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Healing by Secondary Intention

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61. Systematic review and meta-analysis of wound dressings in the prevention of surgical-site infections in surgical wounds healing by primary intention. (PubMed)

Systematic review and meta-analysis of wound dressings in the prevention of surgical-site infections in surgical wounds healing by primary intention. Postoperative surgical-site infections are a major source of morbidity and cost. This study aimed to identify and present all randomized controlled trial evidence evaluating the effects of dressings on surgical-site infection rates in surgical wounds healing by primary intention; the secondary outcomes included comparisons of pain, scar

2012 British Journal of Surgery

62. Guidelines for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack (Secondary Stroke Prevention)

Guidelines for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack (Secondary Stroke Prevention) 2160 E ach year in the United States, >690 000 adults experience an ischemic stroke. 1 The enormous morbidity of ischemic stroke is the result of interplay between the resulting neuro- logical impairment, the emotional and social consequences of that impairment, and the high risk for recurrence. An addi- tional large number of US adults, estimated at 240 000 (...) , will experience a transient ischemic attack (TIA). 2 Although a TIA leaves no immediate impairment, affected individuals have a Abstract—The aim of this updated guideline is to provide comprehensive and timely evidence-based recommendations on the prevention of future stroke among survivors of ischemic stroke or transient ischemic attack. The guideline is addressed to all clinicians who manage secondary prevention for these patients. Evidence-based recommendations are provided for control of risk factors

2014 Congress of Neurological Surgeons

63. Does Continuous Diffusion of Oxygen Improve Diabetic Foot Ulcer Healing? (Full text)

Does Continuous Diffusion of Oxygen Improve Diabetic Foot Ulcer Healing? The objective of this article is to evaluate the study design, rational and results of Continuous Diffusion of Oxygen Therapy (CDOT) to heal diabetic foot ulcers (DFUs). The study was a double-blinded placebo controlled randomized clinical study to evaluate DFUs over a 12-week period. The primary outcome was the proportion of ulcers that healed and the secondary outcome that was reported was the time to ulcer healing (...) . In the per protocol analysis and in the intent to treat analysis, a higher proportion of DFUs healed in the CDOT group (per protocol 46% vs 22%, P = .02, intent to treat 31.5% vs 15.1%, P = .03). CDOT patients healed ulcers faster compared to the in the sham treatment arm ( P = .026).

2017 Journal of diabetes science and technology Controlled trial quality: predicted high

64. Low-intensity pulsed ultrasound does not influence bone healing by distraction osteogenesis: a multicentre double-blind randomised control trial. (PubMed)

Low-intensity pulsed ultrasound does not influence bone healing by distraction osteogenesis: a multicentre double-blind randomised control trial. The aim of this double-blind prospective randomised controlled trial was to assess whether low intensity pulsed ultrasound (LIPUS) accelerated or enhanced the rate of bone healing in adult patients undergoing distraction osteogenesis.A total of 62 adult patients undergoing limb lengthening or bone transport by distraction osteogenesis were randomised (...) to treatment with either an active (n = 32) or a placebo (n = 30) ultrasound device. A standardised corticotomy was performed in the proximal tibial metaphysis and a circular Ilizarov frame was used in all patients. The rate of distraction was also standardised. The primary outcome measure was the time to removal of the frame after adjusting for the length of distraction in days/cm for both the per protocol (PP) and the intention-to-treat (ITT) groups. The assessor was blinded to the form of treatment

2017 The Bone & Joint Journal Controlled trial quality: predicted high

65. Healing Nipple Wounds: Comparison Between 2 Treatment Modalities

about their intentions to breastfeed. Only 70.9% are still breastfeeding 2 months postpartum. Nipple pain is a highly prevalent, significant reason for breastfeeding cessation. In the past, we encouraged wound healing nipples by drying (air drying; sun; other heat source). It turned out that this drying only delays the healing due to lack of moisture, causing cracks in the outer layer of the nipple. Today, nipple wound care needs treatment approaches consistent with wounds treatment in other body (...) Healing Nipple Wounds: Comparison Between 2 Treatment Modalities Healing Nipple Wounds: Comparison Between 2 Treatment Modalities - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Healing Nipple Wounds

2017 Clinical Trials

66. Reducing the pathogen burden and promoting healing with polyhexanide in non-healing wounds: a prospective study. (PubMed)

=0.181) patients were treated successfully by closure of surgically sutured wounds or healing by secondary intention, the wound tissue cultures of 19 of 31 patients (47.4% PHMB, 52.6% RLS, p=0.886) were negative, and wound size of all the patients were significantly reduced in clinical observations. Although the CRP levels were reduced significantly within group comparisons in both groups (p<0.001), it was significantly lower after 12 days (p<0.05) in the PHMB group compared with the RLS group.The (...) , was created. Classic moist dressings and wet compresses during dressing changes were applied at least once a day or as needed. During the 21 days of hospitalisation the team collected data on the wound healing status daily, on infection parameters every third day, and wound tissue for culture weekly.There were 40 patients recruited of which 9 were excluded, leaving 31 in the intention-to-treat analysis. Of these 15 received PHMB and 16 received RLS. Overall 17 of 31 (66.7% PHMB group, 43.8% RLS group, p

2015 Journal of wound care Controlled trial quality: uncertain

67. Wound Healing, Healing and Repair

described, the ultimate outcome of any healing process is repair of a tissue defect. Primary healing, delayed primary healing, and healing by secondary intention are the 3 main categories of wound healing. Even though different categories exist, the interactions of cellular and extracellular constituents are similar. A fourth category is healing that transpires with wounds that are only partial skin thickness. [ ] Previous Next: Categories of Wound Healing Category 1 Primary wound healing or healing (...) are occurring. Foreign materials are walled off by macrophages that may metamorphose into epithelioid cells, which are encircled by mononuclear leukocytes, forming granulomas. Usually the wound is closed surgically at this juncture, and if the "cleansing" of the wound is incomplete, chronic inflammation can ensue, resulting in prominent scarring. Category 3 A third type of healing is known as secondary healing or healing by secondary intention. In this type of healing, a full-thickness wound is allowed

2014 eMedicine Surgery

68. A Comparison Between Primary and Secondary Flap Coverage in Extraction Sites: A Pilot Study

-resorbable membrane Device: MinerOss® Cortical and Cancellous Chips (FDBA) Mixture of allograft mineralized cortical and cancellous chips Procedure: Closed Flap Technique After extraction, the socket wound is closed by primary closure Active Comparator: Open Flap Technique Healing by secondary intention: Extraction and ridge preservation, utilizing non-resorbable membrane (Cytoplast® TXT-200) and freeze dried bone allograft (MinerOss® Cortical and Cancellous Chips (FDBA)), with flaps in position (...) for healing by secondary intention. Device: Cytoplast® TXT-200 Non-resorbable membrane Device: MinerOss® Cortical and Cancellous Chips (FDBA) Mixture of allograft mineralized cortical and cancellous chips Procedure: Open Flap Technique After extraction, the socket wound is left open to heal by secondary intention Outcome Measures Go to Primary Outcome Measures : Mean difference in alveolar bone height change [ Time Frame: Up to 5 months post extraction and ridge preservation ] Models/casts will be made

2017 Clinical Trials

69. T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study (...) Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S

2017 Clinical Trials

70. Survival rate of teeth with periodontally hopeless prognosis after therapies with intentional replantation and perioprosthetic procedures ‐ a study of case series for 5–12 years (Full text)

Survival rate of teeth with periodontally hopeless prognosis after therapies with intentional replantation and perioprosthetic procedures ‐ a study of case series for 5–12 years The purpose of the present study was to evaluate the longitudinal survival rate of the treatment of teeth affected with periodontally hopeless prognosis and secondary occlusal traumatism (SOT) using intentional replantation (IR) and periodontal prosthesis. We collected data from 17 individuals who received IR (...) resorption. Ankylosis was not observed during the study. Periapical radiographs demonstrated that satisfactory periodontal healing of lamina dura and bone fills occurred in all replanted teeth with SOT. Generally, tooth mobility and SOT were significantly improved after therapy. Most treated teeth functioned well and remained stable clinically throughout the periods of study. The present study documented a promising outcome for autogenous IR and periprosthetic therapy of 17 periodontally hopeless teeth

2016 Clinical and Experimental Dental Research

71. Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment

OBJECTIVES: I. To determine the 3-year disease free survival in patients with T3, T4 or node-positive rectal adenocarcinoma who received regorafenib maintenance therapy following the completion of curative-intent standard treatment. SECONDARY OBJECTIVES: I. To determine the cumulative incidence of local recurrence, distant recurrence and overall survival at 3 years. II. To explore for biomarkers associated with anti-cancer effects of regorafenib maintenance therapy in curatively treated rectal cancer (...) will be estimated by a 95% confidence interval, obtained using the method proposed by Breslow and Day, using the intent-to-treat approach. Secondary Outcome Measures : Biomarkers associated with anti-cancer effects of regorafenib maintenance therapy [ Time Frame: Up to 5 years ] The potential association between selected biomarkers and time-to-event outcomes will be evaluated using Cox regression models. Hazard ratios and corresponding confidence intervals will be obtained. All secondary analysis

2014 Clinical Trials

72. Healing by primary versus secondary intention after surgical treatment for pilonidal sinus. (PubMed)

Healing by primary versus secondary intention after surgical treatment for pilonidal sinus. Pilonidal sinus arises in the hair follicles in the buttock cleft. The estimated incidence is 26 per 100,000, people, affecting men twice as often as women. These chronic discharging wounds cause pain and impact upon quality of life. Surgical strategies centre on excision of the sinus tracts followed by primary closure and healing by primary intention or leaving the wound open to heal by secondary (...) intention. There is uncertainty as to whether open or closed surgical management is more effective.To determine the relative effects of open compared with closed surgical treatment for pilonidal sinus on the outcomes of time to healing, infection and recurrence rate.For this first update we searched the Wounds Group Specialised Register (24/9/09); The Cochrane Central Register of Controlled Trials (CENTRAL) - The Cochrane Library Issue 3 2009; Ovid MEDLINE (1950 - September Week 3, 2009); Ovid MEDLINE(R

2010 Cochrane database of systematic reviews (Online)

73. Autologous Bone Marrow Aspirate Therapy in Wound Healing (Full text)

wound bed preparation with ABMAT. End point of the study was complete wound healing. Results: ABMAT helped in complete healing of chronic nonhealing wounds by secondary intention in group 1 patients and enhanced process of wound bed preparation for reconstruction in group 2 patients. Innovation: This study highlights the importance of ABMAT in the management of chronic nonhealing wounds. Conclusion: ABMAT helps in wound bed preparation to allow the wound to heal completely or cover by skin graft (...) Autologous Bone Marrow Aspirate Therapy in Wound Healing Objective: To study the role of autologous bone marrow aspirate therapy (ABMAT) in wound healing. Approach: This is a retrospective analysis of 9 patients (11 chronic nonhealing wounds) in whom ABMAT was used. Patients (wounds) were grouped into two groups. Group 1 included 4 patients (5 wounds) refusing/unfit for reconstruction and managed only with ABMAT. Group 2 included 5 patients (6 wounds) who agreed/fit for reconstruction after

2016 Advances in wound care

74. ECAMulticapa: Effectiveness of double-layered compression therapy for healing venous ulcers in primary care: a Study Protocol (Full text)

in primary care nursing consultations, at 12 weeks of follow-up. The study will include 216 individuals (108 per branch) with venous ulcers treated in primary care nursing consultations. The primary endpoint is complete healing at 12 weeks of follow-up. The secondary endpoints are the degree of healing (Resvech.2), quality of life (CCVUQ-e), adverse reactions related to the healing process. Prognosis and demographic variables are also recorder. Effectiveness analysis using Kaplan-Meier curves, a log-rank (...) test and a Cox regression analysis. The analysis was performed by intention to treat.The study results can contribute to improving the care and quality of life of patients with venous ulcers, decreasing healing times and healthcare expenditure and contributing to the consistent treatment of these lesions.This study has been recorded in the Clinical Trials.gov site with the code NCT02364921. 17 February 2015.

2016 BMC nursing Controlled trial quality: predicted high

75. ADding negative pRESSure to improve healING (the DRESSING trial): a RCT protocol. (Full text)

ADding negative pRESSure to improve healING (the DRESSING trial): a RCT protocol. Obese women are more likely to develop a surgical site infection (SSI) following caesarean section (CS) than non-obese women. Negative pressure wound therapy (NPWT) is increasingly being used to reduce SSI with limited evidence for its effectiveness.To determine the clinical and cost-effectiveness of using NPWT in obese women having elective and semiurgent CS.A multisite, superiority parallel pragmatic randomised (...) controlled trial with an economic evaluation. Women with a body mass index (BMI) of ≥ 30, booked for elective and semiurgent CS at 4 Australian acute care hospitals will be targeted. A total of 2090 women will be enrolled. A centralised randomisation service will be used with participants block randomised to either NPWT or standard surgical dressings in a 1:1 ratio, stratified by hospital. The primary outcome is SSI; secondary outcomes include type of SSI, length of stay, readmission, wound complications

2016 BMJ open Controlled trial quality: predicted high

76. Efficacy of Healing meditation in reducing anxiety of individuals at the phase of weight loss maintenance: A randomized blinded clinical trial. (PubMed)

Efficacy of Healing meditation in reducing anxiety of individuals at the phase of weight loss maintenance: A randomized blinded clinical trial. To verify the efficacy of Healing Meditation in reducing anxiety levels in individuals on a weight loss maintenance program.A randomized, controlled, evaluator-blinded clinical trial, conducted between January and October 2014, with a follow-up of 12 weeks.A weight loss secondary care facility in Salvador, Brazil., of 41 patients at the weight (...) maintenance phase (Mean initial BMI 33.6±4.7kg/m2, who had attained a mean BMI of 24.5±1.6kg/m2 in a median period of 7 months).An 8-week Healing Meditation program (n=20), consisting of a 1h weekly meeting, or for a control group on the waiting list (n=21), in addition to the standard clinical program.Total anxiety was measured by the Hamilton Anxiety Scale (HAM-A), before and after the intervention. Secondary analyses included comparison of the effect of meditation on the somatic and psychic components

2016 Complementary Therapies In Medicine Controlled trial quality: uncertain

77. Effects of tretinoin on wound healing in aged skin. (PubMed)

Effects of tretinoin on wound healing in aged skin. Aged and adult populations have differences in the structural, biological, and healing properties of skin. Comparative studies of healing under the influence of retinoids in both these populations are very important and, to the best of our knowledge, have not been performed to date. The purpose of this study was to compare the activities of topical tretinoin in aged and adult animal models of wound healing by secondary intention. Male aged (...) rats (24 months old, n = 7) and adult rats (6 months old, n = 8) were used. The rats were assigned to the following groups according to the dates on which wound samples were excised (day 14 or 21 after model creation): treated group, control group, and naive group. Topical application of tretinoin cream was used only on the proximal wound and was applied daily for 7 days. Wound healing areas were measured using metal calipers, and morphological analysis was performed. Slides were stained

2016 Wound Repair and Regeneration

78. Evaluating the effectiveness of a self-management exercise intervention on wound healing, functional ability and health-related quality of life outcomes in adults with venous leg ulcers: a randomised controlled trial. (Full text)

ability and health-related quality of life for adults with venous leg ulcers (VLUs). This study included 63 patients with VLUs. Patients were randomised to receive either a 12-week exercise intervention with a telephone coaching component or usual care plus telephone calls at the same timepoints. The primary outcome evaluated the effectiveness of the intervention in relation to wound healing. The secondary outcomes evaluated physical activity, functional ability and health-related quality of life (...) measures between groups at the end of the 12 weeks. A per protocol analysis complemented the effectiveness (intention-to-treat) analysis to highlight the importance of adherence to an exercise intervention. Intention-to-treat analyses for the primary outcome showed 77% of those in the intervention group healed by 12 weeks compared to 53% of those in the usual care group. Although this difference was not statistically significant due to a smaller than expected sample size, a 24% difference in healing

2016 International wound journal Controlled trial quality: predicted high

79. Buccal Mucosa Healing Trial With Tissue Matrix Placement

Study Details Study Description Go to Brief Summary: Prior studies have been performed to understand the optimal way to minimize the morbidity rate of buccal mucosa. While some studies have reported primary closure to be inferior to healing by secondary intention, this appears to be true for large defects greater than 2 cm in width. For small defects for which the wound can be closed without tension, the most recent study has shown improved pain outcomes in the immediate post-operative setting (...) , although no difference is seen long term whether or not the wound was primarily closed. However, for larger defects, standard practice is to allow delayed healing by secondary intention. The use of Alloderm graft placement for donor site coverage was first described in Armenakas' group. Alloderm is an acellular dermal lattice from human allograft skin. The only study to report the use of Alloderm failed to find a significant improvement in patient outcomes; however, very small defects were included

2016 Clinical Trials

80. Immediate or Delayed Provisionalization in Posterior Healed Sites

Immediate or Delayed Provisionalization in Posterior Healed Sites Immediate or Delayed Provisionalization in Posterior Healed Sites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Immediate or Delayed (...) Provisionalization in Posterior Healed Sites The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02387970 Recruitment Status : Recruiting First Posted : March 13, 2015 Last Update Posted : September 20, 2018 See Sponsor: Columbia

2015 Clinical Trials

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