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Headache-Related Neuroimaging

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181. Low Back Pain: Unveiling the Contribution of Motor Control Adaption Using Biomechanical Modeling and Neuroimaging

Biomechanical Modeling and Neuroimaging Estimated Study Start Date : April 1, 2019 Estimated Primary Completion Date : June 1, 2022 Estimated Study Completion Date : December 1, 2022 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Healthy subjects Spine kinematics assessment during daily activities and brain responses to thoracolumbar mechanical and vibrotactile stimulation Other: mechanical stimulation (...) Low Back Pain: Unveiling the Contribution of Motor Control Adaption Using Biomechanical Modeling and Neuroimaging Low Back Pain: Unveiling the Contribution of Motor Control Adaption Using Biomechanical Modeling and Neuroimaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

182. Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain (Neuroimaging Supplement)

conditions (BAS+ or SC) as part of the main (parent) study. Masking: Single (Participant) Primary Purpose: Other Official Title: Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain (Neuroimaging Supplement) Actual Study Start Date : August 9, 2017 Estimated Primary Completion Date : April 2019 Estimated Study Completion Date : April 2019 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention (...) Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain (Neuroimaging Supplement) Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain (Neuroimaging Supplement) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

183. Neuroimaging Studies of Smoking and Treatment

Neuroimaging Studies of Smoking and Treatment Neuroimaging Studies of Smoking and Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neuroimaging Studies of Smoking and Treatment The safety (...) : Interventional (Clinical Trial) Estimated Enrollment : 56 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention Official Title: Smoking Cessation, Cognitive Control and Reward Processing: An fMRI Pilot Study Actual Study Start Date : December 2014 Estimated Primary Completion Date : November 15, 2018 Estimated Study Completion Date : February 28, 2019 Resource links provided by the National Library of Medicine related topics: Arms

2017 Clinical Trials

184. Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes

) Primary Purpose: Treatment Official Title: Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes Study Start Date : January 2015 Estimated Primary Completion Date : July 2020 Estimated Study Completion Date : July 2020 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Child STEPS Child STEPs includes (1) a treatment protocol, Modular Approach to Therapy (...) Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

185. Pharmacologically Triggered Migraine Without Aura and Neuroimaging

Triggered Migraine Without Aura and Neuroimaging The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03143465 Recruitment Status : Active, not recruiting First Posted : May 8, 2017 Last Update Posted : February 15, 2019 Sponsor: Danish Headache Center Information provided by (Responsible Party): Samaira (...) Younis, Danish Headache Center Study Details Study Description Go to Brief Summary: Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO. One of the most fundamental questions of migraine, which remains to be elucidated, is the mechanism behind the generation of migraine attacks. The investigators will use calcitonin gene-related peptide (CGRP) and sildenafil as pharmacological triggers

2017 Clinical Trials

186. Are Parkinson’s Patients More Vulnerable to the Effects of Cardiovascular Risk: A Neuroimaging and Neuropsychological Study (PubMed)

Are Parkinson’s Patients More Vulnerable to the Effects of Cardiovascular Risk: A Neuroimaging and Neuropsychological Study This study examined whether individuals with Parkinson's disease (PD) are at increased vulnerability for vascular-related cognitive impairment relative to controls. The underlying assumption behind this hypothesis relates to brain reserve and that both PD and vascular risk factors impair similar fronto-executive cognitive systems.The sample included 67 PD patients and 61 (...) risk was related to worse executive functioning, processing speed, and delayed verbal recall in both Parkinson patients and controls. More severe cardiovascular risk was related to worse language functioning in the PD group, but not controls. In contrast, leukoaraiosis related to both cardiovascular risk and executive functioning for controls, but not the PD group.Overall, results revealed that PD and cardiovascular risk factors are independent risk factors for cognitive impairment. Generally

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2017 Journal of the International Neuropsychological Society : JINS

187. Emotional anticipation after delivery – a longitudinal neuroimaging study of the postpartum period (PubMed)

Emotional anticipation after delivery – a longitudinal neuroimaging study of the postpartum period Neuroimaging research has begun to unveil the mechanisms behind emotion processing during the postpartum period, which, in turn, may be of relevance for the development of postpartum depression. The present study sought to longitudinally investigate the neural correlates of emotion anticipation during the postpartum period in healthy women. Functional magnetic resonance imaging was employed (...) the late postpartum period. This was accompanied by a negative relationship with insular reactivity during the early postpartum period and a trend towards an increase in insular reactivity in the late postpartum period. Thus, during the first four weeks of the postpartum period, a diminished top-down regulatory feedback on emotion-related areas of the brain was noted. This finding suggests a physiologically important adaptation during the healthy postpartum period.

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2017 Scientific reports

188. The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study (PubMed)

The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study Suicidal behaviors result from a complex interaction between social stressors and individual vulnerability. However, little is known of the specific neural network supporting the sensitivity to social stressors in patients at risk of suicidal acts. Using functional Magnetic Resonance Imaging, we investigated brain processing of social rejection in suicide attempters. Thirty-six euthymic women (...) with a history of depression and suicidal behavior were compared to 41 euthymic women with a history of depression but no suicidal attempt, and 28 healthy controls. The Cyberball Game was used as a validated social exclusion paradigm. Relative to healthy controls, both patient groups reported higher levels of social distress related to the task, without significant differences according to suicidal status. Compared to patients without any history of suicide attempt and healthy controls, suicide attempters

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2017 Scientific reports

189. Hyperarousal and Beyond: New Insights to the Pathophysiology of Insomnia Disorder through Functional Neuroimaging Studies (PubMed)

Hyperarousal and Beyond: New Insights to the Pathophysiology of Insomnia Disorder through Functional Neuroimaging Studies Neuroimaging studies have produced seemingly contradictory findings in regards to the pathophysiology of insomnia. Although most study results are interpreted from the perspective of a "hyperarousal" model, the aggregate findings from neuroimaging studies suggest a more complex model is needed. We provide a review of the major findings from neuroimaging studies, then discuss (...) them in relation to a heuristic model of sleep-wake states that involves three major factors: wake drive, sleep drive, and level of conscious awareness. We propose that insomnia involves dysregulation in these factors, resulting in subtle dysregulation of sleep-wake states throughout the 24 h light/dark cycle.

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2017 Brain sciences

190. New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features (PubMed)

New-Onset Refractory Status Epilepticus with Claustrum Damage: Definition of the Clinical and Neuroimaging Features New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign characterized by bilateral lesions of the claustrum. The group (...) vegetative state. Among survivors, 80% developed drug-resistant epilepsy. Febrile illness-related SE associated with bilateral claustrum hyperintensity on MRI represents a condition with defined clinical features and a presumed but unidentified autoimmune etiology. A better characterization of de novo SE is mandatory for the search of specific etiologies.

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2017 Frontiers in neurology

191. A systemic literature review of neuroimaging studies in women with breast cancer treated with adjuvant chemotherapy (PubMed)

with chemotherapy (CTx). First, we discuss the host-related and disease-related mechanisms underlying cognitive impairment after CTx. We point out the direct and indirect neurotoxic effect of cytostatics, which may cause: a damage to neurons or glial cells, changes in neurotransmitter levels, deregulation of the immune system and/or cytokine release. Second, we focus on the results of neuroimaging studies on brain structure and function that revealed decreased: density of grey matter, integrity of white matter (...) A systemic literature review of neuroimaging studies in women with breast cancer treated with adjuvant chemotherapy Chemotherapy-induced cognitive deficits in patients with breast cancer, predominantly in attention and verbal memory, have been observed in numerous studies. These neuropsychological findings are corroborated by the results of neuroimaging studies. The aim of this paper was to survey the reports on cerebral structural and functional alterations in women with breast cancer treated

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2017 Contemporary Oncology

192. Behind binge eating: A review of food-specific adaptations of neurocognitive and neuroimaging tasks (PubMed)

and control-related processes may contribute to dysregulated eating and other impulsive behaviors in binge-eating populations, but the best methods for reliably assessing the contributions of these processes to binge eating are unclear. In this review, we summarize standard neurocognitive and neuroimaging tasks that assess reward and control-related processes, describe adaptations of these tasks used to study eating and food-specific responsivity and deficits, and consider the advantages and limitations (...) Behind binge eating: A review of food-specific adaptations of neurocognitive and neuroimaging tasks Recurrent binge eating, or overeating accompanied by a sense of loss of control, is a major public health concern. Identifying similarities and differences among individuals with binge eating and those with other psychiatric symptoms and characterizing the deficits that uniquely predispose individuals to eating problems are essential to improving treatment. Research suggests that altered reward

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2017 Physiology & behavior

193. Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging (PubMed)

Cerebral Pathology and Cognition in Diabetes: The Merits of Multiparametric Neuroimaging Type 2 diabetes mellitus is associated with accelerated cognitive decline and various cerebral abnormalities visible on MRI. The exact pathophysiological mechanisms underlying cognitive decline in diabetes still remain to be elucidated. In addition to conventional images, MRI offers a versatile set of novel contrasts, including blood perfusion, neuronal function, white matter microstructure, and metabolic (...) function. These more-advanced multiparametric MRI contrasts and the pertaining parameters are able to reveal abnormalities in type 2 diabetes, which may be related to cognitive decline. To further elucidate the nature of the link between diabetes, cognitive decline, and brain abnormalities, and changes over time thereof, biomarkers are needed which can be provided by advanced MRI techniques. This review summarizes to what extent MRI, especially advanced multiparametric techniques, can elucidate

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2017 Frontiers in neuroscience

194. Neuroimaging Markers Associated with Maintenance of Optimal Memory Performance in Late-Life (PubMed)

Neuroimaging Markers Associated with Maintenance of Optimal Memory Performance in Late-Life Age-related memory decline has been well-documented; however, some individuals reach their 8th-10th decade while maintaining strong memory performance.To determine which demographic and biomarker factors differentiated top memory performers (aged 75+, top 20% for memory) from their peers and whether top memory performance was maintained over 3 years.Clinically normal adults (n=125, CDR=0; age: 79.5±3.57 (...) years) from the Harvard Aging Brain Study underwent cognitive testing and neuroimaging (amyloid PET, MRI) at baseline and 3-year follow-up. Participants were grouped into Optimal (n=25) vs. Typical (n=100) performers using performance on 3 challenging memory measures. Non-parametric tests were used to compare groups.There were no differences in age, sex, or education between Optimal vs. Typical performers. The Optimal group performed better in Processing Speed (p=0.016) and Executive Functioning (p

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2017 Neuropsychologia

195. Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging (PubMed)

discusses evidence from neurophysiological and neuroimaging studies in schizophrenia patients that nicotinic agonists may effectively target dysfunctional neuronal circuits in the illness. Evidence suggests that nicotine significantly modulates a number of these circuits, although relatively few studies have used modern neuroimaging techniques (e.g. functional magnetic resonance imaging (fMRI)) to examine the effects of nicotinic drugs on disease-related neurobiology. The neuronal effects of nicotine (...) Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging Patients with schizophrenia self-administer nicotine at rates higher than is self-administered for any other psychiatric illness. Although the reasons are unclear, one hypothesis suggests that nicotine is a form of 'self-medication' in order to restore normal levels of nicotinic signaling and target abnormalities in neuronal function associated with cognitive processes. This brief review

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2017 Journal of psychopharmacology (Oxford, England)

196. Differentiating Emotional Processing and Attention in Psychopathy with Functional Neuroimaging (PubMed)

Differentiating Emotional Processing and Attention in Psychopathy with Functional Neuroimaging Individuals with psychopathy are often characterized by emotional processing deficits, and recent research has examined the specific contexts and cognitive mechanisms that underlie these abnormalities. Some evidence suggests that abnormal features of attention are fundamental to emotional deficits in persons with psychopathy, but few studies have demonstrated the neural underpinnings responsible (...) for such effects. Here, we use functional neuroimaging to examine attention-emotion interactions among incarcerated individuals (n = 120) evaluated for psychopathic traits using the Hare Psychopathy Checklist-Revised (PCL-R). Using a task designed to manipulate attention to emotional features of visual stimuli, we demonstrate effects representing implicit emotional processing, explicit emotional processing, attention-facilitated emotional processing, and vigilance for emotional content. Results confirm

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2017 Cognitive, affective & behavioral neuroscience

197. Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease (PubMed)

of APOE with cerebrospinal fluid (CSF) and neuroimaging biomarkers of LOAD.Whole genome sequencing (WGS) was performed on 817 blood DNA samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Sequence data from 757 non-Hispanic Caucasian participants was used in the present analysis. We extracted all rare variants (MAF (minor allele frequency) < 0.05) within a 312 kb window in APOE's vicinity encompassing 12 genes. We assessed CSF and neuroimaging (MRI and PET) biomarkers as LOAD-related (...) -related CSF Aβ1-42 and neuroimaging biomarkers after adjusting for APOE genotype. These findings warrant further investigation and illustrate the role of next generation sequencing and quantitative endophenotypes in assessing rare variants which may help explain missing heritability in AD and other complex diseases.

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2017 BMC medical genomics

198. Neuroimaging the traumatized self: fMRI reveals altered response in cortical midline structures and occipital cortex during visual and verbal self- and other-referential processing in women with PTSD (PubMed)

Neuroimaging the traumatized self: fMRI reveals altered response in cortical midline structures and occipital cortex during visual and verbal self- and other-referential processing in women with PTSD Background: Changes to the diagnostic criteria for PTSD in DSM-5 reflect an increased emphasis on negative cognition referring to self and other, including self-blame, and related pervasive negative affective states including for self-conscious emotions such as guilt and shame. Objective (...) : Investigate the neural correlates of valenced self-referential processing (SRP) and other-referential processing (ORP) in persons with PTSD. Method: We compared response to the Visual-Verbal Self-Other Referential Processing Task in an fMRI study of women with (n = 20) versus without (n = 24) PTSD primarily relating to childhood and interpersonal trauma histories using statistical parametric mapping and group independent component analysis. Results: As compared to women without PTSD, women with PTSD

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2017 European Journal of Psychotraumatology

199. “Embodied Body Language”: an electrical neuroimaging study with emotional faces and bodies (PubMed)

“Embodied Body Language”: an electrical neuroimaging study with emotional faces and bodies To date, most investigations in the field of affective neuroscience mainly focused on the processing of facial expressions, overlooking the exploration of emotional body language (EBL), its capability to express our emotions notwithstanding. Few electrophysiological studies investigated the time course and the neural correlates of EBL and the integration of face and body emotion-related information (...) window and results showed that incongruent stimuli elicited a modulation of the N400 in all comparisons except for body-face condition. This modulation was mainly detected in the Middle Temporal Gyrus and within regions related to the mirror mechanism. More specifically, while the perception of incongruent facial expressions activates somatosensory-related representations, incongruent emotional body postures also require the activation of motor and premotor representations, suggesting a strict link

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2017 Scientific reports

200. Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies (PubMed)

using behavioral and polysomnography outcomes has not definitively disentangled the reduced-sleep-need and reduced-sleep-ability views. Therefore, this review examines the neuroimaging literature to determine whether age-related changes in sleep cause-or are caused by-age-related changes in brain structure, function, and pathology.In middle-aged and older adults, poorer sleep quality, greater nighttime hypoxia, and shorter sleep duration related to cortical thinning in frontal regions implicated (...) Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies Sleep habits, sleep physiology, and sleep disorders change with increasing age. However, there is a longstanding debate regarding whether older adults need sleep to maintain health and daily functioning (reduced-sleep-need view). An alternative possibility is that all older adults need sleep, but that many older adults have lost the ability to obtain restorative sleep (reduced-sleep-ability view). Prior research

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2017 Current Sleep Medicine Reports

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