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Healing by Secondary Intention

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121. Guidelines on Chronic Coronary Syndromes Full Text available with Trip Pro

in asymptomatic apparently healthy subjects (primary prevention) and patients with established chronic coronary syndromes (secondary prevention) 21 Figure 7 The five As of smoking cessation 24 Figure 8 Suggested stepwise strategy for long-term anti-ischaemic drug therapy in patients with chronic coronary syndromes and specific baseline characteristics 28 Figure 9 Decision tree for patients undergoing invasive coronary angiography 36 Figure 10 Proposed algorithm according to patient types commonly observed (...) tomography-based fractional flow reserve GEMINI- ACS A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome GFR Glomerular filtration rate GLS Global longitudinal strain GOSPEL Global secondary prevention strategies to limit event recurrence after myocardial infarction HbA1c Glycated haemoglobin HF Heart failure ICA Invasive coronary angiography IMR Index of microcirculatory resistance

2019 European Society of Cardiology

122. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD Full Text available with Trip Pro

Management of blood pressure lowering 20 6.3.2.1 Effects of lifestyle intervention and weight loss 20 6.3.2.2 Pharmacological treatments 20 6.3.2.3 Blood pressure changes with glucose-lowering treatments 20 6.4 Lipids 21 6.4.1 Lipid-lowering agents 21 6.4.1.1 Statins 21 6.4.1.2 Ezetimibe 22 6.4.1.3 Proprotein convertase subtilisin/kexin type 22 6.4.1.4 Fibrates 22 6.5 Platelets 23 6.5.1 Aspirin 23 6.5.1.1 Primary prevention 24 6.5.1.2 Secondary prevention 24 6.6 Multifactorial approaches 24 6.6.1

2019 European Society of Cardiology

123. A palliative approach to care in the last 12 months of life

pets)” (4).8 REGISTERED NURSES’ ASSOCIATION OF ONTARIO BACKGROUND A Palliative Approach to Care in the Last 12 Months of Life Family caregiver: “ Any relative, partner, friend or neighbor who has a significant personal relationship with, and provides a broad range of assistance for, an older person or an adult with a chronic or disabling condition. These individuals may be primary or secondary caregivers and live with, or separately from, the person receiving care” (5). Health provider: Refers

2020 Registered Nurses' Association of Ontario

124. ASTRO Guideline on Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin

) with a diagnosis of nonmetastatic invasive BCC and cSCC, to be published in English, from May 1988 through June 2018 and RT to be delivered with curative intent. The literature search excluded preclinical and dosimetric studies, as well as publications addressing re-irradiation or palliation. KQ1 studies were limited to those with =100 patients, KQs 2 to 4 used =50 patients and KQ5 reduced the patient number to =15 since minimal evidence exists on chemotherapy, biologic, and immunotherapy agents. See Appendix (...) led to slightly higher local control and better cosmetic results, but it is notable that the 4-year actuarial failure rate in the RT arm was only 7.5%, suggesting that RT is a highly effective alternative to surgery if surgical options are limited. 3 Given the noninvasive nature of RT, physician- and patient-reported cosmetic outcome has been an important secondary endpoint in most studies. 7,12-14 In contrast to randomized data, there is ample retrospective and single-arm prospective evidence

2020 American Society for Radiation Oncology

125. The promotion of well?being among children exposed to intimate partner violence: A systematic review of interventions Full Text available with Trip Pro

rigorous evaluations, including RCTs (Chamberlain, ). 3.2 The intervention This review is focused on psychosocial interventions where the primary or secondary aim is the promotion of child well‐being following exposure to IPV. Psychosocial interventions are defined broadly to include a wide variety of services that emphasize psychological and/or social factors rather than biological factors. Interventions may be psychological in nature, such as psychotherapies of various orientations (e.g., cognitive (...) , group interventions, and education and support services that include a psychological and/or social component) that emphasize psychological and/or social factors rather than biological factors (England et al., ). Our secondary goal was to examine whether interventions with particular characteristics (e.g., modality, theoretical orientation) are more effective than others in promoting well‐being. Through this process, we aimed to identify gaps in the current scientific literature and highlight

2019 Campbell Collaboration

126. Improving outdoor air quality and health: review of interventions

). Reducing exposure to pollution from local industry and agriculture. Local authorities can work with regulators and local operators towards site-specific interventions. For industry, technological interventions include dust abatement and primary and secondary control measures. For agriculture, interventions include livestock housing design/management, change in diet or feeding regime, changes in storage, handling and application of manure, and applying alternative fertilisation practices. In both cases (...) The complex nature of air pollution chemistry means that air pollutant emissions reductions do not always produce a corresponding drop in atmospheric concentrations in the UK (8, 10). It is, therefore, important to measure ambient air quality as well as emissions to understand local pollution concentration levels and people’s exposure. For example, from a UK perspective, only about half the exposure of the UK population to secondary inorganic aerosol pollution (see following section) is due to UK

2019 Public Health England

127. Evidence Map - Art Therapy

among women with breast cancer. Palliative & supportive care. 2006;4(1478-9515 (Print)):57-64. 26. Radl DM. The effects of Self-Book(c) art therapy on emotional distress in female cancer patients: A randomized controlled trial. Dissertation Abstracts International: Section B: The Sciences and Engineering S2- Dissertation Abstracts International. 2016;76(9-B(E)). 27. Warson E. Healing pathways: art therapy for American Indian cancer survivors. Journal of cancer education : the official journal (...) al. Moderating factors for the effectiveness of group art therapy for schizophrenia: secondary analysis of data from the MATISSE randomised controlled trial. Pain Med 2014 Apr;15 Suppl 1:S66-75 doi: 101111/pme12409. 2014;49(1433-9285 (Electronic)):1703-1710. 62. Richardson P, Jones K, Evans C, Stevens P, Rowe A. Exploratory RCT of art therapy as an adjunctive treatment in schizophrenia. Journal of Mental Health. 2007;16(4):483-491. 63. Attard A, Larkin M. Art therapy for people with psychosis

2019 Veterans Affairs Evidence-based Synthesis Program Reports

128. Palliative Care for Adults

care refers to care that is palliative in its scope and intent, given to patients with serious illness by health care clinicians who are not palliative specialists. (Quill, 2013) This includes primary care clini- cians or specialists (e.g., oncology care team members, intensive care unit care team members) who care for patients with serious illness. These clinicians routinely should provide primary palliative care such as symptom and quality-of-life assessments and treatments, empathetic and clear (...) within 12 months • Frequent admissions (e.g., more than one admission for same condition within several months) • Admission prompted by difficult-to-control physical or psychological symptoms (e.g., moderate-to-severe symptom intensity for more than 24–48 hours) • Complex care requirements (e.g., functional dependency; complex home support for ventilator/antibiotics/feedings) • Decline in function, feeding intolerance, or unintended decline in weight (e.g., failure to thrive) Secondary Criteria b

2020 Institute for Clinical Systems Improvement

129. Treatment of Patients with Schizophrenia

such as electroconvulsive therapy or transcranial magnetic stimulation • Prior psychiatric diagnoses and symptoms including: o Hallucinations (including command hallucinations), delusions, and negative symptoms o Aggressive ideas or behaviors (e.g., homicide, domestic or workplace violence, other physically or sexually aggressive threats or acts) o Impulsivity o Suicidal ideas, suicide plans, and suicide attempts, including details of each attempt (e.g., context, method, damage, potential lethality, intent (...) ) and attempts that were aborted or interrupted o Intentional self-injury in which there was no suicide intent Substance Use History • Use of tobacco, alcohol, and other substances (e.g., vaping, marijuana, cocaine, heroin, hallucinogens) and any misuse of prescribed or over-the-counter medications or supplements • Current or recent substance use disorder or change in use of alcohol or other substances Medical History • Whether or not the patient has an ongoing relationship with a primary care health

2020 American Psychiatric Association

130. Management of Pilonidal Disease

-analysis. BMJ. 2008;336:868–871. 66. Mentes O, Bagci M, Bilgin T, Coskun I, Ozgul O, Ozdemir M. Management of pilonidal sinus disease with oblique excision and primary closure: results of 493 patients. Dis Colon Rectum. 2006;49:104–108. 67. Al-Khamis A, McCallum I, King PM, Bruce J. Healing by pri- mary versus secondary intention after surgical treatment for pi- lonidal sinus. Cochrane Database Syst Rev. 2010;(1):CD006213. 68. Fazeli MS, Adel MG, Lebaschi AH. Comparison of outcomes in Z-plasty (...) and delayed healing by secondary intention of the wound after excision of the sacral pilonidal sinus: results of a ran- domized, clinical trial. Dis Colon Rectum. 2006;49:1831–1836. 69. Mohamed HA, Kadry I, Adly S. Comparison between three therapeutic modalities for non-complicated pilonidal sinus dis- ease. Surgeon. 2005;3:73–77. 70. Gencosmanoglu R, Inceoglu R. Modified lay-open (incision, curettage, partial lateral wall excision and marsupialization) versus total excision with primary closure

2020 American Society of Colon and Rectal Surgeons

131. Sutures v staples for skin closure in lower limb orthopaedic surgery: A Rapid Review

was searched using Google (Table 2). Titles and abstracts identified were exported to EndNote X7 (Thompson, Reuters, Carlsbad, California, USA). Papers identified were screened using inclusion and exclusion criteria established a priori (Table 3). Searches of Medline, EMBASE, Cochrane Library, NICE and Google were screened by one reviewer (CJ). Secondary searching of reference lists and citing articles was also performed to ensure any other studies not identified through the searching were discovered (...) . Quality Appraisal To keep in line with the previous review, (1) one author (CJ) replicated and performed a quality appraisal of any new trials so that a comparison with any current evidence was possible. Studies were critically appraised for adequate randomisation, allocation concealment, baseline similarity, blinding, follow-up completion and intention-to-treat analysis. Articles were assigned an overall grade of high, moderate or low quality evidence. Results Following searching of Medline, EMBASE

2019 Monash Health Evidence Reviews

132. Ustekinumab for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic, or have medical contrai

of ustekinumab versus other active therapies in UC have been conduct- ed. Ustekinumab versus placebo In the UNIFI induction trial of ustekinumab versus placebo in UC (Table 0.1), results were statisti- cally significant for both induction doses of ustekinumab (~6 mg/kg and 130 mg) for all primary and major secondary efficacy endpoints, including clinical remission, clinical response, endoscop- ic healing and mucosal healing (combination of endoscopic and histologic evidence of healing) at week 8 (all p 1 (...) FOR DIAGNOSIS AND MANAGEMENT 128 APPENDIX 2: DETAILS METHOD AND RESULTS SECTIONS OF MAIN TEXT 131 APPENDIX 3: EVIDENCE GAPS 229 PTJA07 - Ustekinumab for active ulcerative colitis October 2019 EUnetHTA Joint Action 3 WP4 4 LIST OF TABLES AND FIGURES Tables Table 0.1. UNIFI-I trial of ustekinumab versus placebo: summary of results for outcomes (clinical response, clinical remission, endoscopic healing) at week 8 in the ITT analysis 15 Table 0.2. UNIFI-M trial of ustekinumab versus placebo: summary of results

2020 EUnetHTA

134. Nosebleed (Epistaxis) Full Text available with Trip Pro

, as the guideline development group (GDG) felt that very young, otherwise healthy children rarely required evaluation for nosebleeds. The group also recognized that literature informing treatment of nosebleeds in infants and toddlers was scant. Additionally, while bleeding from the nose may occur secondary to a variety of systemic diseases and head and neck disorders, this guideline does not apply to patients who have a diagnosed bleeding disorder, tumors of the nose or nasopharynx, vascular malformations (...) , and statement of costs. Additionally, there is an explicit statement of any value judgments, the role of patient preferences, clarification of any intentional vagueness by the panel, exclusions to the statement, any differences of opinion, and a repeat statement of the strength of the recommendation. Several paragraphs subsequently discuss the evidence base supporting the statement. presents an overview of each evidence-based statement in this guideline. Table 4. Summary of Evidence-Based Statements. Table

2020 American Academy of Otolaryngology - Head and Neck Surgery

135. Opioid Treatments for Chronic Pain

and Burden of Chronic Pain Chronic pain, often defined as pain lasting longer than 3 to 6 months, or past the time of normal tissue healing, is common. 1 The Centers for Disease Control and Prevention (CDC) estimates that 20.4 percent of U.S. adults in 2016 had chronic pain and 8.0 percent had high impact (resulting in limitations in major life domains) chronic pain. 2 Chronic pain is associated with an annual cost conservatively estimated at $560 to $635 billion, can result in impaired physical

2020 Effective Health Care Program (AHRQ)

136. Nonopioid Pharmacologic Treatments for Chronic Pain

: An Update. Rockville, MD: Agency for Healthcare and Research Quality; Forthcoming. 18. Busse J, Guyatt G, Carrasco A. The 2017 Canadian Guideline for Opioids for Chronic Non-Cancer pain. Hamilton, ON: McMaster University; 2017. 1 Background and Objectives Understanding Chronic Pain Chronic pain is typically defined as pain lasting at least 3 to 6 months or that which persists past the time for normal tissue healing. 1 From a strictly biological perspective, pain is activation of the sensory nervous

2020 Effective Health Care Program (AHRQ)

138. AACE Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis

maintaining the quality of life for people with osteopo- rosis. The guidelines use the best evidence, taking into consideration the economic impact of the disease and the need for efficient and effective evaluation and treatment of postmenopausal women with osteoporosis. The intent is to provide evidence-based information about the diag- nosis, evaluation, and treatment of postmenopausal osteo- porosis for endocrinologists, physicians in general, regu- latory bodies, health-related organizations (...) . Reprinted with permission from Mechanick et al. Endocr Pract. 2017;23:1006-1021 (1). Table 2 2017 AACE Protocol for Production of Clinical Practice Guidelines Revised Evaluation of Studies (Step II: Scientific Analysis and Subjective Factors) Study design Data analysis Interpretation Allocation concealment (randomization) Intent-to-treat Generalizability Blinding Modeling (e.g., Markov) Incompleteness Comparator group Network analysis Logical Endpoints (real clinical vs. surrogate) Statistics Overstated

2020 American Association of Clinical Endocrinologists

139. Guideline on the management of patients with giant cell arteritis Full Text available with Trip Pro

performed in PMR at presentation. Need for the guideline As GCA is considered a medical emergency, it is treated at the point of diagnosis by clinicians in primary and secondary care who have a wide variety of clinical backgrounds. It is therefore necessary to provide clear guidance about current best practice and the underlying evidence including areas of uncertainty. Recent years have seen new evidence emerge regarding the diagnosis and treatment of GCA. For this reason, a major revision to the 2010 (...) of age [ ], generalizability below this age limit cannot be assured. Areas the guideline does not cover Takayasu arteritis and other forms of vasculitis (e.g. secondary large vessel vasculitis) are not covered by this guideline. The treatment of uncomplicated PMR is outside the scope of this guideline; readers are referred to the most recent BSR and ACR/EULAR guidance on the management of PMR [ , ]. Guidance regarding immunizations and prophylaxis of glucocorticoid-induced osteoporosis is available

2020 British Society for Rheumatology

140. BTS Guideline for Long Term Macrolide Use

and PEFR deterio- ration. 4 25 Exacerbation rate is the definitive outcome measure in regard to the clinical efficacy of macrolides in other respi- ratory diseases, and the major purported driver for their use in cystic fibrosis, bronchiectasis and COPD. 14 T wo studies 30 40 have been specifically designed to address this question in asthma. In other studies, exacerbations have been measured as a secondary outcome, with differing definitions between studies and insuf- ficient statistical power

2020 British Thoracic Society

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