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Healing by Secondary Intention

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161. Colorectal Cancer

of Colorectal Liver Metastases 111 7.4.3. Tumor Markers 113 7.4.4. Specific Diagnostics for Rectal Cancer 114 7.5. Surgical Therapy with Curative Intention 117 7.5.1. Intraoperative Staging 117 7.5.1.1. Intra-Operative Pathological Examination 117 7.5.2. Radical Surgical Therapy of Colon Cancer 118 7.5.2.1. Extent of Lymph Node Dissection: 118 7.5.2.2. Complete Mesocolic Excision (CME) 120 7.5.2.3. Local Ablative Therapies for Liver Metastases 121 7.5.2.3.1. Radio-Frequency Ablation (RFA) 121 7.5.2.3.2 (...) Guideline Program in Oncology | Evidenced-based Guideline for Colorectal Cancer | Version 2.1 | Januar 2019 10 10.8.2.4. Alternative Healing Methods 241 11. Quality Indicators 242 12. Appendix 248 12.1. UICC-Classification of Colorectal Cancer 248 12.2. Amsterdam Criteria 249 12.3. Revised Bethesda-Criteria 249 12.4. Changes to the Recommendations Due to the 2017 Update 250 13. List of Figures 269 14. List of Tables 269 15. References 271 1.1 Editors © German Guideline Program in Oncology | Evidenced

2019 German Guideline Program in Oncology

162. Child Abuse, Elder Abuse, and Intimate Partner Violence

abuse. Suspicion of abuse is often triggered when the story does not match the injury pattern, the story changes over time, multiple injuries result from a simple mechanism, or injuries are present in various stages of healing. The goal of this BPG is to provide a resource for trauma center health professionals to identify, evaluate, manage, document, and report patients that are victims of abuse. It also provides tools for collecting data, injury coding, and quality indicators to monitor, compare (...) , and improve care. Each of the sections—child abuse, elder abuse, and intimate partner violence—separately address definition, epidemiology, assessment and screening, management, and reporting. Documentation for all forms of abuse follows the family violence sections. Quality and process improvement measures are addressed in a separate section at the end, with specific recommendations for each type of abuse. Important Note The intent of the ACS Trauma Quality Programs (TQP) Best Practices Guidelines

2019 American College of Surgeons

163. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures

patients. In particular, patients who smoke cigarettes should stop as soon as possible, preferably 1 year, but at the very least, 6 weeks before bariatric procedures (Grade A; BEL 2, upgraded by consensus). Also, tobacco use must be avoided after bariatric procedures given the increased risk of poor wound healing, anastomotic ulcer, and overall impaired health (Grade A; BEL 1). Structured intensive cessation programs are preferable to general advice and should be implemented (Grade D). DOI:10.4158/GL

2019 American Association of Clinical Endocrinologists

164. AACE/ACE Guidelines for Management of Growth Hormone Deficiency in Adults and Patients Transitioning from Pediatric to Adult Care

of considering test- ing patients with a reasonable level of clinical suspicion of GHD using appropriate growth hormone (GH) cut-points for various GH–stimulation tests to accurately diagnose adult GHD, and to exercise caution interpreting serum GH and insulin-like growth factor-1 (IGF-1) levels, as various GH and IGF-1 assays are used to support treatment deci- sions. The intention to treat often requires sound clinical judgment and careful assessment of the benefits and risks specific to each individual (...) to suggest that the risk of cancer, secondary neoplasms (SN) and hypothalamic-pituitary tumor recurrence is increased, although it remains possible that a longer period of follow- up may still be needed to discern any small increases in these risks. Early studies utilized rhGH doses in replacement regimens that took into consideration of body weight or body surface area, and dose adjustments were based on body composition outcomes, analogous to pediatric prac- tice (42-44), but side effects were

2019 American Association of Clinical Endocrinologists

165. Ustekinumab for the treatment of adult patients with moderately to severely active ulcerative colitis (UC)

as an important source of hetero- geneity in maintenance trials but not induction trials. To make the maintenance endpoint data comparable between the study designs, the MAH proposed an intention-to-treat (ITT) approach mimicking a treat-through trial design (also called a base case approach) in which conditional probabilities were used to recalculate maintenance endpoints in a re-randomisation trial (clinical response, remission or mucosal healing) to mimic those from a treat-through design. Placebo (...) placebo In the UNIFI induction trial of ustekinumab versus placebo in UC (Table 0.1), results were statisti- cally significant for both induction doses of ustekinumab (~6 mg/kg and 130 mg) for all primary and major secondary efficacy endpoints, including clinical remission, clinical response, endoscop- ic healing and mucosal healing (combination of endoscopic and histologic evidence of healing) at week 8 (all p 1 indicates a higher likelihood of a response with usteki- numab than with the comparator

2019 EUnetHTA

166. What is the evidence on the role of the arts in improving health and well-being? A scoping review

national arts councils (5–7); consequently, WHAT IS THE EVIDENCE ON THE ROLE OF THE ARTS IN IMPROVING HEALTH AND WELL-BEING? A SCOPING REVIEW HEALTH EVIDENCE NETWORK SYNTHESIS REPORT 2 these were not included in the review (4). Similarly, this review did not focus on architecture or the design of buildings. However, some secondary references to the use of visual art in health settings are made. 1.1.2 Defining health WHO defines health as “a state of complete physical, mental and social well-being (...) combinations of these health-promoting components, whether undertaken in everyday life (not for a health purpose but having a secondary benefit for health) or within bespoke arts programmes designed with targeted health or well-being goals, or therapeutic arts programmes delivered by trained arts therapists (22). For certain populations, or when aiming to influence certain health conditions, particular types of arts activities (whether everyday, bespoke or therapy) and particular art forms may be more

2019 WHO Health Evidence Network

167. Management of Pilonidal Disease

-analysis. BMJ. 2008;336:868–871. 66. Mentes O, Bagci M, Bilgin T, Coskun I, Ozgul O, Ozdemir M. Management of pilonidal sinus disease with oblique excision and primary closure: results of 493 patients. Dis Colon Rectum. 2006;49:104–108. 67. Al-Khamis A, McCallum I, King PM, Bruce J. Healing by pri- mary versus secondary intention after surgical treatment for pi- lonidal sinus. Cochrane Database Syst Rev. 2010;(1):CD006213. 68. Fazeli MS, Adel MG, Lebaschi AH. Comparison of outcomes in Z-plasty (...) and delayed healing by secondary intention of the wound after excision of the sacral pilonidal sinus: results of a ran- domized, clinical trial. Dis Colon Rectum. 2006;49:1831–1836. 69. Mohamed HA, Kadry I, Adly S. Comparison between three therapeutic modalities for non-complicated pilonidal sinus dis- ease. Surgeon. 2005;3:73–77. 70. Gencosmanoglu R, Inceoglu R. Modified lay-open (incision, curettage, partial lateral wall excision and marsupialization) versus total excision with primary closure

2019 American Society of Colon and Rectal Surgeons

168. What are the roles of intercultural mediators in health care and what is the evidence on their contributions and effectiveness in improving accessibility and quality of care for refugees and migrants in the WHO European Region?

(26,38,53,54). An example would be translating and adapting health education materials to the cultural characteristics and needs of the target population (32,55,62,97). 2.1.3 Preventing conflict and supporting resolution A common role of intercultural mediators is to anticipate, prevent, negotiate and resolve divergent viewpoints or conflicts between health-care providers and patients (46–48,51,53). These issues may relate to divergent views of health and healing, and highlight the possibility (...) for training programmes vary from completion of lower secondary education to a university degree (for access to a postgraduate

2019 WHO Health Evidence Network

169. What is the evidence on the methods, frameworks and indicators used to evaluate health literacy policies, programmes and interventions at the regional, national and organizational levels?

instruments 65iv ABBREVIATIONS AAHLS All Aspects of Health Literacy Scale e-HEALS e-Health Literacy Scale HeLLO Tas! self-assessment checklist for an organization's health literacy HEN Health Evidence Network HLQ Health Literacy Questionnaire HLS-EU European Health Literacy Survey MiMi With Migrants for Migrants – Intercultural Health in Germany (programme) M-POHL Network WHO Action Network on Population and Organizational Health Literacy ÖPGK Austrian Platform for Health Literacy SILS Single Item (...) interaction with health providers and services included adherence to medication, changes in help-seeking intentions and behaviours, changes in access to services, engagement with health providers (including communication) and trust in health providers. Domains relating to organizational health literacy (responsiveness) included changes in the confidence, behaviours and health literacy practices of health practitioners; increased knowledge and awareness of health providers; increased understanding

2019 WHO Health Evidence Network

170. Heart Disease and Stroke Statistics (Full text)

of hospital discharges and numbers of procedures performed are for inpatients discharged from short-stay hospitals. Discharges include those discharged alive, dead, or with unknown status. Unless otherwise specified, discharges are listed according to the first-listed (primary) diagnosis, and procedures are listed according to all listed procedures (primary plus secondary). These estimates are from the HCUP 2014. Ambulatory care visit data include patient visits to primary providers’ offices and hospital

2019 American Heart Association

171. Rivaroxaban (Xarelto) - Co-administered with acetylsalicylic acid for the prevention of atherothrombotic events in adult patients

. The primary outcome was a composite of myocardial infarction, stroke and cardiovascular death in the intention-to-treat population, which comprised all randomised patients. 2,3 3 On the advice of an independent data and safety monitoring board the anti-thrombotic part of the study was stopped early at the first interim analysis, after mean follow-up of 23 months. At this point the primary outcome had occurred significantly less often in both the rivaroxaban plus aspirin group and rivaroxaban group (...) compared with low-dose aspirin in the total study population and CAD subgroup representative of the positioning. This was mainly due to reductions in stroke and cardiovascular deaths, with rates of myocardial infarction similar across the groups. 2,3 Results for the licensed regimen, rivaroxaban plus aspirin, are in table 1 below. Table 1: Primary, secondary and some tertiary outcomes of COMPASS study. 2-4 Total Study Population Coronary Artery Disease (CAD) Subgroup Rivaroxaban Aspirin Aspirin Hazard

2019 Scottish Medicines Consortium

172. Urological Trauma

violence, child and sexual abuse, and MVAs . 3.2. Classification of trauma Traumatic injuries are classified by the World Health Organization (WHO) into intentional (either interpersonal violence related, war-related or self-inflicted injuries), and unintentional injuries (mainly MVAs, falls, and other domestic accidents). Intentional trauma accounts for approximately half of the trauma-related deaths worldwide [ ]. A specific type of unintentional injury is iatrogenic injury which occurs during

2019 European Association of Urology

173. Male Sexual Dysfunction

prostate biopsy. BJU Int, 2015. 116(2)190. 66. Mottet, N., et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol, 2016. 67. Salonia, A., et al. Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function. Eur Urol, 2012. 62: 273. 68. Salonia, A., et al. Prevention and management of postprostatectomy sexual dysfunctions. Part (...) . part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol, 2014. 65: 124. 98. Maggi, M., et al. Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA). J Sex Med, 2013. 10: 661. 99. Laumann, E.O., et al. The epidemiology of erectile dysfunction: results from the National Health and Social Life Survey. Int J Impot Res, 1999. 11 Suppl 1: S60. 100. Miner, M., et al. Cardiometabolic risk

2019 European Association of Urology

174. Muscle-invasive and Metastatic Bladder Cancer

. Chrouser, K., et al. Bladder cancer risk following primary and adjuvant external beam radiation for prostate cancer. J Urol, 2005. 174: 107. 26. Nieder, A.M., et al. Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population based cohort study. J Urol, 2008. 180: 2005. 27. Zelefsky, M.J., et al. Incidence of secondary cancer development after high-dose intensity-modulated radiotherapy and image-guided brachytherapy for the treatment of localized prostate

2019 European Association of Urology

176. Prostate Cancer

Guidelines Associates: T. Van den Broeck, M. Cumberbatch, N. Fossati, T. Gross, M. Lardas, M. Liew, L. Moris, I.G. Schoots, P-P.M. Willemse TABLE OF CONTENTS REFERENCES 1. Drost, F.J.H., et al. Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer. Cochrane Database of Systematic Reviews, 2019. In press. 2. Van den Broeck, T., et al. Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review (...) Broeck T., et al. A systematic review of oncological effectiveness and harms of primary local interventions for high-risk localized and locally advanced prostate cancer. PROSPERO International prospective register of systematic reviews, 2017. CRD42017078862 8. Willemse, P.M., et al. Systematic review of deferred treatment with curative intent for localised prostate cancer to explore heterogeneity of definitions, thresholds and criteria and clinical effectiveness. PROSPERO International prospective

2019 European Association of Urology

177. AIM Clinical Appropriateness Guidelines for Spine Surgery

, also known as lumbar artificial disc surgery or total disc arthroplasty (TDA), was developed as an alternative to lumbar fusion for treatment of back pain due to severe degenerative disc disease. The procedure is similar to lumbar interbody fusion, in that an anterior approach is required. Unlike fusion, motion at the level of disc replacement is maintained, which would seem to be advantageous in terms of preventing secondary degenerative changes and preserving spine mechanics. This document

2019 AIM Specialty Health

178. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease

: TNF; 5-ASA; Guidance; Mucosal Healing Crohn’s disease (CD) is a lifelong illness with substantial mor- bidity and mortality. Studies have shown that up to one-third of patients require hospitalization within the first year after diagnosis and more than half within 5 years. 1 In addition to in- creased risk of mortality from digestive conditions, CD is also associated with a significantly increased risk of all-cause mortal - ity compared with the general population (standardized mor- tality ratio (...) that certain clinical parameters carry an increased risk of progres- sive and disabling disease. In addition, as the association be- tween mucosal healing and improved short-term and long-term outcomes has been increasingly recognized, 4,5 this is becoming an important treatment goal. 6 Evidence suggests that initia- tion of highly effective therapies can lead to symptomatic im- provement and mucosal healing. For this reason the present consensus statements generally recommend that management strategies

2019 Canadian Association of Gastroenterology

179. Negative Pressure Wound Therapy (NPWT)

: pressure ulcers; venous leg ulcers; burns; open traumatic wounds; open abdomen; wounds healing by primary intention (including split-thickness skin grafts, caesarean section wounds and closed incision wounds); surgical wounds healing by secondary intention; and sternal wound infections after cardiothoracic surgery. Consensus statements to guide best practice • Exploratory work by SHTG highlighted the need for guidance on the appropriate and safe use of NPWT in NHSScotland. Therefore consensus (...) and standard care for any type of open traumatic wound (including open fracture wounds). Other wound types ? In the following wound types, evidence from robust RCTs is either lacking, insufficient and/or inconsistent: pressure ulcers; venous leg ulcers; burns; open abdomen; wounds healing by primary intention (including split thickness skin grafts, caesarean section wounds and closed incision wounds); surgical wounds healing by secondary intention; and sternal wound infections after cardiothoracic surgery

2019 SHTG Advice Statements

180. Optimal Care Pathway for Aboriginal and Torres Strait Islander people with cancer

is available at cancer.org.au/ocp and canceraustralia.gov.auForeword i Summary 1 Context 5 Intent and key principles 8 Supporting the delivery of optimal care for Aboriginal and Torres Strait Islander people with cancer 18 Optimal cancer care pathway 26 Step 1: Prevention and early detection 27 Step 2: Presentation, initial investigations and referral 35 Step 3: Diagnosis, staging and treatment planning 39 Step 4: Treatment 45 Step 5: Care after initial treatment and recovery 51 Step 6: Managing recurrent (...) step of the pathway and refer to appropriate health professionals or organisations. Step 4 Treatment Treatment intent: Establish and document if treatment is • curative • anti-cancer therapy to improve quality of life and/or longevity without expectation of cure or • symptom palliation. When discussing death or dying with Aboriginal and Torres Strait Islander people, the terms ‘passing’, ‘not going to get better’ or ‘returning to Country’ may be more accepted due to spiritual belief around the life

2018 Cancer Australia

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