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Healing by Secondary Intention

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121. Evidence Map - Art Therapy

among women with breast cancer. Palliative & supportive care. 2006;4(1478-9515 (Print)):57-64. 26. Radl DM. The effects of Self-Book(c) art therapy on emotional distress in female cancer patients: A randomized controlled trial. Dissertation Abstracts International: Section B: The Sciences and Engineering S2- Dissertation Abstracts International. 2016;76(9-B(E)). 27. Warson E. Healing pathways: art therapy for American Indian cancer survivors. Journal of cancer education : the official journal (...) al. Moderating factors for the effectiveness of group art therapy for schizophrenia: secondary analysis of data from the MATISSE randomised controlled trial. Pain Med 2014 Apr;15 Suppl 1:S66-75 doi: 101111/pme12409. 2014;49(1433-9285 (Electronic)):1703-1710. 62. Richardson P, Jones K, Evans C, Stevens P, Rowe A. Exploratory RCT of art therapy as an adjunctive treatment in schizophrenia. Journal of Mental Health. 2007;16(4):483-491. 63. Attard A, Larkin M. Art therapy for people with psychosis

2019 Veterans Affairs Evidence-based Synthesis Program Reports

122. Effects of trauma-informed approaches in schools: A systematic review (Full text)

of article. I have read and accept the Wiley Online Library Terms and Conditions of Use. Shareable Link Use the link below to share a full-text version of this article with your friends and colleagues. Copy URL Share a link Share on ). While the intent of creating trauma‐informed approaches in schools is a noble one, relatively little is known about the benefits, costs, and how trauma‐informed approaches are being defined and evaluated (Berliner & Kolko, ). Adopting a trauma‐informed approach (...) of trauma, respond by integrating knowledge about trauma policies and practices, and seeks to reduce retraumatization. At least two of the three key elements of a trauma‐informed approach must have been present: Workforce development, trauma‐focused services, and organizational environment and practices, which differ from trauma‐specific interventions designed to treat or otherwise address the impact/symptoms of trauma and facilitate healing. What is the aim of this review? This Campbell systematic

2019 Campbell Collaboration

123. Guidelines on Diabetes, Pre-Diabetes and Cardiovascular Diseases developed in collaboration with the EASD (Full text)

Management of blood pressure lowering 20 6.3.2.1 Effects of lifestyle intervention and weight loss 20 6.3.2.2 Pharmacological treatments 20 6.3.2.3 Blood pressure changes with glucose-lowering treatments 20 6.4 Lipids 21 6.4.1 Lipid-lowering agents 21 6.4.1.1 Statins 21 6.4.1.2 Ezetimibe 22 6.4.1.3 Proprotein convertase subtilisin/kexin type 22 6.4.1.4 Fibrates 22 6.5 Platelets 23 6.5.1 Aspirin 23 6.5.1.1 Primary prevention 24 6.5.1.2 Secondary prevention 24 6.6 Multifactorial approaches 24 6.6.1

2019 European Society of Cardiology

124. Guidelines on Chronic Coronary Syndromes (Full text)

in asymptomatic apparently healthy subjects (primary prevention) and patients with established chronic coronary syndromes (secondary prevention) 21 Figure 7 The five As of smoking cessation 24 Figure 8 Suggested stepwise strategy for long-term anti-ischaemic drug therapy in patients with chronic coronary syndromes and specific baseline characteristics 28 Figure 9 Decision tree for patients undergoing invasive coronary angiography 36 Figure 10 Proposed algorithm according to patient types commonly observed (...) tomography-based fractional flow reserve GEMINI- ACS A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome GFR Glomerular filtration rate GLS Global longitudinal strain GOSPEL Global secondary prevention strategies to limit event recurrence after myocardial infarction HbA1c Glycated haemoglobin HF Heart failure ICA Invasive coronary angiography IMR Index of microcirculatory resistance

2019 European Society of Cardiology

125. Sutures v staples for skin closure in lower limb orthopaedic surgery: A Rapid Review

was searched using Google (Table 2). Titles and abstracts identified were exported to EndNote X7 (Thompson, Reuters, Carlsbad, California, USA). Papers identified were screened using inclusion and exclusion criteria established a priori (Table 3). Searches of Medline, EMBASE, Cochrane Library, NICE and Google were screened by one reviewer (CJ). Secondary searching of reference lists and citing articles was also performed to ensure any other studies not identified through the searching were discovered (...) . Quality Appraisal To keep in line with the previous review, (1) one author (CJ) replicated and performed a quality appraisal of any new trials so that a comparison with any current evidence was possible. Studies were critically appraised for adequate randomisation, allocation concealment, baseline similarity, blinding, follow-up completion and intention-to-treat analysis. Articles were assigned an overall grade of high, moderate or low quality evidence. Results Following searching of Medline, EMBASE

2019 Monash Health Evidence Reviews

127. Diagnosis and management of gonorrhoea and syphilis

and syphilis 1 ? TABLE OF CONTENTS LIST OF FIGURES 7 LIST OF TABLES 8 LIST OF ABBREVIATIONS 11 ? SCIENTIFIC REPORT 14 1 INTRODUCTION 14 1.1 BACKGROUND 14 Etiology, transmission, clinical features and epidemiological trends 14 Notification of infectious diseases in Belgium 21 1.2 THE NEED FOR A NATIONAL GUIDELINE 22 1.3 SCOPE 23 1.4 REMIT OF THE GUIDELINE 24 Overall objectives 24 Patient-centred care 24 Policy relevance and target users of the guideline 24 1.5 STATEMENT OF INTENT 25 1.6 FUNDING (...) oral-anal or genital-anal contact. Intravenous drug use (sharing needles) and blood transfusion (rare as routine screening is performed and treponemal survival beyond 24–48h at 4°C is unlikely) are also potential routes of transmission. 6 The stages of syphilis are presented in Table 2. After infection, patients present with signs of early primary disease. Untreated, 25% of patients will develop signs of early secondary syphilis. Secondary syphilis will resolve spontaneously in 3–12 weeks

2019 Belgian Health Care Knowledge Centre

129. Juxta Range of Products (Juxtacures, Juxtalite, Juxtafit)

size, improved healing or improved quality of life for patients. The evidence for Juxtalite is lacking, with one case study submitted by the manufacturer reporting fast healing and a significant reduction in exudate in one patient. Based on this low quality and non-comparative evidence it is not possible to determine how these products compare with traditional multilayer bandages in their effectiveness at healing leg ulcers. For Juxtafit, the evidence is more developed, with two randomised (...) controlled trials (RCTs) demonstrating that Juxtafit achieves a significantly better short-term reduction in leg volume compared to traditional multi-layered compression bandages in patients with moderate to severe lymphoedema and chronic venous oedema. The trials had a very short follow-up (24h and 7 days), small sample sizes, and the demonstrated reduction in wound volume does not necessarily equate to healing – an issue noted by clinical experts. Economic considerations The unit cost of Juxta products

2018 Scottish Health Technologies Group - Innovative medical technology overviews

130. The Patient Centred Medical Home: barriers and enablers to implementation

• Incorporating new roles into the practice, such as community care worker, clinical pharmacist, medical assistant. 10 THE PATIENT CENTRED MEDICAL HOME: BARRIERS AND ENABLERS TO IMPLEMENTATION | SAX INSTITUTE Component of change and why it’s important Barriers/challenges Enablers Teamwork: Key feature of the PCMH model and central to achieving quality care. • Lack of intentional focus on developing teams • Preoccupation with data/measurement • Workflow is too prescriptive • Inadequate re-distribution of tasks (...) systems for care coordination • Lack of dedicated care-coordination position(s) • Lack of knowledge amongst primary care providers about the availability of community supports, and lack of infrastructure to support collaboration between primary care and community services • Lack of specialty care or hospital involvement with patient care and other linkages between secondary and tertiary care • Inability to share patient information across different providers and organisations. • Use of mechanisms

2018 Sax Institute Evidence Check

131. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

intent-to-treat MRC Medical Research Council MRD minimal residual disease MS mass spectrometry MS/MS tandem mass spectrometry NAc N-acetyl MCB Master Cell Bank NCCN National Comprehensive Cancer Network NCI National Cancer Institute NCRI National Cancer Research Institute NDA New Drug Application NE not estimable NEC not elsewhere classified NMR nuclear magnetic resonance spectroscopy No GO chemotherapy alone, without GO NOPHO Nordic Society of Paediatric Hematology and Oncology NPM nucleophosmin (...) and peripheral blood, which leads to anaemia, neutropenia, and thrombocytopenia. This is associated with symptoms of fatigue, shortness of breath, disturbed wound healing, infections and bleedings. If left untreated, AML results in death within a few weeks to months. Long-term survival in adult patients with AML is only 35% to 40% for patients =60 years of age, and drops to 5% to 15% in patients who are >60 years of age. (6) The majority of patients with AML will have relapsed disease within 3 years. (7

2018 European Medicines Agency - EPARs

132. Recommendations for the Delivery of Psychosocial Oncology Services in Ontario

Regional Cancer Programs continue to consistently use symptom screening tools as a component of the screen for PSO needs. 2.2 All sites develop an inter-professional approach for responding to clinically significant screening for all issues and/ or elevated symptom screen scores. Teams consider secondary assessment tools for elevated scores. 2.3 Symptom screens be addressed routinely at clinic visits; the symptom scores should be acknowledged followed by assessment, interventions and referral (...) for this report are clinicians and administrators from the Regional Cancer Programs and Cancer Care Ontario. The secondary audiences are patients and families, community-based organizations, and provincial and federal organizations. This recommendation report provides a comprehensive overview and articulates the need for necessary PSO services across Ontario. It is intended to foster further discussions and consultation within Regional Cancer Programs about the “how” to improve PSO service delivery

2018 Cancer Care Ontario

133. Proton beam therapy in adults

3.3.6 Locally recurrent rectal cancer 20 3.3.7 Key points 20 3.4 SAFETY 21 3.4.1 Low-grade glioma 21 3.4.2 Primary sinonasal tumours and recurrences of head & neck tumours 22 3.4.3 Breast cancer 23 3.4.4 Pancreatic cancer 24 3.4.5 Hepatocellular cancer 25 3.4.6 Locally recurrent rectal cancer 28 3.4.7 Key points 28 3.5 SECONDARY TUMOURS 29 3.6 ONGOING TRIALS 29 4 DISCUSSION 31 4.1 SCARCE AND FLAWED EVIDENCE ON THE EFFECTIVENESS OF PROTON TREATMENT 31 4.2 UNCERTAINTY ABOUT THE SAFETY OF PROTON (...) TREATMENT 32 4.3 FEW DATA ON SECONDARY TUMOURS 32 4.4 SOME RCTS UNDERWAY, BUT NOT IN THE VERY NEAR FUTURE 33 4.5 LIMITATIONS OF THIS REPORT 33 ? REFERENCES 34 KCE Report 307 Proton beam therapy in adults 3 LIST OF TABLES Table 1 – Reimbursed adult indications for Proton Beam Therapy and Carbon Ion Therapy in Belgium 7 Table 2 – Incidence (2016) and survival (2012-2016) of selected non-reimbursed indications for Proton Beam Therapy in Belgium 9 Table 6 – Overview of included single-arm studies (reported

2019 Belgian Health Care Knowledge Centre

134. Darvadstrocel (Alofisel) - Rectal Fistula

for allogeneic eASC is based on immune modulatory and anti-inflammatory properties. Inflammatory cytokines, in particular IFN-? produced by activated immune cells (i.e., lymphocytes), activate eASC in a mechanism which requires induction of indoleamine 2,3-dioxygenase expression. Once activated, eASC suppress proliferation of lymphocytes and inhibit the release of pro-inflammatory cytokines. This immunoregulatory activity reduces inflammation, which may allow the tissues around the fistula tract to heal (...) of new fistulas”. It was considered that the optimum endpoint for demonstrating remission at week 24 would be the combination of complete healing (no discharge after gentle pressing) with complete MRI based closure of the fistulae. The primary efficacy endpoint utilized in the pivotal study deviates from this recommendation and respective guideline, because it was defined as clinical closure of external openings that were draining at baseline despite gentle finger compression and absence

2018 European Medicines Agency - EPARs

135. School-based interventions for reducing disciplinary school exclusion

examined these programmes’ overall effectiveness. OBJECTIVES The main goal of the present research is to systematically examine the available evidence for the effectiveness of different types of school-based interventions aimed at reducing disciplinary school exclusion. Secondary goals include comparing different approaches and identifying those that could potentially demonstrate larger and more significant effects. The research questions underlying this project are as follows: • Do school-based (...) section 9.1 in appendix. 4.1.7 Description of the interventions Table 10 provides a description of the included school-based programmes targeting school exclusion as a primary or secondary outcome. In some specific cases this grouping could be restrictive, because some of the interventions involve multiple components, however we have attempted to create an exhaustive list of categories. 61 The Campbell Collaboration | www.campbellcollaboration.org Table 10: Types of intervention programmes Programme

2018 Campbell Collaboration

136. Bevacizumab (Mvasi) - Cancer, colon, breast, lung, kidney, ovary, cervix

particle counting HIC hydrophobic interaction chromatography HPLC high-performance liquid chromatography HUVEC human umbilical vein endothelial cells HWP high molecular weight ICF informed consent form ICH International Conference on Harmonisation IEC Independent Ethics Committee Ig immunoglobulin IP investigational product IPC in-process control IRB Institutional Review Board ITT intent-to-treat IV intravenous IXRS interactive voice and web response system KM Kaplan-Meier LC light chain LC-MS/MS (...) . Characterisation The elucidation of structure studies were conducted using ABP 215 active substance manufactured at ATO using the intended commercial process and scale. Characterization included biochemical studies (primary structure, glycosylation, disulfide structure, charge variants and size variants), biophysical studies (secondary structure, tertiary structure and thermal stability), biological studies (mechanism of action, including antigen specificity and Fc functionality) and forced degradation studies

2018 European Medicines Agency - EPARs

137. The Foyer model for homeless youth: a systematic mapping review

). For the purpose of this systematic mapping review, we follow the definition for Foyer Model provided by the Australian Government through the National Homelessness Re- search Agenda of the Department for Families, Housing, Community Services and Indig- enous Affairs (2): “The Foyer Model provides a package of accommodation and support to young people aged between 16 and 24, who are homeless (in situations of primary, secondary and tertiary homelessness) or at risk of becoming homeless. Typically, resi- dents (...) criterion was therefore a substantial emphasis on the Foyer model as the subject matter. Additionally, the people receiving foyer must be young people (15–25 years old) who are homeless or at-risk of homelessness. In terms of the population, we adopted the definitions of primary, secondary and tertiary homelessness provided by Steen and Mackenzie in Australia (2), and the definition of at-risk of homelessness provided by the US Department of Housing and Urban Development (10). See glossary in Appendix 1

2018 Norwegian Institute of Public Health

138. Effectiveness of alcohol and other drug interventions in at-risk Aboriginal youth

at risk of AOD related harm, located in metropolitan, rural and regional locations in NSW. The aim is to develop a primary and/or secondary prevention program based in the community or in justice settings, rather than an individual treatment focus in clinical settings. While a population-based approach is ideal, only some interventions will be feasible within the project’s budget and time constraints; others, for example, those with a primary focus on school-based interventions and policy-based (...) questionnaire. Relative to controls, participants receiving the intervention drank less often, less per drinking occasion, less overall and had fewer academic problems. McKennitt et al. 14 conducted a pilot study using a RCT design to ascertain the extent to which a modified school- based program had on future smoking intentions among American Indian children. The study involved 18 Indigenous students in Grade 4. Two schools were randomised to either a culturally sensitive or a standard smoking prevention

2018 Sax Institute Evidence Check

139. PTSD

Oxygen Therapy for TBI and PTSD Health Services Research & Development Management eBrief no. 143 » Issue 143 April 2018 The report is a product of the VA/HSR&D Quality (...) Enhancement Research Initiative (QUERI) Evidence-Based Synthesis Program. Evidence Brief: Hyperbaric Oxygen Therapy for Traumatic Brain Injury and/or PTSD Following certain types of injuries, our bodies may demand more oxygen than is available in the normal air we breathe to supply our cells with the fuel necessary for healing (...) and therapy Behav Res Ther A pilot randomized controlled trial of Dialectical Behavior Therapy with and without the Dialectical Behavior Therapy Prolonged Exposure protocol for suicidal (...) and self-injuring women with borderline personality disorder and PTSD . 7-17 10.1016/j.brat.2014.01.008 S0005-7967(14)00015-1 This study evaluates the efficacy of integrating PTSD treatment into Dialectical Behavior Therapy (DBT) for women with borderline personality disorder, PTSD , and intentional self-injury

2018 Trip Latest and Greatest

140. Infliximab

, that is, top-down, will give more mucosal healing, fewer relapses, less complications, need for surgery and hospitalisation. This international multicentre open-label 2017 10. Comparison Of iNfliximab and ciclosporin in Steroid Resistant Ulcerative Colitis: pragmatic randomised Trial and economic evaluation (CONSTRUCT) Journals Library Journals Library An error has occurred in processing the XML document An error has occurred in processing the XML document An error has occurred in processing the XML (...) patients taking placebo were given the opportunity to cross over to IFX, and an observational phase. Primary treatment efficacy was based on HS Severity Index. Secondary end points included 2010 16. Infliximab versus methotrexate, etanercept, adalimumab, and ustekinumab for plaque psoriasis: a review of the comparative clinical efficacy, safety and cost effectiveness Infliximab versus methotrexate, etanercept, adalimumab, and ustekinumab for plaque psoriasis: a review of the comparative clinical

2018 Trip Latest and Greatest

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