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Healing by Secondary Intention

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81. NPWT PRO vs KCI Ulta® NPWT and to Compare NPWT PRO vs NPWT PRO With Simultaneous Irrigation on Wound Healing

Outcome Measures Go to Primary Outcome Measures : Rate of healing as measured by wound imaging (acetate tracing, photo, ARANZ) [ Time Frame: 12 weeks ] Comparison of reduction in wound volume between wounds treated with NPWT PRO versus KCI Ulta® NPWT and to Compare NPWT PRO versus NPWT PRO with Simultaneous Irrigation Time to closure by secondary intention [ Time Frame: 12 weeks ] Number of wounds ready for closure by secondary intention Number of wounds that recur within 1 year after completion (...) , time to closure by secondary intention, and recurrence rate. Condition or disease Intervention/treatment Phase Partial-thickness Burn Ulcer Device: NPWT PRO without irrigation Device: NPWT PRO with irrigation Device: KCI Ulta Not Applicable Detailed Description: Subjects will be taken to the operating room for the initial debridement procedure of the wound. At the end of the procedure, subjects who continue to meet all inclusion and no exclusion criteria will be randomized in a 1:1:1 ratio

2015 Clinical Trials

82. The topical effect of grape seed extract 2% cream on surgery wound healing. (PubMed)

. Excision of the lesions was done by surgical scissors. The lesions got restored by secondary intention method. After the first day of treatment, the patients were visited on the 3rd, 7th, 10th, 14th, and 21st day. Grape seed extract cream 2% was produced and coded by the Faculty of Pharmacy, Ahvaz University of Medical Sciences. In order to compare the two groups, T-test was used. For time assessing, analysis of variance with repeated measures was employed.The results showed complete repair of wounds (...) The topical effect of grape seed extract 2% cream on surgery wound healing. Reducing the wound healing time is crucial in wound as it lowers the chance of infection and decreases complications and cost. Grape seed extract has the ability to release endothelial growth factor and its topical application results in contraction and closure of the skin wound. Furthermore, it possesses antioxidant and antibacterial properties. In several studies it has been proved effective in animals. Therefore, due

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2015 Global journal of health science Controlled trial quality: uncertain

83. Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. (PubMed)

Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate.Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds.Excisional biopsy (...) ).The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.

2014 Photomedicine and laser surgery Controlled trial quality: uncertain

84. Immediate or Delayed Provisionalization in Posterior Healed Sites

Immediate or Delayed Provisionalization in Posterior Healed Sites Immediate or Delayed Provisionalization in Posterior Healed Sites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Immediate or Delayed (...) Provisionalization in Posterior Healed Sites The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02387970 Recruitment Status : Recruiting First Posted : March 13, 2015 Last Update Posted : September 20, 2018 See Sponsor: Columbia

2015 Clinical Trials

85. Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care

group) Variables:Main: Complete healing after 12 weeks follow-up. Secondary: Degree of healing (Resvech 2.0). Quality of life (CCVUQ-e). Adverse reactions. Related to the healing process: comorbidities, topical and systematic treatments, exercise, BMI. Prognostic factors: location, number and duration of ulcer. Sociodemographic factors Data analysis: By intention to treat. Comparative analysis of the two groups (chi-squared or t-test). Effectiveness analysis sing Kaplan-Meier, log rank test and cox (...) Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2015 Clinical Trials

86. Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment

OBJECTIVES: I. To determine the 3-year disease free survival in patients with T3, T4 or node-positive rectal adenocarcinoma who received regorafenib maintenance therapy following the completion of curative-intent standard treatment. SECONDARY OBJECTIVES: I. To determine the cumulative incidence of local recurrence, distant recurrence and overall survival at 3 years. II. To explore for biomarkers associated with anti-cancer effects of regorafenib maintenance therapy in curatively treated rectal cancer (...) will be estimated by a 95% confidence interval, obtained using the method proposed by Breslow and Day, using the intent-to-treat approach. Secondary Outcome Measures : Biomarkers associated with anti-cancer effects of regorafenib maintenance therapy [ Time Frame: Up to 5 years ] The potential association between selected biomarkers and time-to-event outcomes will be evaluated using Cox regression models. Hazard ratios and corresponding confidence intervals will be obtained. All secondary analysis

2014 Clinical Trials

87. Wound Healing, Keloids

. The most frequently involved sites of keloids are areas of the body that are constantly subjected to high skin tension. Wounds on the anterior chest, shoulders, flexor surfaces of the extremities (eg, deltoid region), and anterior neck and wounds that cross skin tension lines are more susceptible to abnormal scar formation. The most important risk factor for the development of abnormal scars such as keloids is a wound healing by secondary intention, especially if healing time is greater than 3 weeks (...) Wound Healing, Keloids Keloids: Definition and Historical Background, Epidemiology, Race Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI5ODAxMy1vdmVydmlldw== processing > Keloids Updated: Jun 22, 2018 Author

2014 eMedicine Surgery

88. Wound Healing, Skin

and the synthesis of collagen and collagenase. Tumor necrosis factor-α is a mitogen for fibroblasts. Previous Next: Primary and Secondary Healing By definition, primary healing involves uncomplicated healing of noninfected, well-approximated wounds. The 4 phases are respected in this process without interruption. Healing by secondary intention involves generation of granulation tissue and epithelialization over it. Given the fact that angiogenesis and epithelialization take longer in secondary intention healing (...) , these wounds are more prone to infection and poor healing. When properly monitored, healing by secondary intention may lead to acceptable cosmetic results in some areas of the body. When considering secondary intention for wound healing, certain factors need to be considered, including surrounding skin pigmentation and location on the face. The pigmentation of the surrounding skin is important because melanocytes do not migrate into healing wounds; thus, areas left to granulate will be hypopigmented

2014 eMedicine Surgery

89. Wound Healing, Growth Factors

, epithelialization, and collagen formation. Epithelialization is from the basement membrane if the basement membrane remains intact (eg, first-degree burn). If the basement membrane is not intact, the epithelialization is from the wound edges. Fibroblasts produce mainly type III collagen during this phase. Granulation tissue, formed in this phase, is particularly important in wounds healing by secondary intention. When collagen synthesis and breakdown become equal, the next phase of wound healing has begun (...) the cells involved in the phases of wound healing. As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. [ ] Next: Types of Wound Healing The 3 categories of wound closure are primary, secondary, and tertiary. Primary healing involves closure of a wound within hours of its creation. Secondary healing involves no formal wound closure; the wound closes

2014 eMedicine Surgery

90. Long-term results of a one-stage secondary debulking procedure after flap reconstruction for foot. (PubMed)

are not satisfactory.From January of 2002 to July of 2014, one-stage debulking procedures were performed for 42 feet after flap reconstructions. Twelve patients (28.6 percent) had bulky flaps over the weight-bearing area of the foot compared with 30 (71.4 percent) on the non-weight-bearing area. The functional and cosmetic outcomes were reviewed after 12-month follow-up.The overall mean follow-up time was 20 months. All the grafted skin took well, except for partial superficial skin necrosis, which healed by secondary (...) Long-term results of a one-stage secondary debulking procedure after flap reconstruction for foot. Free or local flaps that are used to reconstruct the foot are often associated with a multitude of problems, most with regard to poor aesthetic and functional outcomes. This is because of the bulkiness of the flap and its difference from the native glabrous skin of the weight-bearing region of the foot. Although these can be improved using various debulking procedures, the results

2016 Plastic and reconstructive surgery

91. Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma (PubMed)

bowl of the right ear and conductive hearing loss. Initial management included excision under local anaesthesia. The histological report concluded that it was a pyogenic granuloma. Later, reoccurrence was treated with a more definitive excision under general anaesthesia. During follow-up, the operative site was seen to have healed by secondary intention without reoccurrence. Although a pyogenic granuloma within the conchal bowl is benign, early therapeutic excision is important for histological (...) Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma Pyogenic granuloma is a benign lesion of the skin and mucosa commonly known to occur in the head and neck region. The current literature has not yet identified its occurrence within the conchal bowl, a condition that leads to obstruction of the external auditory meatus. We present the case of a 28-year-old man who presented with a history of 3-4 weeks of a rapidly enlarging pedunculated lesion within the conchal

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2015 BMJ case reports

92. Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses

Clopidogrel versus other antiplatelet agents for secondary prevention of vascular events in adults with acute coronary syndrome or peripheral vascular disease: clinical and cost-effectiveness analyses Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé Supporting Informed Decisions CADTH Technology Report Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary (...) Syndrome or Peripheral Vascular Disease: Clinical and Cost-Effectiveness Analyses Issue 133 November 2010Until April 2006, the Canadian Agency for Drugs and Technologies in Health (CADTH) was known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Cite as: Banerjee S, Brown A, McGahan L, Asakawa K, Hutton B, Clark M, Severn M, Sharma M, Cox JL. Clopidogrel versus Other Antiplatelet Agents for Secondary Prevention of Vascular Events in Adults with Acute Coronary Syndrome

2011 EvidenceUpdates

93. Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin? (PubMed)

acute wound healing and ascertain the level of agreement between modalities for measurement of defined cutaneous structures.Punch biopsies (5 mm) were harvested from 50 healthy volunteers. Wounds healed by secondary intention until they were re-excised 7, 14, 21 or 28 days later depending on random group allocation. Wounds were assessed weekly for 6 weeks using OCT and compared with histological findings derived from time-matched biopsies. Dimensions of four cutaneous structures were measured using (...) Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin? Gold-standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue. However, this process is invasive with recognized side-effects. Optical coherence tomography (OCT) is a noninvasive technique generating high-resolution real-time images of cutaneous architecture.To compare OCT with histological assessment of in vivo

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2013 British Journal of Dermatology Controlled trial quality: uncertain

94. Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study

; daily cigarette smoking; and hypertension, hyperlipidemia, or established vascular disease. Intention to change the targeted risk behaviors will not be required to participate. Utilizing telemedicine technology and Transtheoretical Model-tailored interventions, the trial aims to reach at-risk AN people regardless of residential location or current motivation. The primary outcome is biochemically-confirmed tobacco abstinence using anabasine. Secondary outcomes include moderate-to-vigorous physical (...) Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Healing and Empowering

2014 Clinical Trials

95. Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians

Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians (HTUG-IPT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02124694 Recruitment Status : Unknown Verified June 2015 by University of New Mexico. Recruitment status was: Recruiting First Posted : April 28, 2014

2014 Clinical Trials

96. A Study to Assess the Prevention of Postsurgical Incision Healing Complications in Patients Undergoing Primary or Revision Total Knee Arthroplasty (TKA) or Total Hip Arthroplasty (THA), Treated With Either Single-Use Negative Pressure Wound Therapy (NPWT)

in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative Pressure Wound Therapy), or standard of care dressings. Condition or disease Intervention/treatment Phase Wound of Knee Wound of Hip Device: Single-Use Negative Pressure Wound Therapy Device: Standard postsurgical dressings Not Applicable Detailed Description: Most surgical wounds heal by primary intention, meaning the wound edges are brought together (...) on VAS (Incision Healing Assessment Form) [ Time Frame: 35 days (+/- 14 days) ] Visual Analog Pain Scale (VAS): PICO Study Incision Healing Assessment Form. Used to represent the assessment of incision healing based on in-person visual appearance, or appearance based on standard digital photograph. This number is reported as a total score on a 0-100 scale, with 0 being poor incision healing and 100 being excellent incision healing. Secondary Outcome Measures : Drainage Amount [ Time Frame: 35 days

2014 Clinical Trials

97. DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers

. Ulcer healing rate is defined as the proportion of subjects with complete ulcer-healing (referring to S1 or S2 Scarring stage according to Sakita-Fukutomi classification) as confirmed by endoscopic finding. Secondary Outcome Measures : The improvement rate of each of gastric symptoms [ Time Frame: 4 and 8 weeks ] The improvement rate of each of gastric symptoms at each of the follow-up visits (after 4 and 8 weeks of treatment): abdominal or epigastric pain (middle or upper stomach) nausea (...) DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. DLBS2411 Treatment

2014 Clinical Trials

98. Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial. (PubMed)

with significant PTSD symptoms. Active duty military (n = 123) were randomized to 6 sessions (within 3 weeks) of HT+GI vs. TAU. The primary outcome was PTSD symptoms; secondary outcomes were depression, quality of life, and hostility. Repeated measures analysis of covariance with intent-to-treat analyses revealed statistically and clinically significant reduction in PTSD symptoms (p < 0.0005, Cohen's d = 0.85) as well as depression (p < 0.0005, Cohen's d = 0.70) for HT+GI vs. TAU. HT+GI also showed significant (...) Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial. Post-traumatic stress disorder (PTSD) remains a significant problem in returning military and warrants swift and effective treatment. We conducted a randomized controlled trial to determine whether a complementary medicine intervention (Healing Touch with Guided Imagery [HT+GI]) reduced PTSD symptoms as compared to treatment as usual (TAU) returning combat-exposed active duty military

2012 Military medicine Controlled trial quality: predicted high

99. Flii neutralizing antibodies improve wound healing in porcine preclinical studies. (PubMed)

mice which have impaired wound healing. For the first time, we show that a Flightless I neutralizing monoclonal antibody (FnAb) therapy is effective in a large animal model of wound repair. Porcine 5 cm incisional and 6.25 cm(2) excisional wounds were treated with FnAb at the time of wounding and for two subsequent days. The wounds were dressed in Tegaderm dressings and left to heal by secondary intention for 7 and 35 days, respectively. At the relevant end points, the wounds were excised (...) Flii neutralizing antibodies improve wound healing in porcine preclinical studies. Wound healing is an important area of widely unmet medical need, with millions of procedures carried out worldwide which could potentially benefit from a product to improve the wound repair process. Our studies investigating the actin-remodeling protein Flightless I (Flii) show it to be an important regulator of wound healing. Flii-deficient mice have enhanced wound healing in comparison to Flii overexpressing

2012 Wound Repair and Regeneration

100. Review: evidence on the effectiveness of honey for healing wounds is limited

Dr A B Jull, University of Auckland, Auckland, New Zealand; a.jull@ctru.auckland.ac.nz QUESTION Does topical honey improve rate of healing of acute and chronic wounds? REVIEW SCOPE Included studies compared topical honey, alone or in combination with other dressing components, with dressings or other topical agents for healing acute wounds (burns, lacerations, and other traumatic wounds) and chronic wounds (venous or pressure ulcers and infected wounds healing by secondary intention (...) Review: evidence on the effectiveness of honey for healing wounds is limited Review: evidence on the effectiveness of honey for healing wounds is limitedCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts

2009 Evidence-Based Nursing

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