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Healing by Secondary Intention

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142. The impact of care farms on quality of life, depression and anxiety among different population groups: A systematic review Full Text available with Trip Pro

in changes in quality of life and mental health, this review included quality of life, anxiety and depression as the primary outcomes. Studies that did not use a validated instrument were not included in the analysis. Secondary outcomes Secondary outcomes varied according to the different populations, but we reported any mental health outcomes (in addition to quality of life, depression and anxiety as primary outcomes), social, physical and behavioural outcomes. Although we report all relevant outcomes (...) we do not include in the analysis any secondary outcomes that had been developed in‐house or failed to be defined. The secondary outcomes included were: Mental health outcomes: self‐efficacy, self‐esteem, stress, coping, mood, mental status, mental functioning, positive affect, rehabilitation and cognitive functioning, empowerment Social outcomes: social functioning/interaction, group cohesion, recidivism, employment, school exclusion Physical outcomes: functional performance, physical activity

2019 Campbell Collaboration

144. Management of epithelial ovarian cancer

of the guideline 2 1.3 Definitions 2 1.4 Statement of intent 2 2 Key recommendations 4 2.1 Screening and the role of prophylactic salpingo-oophorectomy 4 2.2 Diagnosis 4 2.3 Surgical management 4 2.4 Chemotherapy 5 2.5 Follow up 5 3 Screening and the role of prophylactic salpingo-oophorectomy 6 3.1 Screening for ovarian cancer in the general population 6 3.2 Identifying women at high risk of developing ovarian cancer 6 3.3 Screening high risk groups 8 3.4 Prophylactic salpingo-oophorectomy 8 4 Diagnosis 10 4.1 (...) Primary care 10 4.2 Secondary care 12 4.3 The role of the clinical nurse specialist 15 5 Surgical management 16 5.1 Preparation for surgery 16 5.2 Pathology 16 5.3 Management of early disease 17 5.4 Optimal surgery for advanced disease 20 5.5 Relapsed disease 21 6 Chemotherapy 23 6.1 Early disease 23 6.2 Advanced disease 24 6.3 Relapsed disease 28 6.4 Chemotherapy for low-grade serous, clear cell and mucinous histological subtypes 31 7 Follow up 32 8 Management of malignant bowel obstruction

2018 SIGN

146. Effectiveness of interventions to reduce homelessness: a systematic review and meta?analysis Full Text available with Trip Pro

. Secondary outcomes: (only included if primary outcomes are available) health‐related outcomes including presence/severity of mental illness or substance abuse, quality of life, marginalization, employment, criminal behaviour, school attendance. Language : No restrictions regarding language. Exclusion criteria Study design: Other study designs, including quasi‐experimental studies with propensity score matching. Outcome : Outcomes only related to admission to hospital/psychiatric treatment, or cost (...) , mental health/substance use status, homelessness status, criminal activity) Intervention characteristics (degree and type of housing support and degree/type of service support and/or therapy offered) Methods of outcome measurement (clinical, self‐report, physical specimens for substance use outcomes) Primary outcomes related to number of days spent in stable housing or homeless Secondary outcomes related to housing (satisfaction with housing, type of housing, etc.), addiction status, mental

2018 Campbell Collaboration

147. School?based interventions for reducing disciplinary school exclusion: a systematic review Full Text available with Trip Pro

. In terms of prevalence, data provided by the UK Department for Education (academic year 2011/12) shows that in England fixed‐term exclusion affects 3.5% of the school population whereas permanent exclusion applies to only 0.06%. The national figures suggest that students in secondary‐level education (6.8% of the school population) as well as those in special education (14.7%) are the most likely to experience fixed‐term exclusion (DfE, 2013). In the United States, data provided by the Department (...) , the school must provide alternative education. Discretionary School principal Repeated failure to follow academic instruction, failure to complete a behavioural sanction (e.g. with a detention, a decision to change the sanction to exclusion would not automatically be unlawful), repeated and persistent breaches of the schools’ behavioural policy. Academic year 2014‐2015 12 3.8% of students (all schools) 7.51% of students (secondary schools) Permanent 0.07% of students (all schools) 0.15% of students

2018 Campbell Collaboration

148. Proton beam therapy in adults

3.3.6 Locally recurrent rectal cancer 20 3.3.7 Key points 20 3.4 SAFETY 21 3.4.1 Low-grade glioma 21 3.4.2 Primary sinonasal tumours and recurrences of head & neck tumours 22 3.4.3 Breast cancer 23 3.4.4 Pancreatic cancer 24 3.4.5 Hepatocellular cancer 25 3.4.6 Locally recurrent rectal cancer 28 3.4.7 Key points 28 3.5 SECONDARY TUMOURS 29 3.6 ONGOING TRIALS 29 4 DISCUSSION 31 4.1 SCARCE AND FLAWED EVIDENCE ON THE EFFECTIVENESS OF PROTON TREATMENT 31 4.2 UNCERTAINTY ABOUT THE SAFETY OF PROTON (...) TREATMENT 32 4.3 FEW DATA ON SECONDARY TUMOURS 32 4.4 SOME RCTS UNDERWAY, BUT NOT IN THE VERY NEAR FUTURE 33 4.5 LIMITATIONS OF THIS REPORT 33 ? REFERENCES 34 KCE Report 307 Proton beam therapy in adults 3 LIST OF TABLES Table 1 – Reimbursed adult indications for Proton Beam Therapy and Carbon Ion Therapy in Belgium 7 Table 2 – Incidence (2016) and survival (2012-2016) of selected non-reimbursed indications for Proton Beam Therapy in Belgium 9 Table 6 – Overview of included single-arm studies (reported

2019 Belgian Health Care Knowledge Centre

149. Esomeprazole

peptic ulcers are a common disorder. However, whether or not aspirin should be continued during treatment (...) for aspirin-related ulcers remains unclear. To compare esomeprazole alone with esomeprazole plus aspirin in the treatment of aspirin-related peptic ulcers and to investigate the independent factors associated with the failure of ulcer healing. From January 2008 to July 2011, patients with aspirin-related peptic ulcers were randomized to receive esomeprazole (40 mg per day) alone (...) 20 mg (standard therapy) or 40 mg (double-dose therapy), each given twice daily. At intention-to-treat analysis, H. pylori infection was cured in 73.9 2016 11. Esomeprazole for the Treatment of GERD in Infants Ages 1-11 Months. 26422097 2015 10 01 2016 06 29 2015 10 01 1536-4801 60 Suppl 1 2015 Jul Journal of pediatric gastroenterology and nutrition J. Pediatr. Gastroenterol. Nutr. Esomeprazole for the Treatment of GERD in Infants Ages 1-11 Months. S9-15 10.1097/MPG.0b013e3182496b35

2018 Trip Latest and Greatest

150. Infliximab

, that is, top-down, will give more mucosal healing, fewer relapses, less complications, need for surgery and hospitalisation. This international multicentre open-label 2017 10. Comparison Of iNfliximab and ciclosporin in Steroid Resistant Ulcerative Colitis: pragmatic randomised Trial and economic evaluation (CONSTRUCT) Journals Library Journals Library An error has occurred in processing the XML document An error has occurred in processing the XML document An error has occurred in processing the XML (...) patients taking placebo were given the opportunity to cross over to IFX, and an observational phase. Primary treatment efficacy was based on HS Severity Index. Secondary end points included 2010 16. Infliximab versus methotrexate, etanercept, adalimumab, and ustekinumab for plaque psoriasis: a review of the comparative clinical efficacy, safety and cost effectiveness Infliximab versus methotrexate, etanercept, adalimumab, and ustekinumab for plaque psoriasis: a review of the comparative clinical

2018 Trip Latest and Greatest

151. PTSD

Oxygen Therapy for TBI and PTSD Health Services Research & Development Management eBrief no. 143 » Issue 143 April 2018 The report is a product of the VA/HSR&D Quality (...) Enhancement Research Initiative (QUERI) Evidence-Based Synthesis Program. Evidence Brief: Hyperbaric Oxygen Therapy for Traumatic Brain Injury and/or PTSD Following certain types of injuries, our bodies may demand more oxygen than is available in the normal air we breathe to supply our cells with the fuel necessary for healing (...) and therapy Behav Res Ther A pilot randomized controlled trial of Dialectical Behavior Therapy with and without the Dialectical Behavior Therapy Prolonged Exposure protocol for suicidal (...) and self-injuring women with borderline personality disorder and PTSD . 7-17 10.1016/j.brat.2014.01.008 S0005-7967(14)00015-1 This study evaluates the efficacy of integrating PTSD treatment into Dialectical Behavior Therapy (DBT) for women with borderline personality disorder, PTSD , and intentional self-injury

2018 Trip Latest and Greatest

152. Effectiveness of alcohol and other drug interventions in at-risk Aboriginal youth

at risk of AOD related harm, located in metropolitan, rural and regional locations in NSW. The aim is to develop a primary and/or secondary prevention program based in the community or in justice settings, rather than an individual treatment focus in clinical settings. While a population-based approach is ideal, only some interventions will be feasible within the project’s budget and time constraints; others, for example, those with a primary focus on school-based interventions and policy-based (...) questionnaire. Relative to controls, participants receiving the intervention drank less often, less per drinking occasion, less overall and had fewer academic problems. McKennitt et al. 14 conducted a pilot study using a RCT design to ascertain the extent to which a modified school- based program had on future smoking intentions among American Indian children. The study involved 18 Indigenous students in Grade 4. Two schools were randomised to either a culturally sensitive or a standard smoking prevention

2018 Sax Institute Evidence Check

153. The Foyer model for homeless youth: a systematic mapping review

). For the purpose of this systematic mapping review, we follow the definition for Foyer Model provided by the Australian Government through the National Homelessness Re- search Agenda of the Department for Families, Housing, Community Services and Indig- enous Affairs (2): “The Foyer Model provides a package of accommodation and support to young people aged between 16 and 24, who are homeless (in situations of primary, secondary and tertiary homelessness) or at risk of becoming homeless. Typically, resi- dents (...) criterion was therefore a substantial emphasis on the Foyer model as the subject matter. Additionally, the people receiving foyer must be young people (15–25 years old) who are homeless or at-risk of homelessness. In terms of the population, we adopted the definitions of primary, secondary and tertiary homelessness provided by Steen and Mackenzie in Australia (2), and the definition of at-risk of homelessness provided by the US Department of Housing and Urban Development (10). See glossary in Appendix 1

2018 Norwegian Institute of Public Health

154. Recommendations for the Delivery of Psychosocial Oncology Services in Ontario

Regional Cancer Programs continue to consistently use symptom screening tools as a component of the screen for PSO needs. 2.2 All sites develop an inter-professional approach for responding to clinically significant screening for all issues and/ or elevated symptom screen scores. Teams consider secondary assessment tools for elevated scores. 2.3 Symptom screens be addressed routinely at clinic visits; the symptom scores should be acknowledged followed by assessment, interventions and referral (...) for this report are clinicians and administrators from the Regional Cancer Programs and Cancer Care Ontario. The secondary audiences are patients and families, community-based organizations, and provincial and federal organizations. This recommendation report provides a comprehensive overview and articulates the need for necessary PSO services across Ontario. It is intended to foster further discussions and consultation within Regional Cancer Programs about the “how” to improve PSO service delivery

2018 Cancer Care Ontario

155. Bevacizumab (Mvasi) - Cancer, colon, breast, lung, kidney, ovary, cervix

particle counting HIC hydrophobic interaction chromatography HPLC high-performance liquid chromatography HUVEC human umbilical vein endothelial cells HWP high molecular weight ICF informed consent form ICH International Conference on Harmonisation IEC Independent Ethics Committee Ig immunoglobulin IP investigational product IPC in-process control IRB Institutional Review Board ITT intent-to-treat IV intravenous IXRS interactive voice and web response system KM Kaplan-Meier LC light chain LC-MS/MS (...) . Characterisation The elucidation of structure studies were conducted using ABP 215 active substance manufactured at ATO using the intended commercial process and scale. Characterization included biochemical studies (primary structure, glycosylation, disulfide structure, charge variants and size variants), biophysical studies (secondary structure, tertiary structure and thermal stability), biological studies (mechanism of action, including antigen specificity and Fc functionality) and forced degradation studies

2018 European Medicines Agency - EPARs

156. The Patient Centred Medical Home: barriers and enablers to implementation

• Incorporating new roles into the practice, such as community care worker, clinical pharmacist, medical assistant. 10 THE PATIENT CENTRED MEDICAL HOME: BARRIERS AND ENABLERS TO IMPLEMENTATION | SAX INSTITUTE Component of change and why it’s important Barriers/challenges Enablers Teamwork: Key feature of the PCMH model and central to achieving quality care. • Lack of intentional focus on developing teams • Preoccupation with data/measurement • Workflow is too prescriptive • Inadequate re-distribution of tasks (...) systems for care coordination • Lack of dedicated care-coordination position(s) • Lack of knowledge amongst primary care providers about the availability of community supports, and lack of infrastructure to support collaboration between primary care and community services • Lack of specialty care or hospital involvement with patient care and other linkages between secondary and tertiary care • Inability to share patient information across different providers and organisations. • Use of mechanisms

2018 Sax Institute Evidence Check

157. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

intent-to-treat MRC Medical Research Council MRD minimal residual disease MS mass spectrometry MS/MS tandem mass spectrometry NAc N-acetyl MCB Master Cell Bank NCCN National Comprehensive Cancer Network NCI National Cancer Institute NCRI National Cancer Research Institute NDA New Drug Application NE not estimable NEC not elsewhere classified NMR nuclear magnetic resonance spectroscopy No GO chemotherapy alone, without GO NOPHO Nordic Society of Paediatric Hematology and Oncology NPM nucleophosmin (...) and peripheral blood, which leads to anaemia, neutropenia, and thrombocytopenia. This is associated with symptoms of fatigue, shortness of breath, disturbed wound healing, infections and bleedings. If left untreated, AML results in death within a few weeks to months. Long-term survival in adult patients with AML is only 35% to 40% for patients =60 years of age, and drops to 5% to 15% in patients who are >60 years of age. (6) The majority of patients with AML will have relapsed disease within 3 years. (7

2018 European Medicines Agency - EPARs

158. Darvadstrocel (Alofisel) - Rectal Fistula

for allogeneic eASC is based on immune modulatory and anti-inflammatory properties. Inflammatory cytokines, in particular IFN-? produced by activated immune cells (i.e., lymphocytes), activate eASC in a mechanism which requires induction of indoleamine 2,3-dioxygenase expression. Once activated, eASC suppress proliferation of lymphocytes and inhibit the release of pro-inflammatory cytokines. This immunoregulatory activity reduces inflammation, which may allow the tissues around the fistula tract to heal (...) of new fistulas”. It was considered that the optimum endpoint for demonstrating remission at week 24 would be the combination of complete healing (no discharge after gentle pressing) with complete MRI based closure of the fistulae. The primary efficacy endpoint utilized in the pivotal study deviates from this recommendation and respective guideline, because it was defined as clinical closure of external openings that were draining at baseline despite gentle finger compression and absence

2018 European Medicines Agency - EPARs

160. Diagnosis and management of gonorrhoea and syphilis

and syphilis 1 ? TABLE OF CONTENTS LIST OF FIGURES 7 LIST OF TABLES 8 LIST OF ABBREVIATIONS 11 ? SCIENTIFIC REPORT 14 1 INTRODUCTION 14 1.1 BACKGROUND 14 Etiology, transmission, clinical features and epidemiological trends 14 Notification of infectious diseases in Belgium 21 1.2 THE NEED FOR A NATIONAL GUIDELINE 22 1.3 SCOPE 23 1.4 REMIT OF THE GUIDELINE 24 Overall objectives 24 Patient-centred care 24 Policy relevance and target users of the guideline 24 1.5 STATEMENT OF INTENT 25 1.6 FUNDING (...) oral-anal or genital-anal contact. Intravenous drug use (sharing needles) and blood transfusion (rare as routine screening is performed and treponemal survival beyond 24–48h at 4°C is unlikely) are also potential routes of transmission. 6 The stages of syphilis are presented in Table 2. After infection, patients present with signs of early primary disease. Untreated, 25% of patients will develop signs of early secondary syphilis. Secondary syphilis will resolve spontaneously in 3–12 weeks

2019 Belgian Health Care Knowledge Centre

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