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Headache-Related Neuroimaging

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161. Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease. (PubMed)

biological knowledge-based binning approach for rare-variant association analysis and then applied the approach to structural neuroimaging endophenotypes related to late-onset Alzheimer's disease (LOAD).For rare-variant analysis, we used the knowledge-driven binning approach implemented in Bin-KAT, an automated tool, that provides 1) binning/collapsing methods for multi-level variant aggregation with a flexible, biologically informed binning strategy and 2) an option of performing unified collapsing (...) and statistical rare variant analyses in one tool. A total of 750 non-Hispanic Caucasian participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort who had both WGS data and magnetic resonance imaging (MRI) scans were used in this study. Mean bilateral cortical thickness of the entorhinal cortex extracted from MRI scans was used as an AD-related neuroimaging endophenotype. SKAT was used for a genome-wide gene- and region-based association analysis of rare variants (MAF (minor allele

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2017 Medical Informatics and Decision Making

162. Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder-a systematic review of the magnetic resonance neuroimaging literature. (PubMed)

studies in cortical gray matter report evidence of decreased neuronal integrity in both disorders. Functional neuroimaging studies typically report similar functional architecture of brain networks in healthy controls and patients across the psychosis spectrum, but find differential extent of alterations in task related activation and resting state connectivity between illnesses. The very limited imaging-genetic literature suggests a relationship between psychosis risk genes and brain structure (...) Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder-a systematic review of the magnetic resonance neuroimaging literature. Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia

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2017 NPJ schizophrenia

163. A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study. (PubMed)

A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study. Aerobic training has some benefits for delaying the onset or progression of Alzheimer's disease (AD). Little is known about the implication of the brain's two main fuels, glucose and ketones (acetoacetate), associated with thesebenefits.To determine whether aerobic exercise training modifies brain energy metabolism in mild AD.In this uncontrolled study (...) , ten patients with mild AD participated in a 3-month, individualized, moderate-intensity aerobic training on a treadmill (Walking). Quantitative measurement of brain uptake of glucose (CMRglu) and acetoacetate (CMRacac) using neuroimaging and cognitive testing were done before and after the Walking program.Four men and six women with an average global cognitive score (MMSE) of 26/30 and an average age of 73 y completed the Walking program. Average total distance and treadmill speed were 8 km/week

2017 Journal of Alzheimer's disease : JAD

164. Neuroimaging of Human Balance Control: A Systematic Review. (PubMed)

Neuroimaging of Human Balance Control: A Systematic Review. This review examined 83 articles using neuroimaging modalities to investigate the neural correlates underlying static and dynamic human balance control, with aims to support future mobile neuroimaging research in the balance control domain. Furthermore, this review analyzed the mobility of the neuroimaging hardware and research paradigms as well as the analytical methodology to identify and remove movement artifact in the acquired (...) brain signal. We found that the majority of static balance control tasks utilized mechanical perturbations to invoke feet-in-place responses (27 out of 38 studies), while cognitive dual-task conditions were commonly used to challenge balance in dynamic balance control tasks (20 out of 32 studies). While frequency analysis and event related potential characteristics supported enhanced brain activation during static balance control, that in dynamic balance control studies was supported by spatial

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2017 Frontiers in human neuroscience

165. Emotion recognition and theory of mind in schizophrenia: a meta-analysis of neuroimaging studies. (PubMed)

Emotion recognition and theory of mind in schizophrenia: a meta-analysis of neuroimaging studies. Patients with schizophrenia have difficulties processing the emotional and cognitive states of others. Neuroimaging studies show inconsistent findings.We used a Seed-based d Mapping meta-analytic method to explore brain activation during facial emotion recognition and theory of mind tasks in schizophrenia patients.The patients showed lesser recruitment of the facial emotion processing network (...) ; behavioural performance was associated with the activation of the precentral gyrus. We found abnormal activation of the mentalising network in schizophrenia patients during reasoning about other people's mental states; patients with worse performances showed lesser activation in the right insula and superior temporal gyrus. Multimodal meta-analysis showed overlaps of brain-related abnormalities for both modalities in schizophrenia, with reduced recruitment of the right insula, anterior cingulate

2017 The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

166. Alterations of Myelin Content in Parkinson's Disease: A Cross-Sectional Neuroimaging Study. (PubMed)

Alterations of Myelin Content in Parkinson's Disease: A Cross-Sectional Neuroimaging Study. Alterations to myelin may be a core pathological feature of neurodegenerative diseases. Although white matter microstructural differences have been described in Parkinson's disease (PD), it is unknown whether such differences include alterations of the brain's myelin content. Thus, the objective of the current study is to measure and compare brain myelin content between PD patients and age-matched (...) in PD. Within the PD group, measures of disease severity, including UPDRS, daily levodopa equivalent dose, and disease duration, were observed to be related with myelin content in diffuse brain regions. The age-by-group interaction suggests that either PD or dopaminergic therapies allay observed age-related myelin changes. The relationships between VFM and disease severity measures suggests that VFM may provide a surrogate marker for microstructural changes related to Parkinson's disease.

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2016 PLoS ONE

167. Antecedents and neuroimaging patterns in cerebral palsy with epilepsy and cognitive impairment: a population-based study in children born at term. (PubMed)

Antecedents and neuroimaging patterns in cerebral palsy with epilepsy and cognitive impairment: a population-based study in children born at term. Antecedents of accompanying impairments in cerebral palsy and their relation to neuroimaging patterns need to be explored.A population-based study of 309 children with cerebral palsy born at term between 1983 and 1994. Prepartum, intrapartum, and postpartum variables previously studied as antecedents of cerebral palsy type and motor severity were (...) analyzed in children with cerebral palsy and cognitive impairment and/or epilepsy, and in children with cerebral palsy without these accompanying impairments. Neuroimaging patterns and their relation to identified antecedents were analyzed. Data were retrieved from the cerebral palsy register of western Sweden, and from obstetric and neonatal records.Children with cerebral palsy and accompanying impairments more often had low birthweight (kg) (odds ratio 0.5, 95% confidence interval 0.3-0.8), brain

2017 Acta Obstetricia et Gynecologica Scandinavica

168. ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: A meta-analysis. (PubMed)

ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: A meta-analysis. With the emergency department (ED) being a high-risk site for diagnostic errors, we sought to estimate ED diagnostic accuracy for identifying acute cerebrovascular events.MEDLINE and Embase were searched for studies (1995-2016) reporting ED diagnostic accuracy for ischemic stroke, TIA, or subarachnoid hemorrhage (SAH). Two independent reviewers determined inclusion. We identified 1,693 unique citations (...) when presenting neurologic complaints are mild, nonspecific, or transient (range 24%-60%). This difference suggests that many misdiagnoses relate to symptom-specific factors. Future research should emphasize studying causes and designing error-reduction strategies in symptom-specific subgroups at greatest risk of misdiagnosis.© 2017 American Academy of Neurology.

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2017 Neurology

169. FUNCTIONAL NEUROIMAGING FINDINGS IN HEALTHY MIDDLE-AGED ADULTS AT RISK OF ALZHEIMER's DISEASE. (PubMed)

FUNCTIONAL NEUROIMAGING FINDINGS IN HEALTHY MIDDLE-AGED ADULTS AT RISK OF ALZHEIMER's DISEASE. It is well established that the neurodegenerative process of Alzheimer's disease (AD) begins many years before symptom onset. This preclinical phase provides a crucial time-window for therapeutic intervention, though this requires biomarkers that could evaluate the efficacy of future disease-modification treatments in asymptomatic individuals. The last decade has witnessed a proliferation of studies (...) tomography (PET) studies of amyloid deposition, glucose metabolism, as well as arterial spin labeling (ASL), task-dependent, resting-state functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) studies. The prevailing evidence points to early brain functional changes in the relative absence of cognitive impairment and structural atrophy, although there is marked variability in the directionality of the changes, which could, in turn, be related to antagonistic pleiotropy

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2017 Ageing research reviews

170. Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis. (PubMed)

Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis. Schizophrenia spectrum disorder (SCZD), autism spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD) are considered as three separate psychiatric conditions with, supposedly, different brain alterations patterns. From a neuroimaging perspective, this meta-analytic study aimed to address whether this nosographical (...) , premotor visual somatic functions. In turn, ASD appears to be uniformly distributed in the two clusters. The three spectra share a significant set of alterations. Our new approach promises to provide insight into the understanding of psychiatric conditions under the aspect of a common neurobiological substrate, possibly related to neuroinflammation during brain development. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1079-1095. © 2017

2017 Autism research : official journal of the International Society for Autism Research

171. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. (PubMed)

Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. Bipolar disorder is associated with high risk for suicidal behavior that often develops in adolescence and young adulthood. Elucidation of involved neural systems is critical for prevention. This study of adolescents and young adults with bipolar disorder with and without a history of suicide attempts combines structural, diffusion tensor (...) , and differences were explored for relationships between imaging modalities and associations with suicide-related symptoms and behaviors.Compared with the nonattempter group, the attempter group showed significant reductions in gray matter volume in the orbitofrontal cortex, hippocampus, and cerebellum; white matter integrity in the uncinate fasciculus, ventral frontal, and right cerebellum regions; and amygdala functional connectivity to the left ventral and right rostral prefrontal cortex. In exploratory

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2017 American Journal of Psychiatry

172. Neuroimaging craving: urge intensity matters.

Neuroimaging craving: urge intensity matters. Functional neuroimaging has become an increasingly common tool for studying drug craving. Furthermore, functional neuroimaging studies, which have addressed an incredibly diverse array of questions regarding the nature and treatment of craving, have had a substantial impact on theoretical models of addiction. Here, we offer three points related to this sizeable and influential body of research. First, we assert that the craving most investigators

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2017 Addiction (Abingdon, England)

173. Acupuncture Treatment for Chronic Sciatica: the Neuroimaging Pain-network Study

Acupuncture Treatment for Chronic Sciatica: the Neuroimaging Pain-network Study Acupuncture Treatment for Chronic Sciatica: the Neuroimaging Pain-network Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Acupuncture Treatment for Chronic Sciatica: the Neuroimaging Pain-network Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03489681 Recruitment Status : Recruiting First Posted : April 5, 2018 Last Update Posted : January

2017 Clinical Trials

174. Neuroimaging During Pure Oxygen Breathing

Neuroimaging During Pure Oxygen Breathing Neuroimaging During Pure Oxygen Breathing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neuroimaging During Pure Oxygen Breathing The safety and scientific (...) Phase 4 Detailed Description: The investigators will conduct a two-arm crossover design clinical trial to compare the effect of room air breathing (21% inspired oxygen) with pure oxygen breathing (100% inspired oxygen) on brain blood flow and cortical electrical activity. The study involves a one-time data collection taking place at University Hospitals Cleveland Medical Center on the Case Western Reserve University campus in Cleveland, OH. The investigators will perform neuroimaging (MRI

2017 Clinical Trials

175. Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury

Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Brain Magnetic Resonance Imaging (MRI) Neuroimaging protocol to assess brain changes after minor head trauma and over the time. Procedure: Brain Magnetic Resonance Imaging (MRI) Outcome Measures Go to Primary Outcome Measures : Fractional anisotropy (FA) measure [ Time Frame: Month 0 ] Fractional anisotropy (FA) measure by Magnetic Resonance Imaging (...) Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury Multimodal Neuroimaging Analysis After Mild Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Multimodal Neuroimaging

2017 Clinical Trials

176. Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders

integrity. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 49 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Actual Study Start Date : September 1, 2017 Estimated Primary Completion Date : August 31, 2022 Estimated Study Completion Date : August 31, 2022 Resource links provided by the National Library of Medicine related topics (...) Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2017 Clinical Trials

177. Novel Neuroimage Study in Tauopathies With Parkinsonism

(Clinical Trial) Estimated Enrollment : 60 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic Official Title: Novel Neuroimage Study in Tauopathies With Parkinsonism Actual Study Start Date : July 31, 2017 Estimated Primary Completion Date : July 31, 2019 Estimated Study Completion Date : July 31, 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment (...) Novel Neuroimage Study in Tauopathies With Parkinsonism Novel Neuroimage Study in Tauopathies With Parkinsonism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Novel Neuroimage Study in Tauopathies

2017 Clinical Trials

178. Motivational Interviewing and Neuroimaging With Adolescents

Motivational Interviewing and Neuroimaging With Adolescents Motivational Interviewing and Neuroimaging With Adolescents - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Motivational Interviewing (...) and Neuroimaging With Adolescents (MINA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03367858 Recruitment Status : Active, not recruiting First Posted : December 11, 2017 Last Update Posted : January 21, 2019 Sponsor: Oregon Health and Science University Information provided by (Responsible Party): Sarah

2017 Clinical Trials

179. Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD

by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD (Sino Longitudinal Study on Cognitive Decline, SILCODE) Actual Study Start Date : March 15, 2017 Estimated Primary Completion Date : December 2019 Estimated Study Completion Date : December 2021 Resource links provided by the National Library of Medicine related topics: resources: Groups and Cohorts Go to Group/Cohort Intervention/treatment Subjective cognitive decline, SCD The inclusion criteria for SCD (...) Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2017 Clinical Trials

180. Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome (PubMed)

Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome People with Down syndrome (DS) develop Alzheimer's disease (AD) at higher rates and a younger age of onset compared to the general population. As the average lifespan of people with DS is increasing, AD is becoming an important health concern in this group. Neuroimaging is becoming an increasingly useful tool in understanding the pathogenesis of dementia development in relation to clinical symptoms. Furthermore (...) and assesses the relationship between cognitive decline and neuroimaging changes. We find that amyloid accumulation seen on PET occurs prior to dementia onset, possibly as a precursor to the atrophy and white matter changes seen in MRI studies. Future PET studies relating tau distribution to clinical symptoms will provide further insight into the role this protein plays in dementia development. Brain activity changes demonstrated by EEG and metabolic changes seen via FDG-PET may also follow predictable

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2017 NeuroImage : Clinical

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