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Healing by Secondary Intention

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21. Defining the Role of Secondary Intention Healing in Full-Thickness Lid Margin Defects. (PubMed)

Defining the Role of Secondary Intention Healing in Full-Thickness Lid Margin Defects. More than 30 years have passed since the first case series was published regarding the phenomenon of secondary intention healing in relation to lid margin defects. Despite the fascinating results, the technique has not gained widespread support. This study looks at a series of 34 marginal lower lid defects allowed to heal without intervention. The results are remarkable for their consistently high quality (...) , in terms of both cosmetic and functional outcomes. Medial lid defects, in particular, yielded results that would be difficult to surpass by conventional reconstructive techniques. The evidence presented here shows that secondary intention healing in lid margin defects should be considered as a genuine alternative to formal reconstruction, challenging the established dogma of bilamellar repair. For certain lid defects it is quite possibly (and unexpectedly) the new treatment of choice.Therapeutic, IV.

2016 Plastic and reconstructive surgery

22. A selected reaction monitoring based analysis of acute phase proteins in interstitial fluids from experimental equine wounds healing by secondary intention. (PubMed)

A selected reaction monitoring based analysis of acute phase proteins in interstitial fluids from experimental equine wounds healing by secondary intention. In horses, pathological healing with formation of exuberant granulation tissue (EGT) is a particular problem in limb wounds, whereas body wounds tend to heal without complications. Chronic inflammation has been proposed to be central to the pathogenesis of EGT. This study aimed to investigate levels of inflammatory acute phase proteins (...) pore microdialysis from experimental body and limb wounds from five horses at days 1, 2, 7, and 14 after wounding and healing without (body) and with (limb) the formation of EGT. The QconCAT included proteotypic peptides representing each of the protein targets and was used to direct the design of a gene, which was expressed in Escherichia coli in a media supplemented with stable isotopes for metabolically labeling of standard peptides. Co-analysis of wound interstitial fluid samples

2016 Wound Repair and Regeneration

23. Healing Septal Perforations by Secondary Intention Using Acellular Dermis as a Bioscaffold. (PubMed)

Healing Septal Perforations by Secondary Intention Using Acellular Dermis as a Bioscaffold. Several techniques are described in the literature for nasal septal perforation repair. Most of these involve interposition grafts in conjunction with local pedicled mucosal flaps. The following article describes our experience using acellular dermis as a bioscaffold to support the regrowth of nasal septal mucosa by secondary intention.Retrospective chart review of all patients who underwent repair (...) technique and were able to be completely closed with a single additional procedure.Acellular dermis offers an alternative to most currently described complex flaps. The method can be used in patients with defects less than 2 cm, but initial data suggest caution when using in those with wound healing impediments. This technique is also an excellent choice for patients with multiple small septal perforations.© The Author(s) 2014.

2014 Rhinology and Laryngology

24. Pressurised irrigation versus swabbing method in cleansing wounds healed by secondary intention: A randomised controlled trial with cost-effectiveness analysis. (PubMed)

Pressurised irrigation versus swabbing method in cleansing wounds healed by secondary intention: A randomised controlled trial with cost-effectiveness analysis. Wound cleansing should create an optimal healing environment by removing excess debris, exudates, foreign and necrotic material which are commonly present in the wounds that heal by secondary intention. At present, there is no research evidence for whether pressurised irrigation has better wound healing outcomes compared (...) with conventional swabbing practice in cleansing wound.This study investigated the differences between pressurised irrigation and swabbing method in cleansing wounds that healed by secondary intention in relation to wound healing outcomes and cost-effectiveness.Multicentre, prospective, randomised controlled trial.The study took place in four General Outpatient Clinics in Hong Kong.Two hundred and fifty six patients with wounds healing by secondary intention were randomly assigned by having a staff independent

2014 International journal of nursing studies Controlled trial quality: predicted high

25. The Role of the Undermining during Circular Excision of Secondary Intention Healing. (PubMed)

The Role of the Undermining during Circular Excision of Secondary Intention Healing. Circular excision by secondary intention healing is useful for small skin defects. The study compared the effect of the neighboring undermining on wound healing. Patients undergoing circular excision (diameters less than 20 mm) were divided into four groups in sequence by the range of neighboring subcutaneous undermining. Key outcome measures were complication rate, healing time, mature scar width, and quality (...) , but there was no difference between Groups 3 and 4. The undermining of the surrounding tissue is useful to promote secondary intention healing of small skin defects and to improve the cosmetic results of the final scar. The study compared the effect of neighboring undermining on wound secondary healing of circular excision. Key outcome measures were complication rate, healing time, mature scar width, and quality. Statistical differences between different undermining types were used.

2014 The American surgeon Controlled trial quality: uncertain

26. Prospective evaluation of complications of the usage of buffering lidocaine for secondary intention healing. (PubMed)

Prospective evaluation of complications of the usage of buffering lidocaine for secondary intention healing. Circular excision by secondary-intention healing is useful for small skin defects (diameter <10 mm). But the injection pain as the local anesthesia is administered one of the patients' biggest concerns. Buffered lidocaine can effectively relieve the injection pain, but it might increase the potential complications. This study examined the effect of buffered lidocaine on wound (...) healing.Patients undergoing circular excision by secondary-intention healing were divided into 2 groups and were administered buffered or unbuffered lidocaine as the local anesthesia. Comparative parameters included injection pain, postoperative pain, complication rate, scar width, and scar quality at 6 months. Statistical differences between the 2 agents were assessed.The patients in the buffered group experienced 0.9 fewer scaled injection pain units than did the patients in the unbuffered group (p = 0.009

2015 Postgraduate medicine Controlled trial quality: uncertain

27. Hidradenitis suppurativa treated with wide excision and second intention healing: A meaningful local cure rate after 253 procedures. (PubMed)

of an anatomical area was achieved in 49% of the procedures, whereas natural disease progression occurred in 13%. The genital region was the most prone to recurrence. The majority of the patients were glad that they had undergone the procedure and would recommend the surgical procedure to other HS patients.Lesional wide excision (complete excision) with secondary intention healing yields a meaningful local cure rate for HS and is well tolerated.© 2017 European Academy of Dermatology and Venereology. (...) Hidradenitis suppurativa treated with wide excision and second intention healing: A meaningful local cure rate after 253 procedures. Surgery is an important treatment modality for hidradenitis suppurativa (HS). Various methods of HS surgery have been described. Even though wide excision is a common surgical procedure for HS, data on the recurrence rate and patient satisfaction are scarce.To determine the recurrence rate and patient satisfaction of HS lesional wide excision (complete excision

2017 Journal of the European Academy of Dermatology and Venereology

28. Excision and Reconstruction of the Natal Cleft With a Parasacral Perforator Flap Versus Open Excision With Secondary Healing, in the Management of Sacrococcygeal Pilonidal Disease.

sacrococcygeal pilonidal disease is a common acquired condition associated with hirsutism that predominantly affects young male patients. Morbidity from this disease results in pain, embarrassment and loss of normal activities, causing absenteeism from work and school. Various surgical procedures have been described for the treatment of both primary and recurrent pilonidal disease counting: open excision and healing by secondary intention, marsupialization, excision and primary closure (midline or off (...) cluster versus 7.5% in the excision with healing by secondary intention cluster. The time for complete wound healing was also significantly amended . The reconstruction of the natal cleft with a Karydakis or Limberg flap seemed to be superior in terms of recurrence compared to open excision. But those flaps led to a significant and discernable scar. The parasacral perforator flap has been described by Garrido et al. in 2002. It appears to be a good alternative, offering all the benefits

2017 Clinical Trials

29. A prospective case series of secondary intention healing for surgical wounds on the dorsum of the hand. (PubMed)

A prospective case series of secondary intention healing for surgical wounds on the dorsum of the hand. The dorsum of the hand is a common site for squamous cell carcinoma, and excision with appropriate margins often results in surgical defects that cannot be repaired by primary side-to-side closure.To assess healing time, complications and resulting scars when surgical wounds on the dorsum of the hand were allowed to heal by secondary intention.This was a prospective study of 28 surgical (...) defects on the dorsum of the hand, which were allowed to heal by secondary intention. Patients were followed up on days 2, 7 and 14, and then every 2 weeks until the wounds healed. Wound dressings were changed 2-3 times per week. Patients' tolerance of this treatment and their degree of satisfaction with the final results was determined.The defect diameters ranged from 15 to 46 mm (median 24 mm). The time to heal was determined in 24 patients, and ranged from 22 to 63 days (median 44 days). There were

2013 Clinical & Experimental Dermatology

30. Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. (PubMed)

Comparison of negative pressure wound therapy and secondary intention healing after excision of acral lentiginous melanoma on the foot. Melanoma in dark-skinned individuals often develops in an acral lentiginous fashion on the foot and wide excision usually results in a substantial defect. Various repair methods, including free flap, full-thickness skin graft and secondary intention healing (SIH), are used to repair these defects. Recently, use of negative pressure wound treatment (NPWT) has (...) been shown to accelerate wound healing in different types of wound.To compare the functional and cosmetic results of NPWT and SIH in patients who underwent wide excision of melanomas on the foot.The wound defects of 22 patients after wide excision of melanoma on the foot were treated using SIH (n = 13) or NPWT (n = 9).There was no significant difference in time to complete wound healing between the two groups. However, evaluation using the Vancouver Burn Scar Assessment Scale at the time

2013 British Journal of Dermatology

31. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention [Cochrane Protocol]

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention [Cochrane Protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence (...) of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication

2015 PROSPERO

32. Secondary intention healing in skin surgery: our own experience and expanded indications in hidradenitis suppurativa, rhinophyma and non-melanoma skin cancers. (PubMed)

Secondary intention healing in skin surgery: our own experience and expanded indications in hidradenitis suppurativa, rhinophyma and non-melanoma skin cancers. There are many situations in integument surgery in which secondary intention healing (SIH) may bring results comparable or even superior to those obtained with primary intention healing.To present our own methods of employing SIH in surgical treatment of different skin lesions. Moreover, to delineate the extended indications for SIH (...) defects after the excision of non-melanoma skin cancers and hidradenitis suppurativa lesions. Depending on localization, the mean extent of the post-operative wounds prepared for SIH ranged from 0.8to 85.7 cm(2). The healing lasted 2-12 weeks. The most important factor was the size of the wound (r = 0.59; P < 0.001). The assessment at 12 months revealed that cosmetic/functional outcomes were evaluated as 'good' or 'excellent' in 89/83% and 72/70% cases, according to patients and physicians

2013 Journal of the European Academy of Dermatology and Venereology

33. Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention

Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Surgical defect on the lower extremity left to heal by secondary intention. If women of child bearing potential, contraceptive measures should be used Maximum size of wound is 5cm x5cm; there is no minimum size for the wound. Exclusion Criteria: History of porphyria photosensitive eruptions, diabetes mellitus, history of venous insufficiency, known history of peripheral arterial disease (ABI <0.8) Use of any ointments or creams containing (...) Identifier: Other Study ID Numbers: 20120475 First Posted: March 9, 2015 Last Update Posted: November 9, 2017 Last Verified: November 2017 Keywords provided by Keyvan Nouri, University of Miami: wound secondary intention healing lower extremity Additional relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries Surgical Wound

2015 Clinical Trials

34. Ultrasound therapy doesn’t speed healing of leg fracture after surgery

? A broken tibia is the most common long bone fracture. These fractures can take six months or longer to heal and are particularly vulnerable to non-union, when the broken pieces of bone fail to grow back together. LIPUS is commonly used in North America after fracture surgery with the intention of speeding up healing and preventing non-union and is available in the UK. LIPUS involves applying ultrasound waves to skin over the fracture using a wand or probe and gel, similar to those used for pregnancy (...) is commonly used in North America after fracture surgery with the intention of speeding up healing and preventing non-union and is available in the UK. LIPUS involves applying ultrasound waves to skin over the fracture using a wand or probe and gel, similar to those used for pregnancy scans, but it is self-administered. The theory is that the ultrasound waves stimulate bone growth. It is used to promote healing of tibia fracture, both for naturally-healed and surgically-treated fractures, fresh fractures

2019 NIHR Dissemination Centre

35. Wearing a patch after a scratch to the eye probably makes no difference to healing

-randomised controlled trials that compared patching the eye with no patching to treat simple corneal abrasions. DATA COLLECTION AND ANALYSIS: Two authors independently assessed the risk of bias and extracted data. Investigators were contacted for further information regarding the quality of trials. The primary outcome was healing at 24, 48 and 72 hours while secondary outcomes included measures of pain, quality of life and adverse effects. We graded the certainty of the evidence using GRADE. MAIN RESULTS (...) to minimise pain and there is variation in practice with regards to patching the eye to improve comfort and with the intention to promote healing of the ocular surface. Patients often request the eye to be padded to help alleviate their pain symptoms. This review should help healthcare professionals and their patients understand the distilled evidence that this practice may not be helpful for pain relief or for healing and minimise the use of unnecessary padding. Miss Reshma Thampy, Consultant Ophthalmic

2019 NIHR Dissemination Centre

36. Healing by Secondary Intention

Healing by Secondary Intention Healing by Secondary Intention Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Healing by Secondary (...) Intention Healing by Secondary Intention Aka: Healing by Secondary Intention , Secondary Healing From Related Chapters II. Indications Prolonged delay between and treatment See Minor soft tissue amputations without bone loss Less than 1 cm square in size No significant volar pulp loss If unsure Temporize with management below Arrange follow-up and possible graft in 1-2 days III. Management Cleansing Debridement Healing by Secondary Intention Dressing Changes Twice daily for 2 days after injury

2015 FP Notebook

37. Purse-String Suture vs Second Intention Healing: Results of a Randomized, Blind Clinical Trial. (Full text)

for the secondary intention group, a nonsignificant difference (P = .41). Similarly, there were no significant differences for any of the following secondary outcome measures: mean total patient POSAS score (P = .96), mean scar-to-defect area (P = .61), and mean pain level at week 1 (P = .19). Statistical trends toward significance were seen in the mean healing time in favor of purse-string suture (P = .10) and scar relief, which favored second intention healing (P = .07).The purse-string suture results (...) in similar cosmetic outcomes, scar sizes, and pain levels compared with second intention healing for circular or oval wounds on the trunk and extremities. A larger study might better define the potential differences in our secondary outcome measures of healing time and scar relief.clinicaltrials.gov Identifier: NCT02062866.

2014 JAMA dermatology (Chicago, Ill.) Controlled trial quality: predicted high

38. Comparison of Full-Thickness Skin Grafts Versus Second-Intention Healing for Mohs Defects of the Helix. (PubMed)

scale (VAS). Patient questionnaires and retrospective chart analysis were used to assess secondary outcomes.The average second-intention VAS score was 82.1 (standard deviation [SD] = 7.6), and the average FTSG VAS score was 75.2 (SD = 16.7) (difference of 6.9, 95% confidence interval: -1.3 to 15.1, p = .061). A subsequent noninferiority test indicated that cosmetic outcome of second-intention healing was at least as good as that of FTSG in the authors' study (p < .001). Retrospective chart analysis (...) Comparison of Full-Thickness Skin Grafts Versus Second-Intention Healing for Mohs Defects of the Helix. Two repair options for Mohs defects of the helix include full-thickness skin grafting and second-intention healing. Limited long-term data exist comparing these 2 repair options.To compare outcomes of full-thickness skin grafts (FTSG) versus second-intention wound healing for Mohs defects on the helix.In this study, 29 second-intention and 18 FTSG repairs were evaluated using a visual analog

2014 Dermatologic Surgery

39. Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot. (PubMed)

Comparison of Secondary Intention Healing and Full-Thickness Skin Graft After Excision of Acral Lentiginous Melanoma on Foot. Melanoma in dark-skinned individuals often develops in an acral lentiginous fashion on the foot. After wide excision, substantial defects usually develop and they may endure insufficient vascular flow. In addition, the final scar must withstand the mechanical stress of daily walking. Various repair methods are used to repair these defects, but secondary intention healing (...) has not been evaluated in the repair of wounds of the foot.To compare the functional and cosmetic results of secondary intention healing and full-thickness skin graft after wide excision of melanoma on the foot.Retrospective review of 25 patients who were treated using excision for melanoma on the foot. The defects of 13 patients were healed by secondary intention (secondary intention healing group; SIHG), and those of 12 patients were repaired by full-thickness skin graft (skin graft group; SGG

2011 Dermatologic Surgery

40. Free Cartilage Grafts for Alar Defects Coupled with Secondary-Intention Healing. (PubMed)

Free Cartilage Grafts for Alar Defects Coupled with Secondary-Intention Healing. 21388482 2011 06 16 2011 04 12 1524-4725 37 4 2011 Apr Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Free cartilage grafts for alar defects coupled with secondary-intention healing. 510-3 10.1111/j.1524-4725.2011.01909.x Campbell Tracy T Department of Dermatology, University of California at Davis, Sacramento, California 95816, USA. Eisen Daniel B (...) DB eng Case Reports Journal Article 2011 03 09 United States Dermatol Surg 9504371 1076-0512 IM Aged, 80 and over Carcinoma, Basal Cell surgery Ear Cartilage transplantation Follow-Up Studies Free Tissue Flaps Humans Male Mohs Surgery methods Nose Neoplasms surgery Wound Healing 2011 3 11 6 0 2011 3 11 6 0 2011 6 17 6 0 ppublish 21388482 10.1111/j.1524-4725.2011.01909.x

2011 Dermatologic Surgery

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