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Healing by Secondary Intention

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61. Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery

Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery (MomelanMohs) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01442844 Recruitment Status : Terminated (The study sponsor was acquired by a company that focuses on chronic wounds

2011 Clinical Trials

62. Free Cartilage Grafts for Alar Defects Coupled with Secondary-Intention Healing. (Abstract)

Free Cartilage Grafts for Alar Defects Coupled with Secondary-Intention Healing. 21388482 2011 06 16 2011 04 12 1524-4725 37 4 2011 Apr Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Free cartilage grafts for alar defects coupled with secondary-intention healing. 510-3 10.1111/j.1524-4725.2011.01909.x Campbell Tracy T Department of Dermatology, University of California at Davis, Sacramento, California 95816, USA. Eisen Daniel B (...) DB eng Case Reports Journal Article 2011 03 09 United States Dermatol Surg 9504371 1076-0512 IM Aged, 80 and over Carcinoma, Basal Cell surgery Ear Cartilage transplantation Follow-Up Studies Free Tissue Flaps Humans Male Mohs Surgery methods Nose Neoplasms surgery Wound Healing 2011 3 11 6 0 2011 3 11 6 0 2011 6 17 6 0 ppublish 21388482 10.1111/j.1524-4725.2011.01909.x

2011 Dermatologic Surgery

63. Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot. (Abstract)

Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot. Melanoma in dark-skinned individuals often develops in an acral lentiginous fashion on the foot. After wide excision, substantial defects usually develop and they may endure insufficient vascular flow. In addition, the final scar must withstand the mechanical stress of daily walking. Various repair methods are used to repair these defects, but secondary intention healing (...) has not been evaluated in the repair of wounds of the foot.To compare the functional and cosmetic results of secondary intention healing and full-thickness skin graft after wide excision of melanoma on the foot.Retrospective review of 25 patients who were treated using excision for melanoma on the foot. The defects of 13 patients were healed by secondary intention (secondary intention healing group; SIHG), and those of 12 patients were repaired by full-thickness skin graft (skin graft group; SGG

2011 Dermatologic Surgery

64. Wound Healing, Healing and Repair

described, the ultimate outcome of any healing process is repair of a tissue defect. Primary healing, delayed primary healing, and healing by secondary intention are the 3 main categories of wound healing. Even though different categories exist, the interactions of cellular and extracellular constituents are similar. A fourth category is healing that transpires with wounds that are only partial skin thickness. [ ] Previous Next: Categories of Wound Healing Category 1 Primary wound healing or healing (...) are occurring. Foreign materials are walled off by macrophages that may metamorphose into epithelioid cells, which are encircled by mononuclear leukocytes, forming granulomas. Usually the wound is closed surgically at this juncture, and if the "cleansing" of the wound is incomplete, chronic inflammation can ensue, resulting in prominent scarring. Category 3 A third type of healing is known as secondary healing or healing by secondary intention. In this type of healing, a full-thickness wound is allowed

2014 eMedicine Surgery

65. Efficacy of Healing meditation in reducing anxiety of individuals at the phase of weight loss maintenance: A randomized blinded clinical trial. (Abstract)

Efficacy of Healing meditation in reducing anxiety of individuals at the phase of weight loss maintenance: A randomized blinded clinical trial. To verify the efficacy of Healing Meditation in reducing anxiety levels in individuals on a weight loss maintenance program.A randomized, controlled, evaluator-blinded clinical trial, conducted between January and October 2014, with a follow-up of 12 weeks.A weight loss secondary care facility in Salvador, Brazil., of 41 patients at the weight (...) maintenance phase (Mean initial BMI 33.6±4.7kg/m2, who had attained a mean BMI of 24.5±1.6kg/m2 in a median period of 7 months).An 8-week Healing Meditation program (n=20), consisting of a 1h weekly meeting, or for a control group on the waiting list (n=21), in addition to the standard clinical program.Total anxiety was measured by the Hamilton Anxiety Scale (HAM-A), before and after the intervention. Secondary analyses included comparison of the effect of meditation on the somatic and psychic components

2016 Complementary Therapies In Medicine Controlled trial quality: uncertain

66. Evaluating the effectiveness of a self-management exercise intervention on wound healing, functional ability and health-related quality of life outcomes in adults with venous leg ulcers: a randomised controlled trial. (Abstract)

ability and health-related quality of life for adults with venous leg ulcers (VLUs). This study included 63 patients with VLUs. Patients were randomised to receive either a 12-week exercise intervention with a telephone coaching component or usual care plus telephone calls at the same timepoints. The primary outcome evaluated the effectiveness of the intervention in relation to wound healing. The secondary outcomes evaluated physical activity, functional ability and health-related quality of life (...) measures between groups at the end of the 12 weeks. A per protocol analysis complemented the effectiveness (intention-to-treat) analysis to highlight the importance of adherence to an exercise intervention. Intention-to-treat analyses for the primary outcome showed 77% of those in the intervention group healed by 12 weeks compared to 53% of those in the usual care group. Although this difference was not statistically significant due to a smaller than expected sample size, a 24% difference in healing

2016 International wound journal Controlled trial quality: predicted high

67. Effects of tretinoin on wound healing in aged skin. (Abstract)

Effects of tretinoin on wound healing in aged skin. Aged and adult populations have differences in the structural, biological, and healing properties of skin. Comparative studies of healing under the influence of retinoids in both these populations are very important and, to the best of our knowledge, have not been performed to date. The purpose of this study was to compare the activities of topical tretinoin in aged and adult animal models of wound healing by secondary intention. Male aged (...) rats (24 months old, n = 7) and adult rats (6 months old, n = 8) were used. The rats were assigned to the following groups according to the dates on which wound samples were excised (day 14 or 21 after model creation): treated group, control group, and naive group. Topical application of tretinoin cream was used only on the proximal wound and was applied daily for 7 days. Wound healing areas were measured using metal calipers, and morphological analysis was performed. Slides were stained

2016 Wound Repair and Regeneration

68. ADding negative pRESSure to improve healING (the DRESSING trial): a RCT protocol. Full Text available with Trip Pro

ADding negative pRESSure to improve healING (the DRESSING trial): a RCT protocol. Obese women are more likely to develop a surgical site infection (SSI) following caesarean section (CS) than non-obese women. Negative pressure wound therapy (NPWT) is increasingly being used to reduce SSI with limited evidence for its effectiveness.To determine the clinical and cost-effectiveness of using NPWT in obese women having elective and semiurgent CS.A multisite, superiority parallel pragmatic randomised (...) controlled trial with an economic evaluation. Women with a body mass index (BMI) of ≥ 30, booked for elective and semiurgent CS at 4 Australian acute care hospitals will be targeted. A total of 2090 women will be enrolled. A centralised randomisation service will be used with participants block randomised to either NPWT or standard surgical dressings in a 1:1 ratio, stratified by hospital. The primary outcome is SSI; secondary outcomes include type of SSI, length of stay, readmission, wound complications

2016 BMJ open Controlled trial quality: predicted high

69. ECAMulticapa: Effectiveness of double-layered compression therapy for healing venous ulcers in primary care: a Study Protocol Full Text available with Trip Pro

in primary care nursing consultations, at 12 weeks of follow-up. The study will include 216 individuals (108 per branch) with venous ulcers treated in primary care nursing consultations. The primary endpoint is complete healing at 12 weeks of follow-up. The secondary endpoints are the degree of healing (Resvech.2), quality of life (CCVUQ-e), adverse reactions related to the healing process. Prognosis and demographic variables are also recorder. Effectiveness analysis using Kaplan-Meier curves, a log-rank (...) test and a Cox regression analysis. The analysis was performed by intention to treat.The study results can contribute to improving the care and quality of life of patients with venous ulcers, decreasing healing times and healthcare expenditure and contributing to the consistent treatment of these lesions.This study has been recorded in the Clinical Trials.gov site with the code NCT02364921. 17 February 2015.

2016 BMC nursing Controlled trial quality: predicted high

70. Autologous Bone Marrow Aspirate Therapy in Wound Healing Full Text available with Trip Pro

wound bed preparation with ABMAT. End point of the study was complete wound healing. Results: ABMAT helped in complete healing of chronic nonhealing wounds by secondary intention in group 1 patients and enhanced process of wound bed preparation for reconstruction in group 2 patients. Innovation: This study highlights the importance of ABMAT in the management of chronic nonhealing wounds. Conclusion: ABMAT helps in wound bed preparation to allow the wound to heal completely or cover by skin graft (...) Autologous Bone Marrow Aspirate Therapy in Wound Healing Objective: To study the role of autologous bone marrow aspirate therapy (ABMAT) in wound healing. Approach: This is a retrospective analysis of 9 patients (11 chronic nonhealing wounds) in whom ABMAT was used. Patients (wounds) were grouped into two groups. Group 1 included 4 patients (5 wounds) refusing/unfit for reconstruction and managed only with ABMAT. Group 2 included 5 patients (6 wounds) who agreed/fit for reconstruction after

2016 Advances in wound care

71. Safety and Efficacy of Topical AR/101 Compared With Placebo, in Accelerating Granulation Tissue Formation of Hard-to-heal Wounds

Measures Go to Primary Outcome Measures : comparison of the formation of new granulation tissue according to a Granulation Score, between the AR/101 treated group and the placebo group, during the treatment phases [ Time Frame: 28 days ] Secondary Outcome Measures : Percentage of patients ready for skin grafting or healing by secondary intention during treatment phase 1 and treatment phase 2 based on physician's assessment [ Time Frame: 28 days ] Percent of patient responders of equal or more then 75 (...) Safety and Efficacy of Topical AR/101 Compared With Placebo, in Accelerating Granulation Tissue Formation of Hard-to-heal Wounds Safety and Efficacy of Topical AR/101 Compared With Placebo, in Accelerating Granulation Tissue Formation of Hard-to-heal Wounds - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2016 Clinical Trials

72. Buccal Mucosa Healing Trial With Tissue Matrix Placement

Study Details Study Description Go to Brief Summary: Prior studies have been performed to understand the optimal way to minimize the morbidity rate of buccal mucosa. While some studies have reported primary closure to be inferior to healing by secondary intention, this appears to be true for large defects greater than 2 cm in width. For small defects for which the wound can be closed without tension, the most recent study has shown improved pain outcomes in the immediate post-operative setting (...) , although no difference is seen long term whether or not the wound was primarily closed. However, for larger defects, standard practice is to allow delayed healing by secondary intention. The use of Alloderm graft placement for donor site coverage was first described in Armenakas' group. Alloderm is an acellular dermal lattice from human allograft skin. The only study to report the use of Alloderm failed to find a significant improvement in patient outcomes; however, very small defects were included

2016 Clinical Trials

73. Immediate or Delayed Provisionalization in Posterior Healed Sites

Immediate or Delayed Provisionalization in Posterior Healed Sites Immediate or Delayed Provisionalization in Posterior Healed Sites - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Immediate or Delayed (...) Provisionalization in Posterior Healed Sites The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02387970 Recruitment Status : Recruiting First Posted : March 13, 2015 Last Update Posted : September 20, 2018 See Sponsor: Columbia

2015 Clinical Trials

74. NPWT PRO vs KCI Ulta® NPWT and to Compare NPWT PRO vs NPWT PRO With Simultaneous Irrigation on Wound Healing

Outcome Measures Go to Primary Outcome Measures : Rate of healing as measured by wound imaging (acetate tracing, photo, ARANZ) [ Time Frame: 12 weeks ] Comparison of reduction in wound volume between wounds treated with NPWT PRO versus KCI Ulta® NPWT and to Compare NPWT PRO versus NPWT PRO with Simultaneous Irrigation Time to closure by secondary intention [ Time Frame: 12 weeks ] Number of wounds ready for closure by secondary intention Number of wounds that recur within 1 year after completion (...) , time to closure by secondary intention, and recurrence rate. Condition or disease Intervention/treatment Phase Partial-thickness Burn Ulcer Device: NPWT PRO without irrigation Device: NPWT PRO with irrigation Device: KCI Ulta Not Applicable Detailed Description: Subjects will be taken to the operating room for the initial debridement procedure of the wound. At the end of the procedure, subjects who continue to meet all inclusion and no exclusion criteria will be randomized in a 1:1:1 ratio

2015 Clinical Trials

75. Clinical Study to Assess a New Barrier Film's Ability to Provide Skin Protection Against Incontinence & Allow Healing

a single IAD score for each subject. IAD scores ranged from 0 (best) - 720 (worst). Secondary Outcome Measures : Re-epithelialization to a Category 1 or Lower [ Time Frame: Up to 21 days depending on length of hospitalization ] Looking for healing of denuded skin to re-epithelialized skin. Pain Scores During Incontinence Management [ Time Frame: Up to 21 days depending on length of hospitalization ] Pain scores during incontinence management were measured on a 0-10 scale, and analyzed only for subjects (...) Clinical Study to Assess a New Barrier Film's Ability to Provide Skin Protection Against Incontinence & Allow Healing Clinical Study to Assess a New Barrier Film's Ability to Provide Skin Protection Against Incontinence & Allow Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2015 Clinical Trials

76. Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care

group) Variables:Main: Complete healing after 12 weeks follow-up. Secondary: Degree of healing (Resvech 2.0). Quality of life (CCVUQ-e). Adverse reactions. Related to the healing process: comorbidities, topical and systematic treatments, exercise, BMI. Prognostic factors: location, number and duration of ulcer. Sociodemographic factors Data analysis: By intention to treat. Comparative analysis of the two groups (chi-squared or t-test). Effectiveness analysis sing Kaplan-Meier, log rank test and cox (...) Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2015 Clinical Trials

77. The topical effect of grape seed extract 2% cream on surgery wound healing. Full Text available with Trip Pro

. Excision of the lesions was done by surgical scissors. The lesions got restored by secondary intention method. After the first day of treatment, the patients were visited on the 3rd, 7th, 10th, 14th, and 21st day. Grape seed extract cream 2% was produced and coded by the Faculty of Pharmacy, Ahvaz University of Medical Sciences. In order to compare the two groups, T-test was used. For time assessing, analysis of variance with repeated measures was employed.The results showed complete repair of wounds (...) The topical effect of grape seed extract 2% cream on surgery wound healing. Reducing the wound healing time is crucial in wound as it lowers the chance of infection and decreases complications and cost. Grape seed extract has the ability to release endothelial growth factor and its topical application results in contraction and closure of the skin wound. Furthermore, it possesses antioxidant and antibacterial properties. In several studies it has been proved effective in animals. Therefore, due

2015 Global journal of health science Controlled trial quality: uncertain

78. Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment

OBJECTIVES: I. To determine the 3-year disease free survival in patients with T3, T4 or node-positive rectal adenocarcinoma who received regorafenib maintenance therapy following the completion of curative-intent standard treatment. SECONDARY OBJECTIVES: I. To determine the cumulative incidence of local recurrence, distant recurrence and overall survival at 3 years. II. To explore for biomarkers associated with anti-cancer effects of regorafenib maintenance therapy in curatively treated rectal cancer (...) will be estimated by a 95% confidence interval, obtained using the method proposed by Breslow and Day, using the intent-to-treat approach. Secondary Outcome Measures : Biomarkers associated with anti-cancer effects of regorafenib maintenance therapy [ Time Frame: Up to 5 years ] The potential association between selected biomarkers and time-to-event outcomes will be evaluated using Cox regression models. Hazard ratios and corresponding confidence intervals will be obtained. All secondary analysis

2014 Clinical Trials

79. Long-term results of a one-stage secondary debulking procedure after flap reconstruction for foot. (Abstract)

are not satisfactory.From January of 2002 to July of 2014, one-stage debulking procedures were performed for 42 feet after flap reconstructions. Twelve patients (28.6 percent) had bulky flaps over the weight-bearing area of the foot compared with 30 (71.4 percent) on the non-weight-bearing area. The functional and cosmetic outcomes were reviewed after 12-month follow-up.The overall mean follow-up time was 20 months. All the grafted skin took well, except for partial superficial skin necrosis, which healed by secondary (...) Long-term results of a one-stage secondary debulking procedure after flap reconstruction for foot. Free or local flaps that are used to reconstruct the foot are often associated with a multitude of problems, most with regard to poor aesthetic and functional outcomes. This is because of the bulkiness of the flap and its difference from the native glabrous skin of the weight-bearing region of the foot. Although these can be improved using various debulking procedures, the results

2016 Plastic and reconstructive surgery

80. Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma Full Text available with Trip Pro

bowl of the right ear and conductive hearing loss. Initial management included excision under local anaesthesia. The histological report concluded that it was a pyogenic granuloma. Later, reoccurrence was treated with a more definitive excision under general anaesthesia. During follow-up, the operative site was seen to have healed by secondary intention without reoccurrence. Although a pyogenic granuloma within the conchal bowl is benign, early therapeutic excision is important for histological (...) Obstruction of the external auditory meatus secondary to a giant pyogenic granuloma Pyogenic granuloma is a benign lesion of the skin and mucosa commonly known to occur in the head and neck region. The current literature has not yet identified its occurrence within the conchal bowl, a condition that leads to obstruction of the external auditory meatus. We present the case of a 28-year-old man who presented with a history of 3-4 weeks of a rapidly enlarging pedunculated lesion within the conchal

2015 BMJ case reports

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