C or A2143G) were compared before and after eradication therapy.With CAM resistance of H. pylori evaluated by antibiotic susceptibility test as a gold standard, the sensitivity and the specificity of gene mutation detection from fecal DNA were 80% and 84.8

2018 Helicobacter Controlled trial quality: uncertain

20. Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016). (PubMed)

is recommended. Success of therapy should be monitored after 4 to 8 weeks by reliable noninvasive tests.The primary goal of clinical investigation is to identify the cause of upper gastrointestinal symptoms rather than H pylori infection. Therefore, we recommend against a test and treat strategy. Decreasing eradication rates with previously recommended treatments call for changes to first-line therapies and broader availability of culture or molecular-based testing to tailor treatment to the individual child. (...) Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016). Because of the changing epidemiology of Helicobacter pylori infection and low efficacy of currently recommended therapies, an update of the European Society for Paediatric Gastroenterology Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition recommendations for the diagnosis and management of H pylori infection in children

2017 Journal of Pediatric Gastroenterology and Nutrition

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