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Headache-Related Neuroimaging

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1. Headache-Related Neuroimaging

Headache-Related Neuroimaging Headache-Related Neuroimaging Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Headache-Related (...) Neuroimaging Headache-Related Neuroimaging Aka: Headache-Related Neuroimaging , Neuroimaging in Headache II. Indications s III. Protocol: Imaging selection Immunocompromised with and without contrast suspected in age >60 years with and without contrast Requires starting s and obtaining temporal artery biopsy Suspected or without contrast Start antibiotics and obtain Pregnancy and severe (preferred) or Suspected carotid dissection with severe unilateral with and without contrast and MRA of the head and neck

2018 FP Notebook

2. Neuroimaging of headaches in patients with normal neurological examination: protocol for a systematic review. (PubMed)

Neuroimaging of headaches in patients with normal neurological examination: protocol for a systematic review. Headache disorders (HD) are among the most frequent neurological disorders seen in neurology practice. Because secondary HD are rare, patients' examination is most often unremarkable. However, the will to relieve patients' anxiety and the fear of prosecutions lead to overuse of neuroimaging thus resulting in the discovery of incidental findings (IF) or normal variants that can lead (...) to futile or harmful procedures. Knowing the probability of identifying a potentially clinically significant lesion in patients with isolated headache could facilitate decision-making and reduce health costs. This review aims to determine the prevalence of incidental findings and normal anatomic variants (NAV) on neuroimaging studies performed in patients presenting with headache and normal neurological examination.Studies reporting neuroimaging findings in patients with headache and normal neurological

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2018 BMJ open

3. Unnecessary Neuroimaging for Patients With Primary Headaches. (PubMed)

Unnecessary Neuroimaging for Patients With Primary Headaches. Background - Headache may be due to either a primary or secondary disorder, and neuroimaging assessments can play an important role when differentiating between these types of headache. Although many studies have reported no significant differences between primary headache patients and the general population in terms of abnormal neuroimaging findings, others have shown that neuroimaging may be employed to rule out secondary causes (...) of headache that could impact morbidity and mortality. This issue remains under debate. Thus, the present study compared the neuroimaging findings of headache patients and healthy controls. Methods - This study recruited 1070 healthy controls and 1070 primary headache patients from the Chinese People's Liberation Army General Hospital. The primary headache patients were diagnosed by computerized clinical decision support systems, and re-diagnosed by a specialist. All participants were assessed with either

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2018 Headache

4. Emergency Department Use of Neuroimaging in Children and Adolescents Presenting with Headache. (PubMed)

Emergency Department Use of Neuroimaging in Children and Adolescents Presenting with Headache. To evaluate emergency department use and outcomes of neuroimaging for headache in a free-standing children's hospital system.We prospectively enrolled children aged 6-18 years who presented to the emergency department with a chief complaint of headache from September 2015 to September 2016. Standardized data collection was performed in real time, including telephone follow-up as needed, and imaging (...) outcome was determined through a chart review. Using multivariable logistic regression, we estimated the associations between clinically important patient characteristics and neuroimaging.Of 294 enrolled patients, 53 (18%) underwent neuroimaging (computed tomography or magnetic resonance imaging) and 2 (0.7%) had clinically important intracranial findings. Presenting with abnormal neurologic examination findings (OR, 11.55; 95% CI, 3.24-41.22), no history of similar headaches (OR, 2.13; 95% CI, 1.08

2018 Journal of Pediatrics

5. Occipital headaches and neuroimaging in children. (PubMed)

Occipital headaches and neuroimaging in children. To investigate the common thinking, as reinforced by the International Classification of Headache Disorders, 3rd edition (beta), that occipital headaches in children are rare and suggestive of serious intracranial pathology.We performed a retrospective chart review cohort study of all patients ≤18 years of age referred to a university child neurology clinic for headache in 2009. Patients were stratified by headache location: solely occipital (...) , occipital plus other area(s) of head pain, or no occipital involvement. Children with abnormal neurologic examinations were excluded. We assessed location as a predictor of whether neuroimaging was ordered and whether intracranial pathology was found. Analyses were performed with cohort study tools in Stata/SE 13.0 (StataCorp, College Station, TX).A total of 308 patients were included. Median age was 12 years (32 months-18 years), and 57% were female. Headaches were solely occipital in 7% and occipital

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2017 Neurology

6. No evidence for accelerated ageing-related brain pathology in treated HIV: longitudinal neuroimaging results from the Comorbidity in Relation to AIDS (COBRA) project. (PubMed)

No evidence for accelerated ageing-related brain pathology in treated HIV: longitudinal neuroimaging results from the Comorbidity in Relation to AIDS (COBRA) project. Despite successful antiretroviral therapy, people living with human immunodeficiency virus (PLWH) experience higher rates of age-related morbidity, including abnormal brain structure, brain function, and cognitive impairment. This has raised concerns that PLWH may experience accelerated aging-related brain pathology.We performed (...) matter microstructure (P < .005), and greater brain-predicted age difference (P = .01). Longitudinally, there were no significant differences in rates of change in any neuroimaging measure between PLWH and HIV-negative controls (P > .1). Cognitive performance was longitudinally stable in both groups.We found no evidence that middle-aged PLWH, when receiving successful treatment, are at increased risk of accelerated aging-related brain changes or cognitive decline over 2 years.

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2018 Clinical Infectious Diseases

7. The spectrum of neuroimaging findings in febrile infection-related epilepsy syndrome (FIRES): A literature review. (PubMed)

The spectrum of neuroimaging findings in febrile infection-related epilepsy syndrome (FIRES): A literature review. Febrile infection-related epilepsy syndrome (FIRES) is a rare severe epileptic syndrome occurring in previously healthy children and characterized by refractory status epilepticus (SE) following a febrile illness. Brain imaging findings in affected patients have been reported in few case series and some case reports. This article is a comprehensive review of the magnetic resonance

2019 Epilepsia

8. Good practice in food-related neuroimaging. (PubMed)

Good practice in food-related neuroimaging. The use of neuroimaging tools, especially functional magnetic resonance imaging, in nutritional research has increased substantially over the past 2 decades. Neuroimaging is a research tool with great potential impact on the field of nutrition, but to achieve that potential, appropriate use of techniques and interpretation of neuroimaging results is necessary. In this article, we present guidelines for good methodological practice in functional (...) magnetic resonance imaging studies and flag specific limitations in the hope of helping researchers to make the most of neuroimaging tools and avoid potential pitfalls. We highlight specific considerations for food-related studies, such as how to adjust statistically for common confounders, like, for example, hunger state, menstrual phase, and BMI, as well as how to optimally match different types of food stimuli. Finally, we summarize current research needs and future directions, such as the use

2019 American Journal of Clinical Nutrition

9. Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures. (PubMed)

Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures. We aimed to (1) assess and compare baseline plasma and CSF neurofilament light (NfL) for cross-sectional and longitudinal associations with neuroimaging or cognition and (2) determine whether change in plasma NfL corresponded with change in these outcomes.Seventy-nine participants without dementia, median age 76 years, had plasma and CSF NfL, neuropsychological testing, and neuroimaging (MRI (...) , amyloid PET, FDG-PET) at the same study visit, and a repeat visit (15 or 30 months later) with both plasma NfL and neuroimaging. Plasma NfL was measured on the Simoa-HD1 Platform and CSF NfL with an in-house ELISA. Linear mixed effects models were used to examine the associations between baseline plasma or CSF NfL and cognitive and neuroimaging outcomes adjusting for age, sex, and education. The relationship between change in plasma NfL and change in the outcomes was assessed using linear

2019 Neurology

10. Corrigendum to "The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes" [NeuroImage 111 (2015) 611-621]. (PubMed)

Corrigendum to "The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes" [NeuroImage 111 (2015) 611-621]. 27320028 2018 08 22 1095-9572 137 2016 08 15 NeuroImage Neuroimage Corrigendum to "The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes" [NeuroImage 111 (2015) 611-621]. 212 S1053-8119(16)00161-0 10.1016/j.neuroimage.2016.02.052 Fox Kieran C (...) Institute of Cognitive Science, University of Colorado Boulder, UCB 594, Boulder, CO 80309-0594, USA. Christoff Kalina K Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B.C. V6T 1Z4, Canada; Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, B.C. V6T 2B5, Canada. eng Journal Article Published Erratum 2016 03 04 United States Neuroimage 9215515 1053-8119 Neuroimage. 2015 May 1;111:611-21 25725466 2016 6 21 6 0 2016 6 21 6 1 2016 6 21

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2016 NeuroImage

11. Clinical Outcomes and Neuroimaging Profiles in Nondisabled Patients With Anticoagulant-Related Intracerebral Hemorrhage. (PubMed)

Clinical Outcomes and Neuroimaging Profiles in Nondisabled Patients With Anticoagulant-Related Intracerebral Hemorrhage. Background and Purpose- The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K antagonist (VKA)-related intracerebral hemorrhage (ICH). Methods- Prospective 12-month observational study in 15 tertiary stroke centers in the United States (...) , Europe, and Asia. Consecutive patients with premorbid modified Rankin Scale score of <2 with acute nontraumatic anticoagulant-related ICH divided into 2 groups according to the type of anticoagulant: NOAC versus VKA. We recorded baseline ICH volume, significant hematoma expansion (absolute [12.5 mL] or relative [>33%] increase), neurological severity measured by National Institutes of Health Stroke Scale score, 90-day mortality, and functional status (modified Rankin Scale score). Results- Our cohort

2018 Stroke

12. Is formal thought disorder in schizophrenia related to structural and functional aberrations in the language network? A systematic review of neuroimaging findings. (PubMed)

Is formal thought disorder in schizophrenia related to structural and functional aberrations in the language network? A systematic review of neuroimaging findings. Formal thought disorder (FTD) is a core feature of schizophrenia, a marker of illness severity and a predictor of outcome. The underlying neural mechanisms are still a matter of debate. This study aimed at 1) reviewing the literature on the neural correlates of FTD in schizophrenia, and 2) testing the hypothesis that FTD correlates (...) with structural and functional aberrations in the language network. Medline, PsychInfo, and Embase were searched for neuroimaging studies, which applied a clinical measure to assess FTD in adults with schizophrenia and were published in English or German in peer-reviewed journals until December 2016. Of 412 articles identified, 61 studies were included in the review. Volumetric studies reported bilateral grey matter deficits (L > R) to be associated with FTD in the inferior frontal gyrus, the superior

2018 Schizophrenia Research

13. Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders. (PubMed)

Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders. Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case-control differences in the patterns of task-related brain activation. Differently activated regions are often ascribed disorder-specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta-analysis of data from

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2018 Human brain mapping

14. Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases (PubMed)

Role of Neuroimaging on Differentiation of Parkinson’s Disease and Its Related Diseases An accurate diagnosis of Parkinson's disease (PD) is a prerequisite for therapeutic management. In spite of recent advances in the diagnosis of parkinsonian disorders, PD is misdiagnosed in between 6 and 25% of patients, even in specialized movement disorder centers. Although the gold standard for the diagnosis of PD is a neuropathological assessment, neuroimaging has been playing an important role (...) , and vascular parkinsonism. Moreover, difficulties are associated with the clinical differentiation of patients with parkinsonism from those with Alzheimer's disease. In this review, we summarize the typical imaging findings of PD and its related diseases described above using morphological imaging modalities (conventional MR imaging and neuromelanin MR imaging) and functional imaging modalities (99mTc-ethyl cysteinate dimer perfusion single photon emission computed tomography, 123I-metaiodobenzylguanidine

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2018 Yonago acta medica

15. Neuroimaging alterations related to status epilepticus in an adult population: Definition of MRI findings and clinical-EEG correlation. (PubMed)

Neuroimaging alterations related to status epilepticus in an adult population: Definition of MRI findings and clinical-EEG correlation. Magnetic resonance imaging (MRI) provides an opportunity for identifying peri-ictal MRI abnormalities (PMAs) related to status epilepticus (SE). Extremely variable MRI alterations have been reported previously during or after SE, mainly in small selected populations. In a retrospective monocentric study, we analyzed brain MRI changes observed in the ictal (...) /postictal periods of SE in an adult population. We included all consecutive patients observed in a 5-year period with an electroclinical diagnosis of SE and an MRI performed within 30 days from the beginning of SE. We identified 277 patients. Among them, 32 (12%) showed PMAs related to SE. The duration of SE was strongly associated with MRI alterations, showing a mean duration of 6 days vs 2 days (P = .011) in the group with and without MRI alterations, respectively. Focal electroencephalography (EEG

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2018 Epilepsia

16. Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities acutely following a mild traumatic brain injury. (PubMed)

Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities acutely following a mild traumatic brain injury. To determine whether a panel of blood-based biomarkers can discriminate between patients with suspected mild traumatic brain injury (mTBI) with and without neuroimaging findings (CT and MRI).Study participants presented to the emergency department with suspected mTBI (n = 277) with a CT and MRI scan and healthy controls (n = 49). Plasma concentrations of tau, glial (...) with trauma-related intracranial findings on CT compared with those with normal CT, with the only significant predictor being GFAP (AUC 0.77, 95% CI 0.70-0.84). Among patients with mTBI, tau, NFL, and GFAP differentiated subjects with and without MRI abnormalities with an AUC of 0.83, with GFAP being the strongest predictor. Combining tau, NFL, and GFAP showed a good discriminatory power (AUC 0.80, 95% CI 0.69-0.90) for detecting MRI abnormalities, even in patients with mTBI with a normal CT.Our study

2018 Neurology

17. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. (PubMed)

Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. To report radiological findings observed in computed tomography (CT) and magnetic resonance imaging (MRI) scans of the first cases of congenital infection and microcephaly presumably associated with the Zika virus in the current Brazilian epidemic.Retrospective study with a case series.Association for Assistance of Disabled Children

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2016 BMJ

18. Migraine and Tension Headache

Migraine and Tension Headache ? 2018 Kaiser Foundation Health Plan of Washington. All rights reserved. 1 Migraine and Tension Headache Guideline Background 2 Diagnosis Red flag warning signs 2 Differential diagnosis 2 Imaging 3 Migraine versus tension headache 3 Medication overuse headache 3 Menstruation-related migraine 3 Tension Headache Acute treatment 4 Prophylaxis 5 Migraine Headache Acute treatment 6 Treatment of refractory migraine 7 Prophylaxis 8 Menstruation-related migraine (...) -related migraine headache Source: International Headache Society 2013 Episodes of migraine without aura (as defined in Table 1) occurring in the window of 2 days before to 3 days after menstruation, in at least two out of three menstrual cycles. (Menstruation is endometrial bleeding resulting from either the normal menstrual cycle or from the withdrawal of exogenous progestogens, as in the use of combined oral contraceptives or cyclical hormone replacement therapy.) 4 Tension Headache Acute treatment

2018 Kaiser Permanente Clinical Guidelines

19. Headache

[7], Europe, and North America [2,8,9] than by those of Asian countries [10]. A survey of the Canadian population showed that only about 20% of people there are headache free [11]. Prevalence studies on migraine show that genetic factors are related to prevalence as well as gender differences, as migraines affect approximately 15%–18% of women and 6% of men [5,12-14]. Headaches occur most commonly between the ages of 25–55 years. Muscle contraction or tension accounts for most of the nonmigraine (...) headaches 15 or more days per month. The classification of these disorders continues to undergo revision to be more clinically relevant [27]. In adult and pediatric patients with migraine, with no recent change in attack pattern, history of seizures, or other focal neurological symptoms or signs, the routine use of neuroimaging is usually not warranted [28]. The yield of CT or MRI in patients with headache but normal neurological examination was reviewed by Frishberg [29]. The scans examined in most

2019 American College of Radiology

20. Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache

the following clinical questions: (1) In the adult emergency department patient presenting with acute headache, are 60 there risk-stratification strategies that reliably identify the need for emergent neuroimaging? (2) In the adult 61 emergency department patient treated for acute primary headache, are nonopioids preferred to opioid medications? 62 (3) In the adult emergency department patient presenting with acute headache, does a normal noncontrast head 63 computed tomography scan performed within 6 hours (...) presenting with a headache complaint underwent imaging, with up 75 to 5.5% of this imaged group receiving a significant pathologic diagnosis. 2 More recent data have demonstrated up 76 to 31% of headache patients require neuroimaging. 3 Given the potentially complex and often undifferentiated 77 clinical presentation of headache in the acute setting, emergency physicians must determine which patients need 78 neuroimaging in the ED and which can be appropriately referred for evaluation in the outpatient

2019 American College of Emergency Physicians

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