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Healing by Secondary Intention

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101. Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses

Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé Supporting Informed Decisions CADTH Technology Report Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary (...) Syndrome or Peripheral Vascular Disease: Clinical and Cost-Effectiveness Analyses Issue 133 November 2010Until April 2006, the Canadian Agency for Drugs and Technologies in Health (CADTH) was known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Cite as: Banerjee S, Brown A, McGahan L, Asakawa K, Hutton B, Clark M, Severn M, Sharma M, Cox JL. Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary Syndrome

2011 EvidenceUpdates

102. Review: evidence on the effectiveness of honey for healing wounds is limited

Dr A B Jull, University of Auckland, Auckland, New Zealand; a.jull@ctru.auckland.ac.nz QUESTION Does topical honey improve rate of healing of acute and chronic wounds? REVIEW SCOPE Included studies compared topical honey, alone or in combination with other dressing components, with dressings or other topical agents for healing acute wounds (burns, lacerations, and other traumatic wounds) and chronic wounds (venous or pressure ulcers and infected wounds healing by secondary intention (...) Review: evidence on the effectiveness of honey for healing wounds is limited Review: evidence on the effectiveness of honey for healing wounds is limitedCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts

2009 Evidence-Based Nursing

103. Plus Sutures for preventing surgical site infection

place in therapy would be as an alternative to standard care for people who need wound closure after a surgical procedure. The main points from the evidence main points from the evidence summarised in this briefing are from 7 studies, including 3 meta-analyses, 1 systematic review and 3 randomised controlled trials including adults and children in a secondary care setting. Most studies found Plus Sutures more effective than standard care sutures in reducing surgical site infections. Key (...) and children. It should not be used in people with known allergies to triclosan. All absorbable sutures, including Plus Sutures, may not be appropriate for older people, or people who are malnourished, debilitated or have conditions that could delay wound healing. Innovations Innovations Plus Sutures differ from currently available sutures because they are coated with triclosan, an Plus Sutures for preventing surgical site infection (MIB204) © NICE 2020. All rights reserved. Subject to Notice of rights

2020 National Institute for Health and Clinical Excellence - Advice

104. Surgical site infections: prevention and treatment

healing b Dressings for wound healing by secondary intention y secondary intention 1.4.6 Do not use Eusol and gauze, or moist cotton gauze or mercuric antiseptic solutions to manage surgical wounds that are healing by secondary intention. [2008] [2008] 1.4.7 Use an appropriate interactive dressing to manage surgical wounds that are healing by secondary intention. [2008] [2008] 1.4.8 Ask a tissue viability nurse (or another healthcare professional with tissue viability expertise) for advice (...) on appropriate dressings for the management of surgical wounds that are healing by secondary intention. [2008] [2008] Antibiotic treatment of surgical site infection and treatment failure Antibiotic treatment of surgical site infection and treatment failure 1.4.9 When surgical site infection is suspected by the presence of cellulitis, either by a new infection or an infection caused by treatment failure, give the patient an antibiotic that covers the likely causative organisms. Consider local resistance

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

105. The V.A.C. Veraflo Therapy system for infected wounds

the evidence vidence summarised in this briefing are from 5 studies: a randomised control trial, 3 cohort studies with historic cohort control and a retrospective data analysis, including a total of 357 adults with acutely infected or chronic wounds in a secondary care setting. They show that the V.A.C. Veraflo Therapy system is more effective than standard care, including moist wound care and normal NPWT, in treating acutely infected or chronic non-healing wounds. K Ke ey uncertainties y uncertainties (...) The V.A.C. Veraflo Therapy system for infected wounds The V The V .A. .A.C. V C. Ver eraflo Ther aflo Therap apy system for infected y system for infected wounds wounds Medtech innovation briefing Published: 2 September 2019 www.nice.org.uk/guidance/mib189 pathways Summary Summary The technology technology described in this briefing is the V.A.C. Veraflo Therapy system. It is used to promote healing in chronic and acutely infected wounds. The inno innovativ vative aspects e aspects

2019 National Institute for Health and Clinical Excellence - Advice

106. Canadian guidelines on opioid use disorder among older adults

in hospitalizations related to opioid poisonings. Most opioid poisonings in adults in Canada are accidental; however, 30% are intentional. (16) A recent study found that in older adults, opioid misuse was associated with increased odds of suicidal ideation. (17) According to a US national survey in 2016, 0.8% of adults surveyed met Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria for OUD in the past year. (18) There are no comparable Canadian studies that use DSM criteria (...) for both primary and secondary prevention. These issues are outlined in the questions (A & B) and addressed in the recommendations (1–9) listed below. Question A: In older adults, what measures can reduce the risk of developing an OUD? Recommendation 1 In order to avoid the risk of developing an OUD, older adults with acute pain in whom opioids are being considered should receive the lowest effective dose of the least potent immediate release opioid for a duration of = 3 days and rarely > 7 days

2020 CPG Infobase

107. An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model. (Abstract)

kinase 5, because this class of inhibitors has been demonstrated to be effective in minimizing fibrosis in other organs.The rodent model of cutaneous healing consists of uniform full-thickness incisional dermal wounds in rats. Wounds were allowed to heal by secondary intention, generally over a 14-day period. The usefulness of the model was tested by the application of an activin receptor-like kinase 5 inhibitor, CP-639180. Activin receptor-like kinase 5 inhibition antagonizes the transforming growth (...) An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model. Excessive dermal scarring is characterized by an overabundant deposition of extracellular matrix caused by fibrosis. The purpose of this study was to modify a rodent model of cutaneous healing for use in the development of compounds to minimize scarring, and to test the model with a small molecule inhibitor of transforming growth factor-β type I receptor, activin receptor-like

2011 Plastic and reconstructive surgery

108. Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation. Full Text available with Trip Pro

left to heal by secondary intention. The study included an uninfected control group that did not receive any treatment, a contaminated group that did not receive any treatment, and two contaminated groups treated with intraperitoneal tigecycline (2 mg/kg) and teicoplanin (7 mg/kg), respectively.All antibiotic treatments were significantly effective. Tigecycline showed the highest antimicrobial activity, with a better impact on histological results. Infected rats treated with tigecycline showed (...) Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation. We investigated the in vivo efficacy of tigecycline, a new glycylcycline (a tetracycline derivative), in the management of methicillin-resistant Staphylococcus aureus (MRSA)-infected experimental surgical wounds in rats. The main outcome measures were quantitative bacterial culture, histological examination and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9

2011 Journal of Antimicrobial Chemotherapy

109. Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143)

Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143) Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Biomarkers (...) of Intestinal Mucosal Healing in Crohn's Disease (P08143) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01349920 Recruitment Status : Completed First Posted : May 9, 2011 Results First Posted : September 28, 2016 Last Update Posted : October 15, 2018 Sponsor: Merck Sharp & Dohme Corp. Information provided

2011 Clinical Trials

110. Suicide postvention services

of its components were rated as weak. 57 In addition, the instrument assesses the integrity of the intervention and analyses (for example, analysis by intention to treat status). Two researchers (KKr, KA) independently assessed the quality of the included studies and settled any disagreement through discussion. Grey literature Search strategy In consultation with the commissioning agency it was decided to include searches for guidelines for postvention service delivery in the grey literature searches (...) after the loss was the best time for participating Approx. 92% rated the Quilt project as helpful or extremely helpful Qualitative analysis of the interviews found four themes: healing, creating opportunity for dialogue, reclaiming the real person, and raising public awareness Sample: mostly female, self- selected (55% response rate) People who participate in Quilt projects not necessarily representative Grief was not assessed Descriptive study No control group Scocco et al. (2019) 70 . Mindfulness

2020 Sax Institute Evidence Check

111. Convalescent Plasma Therapy for the Treatment of COVID-19 : A Review of Clinical Effectiveness

for COVID-19 is currently available only as an investigational drug treatment for participants in the CONCOR-1 clinical trial. 16 To be eligible for the clinical trial participants must be admitted to a participating hospital, diagnosed with confirmed COVID- 19 respiratory illness, and be receiving supplemental oxygen without intubation. 17 The CONCOR-1 clinical trial is currently underway and involves more than 50 hospitals across Canada with the intention to recruit 1,500 participants. 15 Preliminary (...) in the RCT by Li et al. 1 was the time to clinical improvement within 28 days. Clinical improvement was defined as either hospital discharge or two-point reduction in a six-point disease severity scale used in other COVID-19 trials (scores ranged from 1 [hospital discharge] to 6 [death]). 26 Secondary outcomes considered in the study were 28- day mortality, duration of hospital stay and viral clearance using PCR test in nasopharyngeal swabs assessed at 24, 48 and 72 hours. The pilot study by Duan

2020 Canadian Agency for Drugs and Technologies in Health - Rapid Review

112. Tigecycline

with a physician with appropriate experience in the management of infectious diseases. 3 Children aged 8 to 15 (3.3 %), or with surgically apparent multiple intra-abdominal abscesses (11.4 %). Limited experience is also available in treating patients with concurrent bacteraemia (5.6 %). Therefore, caution is advised when treating such patients. Consideration should be given to the use of combination antibacterial therapy whenever tigecycline is to be administered to severely ill patients with cIAI secondary (...) consecutive days, with the option to be switched to an oral antibiotic on or after day 4. Clinical cure was assessed between 10 and 21 days after the administration of the last dose of treatment. The summary of clinical response in the modified intent-to-treat (mITT) population results is shown in the following table. Clinical Cure, mITT Population 0.75 mg/kg 1 mg/kg 1.25 mg/kg Indication n/N (%) n/N (%) n/N (%) cIAI 6/6 (100.0) 3/6 (50.0) 10/12 (83.3) cSSTI 3/4 (75.0) 5/7 (71.4) 2/4 (50.0) Overall 9/10

2020 European Medicines Agency - EPARs

113. Community-based health promotion for older adults

or attributable to positive changes) 1 Some programs delivered by health professionals could be delivered in the community setting by trained support staff when programs are relatively simple to conduct COMMUNITY-BASED HEALTH PROMOTION FOR OLDER ADULTS APRIL 2019 | SAX INSTITUTE 7 The majority of the studies concluded that there are positive differences in favour of combined interventions in some primary and secondary outcomes between the intervention and control groups, at least in the short term (...) activities (self-reported and measured) Balance and strength Psycho-social health and well-being (self-reported and measured) Behaviours related to key health risk factors: Knowledge and understand of healthy behaviours Intention to change behaviours Changes in behaviours (related to key health risk factors) Presence of key health risk factors Long term sustainability Of outcomes for participants Of program in terms of delivery and fidelity Program reach and acceptability COMMUNITY-BASED HEALTH PROMOTION

2020 Sax Institute Evidence Check

114. PICO negative pressure wound therapy for closed surgical incision wounds

the presence of superficial or deep infections may result in wounds opening or a wound separating along the incision. If a deep infection is ruled out, sometimes a NPWT may be used to manage the dehisced surgical wound to promote healing by secondary intention. Population, setting and intended user PICO would be used in place of conventional post-surgical wound dressings to prevent and treat SSIs in closed surgical incision wounds with low exudate levels. It would be applied by healthcare professionals (...) PICO negative pressure wound therapy for closed surgical incision wounds PICO negativ PICO negative pressure wound ther e pressure wound therap apy for y for closed surgical incision wounds closed surgical incision wounds Medtech innovation briefing Published: 15 June 2018 nice.org.uk/guidance/mib149 pathways Summary Summary The technology technology described in this briefing is the PICO single-use negative pressure wound therapy system. It is intended to promote healing in closed surgical

2018 National Institute for Health and Clinical Excellence - Advice

115. Wound healing Full Text available with Trip Pro

that they are adjacent to each other (re-approximated). Wound closure is performed with sutures (stitches), staples, or adhesive tape or glue. Primary intention can only be implemented when the wound is precise and there is minimal disruption to the local tissue and the epithelial basement membrane, e.g. surgical incisions. This process is faster than healing by secondary intention. There is also less scarring associated with primary intention, as there are no large tissue losses to be filled with granulation tissue (...) . (Primary intention does require some granulation tissue to form.) Examples of primary intention include: well-repaired , well reduced , healing after . Secondary intention [ ] Secondary intention is implemented when primary intention is not possible. This is due to wounds being created by major trauma in which there has been a significant loss in tissue or tissue damage. The wound is allowed to granulate. Surgeon may pack the wound with a gauze or use a drainage system. Granulation results in a broader

2012 Wikipedia

116. Canadian guidelines on opioid use disorder among older adults

: Strong] RECOMMENDATION #28: Contingency management may be offered as part of opioid treatment programs and used if accepted by the patient. [GRADE Quality: Moderate; Strength: Weak] QUESTION J: For older adults with an OUD, what are the treatment considerations for special populations (specifically indigenous peoples)? RECOMMENDATION #29: Traditional healing practices used by indigenous communities can be integrated with buprenorphine treatment to improve outcomes for an OUD. [GRADE Quality: Low (...) ) . As well, during opioid withdrawal, pain can return to old healed injury sites (called withdrawal-associated injury site pain), and it may take weeks to months for pain sensitivity to normalize after opioids are discontinued (Rieb et al ., 2016; 2018) . These issues are particularly important for older adults, since 30% to 40% of older adults suffer from chronic pain, a condition that becomes increasingly prevalent until the age of 85 . As the baby boomer population ages, the use of opioids to treat

2019 CPG Infobase

117. Bariatric surgery in Belgium: organisation and payment of care before and after surgery

be structured depending on its location (a) if in primary or community care it is separate from the surgical MDT and refers in as a hub and spoke and (b) if in secondary care most team members are likely shared between the clinics. Welbourn 2018 41 166 KCE Report 329 Bariatric surgery in Belgium 7 LIST OF TABLES Table 1 – Billing codes for medical fees (Bariatric surgery) 20 Table 2 – Evolution of bariatric surgery in Belgium (2009 - 2017): number of first surgeries since the start of the specific

2020 Belgian Health Care Knowledge Centre

119. Glinides and glitazones in the treatment of type 2 diabetes

POLICY CONTEXT Purpose and Scope: This short report provides a focused assessment of the comparative effectiveness and safety of two glinides (repaglinide and nateglinide) and one glitazone (pioglitazone) for treatment of type 2 diabetes mellitus (T2DM). It summarizes and critically appraises eligible full-text, peer-reviewed, published evidence with the intent of drawing evidence-based conclusions. This short report is intended to summarize evidence for patient-centered clinical outcomes related (...) 2423 . Epidemiology: The prevalence of T2DM is projected to affect more than 500 million adults worldwide by 2030 9 . The disease caused four million deaths worldwide in 2017. An estimate of 500’000 people suffer from diabetes in Switzerland, of which 460’000 are affected by T2DM 25 . Clinical Presentation: Signs and symptoms of T2DM may include thirst, frequent urination, delayed healing, fatigue, and blurred vision 11 . However, these signs may be subtle, delaying diagnosis. T2DM can lead

2020 Swiss Federal Office of Public Health HTA

120. Liposuction for chronic lymphoedema

patients treated by liposuction for chronic lymphoedema. Blood transfusion was reported in 13% (2/15) of patients treated by liposuction in a case series of 15 patients (12 women, 3 men). 5.2 Localised skin loss and healing by second intention was reported in 13% (2/15) of patients in the case series of 15 patients (12 woman, 3 men) treated by liposuction. Wound infection needing surgical debridement was reported in 1 patient in the same case series. Marginal wound necrosis was reported in 1 patient (...) . It leads to chronic swelling that can cause disability, pain and cosmetic issues. Any part of the body can be affected, but the condition is most common in the arms and legs. Lymphoedema can be complicated by recurrent infection (cellulitis), which further damages the lymphatic vessels and aggravates the condition. Primary lymphoedema results from a congenital inadequacy and gradual occlusion of lymphatics. Secondary lymphoedema results from damage to the lymphatic system or removal of lymph nodes

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

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