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Healing by Secondary Intention

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81. A Study to Assess the Prevention of Postsurgical Incision Healing Complications in Patients Undergoing Primary or Revision Total Knee Arthroplasty (TKA) or Total Hip Arthroplasty (THA), Treated With Either Single-Use Negative Pressure Wound Therapy (NPWT)

in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative Pressure Wound Therapy), or standard of care dressings. Condition or disease Intervention/treatment Phase Wound of Knee Wound of Hip Device: Single-Use Negative Pressure Wound Therapy Device: Standard postsurgical dressings Not Applicable Detailed Description: Most surgical wounds heal by primary intention, meaning the wound edges are brought together (...) on VAS (Incision Healing Assessment Form) [ Time Frame: 35 days (+/- 14 days) ] Visual Analog Pain Scale (VAS): PICO Study Incision Healing Assessment Form. Used to represent the assessment of incision healing based on in-person visual appearance, or appearance based on standard digital photograph. This number is reported as a total score on a 0-100 scale, with 0 being poor incision healing and 100 being excellent incision healing. Secondary Outcome Measures : Drainage Amount [ Time Frame: 35 days

2014 Clinical Trials

82. Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians

Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians (HTUG-IPT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02124694 Recruitment Status : Unknown Verified June 2015 by University of New Mexico. Recruitment status was: Recruiting First Posted : April 28, 2014

2014 Clinical Trials

83. Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study

; daily cigarette smoking; and hypertension, hyperlipidemia, or established vascular disease. Intention to change the targeted risk behaviors will not be required to participate. Utilizing telemedicine technology and Transtheoretical Model-tailored interventions, the trial aims to reach at-risk AN people regardless of residential location or current motivation. The primary outcome is biochemically-confirmed tobacco abstinence using anabasine. Secondary outcomes include moderate-to-vigorous physical (...) Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Healing and Empowering

2014 Clinical Trials

84. DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers

. Ulcer healing rate is defined as the proportion of subjects with complete ulcer-healing (referring to S1 or S2 Scarring stage according to Sakita-Fukutomi classification) as confirmed by endoscopic finding. Secondary Outcome Measures : The improvement rate of each of gastric symptoms [ Time Frame: 4 and 8 weeks ] The improvement rate of each of gastric symptoms at each of the follow-up visits (after 4 and 8 weeks of treatment): abdominal or epigastric pain (middle or upper stomach) nausea (...) DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. DLBS2411 Treatment

2014 Clinical Trials

85. Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. (Abstract)

Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate.Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds.Excisional biopsy (...) ).The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.

2014 Photomedicine and laser surgery Controlled trial quality: uncertain

86. Wound Healing, Keloids

. The most frequently involved sites of keloids are areas of the body that are constantly subjected to high skin tension. Wounds on the anterior chest, shoulders, flexor surfaces of the extremities (eg, deltoid region), and anterior neck and wounds that cross skin tension lines are more susceptible to abnormal scar formation. The most important risk factor for the development of abnormal scars such as keloids is a wound healing by secondary intention, especially if healing time is greater than 3 weeks (...) Wound Healing, Keloids Keloids: Definition and Historical Background, Epidemiology, Race Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI5ODAxMy1vdmVydmlldw== processing > Keloids Updated: Jun 22, 2018 Author

2014 eMedicine Surgery

87. Wound Healing, Skin

and the synthesis of collagen and collagenase. Tumor necrosis factor-α is a mitogen for fibroblasts. Previous Next: Primary and Secondary Healing By definition, primary healing involves uncomplicated healing of noninfected, well-approximated wounds. The 4 phases are respected in this process without interruption. Healing by secondary intention involves generation of granulation tissue and epithelialization over it. Given the fact that angiogenesis and epithelialization take longer in secondary intention healing (...) , these wounds are more prone to infection and poor healing. When properly monitored, healing by secondary intention may lead to acceptable cosmetic results in some areas of the body. When considering secondary intention for wound healing, certain factors need to be considered, including surrounding skin pigmentation and location on the face. The pigmentation of the surrounding skin is important because melanocytes do not migrate into healing wounds; thus, areas left to granulate will be hypopigmented

2014 eMedicine Surgery

88. Wound Healing, Growth Factors

, epithelialization, and collagen formation. Epithelialization is from the basement membrane if the basement membrane remains intact (eg, first-degree burn). If the basement membrane is not intact, the epithelialization is from the wound edges. Fibroblasts produce mainly type III collagen during this phase. Granulation tissue, formed in this phase, is particularly important in wounds healing by secondary intention. When collagen synthesis and breakdown become equal, the next phase of wound healing has begun (...) the cells involved in the phases of wound healing. As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. [ ] Next: Types of Wound Healing The 3 categories of wound closure are primary, secondary, and tertiary. Primary healing involves closure of a wound within hours of its creation. Secondary healing involves no formal wound closure; the wound closes

2014 eMedicine Surgery

89. Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers

Outcome Measures Go to Primary Outcome Measures : Effectiveness of the NatroxTM Topical Oxygen Device [ Time Frame: Baseline at week 0 and then at 6 and 12 weeks ] Effectiveness of the NatroxTM Topical Oxygen Device will be established vs. Placebo in patients with non-healing leg ulceration in conjunction with best practice. Effectiveness will measured by the absolute and relative change in wound surface area as measured by digital photography and wound-mapping software. Secondary Outcome Measures (...) Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2013 Clinical Trials

90. Pilonidal Disease Wound Healing Study

Therapy Phase 4 Detailed Description: This pilot study is a prospective randomized open-label study examining the efficacy of Drawtex® Hydroconductive wound dressing and negative pressure wound therapy(NPWT) in pilonidal cystectomy wound healing by secondary intention. Pilonidal disease has a significant impact on the active duty demographic and the treatments for this disease result in a substantial cost to the military in both duty days lost and for the medical care provided. This study examines (...) Negative Pressure Wound Therapy (NPWT) and the Drawtex® Hydroconductive Dressing for the treatment of surgical wounds resulting from limited excision of pilonidal disease. This clinical trial is a prospective, randomized open label examination of two standard wound therapy modalities with the goal of determining which treatment promotes the most rapid wound healing by secondary intention. Secondary goals include determining which treatment is most cost effective and is most acceptable to patients

2013 Clinical Trials

91. Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin? Full Text available with Trip Pro

acute wound healing and ascertain the level of agreement between modalities for measurement of defined cutaneous structures.Punch biopsies (5 mm) were harvested from 50 healthy volunteers. Wounds healed by secondary intention until they were re-excised 7, 14, 21 or 28 days later depending on random group allocation. Wounds were assessed weekly for 6 weeks using OCT and compared with histological findings derived from time-matched biopsies. Dimensions of four cutaneous structures were measured using (...) Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin? Gold-standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue. However, this process is invasive with recognized side-effects. Optical coherence tomography (OCT) is a noninvasive technique generating high-resolution real-time images of cutaneous architecture.To compare OCT with histological assessment of in vivo

2013 British Journal of Dermatology Controlled trial quality: uncertain

92. Comparison of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. Full Text available with Trip Pro

were analyzed there was statistically significant difference in pain, swelling and trismus experienced between both the groups.The findings of this study suggest that the procedure of choice after removal of impacted mandibular third molars is a secondary closure and healing by secondary intention. A secondary closure appears to minimize the postoperative edema, pain and trismus and thus contributes to enhanced patient comfort. (...) Comparison of primary and secondary closure of the surgical wound after removal of impacted mandibular third molars. This comparative study compares the primary and secondary healing after surgical removal of impacted mandibular third molars, evaluating and monitoring the extent of swelling and severity of pain and trismus.60 patients (37 females, 23 males; age range 18-40 years) were included in the series. The patients were randomly subdivided into 2 groups of 30 each. All the patients were

2013 Journal of maxillofacial and oral surgery Controlled trial quality: uncertain

93. Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments

with at first closed belly wounds with wound healing disorder in the postoperative course after surgery without an opening of the underlying layer of fibrous tissue are eligible to be included in the trial if the diagnosis of a wound healing impairment in the postoperative course is manifested as a wound with spontaneous dehiscence, a wound that requires an active reopening of the suture by the treating physician or a wound that cannot be closed by primary intention and requires further treatment to achieve (...) Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2012 Clinical Trials

94. Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer

Eligible for Study: 35 Years to 90 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adult males and females between 35 and 90 years of age Status post skin cancer removal on the scalp, ear or leg with a wound that would otherwise be allowed to heal by secondary intention or grafting Wound considered appropriate by physician to receive epidermal grafting Willingness to participate in study by evidence of informed consent Exclusion (...) micrografts to wounds that otherwise would have healed by second intention alone will hasten healing and possibly reduce scarring. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 12 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Use of the Epidermal Expansion System to Harvest and Place Suction Blister Epidermal Grafts on Wounds in Patients After Mohs

2012 Clinical Trials

95. The Effects of Healing Touch on Post Operative Pediatric Patients

Study Completion Date : February 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Healing Touch Treatment Healing Touch Treatment When enter PACU + usual standard of care. The Healing Touch practitioner will be at the bedside when the patient is first brought to the PACU. The HT practitioner will center and then attune with the child, connecting their energy with the child and setting the intention (...) will be at the bedside when the patient is first brought to the PACU. The HT practitioner will center and then attune with the child, connecting their energy with the child and setting the intention for healing for the child's highest good. The practitioner will then place one hand on the center of the patient's chest in the "high heart" area. The practitioner will hold this position until they feel a deep connection and "quieting" within the patient's energy. When the patient is awake and parents have been called

2012 Clinical Trials

96. Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial. (Abstract)

with significant PTSD symptoms. Active duty military (n = 123) were randomized to 6 sessions (within 3 weeks) of HT+GI vs. TAU. The primary outcome was PTSD symptoms; secondary outcomes were depression, quality of life, and hostility. Repeated measures analysis of covariance with intent-to-treat analyses revealed statistically and clinically significant reduction in PTSD symptoms (p < 0.0005, Cohen's d = 0.85) as well as depression (p < 0.0005, Cohen's d = 0.70) for HT+GI vs. TAU. HT+GI also showed significant (...) Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial. Post-traumatic stress disorder (PTSD) remains a significant problem in returning military and warrants swift and effective treatment. We conducted a randomized controlled trial to determine whether a complementary medicine intervention (Healing Touch with Guided Imagery [HT+GI]) reduced PTSD symptoms as compared to treatment as usual (TAU) returning combat-exposed active duty military

2012 Military medicine Controlled trial quality: predicted high

97. Flii neutralizing antibodies improve wound healing in porcine preclinical studies. (Abstract)

mice which have impaired wound healing. For the first time, we show that a Flightless I neutralizing monoclonal antibody (FnAb) therapy is effective in a large animal model of wound repair. Porcine 5 cm incisional and 6.25 cm(2) excisional wounds were treated with FnAb at the time of wounding and for two subsequent days. The wounds were dressed in Tegaderm dressings and left to heal by secondary intention for 7 and 35 days, respectively. At the relevant end points, the wounds were excised (...) Flii neutralizing antibodies improve wound healing in porcine preclinical studies. Wound healing is an important area of widely unmet medical need, with millions of procedures carried out worldwide which could potentially benefit from a product to improve the wound repair process. Our studies investigating the actin-remodeling protein Flightless I (Flii) show it to be an important regulator of wound healing. Flii-deficient mice have enhanced wound healing in comparison to Flii overexpressing

2012 Wound Repair and Regeneration

98. 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites

research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Healthy Subjects Facial reconstruction surgery in the last 3 months Exclusion Criteria: Age less than 18 years Patients undergoing skin grafting Patients undergoing secondary intent closure Contacts and Locations Go to Information from (...) 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites 3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2012 Clinical Trials

99. Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars

Jun 25 2012 Posted by Classic wound closure following removal of impacted this molars involved the surgeon covering and hermitically closes the socket with a flap, allowing primary wound healing. Proponents of this approach suggest that it decreases the risk of post operative infection. the alternative approach is to allow healing by secondary intention. Those who prefer this approach suggest that it allows drainage of inflammatory exudate, because the socket remains in communication. The aim (...) Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars Search National Elf Service Search National Elf Service » » » » Available evidence suggests little difference in outcomes between primary or secondary closure techniques after surgical removal of third molars

2012 The Dental Elf

100. Primary and secondary closure technique following removal of impacted mandibular third molars: A comparative study. Full Text available with Trip Pro

by primary intention and in the Group B, by secondary closure. A comparison between both groups was done with a follow-up period of 6 h to 6 days with regards to postoperative pain and swelling.The statistical analysis (analysis of variance for repeated measures, P < 0.05) showed that pain was greater in Group A, although it decreased over time similarly in the two groups. Pain and swelling was less severe with secondary healing than with primary healing.The outcome of this study suggested that secondary (...) Primary and secondary closure technique following removal of impacted mandibular third molars: A comparative study. The purpose of this study was to evaluate and compare the post operative healing, using primary versus second closure techniques after impacted mandibular third molar removal.The study consisted of twelve patients, Seven males and five females under 30 years of age were divided into two groups as Group A and Group B in the randomized fashion. In the Group A, closure was done

2012 National journal of maxillofacial surgery Controlled trial quality: uncertain

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