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Healing by Secondary Intention

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181. What is the evidence on the role of the arts in improving health and well-being? A scoping review

national arts councils (5–7); consequently, WHAT IS THE EVIDENCE ON THE ROLE OF THE ARTS IN IMPROVING HEALTH AND WELL-BEING? A SCOPING REVIEW HEALTH EVIDENCE NETWORK SYNTHESIS REPORT 2 these were not included in the review (4). Similarly, this review did not focus on architecture or the design of buildings. However, some secondary references to the use of visual art in health settings are made. 1.1.2 Defining health WHO defines health as “a state of complete physical, mental and social well-being (...) combinations of these health-promoting components, whether undertaken in everyday life (not for a health purpose but having a secondary benefit for health) or within bespoke arts programmes designed with targeted health or well-being goals, or therapeutic arts programmes delivered by trained arts therapists (22). For certain populations, or when aiming to influence certain health conditions, particular types of arts activities (whether everyday, bespoke or therapy) and particular art forms may be more

2019 WHO Health Evidence Network

182. Rivaroxaban (Xarelto) - Co-administered with acetylsalicylic acid for the prevention of atherothrombotic events in adult patients

. The primary outcome was a composite of myocardial infarction, stroke and cardiovascular death in the intention-to-treat population, which comprised all randomised patients. 2,3 3 On the advice of an independent data and safety monitoring board the anti-thrombotic part of the study was stopped early at the first interim analysis, after mean follow-up of 23 months. At this point the primary outcome had occurred significantly less often in both the rivaroxaban plus aspirin group and rivaroxaban group (...) compared with low-dose aspirin in the total study population and CAD subgroup representative of the positioning. This was mainly due to reductions in stroke and cardiovascular deaths, with rates of myocardial infarction similar across the groups. 2,3 Results for the licensed regimen, rivaroxaban plus aspirin, are in table 1 below. Table 1: Primary, secondary and some tertiary outcomes of COMPASS study. 2-4 Total Study Population Coronary Artery Disease (CAD) Subgroup Rivaroxaban Aspirin Aspirin Hazard

2019 Scottish Medicines Consortium

183. Heart Disease and Stroke Statistics Full Text available with Trip Pro

of hospital discharges and numbers of procedures performed are for inpatients discharged from short-stay hospitals. Discharges include those discharged alive, dead, or with unknown status. Unless otherwise specified, discharges are listed according to the first-listed (primary) diagnosis, and procedures are listed according to all listed procedures (primary plus secondary). These estimates are from the HCUP 2014. Ambulatory care visit data include patient visits to primary providers’ offices and hospital

2019 American Heart Association

184. AIM Clinical Appropriateness Guidelines for Spine Surgery

, also known as lumbar artificial disc surgery or total disc arthroplasty (TDA), was developed as an alternative to lumbar fusion for treatment of back pain due to severe degenerative disc disease. The procedure is similar to lumbar interbody fusion, in that an anterior approach is required. Unlike fusion, motion at the level of disc replacement is maintained, which would seem to be advantageous in terms of preventing secondary degenerative changes and preserving spine mechanics. This document

2019 AIM Specialty Health

185. Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for

transplantation was defined as ‘‘a transfer of biologic material containing a minimally manipulated community of microorganisms from a human donor to a human recipient (including autologous use) with the intent of affecting the microbiota of the recipient’’ (1). In the case of FMT, fecal material is used. Throughout this manuscript, the term FMT is used. Other Received April 4, 2018; accepted October 3, 2018. From the Department of Pediatric Gastroenterology, Digestive Diseases, Hepatology, and Nutrition (...) microbiome may affect its ability to tolerate or resist a transplanted microbiome and enable mucosal healing. Furthermore, both safety and efficacy take on a new meaning when applied to children with 20 to 30 additional life-years compared to adults. In a letter to the FDA, the Joint Society Consensus Recommendation (JSCR) (102) states that ‘‘children could also potentially serve as donors as long as both parental consent and child assent are obtained.’’ Further research on age-matched donors

2019 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

186. Negative Pressure Wound Therapy (NPWT)

: pressure ulcers; venous leg ulcers; burns; open traumatic wounds; open abdomen; wounds healing by primary intention (including split-thickness skin grafts, caesarean section wounds and closed incision wounds); surgical wounds healing by secondary intention; and sternal wound infections after cardiothoracic surgery. Consensus statements to guide best practice • Exploratory work by SHTG highlighted the need for guidance on the appropriate and safe use of NPWT in NHSScotland. Therefore consensus (...) and standard care for any type of open traumatic wound (including open fracture wounds). Other wound types ? In the following wound types, evidence from robust RCTs is either lacking, insufficient and/or inconsistent: pressure ulcers; venous leg ulcers; burns; open abdomen; wounds healing by primary intention (including split thickness skin grafts, caesarean section wounds and closed incision wounds); surgical wounds healing by secondary intention; and sternal wound infections after cardiothoracic surgery

2019 SHTG Advice Statements

187. Syphilis in pregnancy

Primary · Lesions begin as a raised papule that ulcerates (chancre) and may 16,26,4 : o Be painless or painful (approximately half reported as painful) 33 o Be solitary or multiple (approximately one third reported as multiple) 33 o Typically occur at the site of inoculation (e.g. vagina, penis, anus, rectum, lips, in or on the mouth) o Discharge clear serum—may also be purulent, destructive o Spontaneously heals within three to six weeks without treatment Secondary · Follows untreated primary stage (...) primary, secondary and early latent stages). Consider the possibility of infectious syphilis if duration is unknown and there are no symptoms and/or no evidence of adequate treatment. Syphilis requiring treatment in pregnancy In this guideline, syphilis requiring treatment in pregnancy is used to mean infectious syphilis that is treated during the current pregnancy OR syphilis of unknown duration or late latent syphilis that is untreated, has been inadequately treated, or where there is no history

2019 Queensland Health

188. British Association of Dermatologists and U.K. Curaneous Lymphoma Group (CLG) guidelines for the management of primary cutaneous lymphomas

of primary cutaneous CD30 + lymphoproliferative disorders and is de?ned by a history of recurrent, self-healing papules and nodules, and characteristic pathology. CBCL presents with nodules, plaques and tumours with a characteristic pathology and immunophenotype, and site local- ization can be an important distinguishing feature. A de?nitive diagnosis can only be made on a representative biopsy, prefer- ably an excision or elliptical biopsy. Borrelia burgdorferi infection has been reported in association (...) required for other CTCL variants and for high- grade PCLBCL leg type. Bone marrow biopsy and aspirate is considered optional for low-grade PCMZL but should be con- sidered for PCFCL, as systemic follicle centre lymphoma with secondary cutaneous involvement may occur. 19,20 Serum lac- tate dehydrogenase has prognostic signi?cance and should be checked at diagnosis. 21 Existing staging systems for nodal lymphomas are not appli- cable for primary cutaneous lymphomas. The original TNM (primary tumour

2019 British Association of Dermatologists

189. Optimal Care Pathway for Aboriginal and Torres Strait Islander people with cancer

is available at cancer.org.au/ocp and canceraustralia.gov.auForeword i Summary 1 Context 5 Intent and key principles 8 Supporting the delivery of optimal care for Aboriginal and Torres Strait Islander people with cancer 18 Optimal cancer care pathway 26 Step 1: Prevention and early detection 27 Step 2: Presentation, initial investigations and referral 35 Step 3: Diagnosis, staging and treatment planning 39 Step 4: Treatment 45 Step 5: Care after initial treatment and recovery 51 Step 6: Managing recurrent (...) step of the pathway and refer to appropriate health professionals or organisations. Step 4 Treatment Treatment intent: Establish and document if treatment is • curative • anti-cancer therapy to improve quality of life and/or longevity without expectation of cure or • symptom palliation. When discussing death or dying with Aboriginal and Torres Strait Islander people, the terms ‘passing’, ‘not going to get better’ or ‘returning to Country’ may be more accepted due to spiritual belief around the life

2018 Cancer Australia

190. Child Abuse, Elder Abuse, and Intimate Partner Violence

abuse. Suspicion of abuse is often triggered when the story does not match the injury pattern, the story changes over time, multiple injuries result from a simple mechanism, or injuries are present in various stages of healing. The goal of this BPG is to provide a resource for trauma center health professionals to identify, evaluate, manage, document, and report patients that are victims of abuse. It also provides tools for collecting data, injury coding, and quality indicators to monitor, compare (...) , and improve care. Each of the sections—child abuse, elder abuse, and intimate partner violence—separately address definition, epidemiology, assessment and screening, management, and reporting. Documentation for all forms of abuse follows the family violence sections. Quality and process improvement measures are addressed in a separate section at the end, with specific recommendations for each type of abuse. Important Note The intent of the ACS Trauma Quality Programs (TQP) Best Practices Guidelines

2019 American College of Surgeons

191. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures

patients. In particular, patients who smoke cigarettes should stop as soon as possible, preferably 1 year, but at the very least, 6 weeks before bariatric procedures (Grade A; BEL 2, upgraded by consensus). Also, tobacco use must be avoided after bariatric procedures given the increased risk of poor wound healing, anastomotic ulcer, and overall impaired health (Grade A; BEL 1). Structured intensive cessation programs are preferable to general advice and should be implemented (Grade D). DOI:10.4158/GL

2019 American Association of Clinical Endocrinologists

192. AACE/ACE Guidelines for Management of Growth Hormone Deficiency in Adults and Patients Transitioning from Pediatric to Adult Care

of considering test- ing patients with a reasonable level of clinical suspicion of GHD using appropriate growth hormone (GH) cut-points for various GH–stimulation tests to accurately diagnose adult GHD, and to exercise caution interpreting serum GH and insulin-like growth factor-1 (IGF-1) levels, as various GH and IGF-1 assays are used to support treatment deci- sions. The intention to treat often requires sound clinical judgment and careful assessment of the benefits and risks specific to each individual (...) to suggest that the risk of cancer, secondary neoplasms (SN) and hypothalamic-pituitary tumor recurrence is increased, although it remains possible that a longer period of follow- up may still be needed to discern any small increases in these risks. Early studies utilized rhGH doses in replacement regimens that took into consideration of body weight or body surface area, and dose adjustments were based on body composition outcomes, analogous to pediatric prac- tice (42-44), but side effects were

2019 American Association of Clinical Endocrinologists

193. Colorectal Cancer

of Colorectal Liver Metastases 111 7.4.3. Tumor Markers 113 7.4.4. Specific Diagnostics for Rectal Cancer 114 7.5. Surgical Therapy with Curative Intention 117 7.5.1. Intraoperative Staging 117 7.5.1.1. Intra-Operative Pathological Examination 117 7.5.2. Radical Surgical Therapy of Colon Cancer 118 7.5.2.1. Extent of Lymph Node Dissection: 118 7.5.2.2. Complete Mesocolic Excision (CME) 120 7.5.2.3. Local Ablative Therapies for Liver Metastases 121 7.5.2.3.1. Radio-Frequency Ablation (RFA) 121 7.5.2.3.2 (...) Guideline Program in Oncology | Evidenced-based Guideline for Colorectal Cancer | Version 2.1 | Januar 2019 10 10.8.2.4. Alternative Healing Methods 241 11. Quality Indicators 242 12. Appendix 248 12.1. UICC-Classification of Colorectal Cancer 248 12.2. Amsterdam Criteria 249 12.3. Revised Bethesda-Criteria 249 12.4. Changes to the Recommendations Due to the 2017 Update 250 13. List of Figures 269 14. List of Tables 269 15. References 271 1.1 Editors © German Guideline Program in Oncology | Evidenced

2019 German Guideline Program in Oncology

194. Urological Trauma

violence, child and sexual abuse, and MVAs . 3.2. Classification of trauma Traumatic injuries are classified by the World Health Organization (WHO) into intentional (either interpersonal violence related, war-related or self-inflicted injuries), and unintentional injuries (mainly MVAs, falls, and other domestic accidents). Intentional trauma accounts for approximately half of the trauma-related deaths worldwide [ ]. A specific type of unintentional injury is iatrogenic injury which occurs during

2019 European Association of Urology

195. Male Sexual Dysfunction

prostate biopsy. BJU Int, 2015. 116(2)190. 66. Mottet, N., et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol, 2016. 67. Salonia, A., et al. Prevention and management of postprostatectomy sexual dysfunctions part 2: recovery and preservation of erectile function, sexual desire, and orgasmic function. Eur Urol, 2012. 62: 273. 68. Salonia, A., et al. Prevention and management of postprostatectomy sexual dysfunctions. Part (...) . part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol, 2014. 65: 124. 98. Maggi, M., et al. Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA). J Sex Med, 2013. 10: 661. 99. Laumann, E.O., et al. The epidemiology of erectile dysfunction: results from the National Health and Social Life Survey. Int J Impot Res, 1999. 11 Suppl 1: S60. 100. Miner, M., et al. Cardiometabolic risk

2019 European Association of Urology

196. Muscle-invasive and Metastatic Bladder Cancer

. Chrouser, K., et al. Bladder cancer risk following primary and adjuvant external beam radiation for prostate cancer. J Urol, 2005. 174: 107. 26. Nieder, A.M., et al. Radiation therapy for prostate cancer increases subsequent risk of bladder and rectal cancer: a population based cohort study. J Urol, 2008. 180: 2005. 27. Zelefsky, M.J., et al. Incidence of secondary cancer development after high-dose intensity-modulated radiotherapy and image-guided brachytherapy for the treatment of localized prostate

2019 European Association of Urology

198. The EAU – EANM – ESTRO – ESUR – SIOG Guidelines on Prostate Cancer

Kwast, H.G. van der Poel, O. Rouvière, I.G. Schoots, D. Tilki, T. Wiegel Guidelines Associates: T. Van den Broeck, M. Cumberbatch, N. Fossati, G. Gandaglia, N. Grivas, M. Lardas, M. Liew, L. Moris, D.E. Oprea-Lager, P-P.M. Willemse TABLE OF CONTENTS REFERENCES 1. Mottet, N., et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol, 2017. 71: 618. 2. Cornford, P., et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II (...) . Going from evidence to recommendations. BMJ, 2008. 336: 1049. 7. Lam, T.B.L., et al. EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study). Eur Urol, 2019. 76: 790. 8. Willemse, P.M., et al. Systematic review of deferred treatment with curative intent for localised prostate cancer to explore heterogeneity of definitions, thresholds and criteria

2020 European Association of Nuclear Medicine

199. Interventions for managing medication-related osteonecrosis of the jaw. Full Text available with Trip Pro

trials and add them to CENTRAL.We included randomised controlled trials (RCTs) comparing one modality of intervention with another for the prevention or treatment of MRONJ. For 'prophylaxis of MRONJ', the primary outcome of interest was the incidence of MRONJ; secondary outcomes were QoL, time-to-event, and rate of complications and side effects of the intervention. For 'treatment of established MRONJ', the primary outcome of interest was healing of MRONJ; secondary outcomes were QoL, recurrence (...) 0.08, 95% CI 0.00 to 1.51; 176 participants; very low-quality evidence). Secondary outcomes were not reported. In another trial comparing wound closure by primary intention with wound closure by secondary intention after dental extractions in people treated with oral bisphosphonates (700 participants), no cases of intraoperative complications or postoperative MRONJ were observed. QoL was not investigated. Treatment of MRONJOne trial analysed hyperbaric oxygen (HBO) treatment used in addition

2017 Cochrane

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