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Healing by Secondary Intention

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1821. Platelets for Acute Wound Healing

: Other Study ID Numbers: APG-01-0605 APG-01-0605 First Posted: July 29, 2005 Last Update Posted: September 14, 2005 Last Verified: September 2005 Keywords provided by Medtronic: wounds healing Acute wounds healing by secondary intention Additional relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries (...) Platelets for Acute Wound Healing Platelets for Acute Wound Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Platelets for Acute Wound Healing The safety and scientific validity of this study

2005 Clinical Trials

1822. Healing Touch and Health-Related Quality of Life in Women With Breast Cancer Receiving Radiation Therapy

) who studied Healing Touch and HRQOL in women receiving radiation therapy for breast and gynecologic cancers. Outcome measures of HRQOL as measured by Short Form-36 (SF-36) tool were used (Norris et al. 2004). The SF-36 is a tool to measure HRQOL, a 36 item tool that measures nine domains of health: a) functional limitations in physical activity secondary to health problems, b) limitations in social activity secondary to physical or mental health issues, c) limitation in role activities secondary (...) to physical health problems, d) limitation in role activities secondary emotional health problems, e) to pain, f) overall mental health, g) vitality, h) perceptions of health and i) health transitions (Norris et. al., 2004). Measurements were taken at baseline and end of study. Cook et al (2004) found that all women in the study had improved scores on the HRQOL Short Form-36 (SF-36) tool used (Norris et al. 2004). Equally important, the women who received Healing Touch had greater improvement in all

2008 Clinical Trials

1823. Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study

at follow-up. Secondary Outcome Measures : Percent of Subjects With Moderate Esophagitis (LA Grade C) Who Healed, Improved, or Stayed the Same or Worsened After 8 Weeks of Treatment [ Time Frame: 8 weeks ] After 8 weeks of treatment a follow-up esophagogastroduodenoscopy (EGD) was performed by an endoscopist blinded to the study and subject allocation. The evaluation results were grouped as follows: LA C esophagitis at baseline: healed = no erosions in the esophagus; improved= LA grades A or B; Same (...) Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2008 Clinical Trials

1824. The Effect of Magnetic Fields on Wound Healing: Experimental Study and Review of the Literature Full Text available with Trip Pro

wounds were created on the backs of 33 Sprague-Dawley rats, which were divided into 3 groups with either a 23 gauss magnet (group 1), a sham magnet (group 2), or nothing (group 3) positioned over the wound. The rate of wound closure by secondary intention was compared between the groups. Literature review was conducted through searches of PubMed and Ovid databases for articles pertinent to magnets and wound healing.Wounds in the magnet group healed in an average of 15.3 days, significantly faster (...) than those in either the sham group (20.9 days, P = .006) or control group (20.3 days, P < .0001). There was no statistically significant difference between the sham and control groups (P = .45).An externally applied, low-power, static magnetic field increases the rate of secondary healing. Review of the literature reveals conflicting evidence regarding the use of magnetic energy to aid the healing of bone, tendon, and skin. Level I studies are lacking and difficult to execute but are needed

2008 Eplasty

1825. The efficacy of distant healing for human immunodeficiency virus--results of a randomized trial. (Abstract)

The efficacy of distant healing for human immunodeficiency virus--results of a randomized trial. While data are conflicting, studies have appeared in the literature suggesting that mental intentions sent from a distance (eg, intercessory prayer, spiritual healing) can possibly influence clinical outcomes in patients suffering from an array of medical conditions. The purpose of this study was to examine the potential efficacy of distant healing in a population of patients with human (...) professional healers or nurses on any of the primary or secondary outcomes. Despite being blind to group assignment, subjects receiving distant healing (from healers or nurses) were significantly more likely to guess that they had been receiving healing than were subjects randomized to the no-treatment control group.Distant healing or prayer from a distance does not appear to improve selected clinical outcomes in HIV patients who are on a combination antiretroviral therapy.

2006 Alternative Therapies in Health & Medicine Controlled trial quality: uncertain

1826. Live imaging of Smad2/3 signaling in mouse skin wound healing. (Abstract)

was randomized to suture closure and the other allowed to heal by secondary intention (n=8 each wound). Bioluminescence was measured at fixed time points following surgery. Phospho-Smad2/3 immunohistochemistry was performed to localize expression in skin wound samples. In vivo bioluminescence increased following skin wounding. Peak activity occurred on day 17 and was fourfold that of baseline (p<0.05). Subgroup analysis of primary and secondary healing showed that primarily sutured wounds had peak activities (...) earlier than those with secondary healing, although this did not reach statistical significance. Intense phospho-Smad2/3 staining was found in the hair follicles. In vivo bioluminescence tracks Smad2/3-dependent TGF-beta signaling in the in vivo wound healing process. Our findings suggest that signaling increases after wound healing, which contrasts with other studies that show raised TGF-beta signaling in the initial days following wounding.

2007 Wound Repair and Regeneration

1827. Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice. (Abstract)

describe a novel method for establishing mouse wounds that require up to 3 weeks or more for complete closure, and we show the validity of this model in Smad3 null mice, which are known to display accelerated healing. Full-thickness wounds, measuring 0.3 by 1.0 cm, were made down to fascia on the dorsal aspect of the mouse tail in Smad3 knock-out mice and control littermates, approximately 1 cm distal to the body of the animal. The wounds were left to heal by secondary intention and were assessed (...) Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice. Experimentally induced wounds in animal models are useful in gaining a better understanding of the cellular and molecular processes of wound healing, and in the initial evaluation of the safety and effectiveness of potential therapeutic agents. However, studying delayed healing has proved difficult in animals, whose wounds heal within a few days. In this report, we

2004 Wound Repair and Regeneration

1828. Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing by secondary intention in the US and UK Full Text available with Trip Pro

Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing by secondary intention in the US and UK Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing by secondary intention in the US and UK Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing (...) . Two separate cases were considered in order to reflect the treatment of an abscess and other wound healing by secondary intention. A graphical representation of the decision tree was provided. Outcomes assessed in the review The outcomes estimated from the literature were the rates of healing associated with traditional gauzes and CMCDs at different intervals (2, 4 and 6 weeks). Study designs and other criteria for inclusion in the review A systematic review of the literature was undertaken

2005 NHS Economic Evaluation Database.

1829. Topical heparin for the treatment of acute superficial phlebitis secondary to indwelling intravenous catheter. A double-blind, randomized, placebo-controlled trial. (Abstract)

in the control group completed the trial. The main outcome measure was the disappearance of the symptoms and signs of superficial phlebitis. Clinical course, investigator's global impression and adverse events were also recorded.According to the intention-to-treat analysis, after treatment for 7 days superficial phlebitis healed in 27 of the 61 patients (44.3%) who received topical heparin, and in 17 of the 65 patients (26.1%) receiving placebo, giving a relative risk [95% confidence interval (CI)] of 1.69 (...) (1.03-2.78). This indicates that six patients (95% CI, 3-72) have to be treated in order to induce one additional healing. The clinical course and the overall clinical impression were similar in both groups. One patient treated with topical heparin developed mild urticaria.Topical heparin is safe and effective for the treatment of superficial phlebitis secondary to indwelling intravenous catheter.

1999 European journal of clinical pharmacology Controlled trial quality: predicted high

1830. Cultured skin as a 'smart material' for healing wounds: experience in venous ulcers. (Abstract)

for 233 patients over 6 months of treatment. All venous ulcer patients will be followed for up to 1 year. We report on three basic scenarios of healing: (i) promotion of healing by secondary intention, (ii) persistent biological wound closure with stimulation of underlying healing, and (iii) healing by frank graft take of the cultured material with remodelling of the tissue over time. Our results indicate that the cultured skin equivalent is responsive to individual wound conditions and thus acts (...) Cultured skin as a 'smart material' for healing wounds: experience in venous ulcers. The healing of chronic wounds is a difficult and varied problem. The engineering of a cultured skin tissue offers an adaptive therapy for chronic wounds. Our hypothesis has been that living tissue can act as a 'smart material' to heal wounds. We have examined the healing characteristics of a bilayered cultured skin equivalent (Graftskin) in a controlled study and present clinical data from interim analyses

1996 Biomaterials Controlled trial quality: uncertain

1831. Review article: esomeprazole, 40 mg once daily, compared with lansoprazole, 30 mg once daily, in healing and symptom resolution of erosive oesophagitis. (Abstract)

-blind trial and included 5241 adult patients (intention-to-treat) with endoscopically documented erosive oesophagitis. Patients were randomized to esomeprazole, 40 mg once daily, or lansoprazole, 30 mg once daily, for up to 8 weeks. The primary end-point, endoscopic healing at Week 8, was assessed using life-table analysis and a log-rank test. Secondary endpoints included healing at Week 4, healing according to baseline severity of oesophagitis, control of heartburn and side-effects.Healing rates (...) Review article: esomeprazole, 40 mg once daily, compared with lansoprazole, 30 mg once daily, in healing and symptom resolution of erosive oesophagitis. Proton pump inhibitors are the most effective agents for treating erosive oesophagitis, but their relative efficacies have not been well characterized in large clinical trials.To compare standard doses of esomeprazole and lansoprazole in healing oesophagitis and resolving accompanying symptoms.This was a US, multicentre, randomized, double

2003 Alimentary pharmacology & therapeutics Controlled trial quality: predicted high

1832. Healing pressure ulcers with collagen or hydrocolloid: a randomized, controlled trial. (Abstract)

criteria included cellulitis and osteomyelitis.Thirty-five patients were allocated to topical collagen daily, 30 to topical hydrocolloid twice weekly.The primary outcome was complete healing within 8 weeks. Secondary outcomes were time to heal, ulcer area healed per day, linear healing of wound edge, and cost of therapy.Analysis by intention to treat revealed similar complete ulcer healing within 8 weeks in collagen (51%) and hydrocolloid (50%) recipients (difference 1%, 95% confidence interval (CI (...) Healing pressure ulcers with collagen or hydrocolloid: a randomized, controlled trial. To compare the effects of topical collagen and hydrocolloid on pressure ulcer healing.Randomized (allocation concealed), single-blind (outcome assessors), controlled trial with 8-week follow-up.Eleven nursing homes in central Illinois.Sixty-five patient-residents with Stage II or III pressure ulcers: median age 83.1, median Braden score 12, 63% female, 80% Stage II ulcers, and 20% Stage III ulcers. Exclusion

2003 Journal of the American Geriatrics Society Controlled trial quality: predicted high

1833. The healing properties of Promogran in venous leg ulcers. (Abstract)

The healing properties of Promogran in venous leg ulcers. To evaluate the healing rate of venous leg ulcers treated with Promogran.Patients with stagnating venous leg ulcers were recruited. Target wounds were > or = 2 cm but < or = 10 cm in any one dimension. Subjects were randomly allocated to receive either Promogran or a non-adherent dressing (Adaptic) with a secondary dressing of gauze followed by short-stress compression (Biflex). Weekly wound assessments occurred over 12 weeks (...) and dressings were changed twice weekly by the investigator and/or nurse team. Planimetry tracings and photographs were blindly reviewed and assessed by two independent investigators. An intent-to-treat analysis was performed.Seventy-three patients were included. Thirty-seven were randomly allocated Promogran and 36 Adaptic. Twenty-nine patients completed the 12-week follow-up visit, 25 healed before week 12 and 19 stopped follow-up before week 12 for reasons unrelated to healing. Significantly more

2002 Journal of wound care Controlled trial quality: uncertain

1834. Rabeprazole, 20 mg once daily or 10 mg twice daily, is equivalent to omeprazole, 20 mg once daily, in the healing of erosive gastrooesophageal reflux disease. (Abstract)

dosages, with that of omeprazole in the healing of erosive GERD.Rabeprazole 20 mg once daily (QD) and 10 mg twice daily (BID) were compared with omeprazole 20 mg QD in a double-blind, multicentre, parallel group study involving 310 patients with erosive GERD. The primary efficacy endpoint was oesophageal mucosal healing determined by endoscopy. Secondary endpoints included reduction in symptoms and improvements in quality-of-life scores.The healing rates between both rabeprazole groups (...) and the omeprazole group were equivalent in both the per-protocol and intent-to-treat populations. In the per-protocol population, rabeprazole 20 mg was noted to have a numerical trend toward more rapid daytime heartburn relief. However, by 4 and 8 weeks of treatment, no significant differences were found between groups for secondary endpoints, adverse events, or laboratory abnormalities including elevation of serum gastrin levels.Rabeprazole 20 mg in two different dosing schedules is as effective as omeprazole

2000 Scandinavian journal of gastroenterology Controlled trial quality: uncertain

1835. Effect of intentional cryo-injury to the renal collecting system. (Abstract)

the kidneys with or without warm pelvicaliceal irrigation.Our data suggest that absent physical puncture injury of the collecting system with the cryoprobe tip the cryodamaged renal collecting system heals by secondary intention in a watertight manner. These data have clinical relevance for facilitating cryoablation of a small, localized, central renal tumor in proximity to the pelvicaliceal system. (...) Effect of intentional cryo-injury to the renal collecting system. We determined the short-term and long-term sequelae of intentional cryoablation of the renal pelvicaliceal system and evaluated whether continuous irrigation of the renal pelvicaliceal system with warm saline protects it against cryo-injury.In 12 swine open bilateral renal cryoablation using an argon gas based system was performed to create a cryolesion in the lower pole that was intentionally extended into the collecting system

2003 Journal of Urology

1836. A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention Lewis R (...) , Whiting P, ter Riet G, O'Meara S, Glanville J Authors' objectives The review had two main objectives: (1) to determine the clinical and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention; and (2) to evaluate the clinical and cost-effectiveness of treating patients with such wounds at specialised wound care clinics. Cost-effectiveness issues are only briefly discussed in this abstract. Searching The reviewers searched a range of electronic databases up

2001 DARE.

1837. A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention

A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention Lewis R (...) , Whiting P, ter Riet G, O'Meara S, Glanville J Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Lewis R, Whiting P, ter Riet G, O'Meara S, Glanville J. A rapid and systematic review of the clinical effectiveness and cost-effectiveness of debriding agents in treating surgical wounds healing by secondary intention. Health Technology Assessment 2001

2001 Health Technology Assessment (HTA) Database.

1838. Is there any difference in return to normal activities after an achilles tendon rupture if the treatment is repair or left to heal by secondary intention?

Is there any difference in return to normal activities after an achilles tendon rupture if the treatment is repair or left to heal by secondary intention? Is there any difference in return to normal activities after an achilles tendon rupture if the treatment is repair or left to heal by secondary intention? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document (...) if the treatment is repair or left to heal by secondary intention? We searched the NLH Specialist Library for Trauma and Orthopaedics, Cochrane, TRIP and Medline databases and identified two meta-analyses comparing surgery to non-operative/conservative management of Achilles tendon ruptures employing return to normal function as an outcome measure. Six randomised controlled trials (n=448) met the inclusion criteria in Bhandari's systematic review: “ Studies that compared surgical repair with non-operative

2007 TRIP Answers

1839. The use of second-intention healing for partial-thickness Mohs defects involving the vermilion and/or mucosal surfaces of the lip. (Abstract)

carcinoma of the lip underwent Mohs micrographic surgery, which resulted in partial-thickness defects predominantly confined to the vermilion and/or mucosa of the lip. All defects were allowed to heal by secondary intention.Twelve patients had good to excellent cosmetic results, and functional impairment was not noted in any of the patients. One patient whose defect extended to the cutaneous portion of the lip had deformation of the vermilion border.Second-intention healing yields good to excellent (...) The use of second-intention healing for partial-thickness Mohs defects involving the vermilion and/or mucosal surfaces of the lip. Partial-thickness defects involving the vermilion and mucosa of the lip are difficult to repair surgically.The purpose of this study was to evaluate the cosmetic and functional effectiveness of second-intention healing in the repair of partial-thickness defects confined predominantly to the vermilion and mucosa of the lip.Thirteen patients with squamous cell

2002 Journal of American Academy of Dermatology

1840. Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus

Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Karydakis Procedure Versus Excision With Healing by Secondary Intention (EHSI) in Sacrococcygeal Pilonidal Sinus The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00716937 Recruitment Status : Completed First Posted : July 16, 2008 Last

2008 Clinical Trials

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