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Healing by Secondary Intention

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101. Flii neutralizing antibodies improve wound healing in porcine preclinical studies. (PubMed)

mice which have impaired wound healing. For the first time, we show that a Flightless I neutralizing monoclonal antibody (FnAb) therapy is effective in a large animal model of wound repair. Porcine 5 cm incisional and 6.25 cm(2) excisional wounds were treated with FnAb at the time of wounding and for two subsequent days. The wounds were dressed in Tegaderm dressings and left to heal by secondary intention for 7 and 35 days, respectively. At the relevant end points, the wounds were excised (...) Flii neutralizing antibodies improve wound healing in porcine preclinical studies. Wound healing is an important area of widely unmet medical need, with millions of procedures carried out worldwide which could potentially benefit from a product to improve the wound repair process. Our studies investigating the actin-remodeling protein Flightless I (Flii) show it to be an important regulator of wound healing. Flii-deficient mice have enhanced wound healing in comparison to Flii overexpressing

2012 Wound Repair and Regeneration

102. Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer

Eligible for Study: 35 Years to 90 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adult males and females between 35 and 90 years of age Status post skin cancer removal on the scalp, ear or leg with a wound that would otherwise be allowed to heal by secondary intention or grafting Wound considered appropriate by physician to receive epidermal grafting Willingness to participate in study by evidence of informed consent Exclusion (...) micrografts to wounds that otherwise would have healed by second intention alone will hasten healing and possibly reduce scarring. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 12 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Use of the Epidermal Expansion System to Harvest and Place Suction Blister Epidermal Grafts on Wounds in Patients After Mohs

2012 Clinical Trials

103. Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments

with at first closed belly wounds with wound healing disorder in the postoperative course after surgery without an opening of the underlying layer of fibrous tissue are eligible to be included in the trial if the diagnosis of a wound healing impairment in the postoperative course is manifested as a wound with spontaneous dehiscence, a wound that requires an active reopening of the suture by the treating physician or a wound that cannot be closed by primary intention and requires further treatment to achieve (...) Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2012 Clinical Trials

104. The Effects of Healing Touch on Post Operative Pediatric Patients

Study Completion Date : February 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Healing Touch Treatment Healing Touch Treatment When enter PACU + usual standard of care. The Healing Touch practitioner will be at the bedside when the patient is first brought to the PACU. The HT practitioner will center and then attune with the child, connecting their energy with the child and setting the intention (...) will be at the bedside when the patient is first brought to the PACU. The HT practitioner will center and then attune with the child, connecting their energy with the child and setting the intention for healing for the child's highest good. The practitioner will then place one hand on the center of the patient's chest in the "high heart" area. The practitioner will hold this position until they feel a deep connection and "quieting" within the patient's energy. When the patient is awake and parents have been called

2012 Clinical Trials

105. 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites

research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Healthy Subjects Facial reconstruction surgery in the last 3 months Exclusion Criteria: Age less than 18 years Patients undergoing skin grafting Patients undergoing secondary intent closure Contacts and Locations Go to Information from (...) 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2012 Clinical Trials

106. Review: evidence on the effectiveness of honey for healing wounds is limited

Dr A B Jull, University of Auckland, Auckland, New Zealand; a.jull@ctru.auckland.ac.nz QUESTION Does topical honey improve rate of healing of acute and chronic wounds? REVIEW SCOPE Included studies compared topical honey, alone or in combination with other dressing components, with dressings or other topical agents for healing acute wounds (burns, lacerations, and other traumatic wounds) and chronic wounds (venous or pressure ulcers and infected wounds healing by secondary intention (...) Review: evidence on the effectiveness of honey for healing wounds is limited Review: evidence on the effectiveness of honey for healing wounds is limitedCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts

2009 Evidence-Based Nursing

107. Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars

Jun 25 2012 Posted by Classic wound closure following removal of impacted this molars involved the surgeon covering and hermitically closes the socket with a flap, allowing primary wound healing. Proponents of this approach suggest that it decreases the risk of post operative infection. the alternative approach is to allow healing by secondary intention. Those who prefer this approach suggest that it allows drainage of inflammatory exudate, because the socket remains in communication. The aim (...) Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars Search National Elf Service Search National Elf Service » » » » Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars

2012 The Dental Elf

108. Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation. (Full text)

left to heal by secondary intention. The study included an uninfected control group that did not receive any treatment, a contaminated group that did not receive any treatment, and two contaminated groups treated with intraperitoneal tigecycline (2 mg/kg) and teicoplanin (7 mg/kg), respectively.All antibiotic treatments were significantly effective. Tigecycline showed the highest antimicrobial activity, with a better impact on histological results. Infected rats treated with tigecycline showed (...) Tigecycline accelerates staphylococcal-infected burn wound healing through matrix metalloproteinase-9 modulation. We investigated the in vivo efficacy of tigecycline, a new glycylcycline (a tetracycline derivative), in the management of methicillin-resistant Staphylococcus aureus (MRSA)-infected experimental surgical wounds in rats. The main outcome measures were quantitative bacterial culture, histological examination and immunohistochemical expression of matrix metalloproteinase-9 (MMP-9

2011 Journal of Antimicrobial Chemotherapy

109. Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143)

Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143) Biomarkers of Intestinal Mucosal Healing in Crohn's Disease (P08143) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Biomarkers (...) of Intestinal Mucosal Healing in Crohn's Disease (P08143) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01349920 Recruitment Status : Completed First Posted : May 9, 2011 Results First Posted : September 28, 2016 Last Update Posted : October 15, 2018 Sponsor: Merck Sharp & Dohme Corp. Information provided

2011 Clinical Trials

110. Comparison of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. (Full text)

were analyzed there was statistically significant difference in pain, swelling and trismus experienced between both the groups.The findings of this study suggest that the procedure of choice after removal of impacted mandibular third molars is a secondary closure and healing by secondary intention. A secondary closure appears to minimize the postoperative edema, pain and trismus and thus contributes to enhanced patient comfort. (...) Comparison of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. This comparative study compares the primary and secondary healing after surgical removal of impacted mandibular third molars, evaluating and monitoring the extent of swelling and severity of pain and trismus.60 patients (37 females, 23 males; age range 18-40 years) were included in the series. The patients were randomly subdivided into 2 groups of 30 each. All the patients were

2013 Journal of maxillofacial and oral surgery Controlled trial quality: uncertain

111. Primary and secondary closure technique following removal of impacted mandibular third molars: A comparative study. (Full text)

by primary intention and in the Group B, by secondary closure. A comparison between both groups was done with a follow-up period of 6 h to 6 days with regards to postoperative pain and swelling.The statistical analysis (analysis of variance for repeated measures, P < 0.05) showed that pain was greater in Group A, although it decreased over time similarly in the two groups. Pain and swelling was less severe with secondary healing than with primary healing.The outcome of this study suggested that secondary (...) Primary and secondary closure technique following removal of impacted mandibular third molars: A comparative study. The purpose of this study was to evaluate and compare the post operative healing, using primary versus second closure techniques after impacted mandibular third molar removal.The study consisted of twelve patients, Seven males and five females under 30 years of age were divided into two groups as Group A and Group B in the randomized fashion. In the Group A, closure was done

2012 National journal of maxillofacial surgery Controlled trial quality: uncertain

112. Wound healing (Full text)

that they are adjacent to each other (re-approximated). Wound closure is performed with sutures (stitches), staples, or adhesive tape or glue. Primary intention can only be implemented when the wound is precise and there is minimal disruption to the local tissue and the epithelial basement membrane, e.g. surgical incisions. This process is faster than healing by secondary intention. There is also less scarring associated with primary intention, as there are no large tissue losses to be filled with granulation tissue (...) . (Primary intention does require some granulation tissue to form.) Examples of primary intention include: well-repaired , well reduced , healing after . Secondary intention [ ] Secondary intention is implemented when primary intention is not possible. This is due to wounds being created by major trauma in which there has been a significant loss in tissue or tissue damage. The wound is allowed to granulate. Surgeon may pack the wound with a gauze or use a drainage system. Granulation results in a broader

2012 Wikipedia

113. Surgical site infections: prevention and treatment

healing b Dressings for wound healing by secondary intention y secondary intention 1.4.6 Do not use Eusol and gauze, or moist cotton gauze or mercuric antiseptic solutions to manage surgical wounds that are healing by secondary intention. [2008] [2008] 1.4.7 Use an appropriate interactive dressing to manage surgical wounds that are healing by secondary intention. [2008] [2008] 1.4.8 Ask a tissue viability nurse (or another healthcare professional with tissue viability expertise) for advice (...) on appropriate dressings for the management of surgical wounds that are healing by secondary intention. [2008] [2008] Antibiotic treatment of surgical site infection and treatment failure Antibiotic treatment of surgical site infection and treatment failure 1.4.9 When surgical site infection is suspected by the presence of cellulitis, either by a new infection or an infection caused by treatment failure, give the patient an antibiotic that covers the likely causative organisms. Consider local resistance

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

114. The V.A.C. Veraflo Therapy system for infected wounds

the evidence vidence summarised in this briefing are from 5 studies: a randomised control trial, 3 cohort studies with historic cohort control and a retrospective data analysis, including a total of 357 adults with acutely infected or chronic wounds in a secondary care setting. They show that the V.A.C. Veraflo Therapy system is more effective than standard care, including moist wound care and normal NPWT, in treating acutely infected or chronic non-healing wounds. K Ke ey uncertainties y uncertainties (...) The V.A.C. Veraflo Therapy system for infected wounds The V The V .A. .A.C. V C. Ver eraflo Ther aflo Therap apy system for infected y system for infected wounds wounds Medtech innovation briefing Published: 2 September 2019 www.nice.org.uk/guidance/mib189 pathways Summary Summary The technology technology described in this briefing is the V.A.C. Veraflo Therapy system. It is used to promote healing in chronic and acutely infected wounds. The inno innovativ vative aspects e aspects

2019 National Institute for Health and Clinical Excellence - Advice

115. An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model. (PubMed)

kinase 5, because this class of inhibitors has been demonstrated to be effective in minimizing fibrosis in other organs.The rodent model of cutaneous healing consists of uniform full-thickness incisional dermal wounds in rats. Wounds were allowed to heal by secondary intention, generally over a 14-day period. The usefulness of the model was tested by the application of an activin receptor-like kinase 5 inhibitor, CP-639180. Activin receptor-like kinase 5 inhibition antagonizes the transforming growth (...) An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model. Excessive dermal scarring is characterized by an overabundant deposition of extracellular matrix caused by fibrosis. The purpose of this study was to modify a rodent model of cutaneous healing for use in the development of compounds to minimize scarring, and to test the model with a small molecule inhibitor of transforming growth factor-β type I receptor, activin receptor-like

2011 Plastic and reconstructive surgery

116. PICO negative pressure wound therapy for closed surgical incision wounds

the presence of superficial or deep infections may result in wounds opening or a wound separating along the incision. If a deep infection is ruled out, sometimes a NPWT may be used to manage the dehisced surgical wound to promote healing by secondary intention. Population, setting and intended user PICO would be used in place of conventional post-surgical wound dressings to prevent and treat SSIs in closed surgical incision wounds with low exudate levels. It would be applied by healthcare professionals (...) PICO negative pressure wound therapy for closed surgical incision wounds PICO negativ PICO negative pressure wound ther e pressure wound therap apy for y for closed surgical incision wounds closed surgical incision wounds Medtech innovation briefing Published: 15 June 2018 nice.org.uk/guidance/mib149 pathways Summary Summary The technology technology described in this briefing is the PICO single-use negative pressure wound therapy system. It is intended to promote healing in closed surgical

2018 National Institute for Health and Clinical Excellence - Advice

117. Canadian guidelines on opioid use disorder among older adults

: Strong] RECOMMENDATION #28: Contingency management may be offered as part of opioid treatment programs and used if accepted by the patient. [GRADE Quality: Moderate; Strength: Weak] QUESTION J: For older adults with an OUD, what are the treatment considerations for special populations (specifically indigenous peoples)? RECOMMENDATION #29: Traditional healing practices used by indigenous communities can be integrated with buprenorphine treatment to improve outcomes for an OUD. [GRADE Quality: Low (...) ) . As well, during opioid withdrawal, pain can return to old healed injury sites (called withdrawal-associated injury site pain), and it may take weeks to months for pain sensitivity to normalize after opioids are discontinued (Rieb et al ., 2016; 2018) . These issues are particularly important for older adults, since 30% to 40% of older adults suffer from chronic pain, a condition that becomes increasingly prevalent until the age of 85 . As the baby boomer population ages, the use of opioids to treat

2019 CPG Infobase

118. Liposuction for chronic lymphoedema

patients treated by liposuction for chronic lymphoedema. Blood transfusion was reported in 13% (2/15) of patients treated by liposuction in a case series of 15 patients (12 women, 3 men). 5.2 Localised skin loss and healing by second intention was reported in 13% (2/15) of patients in the case series of 15 patients (12 woman, 3 men) treated by liposuction. Wound infection needing surgical debridement was reported in 1 patient in the same case series. Marginal wound necrosis was reported in 1 patient (...) . It leads to chronic swelling that can cause disability, pain and cosmetic issues. Any part of the body can be affected, but the condition is most common in the arms and legs. Lymphoedema can be complicated by recurrent infection (cellulitis), which further damages the lymphatic vessels and aggravates the condition. Primary lymphoedema results from a congenital inadequacy and gradual occlusion of lymphatics. Secondary lymphoedema results from damage to the lymphatic system or removal of lymph nodes

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

119. A randomized trial of secondary closure of superficial wound dehiscence by surgical tape or suture. (PubMed)

closure of wound dehiscence based on the primary outcome of time to complete healing for this study. Therefore, suture closure seems to be the best option for secondary closure of superficial wound dehiscence.However, both suture and surgical tape are effective treatments when historically compared with second intention. (...) randomized to each arm over a 20-month period. Demographics and wound characteristics were similar between groups. Pain scores were significantly less in the tape group (21.4 ± 17.0 vs 60.7 ± 23.0 mm, P < 0.001) as was time for closure (12.3 ± 3.6 vs 31.0 ± 6.8 minutes, P < 0.001). Time for complete healing was significantly less in the suture group (23.0 ± 7.9 vs 16.1 ± 3.36 days, P < 0.001). One wound (7%) in each group was reopened.: Suture closure seems to be the superior technique for secondary

2010 Female pelvic medicine & reconstructive surgery Controlled trial quality: uncertain

120. Improving outdoor air quality and health: review of interventions

). Reducing exposure to pollution from local industry and agriculture. Local authorities can work with regulators and local operators towards site-specific interventions. For industry, technological interventions include dust abatement and primary and secondary control measures. For agriculture, interventions include livestock housing design/management, change in diet or feeding regime, changes in storage, handling and application of manure, and applying alternative fertilisation practices. In both cases (...) The complex nature of air pollution chemistry means that air pollutant emissions reductions do not always produce a corresponding drop in atmospheric concentrations in the UK (8, 10). It is, therefore, important to measure ambient air quality as well as emissions to understand local pollution concentration levels and people’s exposure. For example, from a UK perspective, only about half the exposure of the UK population to secondary inorganic aerosol pollution (see following section) is due to UK

2019 Public Health England

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