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Healing by Secondary Intention

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41. Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery

Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Secondary Intention Wound Healing Versus Micrografting in Patients Undergoing Mohs Surgery (MomelanMohs) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01442844 Recruitment Status : Terminated (The study sponsor was acquired by a company that focuses on chronic wounds

2011 Clinical Trials

42. Ultrasound therapy doesn’t speed healing of leg fracture after surgery

? A broken tibia is the most common long bone fracture. These fractures can take six months or longer to heal and are particularly vulnerable to non-union, when the broken pieces of bone fail to grow back together. LIPUS is commonly used in North America after fracture surgery with the intention of speeding up healing and preventing non-union and is available in the UK. LIPUS involves applying ultrasound waves to skin over the fracture using a wand or probe and gel, similar to those used for pregnancy (...) is commonly used in North America after fracture surgery with the intention of speeding up healing and preventing non-union and is available in the UK. LIPUS involves applying ultrasound waves to skin over the fracture using a wand or probe and gel, similar to those used for pregnancy scans, but it is self-administered. The theory is that the ultrasound waves stimulate bone growth. It is used to promote healing of tibia fracture, both for naturally-healed and surgically-treated fractures, fresh fractures

2018 NIHR Dissemination Centre

43. Wearing a patch after a scratch to the eye probably makes no difference to healing

-randomised controlled trials that compared patching the eye with no patching to treat simple corneal abrasions. DATA COLLECTION AND ANALYSIS: Two authors independently assessed the risk of bias and extracted data. Investigators were contacted for further information regarding the quality of trials. The primary outcome was healing at 24, 48 and 72 hours while secondary outcomes included measures of pain, quality of life and adverse effects. We graded the certainty of the evidence using GRADE. MAIN RESULTS (...) to minimise pain and there is variation in practice with regards to patching the eye to improve comfort and with the intention to promote healing of the ocular surface. Patients often request the eye to be padded to help alleviate their pain symptoms. This review should help healthcare professionals and their patients understand the distilled evidence that this practice may not be helpful for pain relief or for healing and minimise the use of unnecessary padding. Miss Reshma Thampy, Consultant Ophthalmic

2018 NIHR Dissemination Centre

44. Primary & Secondary Prevention of CVD

Primary & Secondary Prevention of CVD 2016 1 STATEMENT OF INTENT This guideline was developed to be a guide for best clinical practice in the prevention of cardiovascular disease, based on the best available evidence at the time of development. Specific attempts were made to use local data and publications to ensure local relevance. Adherence to this guideline does not necessarily lead to the best clinical outcome in individual patient care as this depends on other clinical factors like co (...) in mortality rates in overweight diabetic individuals following an intentional weight loss of 20-29 lb (9-13 kg). 96 A randomized trial however, focusing on weight loss using intensive lifestyle intervention, did not reduce the rate of CV events in overweight or obese adults with type 2 diabetes. 97 Bariatric surgery in obese individuals has been associated with improved survival in the long term. 98-100 Primary & Secondary Prevention of Cardiovascular Disease 201738 5.2.5 Hypertension Epidemiological

2017 Ministry of Health, Malaysia

45. Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly

Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should (...) identified. PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: 1-866-898-8439 www.cadth.ca Topical Nitroglycerin for Peripheral Circulation and Wound Healing in the Elderly 4 APPENDIX – FURTHER INFORMATION: Systematic Reviews and Meta-analyses – Unclear Population Age 1. Herrick A. Raynaud's phenomenon (secondary). Clin Evid (Online) [Internet]. 2008;2008 [cited 2015 Feb 17]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907943 PubMed: PM19445801 Randomized Controlled

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

46. Efficacy of hypnosis on pain, wound-healing, anxiety, and stress in children with acute burn injuries: a randomized controlled trial (Full text)

presenting for their first dressing change were randomly assigned to a Hypnosis Group who received hypnosis plus standard care or a Standard Care Group who received standard pharmacological and nonpharmacological intervention. Repeated measures of pain intensity, anxiety, stress, and wound-healing were taken at dressing changes until ≥95% wound re-epithelialization. Data for 62 children were analyzed on an intent-to-treat basis using Generalized Estimating Equations (n = 35 Standard Care Group; n = 27 (...) Hypnosis Group). An effect on the primary outcomes of pain and wound healing was not supported {self-reported pain intensity largest Mean Difference [MD] = -0.85 (95% confidence interval [CI]: -1.91 to 0.22), P = 0.12; MD for re-epithelialization = -0.46 [95% CI: -4.27 to 3.35], P = 0.81}. Some support was found for an effect on the secondary outcomes of preprocedural anxiety (MD = -0.80 [95% CI: -1.50 to -0.10], P = 0.03 before the second dressing change) and heart rate as a measure of stress (MD

2018 EvidenceUpdates

47. Advanced Wound Care Therapies for Non-Healing Diabetic, Venous, and Arterial Ulcers

attributed to either diabetes, venous disease, or arterial disease comprise a substantial proportion of chronic ulcers. Approximately 15% to 25% of individuals with diabetes develop a foot ulcer at some point in their lifetime and an estimated 12% of those patients require lower extremity amputation. Healing is complicated by diabetic neuropathy and susceptibility to infection. Venous disease accounts for the majority of chronic lower extremity ulcers. Venous hypertension secondary to various cuases (...) systematic reviews, and reference lists of pertinent studies. Study, patient, ulcer and treatment characteristics, primary and secondary outcomes, and adverse events were extracted by trained research associates under the supervision of the Principal Investigator. Our primary outcome was the percentage of ulcers healed at study completion. Additional “primary outcomes” included time to complete ulcer healing, patient global assessment, and return to daily activities. Secondary outcomes included ulcer

2012 Veterans Affairs Evidence-based Synthesis Program Reports

48. Intentional partial odontectomy—a long-term follow-up study (Full text)

Intentional partial odontectomy—a long-term follow-up study The surgical extraction of the third molar is the most frequently encountered procedure in oral and maxillofacial surgery and is related with a variety of complications. This study examined the efficacy of intentional partial odontectomy (IPO) in the third molars which have no periapical lesions and are located near important anatomical structures such as inferior alveolar nerve.Seven patients (four males, three females, 39.1 ± 11.6 (...)  years), who received IPO to reduce the risk of inferior alveolar nerve injury (IANI), were followed long-term. The treated teeth were horizontally impacted third molars in the mandibular left (n = 5) or mandibular right (n = 4) areas and were all ankylosed with the surrounding alveolar bone. During the IPO, the bone around the crown was removed to expose the crown, and then the tooth was resected at cement-enamel junction (CEJ). Any secondary trauma to the healthy root was minimized and remained

2017 Maxillofacial Plastic and Reconstructive Surgery

49. Consciousness Field Project: Intention Host Device-mediated Distant Intentionality

for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Dr. Gabriele Hilberg, PhD, MFT, Merraki Institute: Intention Distant Healing Wellness Distant Intentionality Distant Healing Intention (...) Consciousness Field Project: Intention Host Device-mediated Distant Intentionality Consciousness Field Project: Intention Host Device-mediated Distant Intentionality - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

50. Secondary suturing compared to non-suturing for broken down perineal wounds following childbirth. (PubMed)

scientific evidence and no clear guidelines to inform best practice. For most women the wound will be managed expectantly whereas, others may be offered secondary suturing.To evaluate the therapeutic effectiveness of secondary suturing of dehisced perineal wounds compared to non-suturing (healing by secondary intention, expectancy).We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 July 2013) and reference lists of retrieved studies.Randomised controlled trials of secondary (...) Secondary suturing compared to non-suturing for broken down perineal wounds following childbirth. Each year approximately 350,000 women in the United Kingdom and millions more worldwide, experience perineal suturing following childbirth. The postpartum management of perineal trauma is a core component of routine maternity care. However, for those women whose perineal wound dehisces (breaks down), the management varies depending on individual practitioners preferences as there is limited

2013 Cochrane

51. Islamic Trauma Healing: Feasibility Study

Islamic Trauma Healing: Feasibility Study Islamic Trauma Healing: Feasibility Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Islamic Trauma Healing: Feasibility Study The safety and scientific (...) Seattle Pacific University Information provided by (Responsible Party): Lori Zoellner, University of Washington Study Details Study Description Go to Brief Summary: This study will examine the initial feasibility of a program called Islamic Trauma Healing by conducting a small feasibility study (N = 20) of Islamic Trauma Healing in Somalia on key targets of PTSD, depression, somatic symptoms, and quality of life. The hypothesis is that those in Islamic Trauma Healing will show a reduction of PTSD

2018 Clinical Trials

52. The Use of a Novel Super-Oxidized Solution on Top of Standard Treatment in the Home Care Management of Postsurgical Lesions of the Diabetic Foot Reduces Reinfections and Shortens Healing Time. (PubMed)

in improving diabetic foot outcome. We selected 50 patients admitted in our department to be submitted to surgery for acute diabetic foot infection. All patients were left open to heal for secondary intent. We divided patients into 2 groups: Group A (n = 25, male/female = 17/8, age = 67.3 ± 12.1 years, hemoglobin A1C = 7.9 ± 1.1%), patients treated with standard of care and, on top of this, Nexodyn solution, and Group B, treated only with standard of care. After discharge, patients continued Nexodyn (...) The Use of a Novel Super-Oxidized Solution on Top of Standard Treatment in the Home Care Management of Postsurgical Lesions of the Diabetic Foot Reduces Reinfections and Shortens Healing Time. There are still many unmet needs in the treatment of chronic wounds, especially regarding microenvironment modulation. Nexodyn is a novel super-oxidized solution capable of contrast bacterial proliferation. We aimed to evaluate if this solution, on top of standard of care, was safe and effective

2018 The international journal of lower extremity wounds

53. Evaluation of wound healing and postoperative pain after oral mucosa laser biopsy with the aid of compound with chlorhexidine and sodium hyaluronate: a randomized double blind clinical trial. (Full text)

Evaluation of wound healing and postoperative pain after oral mucosa laser biopsy with the aid of compound with chlorhexidine and sodium hyaluronate: a randomized double blind clinical trial. The aim of this study is to evaluate secondary intention healing process and postoperative pain of oral soft tissues after laser surgery with the use of a compound containing chlorhexidine and sodium hyaluronate.This double-blind, randomized clinical study included 56 patients affected by benign oral (...) pain.PHI (T1 = 7 days) was 67.25% for SG, 58.67% for CG, and 54.55% for PG. PHI (T2 = 14 days) was 94.35% for SG, 77.79% for CG, and 78.98% for PG. A statistically significant difference was between the groups for PHI at T2 p = 0.001. No difference was detectable for pain index.A solution containing sodium hyaluronate and chlorhexidine is a good support to increase wound healing by secondary intention after laser biopsy, but no differences were in postoperative perception of pain.The use of the tested

2018 Clinical oral investigations Controlled trial quality: uncertain

54. The Effects of Ozone Therapy on Wound Healing

. Condition or disease Intervention/treatment Phase Wound Heal Device: ozone device ( Ozonytron XL ) Not Applicable Detailed Description: Although ozone therapy has often been tried in medical science and has become more popular due to its antimicrobial, biocompatibility and healing properties, the effects of ozone therapy on surgeries that heals with secondary intention were not studied. In the lights of these informations, the aim of present study was to evaluate effects of ozone therapy on wound (...) Summary: the aim of present study was to evaluate effects of ozone therapy on wound healing after gingivectomy and gingivoplasty operations as a model of secondary wound healing.. Twenty three systemically healthy individuals participated in this study. Ozone was applied immediately after surgery, at 1st day and 3rd day after gingivectomy surgery. In the photographs of the wounds, the difference in color were evaluated and measurements were performed at the baseline, 3rd, 7th, 14th days after surgery

2018 Clinical Trials

55. Clinical Trial Using the Proteolytic Fraction P1G10 From V. Cundinamarcensis to Heal Diabetic Foot Ulcer

to estimate the wound area. Normal distribution of data was evaluated with Shapiro-Wilk test. The differences in values between groups were assessed by t- test. Wound healing incidence was expressed as 1000 person-day with 95% confidence interval in both groups. To minimize the effect of noncompliance and missing outcomes, the data were analyzed as "intention to treat" thus including every subject enrolled in each group during the initial assignment. Secondary Outcome Measures : 80% epithelization [ Time (...) Frame: The secondary outcome (80% epithelization) is measured at the time of the intervention (1-16 weeks). If this endpoint is attained at a given date, the interval between the first intervention and the endpoint date is the period scored for the event. ] A secondary end point was considered as 80% re-epithelization of the injury assessed by presence of epithelial tissue in 80% of the bed occurring during, or at the end of 48 applications. Quantification of healing is assessed by measure

2018 Clinical Trials

56. Evaluation of the Effects of Platelet Rich Fibrin on the Palatal Mucosal Healing

by (Responsible Party): AYSAN LEKTEMUR ALPAN, Pamukkale University Study Details Study Description Go to Brief Summary: Subepithelial connective tissue graft (SCTG) has greater predictability for root coverage and causes minimal discomfort to patient. Although donor site heals with primary intention causing less scar tissue, in some different harvesting procedures primary flap closure may not be achieved due to nature of thick palatal tissues. Some potential complications may occur at donor site (...) surgical procedures were proposed. Coronally advanced flap and subepithelial connective tissue graft (SCTG) is a good combination to increase the keratinized tissue width and reduce the amount of gingival recession. SCTG has greater predictability for root coverage and causes minimal discomfort to patient. Although donor site heals with primary intention causing less scar tissue, in some different harvesting procedures primary flap closure may not be achieved due to nature of thick palatal tissues

2018 Clinical Trials

57. Oxygen for Vascular Incisional Healing

by (Responsible Party): Neogenix, LLC dba Ogenix Study Details Study Description Go to Brief Summary: The purpose of this clinical trial is to evaluate Transdermal Continuous Oxygen Therapy (TCOT) as an adjunct to surgical wound healing in subjects undergoing vascular surgery for lower extremity arterial occlusive disease. It is the intention of this study to administer oxygen using the TCOT approach to the surgical sites of subjects undergoing the surgery and to monitor the healing of the incision as well (...) Oxygen for Vascular Incisional Healing Oxygen for Vascular Incisional Healing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oxygen for Vascular Incisional Healing The safety and scientific validity

2018 Clinical Trials

58. Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds

of this randomized safety study is to determine the safety and efficacy of 0.25% timolol in promoting wound healing in open surgical wounds less or equal to 1.5 cm. Condition or disease Intervention/treatment Phase Wound of Skin Wound Heal Wound Open Surgical Wound Drug: 0.25% Timolol gel with paraffin gauze dressings Other: Vaseline dressing Phase 2 Phase 3 Detailed Description: Healing of a cutaneous defect by second intention is a complex process. Migration of fibroblasts, keratinocytes, and other cell types (...) surgical wounds [ Time Frame: 7 days' post-surgery, 15 days' post-surgery, 30 days' post-surgery, 3 months' post-surgery, 6 months' post-surgery ] Histogram planimetry is more accessible and less expensive than automated analysis software programs, and it is based on the pixel count of a selected irregular area which is divided by the pixel count of 1 cm2 to find a result in terms of cm2 or mm2 Secondary Outcome Measures : Cosmetic outcomes of open surgical wound healing by blinded physician Vancouver

2018 Clinical Trials

59. Platelet-rich plasma in Achilles tendon healing 2 (PATH-2) trial: statistical analysis plan for a multicentre, double-blinded, parallel-group, placebo-controlled randomised clinical trial (Full text)

. Multivariate linear regression adjusting for the stratification factors (centre and age) and additional prognostic factors will be used to investigate the adjusted effect of the intervention. The analysis will be by modified intention-to-treat. Sensitivity analysis will assess the internal validity of the trial results by performing a per-protocol analysis. Safety will be summarised by treatment arm for all patients who started treatment. Secondary patient-reported outcome measures will be analysed using (...) Platelet-rich plasma in Achilles tendon healing 2 (PATH-2) trial: statistical analysis plan for a multicentre, double-blinded, parallel-group, placebo-controlled randomised clinical trial There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2

2018 Trials Controlled trial quality: predicted high

60. Wool-derived keratin dressings versus usual care dressings for treatment of slow-healing venous leg ulceration: study protocol for a randomised controlled trial (Keratin4VLU). (Full text)

therapy. The primary outcome is the proportion of patients with healed VLU at 24 weeks after randomisation as adjudicated by blinded review of an ulcer photograph. Secondary outcomes are time to healing, estimated change in ulcer area, change in health-related quality of life, agreement between blinded and unblinded assessors and adverse events. The analysis will be intention-to-treat on the primary and secondary outcomes (excepting health-related quality of life).The Keratin4VLU trial received (...) Wool-derived keratin dressings versus usual care dressings for treatment of slow-healing venous leg ulceration: study protocol for a randomised controlled trial (Keratin4VLU). Keratins, filament-forming proteins found in vertebrate epithelium, are downregulated in slow-healing venous leg ulcers (VLU) compared with normal-healing VLU. Laboratory and animal model research has suggested exogenous keratins increase expression of endogenous keratins. A non-randomised controlled trial of an exogenous

2018 BMJ open Controlled trial quality: predicted high

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